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UniProtKB - Q61549 (AGRE1_MOUSE)
Protein
Adhesion G protein-coupled receptor E1
Gene
Adgre1
Organism
Mus musculus (Mouse)
Status
Functioni
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
1 PublicationMiscellaneous
Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity
GO - Molecular functioni
- calcium ion binding Source: InterPro
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- cell surface receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Adaptive immunity, Immunity |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-MMU-373080, Class B/2 (Secretin family receptors) |
Protein family/group databases
MEROPSi | P02.951 |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G protein-coupled receptor E1Alternative name(s): Cell surface glycoprotein F4/80 EGF-like module receptor 1 EGF-like module-containing mucin-like hormone receptor-like 1 EMR1 hormone receptor |
Gene namesi | Name:Adgre1 Synonyms:Emr1, Gpf480 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106912, Adgre1 |
VEuPathDBi | HostDB:ENSMUSG00000004730 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- external side of plasma membrane Source: MGI
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- cell periphery Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 644 | ExtracellularCuratedAdd BLAST | 617 | |
Transmembranei | 645 – 672 | Helical; Name=1Sequence analysisAdd BLAST | 28 | |
Topological domaini | 673 – 679 | CytoplasmicCurated | 7 | |
Transmembranei | 680 – 701 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 702 – 711 | ExtracellularCurated | 10 | |
Transmembranei | 712 – 735 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 736 – 754 | CytoplasmicCuratedAdd BLAST | 19 | |
Transmembranei | 755 – 776 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 777 – 792 | ExtracellularCuratedAdd BLAST | 16 | |
Transmembranei | 793 – 821 | Helical; Name=5Sequence analysisAdd BLAST | 29 | |
Topological domaini | 822 – 839 | CytoplasmicCuratedAdd BLAST | 18 | |
Transmembranei | 840 – 859 | Helical; Name=6Sequence analysisAdd BLAST | 20 | |
Topological domaini | 860 – 874 | ExtracellularCuratedAdd BLAST | 15 | |
Transmembranei | 875 – 897 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 898 – 931 | CytoplasmicCuratedAdd BLAST | 34 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Deficient mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T-cell development.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000012874 | 28 – 931 | Adhesion G protein-coupled receptor E1Add BLAST | 904 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 48 | PROSITE-ProRule annotation | ||
Disulfide bondi | 42 ↔ 57 | PROSITE-ProRule annotation | ||
Disulfide bondi | 59 ↔ 79 | PROSITE-ProRule annotation | ||
Disulfide bondi | 85 ↔ 98 | PROSITE-ProRule annotation | ||
Disulfide bondi | 92 ↔ 107 | PROSITE-ProRule annotation | ||
Disulfide bondi | 109 ↔ 131 | PROSITE-ProRule annotation | ||
Disulfide bondi | 137 ↔ 149 | PROSITE-ProRule annotation | ||
Disulfide bondi | 143 ↔ 158 | PROSITE-ProRule annotation | ||
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 160 ↔ 171 | PROSITE-ProRule annotation | ||
Glycosylationi | 167 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 177 ↔ 189 | PROSITE-ProRule annotation | ||
Disulfide bondi | 183 ↔ 198 | PROSITE-ProRule annotation | ||
Disulfide bondi | 200 ↔ 220 | PROSITE-ProRule annotation | ||
Disulfide bondi | 226 ↔ 239 | PROSITE-ProRule annotation | ||
Glycosylationi | 229 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 233 ↔ 248 | PROSITE-ProRule annotation | ||
Disulfide bondi | 250 ↔ 270 | PROSITE-ProRule annotation | ||
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 276 ↔ 286 | PROSITE-ProRule annotation | ||
Disulfide bondi | 280 ↔ 295 | PROSITE-ProRule annotation | ||
Glycosylationi | 283 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 297 ↔ 317 | PROSITE-ProRule annotation | ||
Disulfide bondi | 323 ↔ 336 | PROSITE-ProRule annotation | ||
Disulfide bondi | 330 ↔ 345 | PROSITE-ProRule annotation | ||
Disulfide bondi | 347 ↔ 366 | PROSITE-ProRule annotation | ||
Glycosylationi | 405 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 417 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 498 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 706 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q61549 |
PaxDbi | Q61549 |
PRIDEi | Q61549 |
ProteomicsDBi | 296129 |
PTM databases
GlyGeni | Q61549, 10 sites |
iPTMneti | Q61549 |
PhosphoSitePlusi | Q61549 |
Expressioni
Tissue specificityi
In macrophages; but absent from those which are localized within T-cell areas of lymph nodes and spleen. Low level of expression on blood monocytes.
