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Protein

Fascin

Gene

Fscn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • actin filament binding Source: MGI
  • drug binding Source: UniProtKB
  • protein binding, bridging Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fascin
Alternative name(s):
Singed-like protein
Gene namesi
Name:Fscn1
Synonyms:Fan1, Snl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1352745 Fscn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00002193802 – 493FascinAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei38PhosphoserineBy similarity1
Modified residuei39Phosphoserine; by PKCBy similarity1
Modified residuei74N6-acetyllysineCombined sources1
Modified residuei127PhosphoserineBy similarity1
Modified residuei234PhosphoserineBy similarity1
Modified residuei239PhosphothreonineBy similarity1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei403PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61553
PaxDbiQ61553
PeptideAtlasiQ61553
PRIDEiQ61553

2D gel databases

REPRODUCTION-2DPAGEiIPI00353563

PTM databases

iPTMnetiQ61553
PhosphoSitePlusiQ61553
SwissPalmiQ61553

Expressioni

Tissue specificityi

Most abundant in brain. Found in other tissues including uterus, small intestine and spleen.

Gene expression databases

BgeeiENSMUSG00000029581 Expressed in 341 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiQ61553 baseline and differential
GenevisibleiQ61553 MM

Interactioni

Subunit structurei

Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development (PubMed:24720729). Associates with beta-catenin (PubMed:8794867). Interacts with PLXNB3 (PubMed:21706053).3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199590, 1 interactor
DIPiDIP-54657N
IntActiQ61553, 5 interactors
MINTiQ61553
STRINGi10090.ENSMUSP00000031565

Structurei

3D structure databases

ProteinModelPortaliQ61553
SMRiQ61553
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Composed of four beta-trefoil domains.By similarity

Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000267034
HOVERGENiHBG000968
InParanoidiQ61553
KOiK17455
OMAiCTAKAPG
OrthoDBiEOG091G0C6S
PhylomeDBiQ61553
TreeFamiTF323992

Family and domain databases

CDDicd00257 Fascin, 4 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030146 FSCN1
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF8 PTHR10551:SF8, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 4 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61553-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTANGTAEAV QIQFGLISCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ
60 70 80 90 100
PPDEAGSAAV CLRSHLGRYL AADKDGNVTC EREVPDGDCR FLVVAHDDGR
110 120 130 140 150
WSLQSEAHRR YFGGTEDRLS CFAQSVSPAE KWSVHIAMHP QVNIYSVTRK
160 170 180 190 200
RYAHLSARPA DEIAVDRDVP WGVDSLITLA FQDQRYSVQT SDHRFLRHDG
210 220 230 240 250
RLVARPEPAT GFTLEFRSGK VAFRDCEGRY LAPSGPSGTL KAGKATKVGK
260 270 280 290 300
DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR
310 320 330 340 350
DTRKCAFRTH TGKYWTLTAT GGVQSTASTK NASCYFDIEW CDRRITLRAS
360 370 380 390 400
NGKFVTAKKN GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV
410 420 430 440 450
TGTLDANRSS YDVFQLEFND GAYNIKDSTG KYWTVGSDSS VTSSSDTPVD
460 470 480 490
FFLEFCDYNK VALKVGGRYL KGDHAGVLKA CAETIDPASL WEY
Length:493
Mass (Da):54,508
Last modified:May 1, 2007 - v4
Checksum:i1C6DCD5211B74969
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7BDR1F7BDR1_MOUSE
Fascin
Fscn1
241Annotation score:
A0A0G2JDU7A0A0G2JDU7_MOUSE
Fascin
Fscn1
332Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64S → T in AAB41126 (PubMed:7738015).Curated1
Sequence conflicti64S → T in AAB58784 (PubMed:8794867).Curated1
Sequence conflicti262Q → E in AAB41126 (PubMed:7738015).Curated1
Sequence conflicti262Q → E in AAB58784 (PubMed:8794867).Curated1
Sequence conflicti271R → G in AAB41126 (PubMed:7738015).Curated1
Sequence conflicti271R → G in AAB58784 (PubMed:8794867).Curated1
Sequence conflicti362 – 363QL → HV in AAB41126 (PubMed:7738015).Curated2
Sequence conflicti362 – 363QL → HV in AAB58784 (PubMed:8794867).Curated2
Sequence conflicti387V → A in AAB41126 (PubMed:7738015).Curated1
Sequence conflicti387V → A in AAB58784 (PubMed:8794867).Curated1
Sequence conflicti396G → A in AAB41126 (PubMed:7738015).Curated1
Sequence conflicti396G → A in AAB58784 (PubMed:8794867).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33726 mRNA Translation: AAB41126.1
U90355 Genomic DNA Translation: AAB58784.1
AK167670 mRNA Translation: BAE39719.1
BC010338 mRNA Translation: AAH10338.1
BC037137 mRNA Translation: AAH37137.2
BC052408 mRNA Translation: AAH52408.1
CCDSiCCDS19834.1
PIRiA56430
RefSeqiNP_032010.2, NM_007984.2
UniGeneiMm.289707

Genome annotation databases

EnsembliENSMUST00000031565; ENSMUSP00000031565; ENSMUSG00000029581
GeneIDi14086
KEGGimmu:14086
UCSCiuc009ajl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33726 mRNA Translation: AAB41126.1
U90355 Genomic DNA Translation: AAB58784.1
AK167670 mRNA Translation: BAE39719.1
BC010338 mRNA Translation: AAH10338.1
BC037137 mRNA Translation: AAH37137.2
BC052408 mRNA Translation: AAH52408.1
CCDSiCCDS19834.1
PIRiA56430
RefSeqiNP_032010.2, NM_007984.2
UniGeneiMm.289707

3D structure databases

ProteinModelPortaliQ61553
SMRiQ61553
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199590, 1 interactor
DIPiDIP-54657N
IntActiQ61553, 5 interactors
MINTiQ61553
STRINGi10090.ENSMUSP00000031565

PTM databases

iPTMnetiQ61553
PhosphoSitePlusiQ61553
SwissPalmiQ61553

2D gel databases

REPRODUCTION-2DPAGEiIPI00353563

Proteomic databases

MaxQBiQ61553
PaxDbiQ61553
PeptideAtlasiQ61553
PRIDEiQ61553

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031565; ENSMUSP00000031565; ENSMUSG00000029581
GeneIDi14086
KEGGimmu:14086
UCSCiuc009ajl.1 mouse

Organism-specific databases

CTDi6624
MGIiMGI:1352745 Fscn1

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000267034
HOVERGENiHBG000968
InParanoidiQ61553
KOiK17455
OMAiCTAKAPG
OrthoDBiEOG091G0C6S
PhylomeDBiQ61553
TreeFamiTF323992

Miscellaneous databases

ChiTaRSiFscn1 mouse
PROiPR:Q61553
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029581 Expressed in 341 organ(s), highest expression level in Ammon's horn
ExpressionAtlasiQ61553 baseline and differential
GenevisibleiQ61553 MM

Family and domain databases

CDDicd00257 Fascin, 4 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030146 FSCN1
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF8 PTHR10551:SF8, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 4 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFSCN1_MOUSE
AccessioniPrimary (citable) accession number: Q61553
Secondary accession number(s): O09099
, O09156, Q05DK3, Q7TN32, Q80V75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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