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UniProtKB - Q61549 (AGRE1_MOUSE)

Entry version 179 (25 May 2022)
Sequence version 1 (01 Nov 1997)
Previous versions | rss
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Protein

Adhesion G protein-coupled receptor E1

Gene

Adgre1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

1 Publication

Miscellaneous

Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processAdaptive immunity, Immunity
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-373080, Class B/2 (Secretin family receptors)

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor E1
Alternative name(s):
Cell surface glycoprotein F4/80
EGF-like module receptor 1
EGF-like module-containing mucin-like hormone receptor-like 1
EMR1 hormone receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Adgre1
Synonyms:Emr1, Gpf480
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:106912, Adgre1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000004730

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 644ExtracellularCuratedAdd BLAST617
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei645 – 672Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini673 – 679CytoplasmicCurated7
Transmembranei680 – 701Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini702 – 711ExtracellularCurated10
Transmembranei712 – 735Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini736 – 754CytoplasmicCuratedAdd BLAST19
Transmembranei755 – 776Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini777 – 792ExtracellularCuratedAdd BLAST16
Transmembranei793 – 821Helical; Name=5Sequence analysisAdd BLAST29
Topological domaini822 – 839CytoplasmicCuratedAdd BLAST18
Transmembranei840 – 859Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini860 – 874ExtracellularCuratedAdd BLAST15
Transmembranei875 – 897Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini898 – 931CytoplasmicCuratedAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T-cell development.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001287428 – 931Adhesion G protein-coupled receptor E1Add BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 48PROSITE-ProRule annotation
Disulfide bondi42 ↔ 57PROSITE-ProRule annotation
Disulfide bondi59 ↔ 79PROSITE-ProRule annotation
Disulfide bondi85 ↔ 98PROSITE-ProRule annotation
Disulfide bondi92 ↔ 107PROSITE-ProRule annotation
Disulfide bondi109 ↔ 131PROSITE-ProRule annotation
Disulfide bondi137 ↔ 149PROSITE-ProRule annotation
Disulfide bondi143 ↔ 158PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 171PROSITE-ProRule annotation
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi177 ↔ 189PROSITE-ProRule annotation
Disulfide bondi183 ↔ 198PROSITE-ProRule annotation
Disulfide bondi200 ↔ 220PROSITE-ProRule annotation
Disulfide bondi226 ↔ 239PROSITE-ProRule annotation
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi233 ↔ 248PROSITE-ProRule annotation
Disulfide bondi250 ↔ 270PROSITE-ProRule annotation
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi276 ↔ 286PROSITE-ProRule annotation
Disulfide bondi280 ↔ 295PROSITE-ProRule annotation
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi297 ↔ 317PROSITE-ProRule annotation
Disulfide bondi323 ↔ 336PROSITE-ProRule annotation
Disulfide bondi330 ↔ 345PROSITE-ProRule annotation
Disulfide bondi347 ↔ 366PROSITE-ProRule annotation
Glycosylationi405N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi706N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q61549

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q61549

PRoteomics IDEntifications database

More...PRIDEi		Q61549

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		296129

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q61549, 10 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q61549

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q61549

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000004730, Expressed in bone marrow macrophage and 289 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q61549, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q61549, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		199441, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q61549, 1 interactor

Molecular INTeraction database

More...MINTi		Q61549

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000083971

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q61549, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q61549

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 80EGF-like 1PROSITE-ProRule annotationAdd BLAST49
Domaini81 – 132EGF-like 2PROSITE-ProRule annotationAdd BLAST52
Domaini133 – 172EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini173 – 221EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini222 – 271EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST50
Domaini272 – 318EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST47
Domaini319 – 367EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini592 – 641GPSPROSITE-ProRule annotationAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi506 – 508Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4193, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002753_3_7_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q61549

Identification of Orthologs from Complete Genome Data

More...OMAi		PGRFICT

Database of Orthologous Groups

More...OrthoDBi		124090at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q61549

TreeFam database of animal gene trees

More...TreeFami		TF316380

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.220.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR046338, GAIN_dom_sf
IPR017981, GPCR_2-like
IPR001740, GPCR_2_EMR1-like_rcpt
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR009030, Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 5 hits
PF01825, GPS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01128, EMR1HORMONER
PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 7 hits
SM00179, EGF_CA, 7 hits
SM00303, GPS, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57184, SSF57184, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 5 hits
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q61549-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGFWLLLFW GFSGMYRWGM TTLPTLGQTL GGVNECQDTT TCPAYATCTD 
        60         70         80         90        100
TTDSYYCTCK RGFLSSNGQT NFQGPGVECQ DVNECLQSDS PCGPNSVCTN 
       110        120        130        140        150
ILGRAKCSCL RGFSSSTGKD WILGSLDNFL CADVDECLTI GICPKYSNCS 
       160        170        180        190        200
NSVGSYSCTC QPGFVLNGSI CEDEDECVTR DVCPEHATCH NTLGSYYCTC 
       210        220        230        240        250
NSGLESSGGG PMFQGLDESC EDVDECSRNS TLCGPTFICI NTLGSYSCSC 
       260        270        280        290        300
PAGFSLPTFQ ILGHPADGNC TDIDECDDTC PLNSSCTNTI GSYFCTCHPG 
       310        320        330        340        350
FASSNGQLNF KDLEVTCEDI DECTQDPLQC GLNSVCTNVP GSYICGCLPD 
       360        370        380        390        400
FQMDPEGSQG YGNFNCKRIL FKCKEDLILQ SEQIQQCQAV QGRDLGYASF 
       410        420        430        440        450
CTLVNATFTI LDNTCENKSA PVSLQSAATS VSLVLEQATT WFELSKEETS 
       460        470        480        490        500
TLGTILLETV ESTMLAALLI PSGNASQMIQ TEYLDIESKV INEECKENES 
       510        520        530        540        550
INLAARGDKM NVGCFIIKES VSTGAPGVAF VSFAHMESVL NERFFEDGQS 
       560        570        580        590        600
FRKLRMNSRV VGGTVTGEKK EDFSKPIIYT LQHIQPKQKS ERPICVSWNT 
       610        620        630        640        650
DVEDGRWTPS GCEIVEASET HTVCSCNRMA NLAIIMASGE LTMEFSLYII 
       660        670        680        690        700
SHVGTVISLV CLALAIATFL LCRAVQNHNT YMHLHLCVCL FLAKILFLTG 
       710        720        730        740        750
IDKTDNQTAC AIIAGFLHYL FLACFFWMLV EAVMLFLMVR NLKVVNYFSS 
       760        770        780        790        800
RNIKMLHLCA FGYGLPVLVV IISASVQPRG YGMHNRCWLN TETGFIWSFL 
       810        820        830        840        850
GPVCMIITIN SVLLAWTLWV LRQKLCSVSS EVSKLKDTRL LTFKAIAQIF 
       860        870        880        890        900
ILGCSWVLGI FQIGPLASIM AYLFTIINSL QGAFIFLIHC LLNRQVRDEY 
       910        920        930 
KKLLTRKTDL SSHSQTSGIL LSSMPSTSKM G
Length:931
Mass (Da):102,130
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52963A667E8B76B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B2WB94A0A3B2WB94_MOUSE
Adhesion G protein-coupled receptor...
Adgre1
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W8A7A0A3B2W8A7_MOUSE
Adhesion G protein-coupled receptor...
Adgre1
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2W7X0A0A3B2W7X0_MOUSE
Adhesion G protein-coupled receptor...
Adgre1
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X93328 mRNA Translation: CAA63720.1
U66888 mRNA Translation: AAC53184.1
BC075688 mRNA Translation: AAH75688.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS50160.1

NCBI Reference Sequences

More...RefSeqi		NP_034260.1, NM_010130.4
XP_006523664.1, XM_006523601.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730
ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730

Database of genes from NCBI RefSeq genomes

More...GeneIDi		13733

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:13733

UCSC genome browser

More...UCSCi		uc008det.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93328 mRNA Translation: CAA63720.1
U66888 mRNA Translation: AAC53184.1
BC075688 mRNA Translation: AAH75688.1
CCDSiCCDS50160.1
RefSeqiNP_034260.1, NM_010130.4
XP_006523664.1, XM_006523601.1

3D structure databases

AlphaFoldDBiQ61549
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi199441, 1 interactor
IntActiQ61549, 1 interactor
MINTiQ61549
STRINGi10090.ENSMUSP00000083971

Protein family/group databases

MEROPSiP02.951

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ61549, 10 sites
iPTMnetiQ61549
PhosphoSitePlusiQ61549

Proteomic databases

MaxQBiQ61549
PaxDbiQ61549
PRIDEiQ61549
ProteomicsDBi296129

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11973, 731 antibodies from 41 providers

The DNASU plasmid repository

More...DNASUi		13733

Genome annotation databases

EnsembliENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730
ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730
GeneIDi13733
KEGGimmu:13733
UCSCiuc008det.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2015
MGIiMGI:106912, Adgre1
VEuPathDBiHostDB:ENSMUSG00000004730

Phylogenomic databases

eggNOGiKOG4193, Eukaryota
GeneTreeiENSGT00940000161354
HOGENOMiCLU_002753_3_7_1
InParanoidiQ61549
OMAiPGRFICT
OrthoDBi124090at2759
PhylomeDBiQ61549
TreeFamiTF316380

Enzyme and pathway databases

ReactomeiR-MMU-373080, Class B/2 (Secretin family receptors)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		13733, 0 hits in 71 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Adgre1, mouse

Protein Ontology

More...PROi		PR:Q61549
RNActiQ61549, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000004730, Expressed in bone marrow macrophage and 289 other tissues
ExpressionAtlasiQ61549, baseline and differential
GenevisibleiQ61549, MM

Family and domain databases

Gene3Di2.60.220.50, 1 hit
InterProiView protein in InterPro
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR046338, GAIN_dom_sf
IPR017981, GPCR_2-like
IPR001740, GPCR_2_EMR1-like_rcpt
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR009030, Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 5 hits
PF01825, GPS, 1 hit
PRINTSiPR01128, EMR1HORMONER
PR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00181, EGF, 7 hits
SM00179, EGF_CA, 7 hits
SM00303, GPS, 1 hit
SUPFAMiSSF57184, SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 5 hits
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRE1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61549
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 25, 2022
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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