Gene expression databases
Bgeei | ENSMUSG00000004730, Expressed in bone marrow macrophage and 289 other tissues |
ExpressionAtlasi | Q61549, baseline and differential |
Genevisiblei | Q61549, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 199441, 1 interactor |
IntActi | Q61549, 1 interactor |
MINTi | Q61549 |
STRINGi | 10090.ENSMUSP00000083971 |
Miscellaneous databases
RNActi | Q61549, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q61549 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 80 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 81 – 132 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 133 – 172 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 173 – 221 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 222 – 271 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 272 – 318 | EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 47 | |
Domaini | 319 – 367 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 592 – 641 | GPSPROSITE-ProRule annotationAdd BLAST | 50 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 506 – 508 | Cell attachment siteSequence analysis | 3 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000161354 |
HOGENOMi | CLU_002753_3_7_1 |
InParanoidi | Q61549 |
OMAi | PGRFICT |
OrthoDBi | 124090at2759 |
PhylomeDBi | Q61549 |
TreeFami | TF316380 |
Family and domain databases
Gene3Di | 2.60.220.50, 1 hit |
InterProi | View protein in InterPro IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR046338, GAIN_dom_sf IPR017981, GPCR_2-like IPR001740, GPCR_2_EMR1-like_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF12662, cEGF, 1 hit PF07645, EGF_CA, 5 hits PF01825, GPS, 1 hit |
PRINTSi | PR01128, EMR1HORMONER PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00181, EGF, 7 hits SM00179, EGF_CA, 7 hits SM00303, GPS, 1 hit |
SUPFAMi | SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 6 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 7 hits PS01187, EGF_CA, 5 hits PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q61549-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWGFWLLLFW GFSGMYRWGM TTLPTLGQTL GGVNECQDTT TCPAYATCTD
60 70 80 90 100
TTDSYYCTCK RGFLSSNGQT NFQGPGVECQ DVNECLQSDS PCGPNSVCTN
110 120 130 140 150
ILGRAKCSCL RGFSSSTGKD WILGSLDNFL CADVDECLTI GICPKYSNCS
160 170 180 190 200
NSVGSYSCTC QPGFVLNGSI CEDEDECVTR DVCPEHATCH NTLGSYYCTC
210 220 230 240 250
NSGLESSGGG PMFQGLDESC EDVDECSRNS TLCGPTFICI NTLGSYSCSC
260 270 280 290 300
PAGFSLPTFQ ILGHPADGNC TDIDECDDTC PLNSSCTNTI GSYFCTCHPG
310 320 330 340 350
FASSNGQLNF KDLEVTCEDI DECTQDPLQC GLNSVCTNVP GSYICGCLPD
360 370 380 390 400
FQMDPEGSQG YGNFNCKRIL FKCKEDLILQ SEQIQQCQAV QGRDLGYASF
410 420 430 440 450
CTLVNATFTI LDNTCENKSA PVSLQSAATS VSLVLEQATT WFELSKEETS
460 470 480 490 500
TLGTILLETV ESTMLAALLI PSGNASQMIQ TEYLDIESKV INEECKENES
510 520 530 540 550
INLAARGDKM NVGCFIIKES VSTGAPGVAF VSFAHMESVL NERFFEDGQS
560 570 580 590 600
FRKLRMNSRV VGGTVTGEKK EDFSKPIIYT LQHIQPKQKS ERPICVSWNT
610 620 630 640 650
DVEDGRWTPS GCEIVEASET HTVCSCNRMA NLAIIMASGE LTMEFSLYII
660 670 680 690 700
SHVGTVISLV CLALAIATFL LCRAVQNHNT YMHLHLCVCL FLAKILFLTG
710 720 730 740 750
IDKTDNQTAC AIIAGFLHYL FLACFFWMLV EAVMLFLMVR NLKVVNYFSS
760 770 780 790 800
RNIKMLHLCA FGYGLPVLVV IISASVQPRG YGMHNRCWLN TETGFIWSFL
810 820 830 840 850
GPVCMIITIN SVLLAWTLWV LRQKLCSVSS EVSKLKDTRL LTFKAIAQIF
860 870 880 890 900
ILGCSWVLGI FQIGPLASIM AYLFTIINSL QGAFIFLIHC LLNRQVRDEY
910 920 930
KKLLTRKTDL SSHSQTSGIL LSSMPSTSKM G
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B2WB94 | A0A3B2WB94_MOUSE | Adhesion G protein-coupled receptor... | Adgre1 | 296 | Annotation score: | ||
A0A3B2W8A7 | A0A3B2W8A7_MOUSE | Adhesion G protein-coupled receptor... | Adgre1 | 104 | Annotation score: | ||
A0A3B2W7X0 | A0A3B2W7X0_MOUSE | Adhesion G protein-coupled receptor... | Adgre1 | 125 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X93328 mRNA Translation: CAA63720.1 U66888 mRNA Translation: AAC53184.1 BC075688 mRNA Translation: AAH75688.1 |
CCDSi | CCDS50160.1 |
RefSeqi | NP_034260.1, NM_010130.4 XP_006523664.1, XM_006523601.1 |
Genome annotation databases
Ensembli | ENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730 ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730 |
GeneIDi | 13733 |
KEGGi | mmu:13733 |
UCSCi | uc008det.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X93328 mRNA Translation: CAA63720.1 U66888 mRNA Translation: AAC53184.1 BC075688 mRNA Translation: AAH75688.1 |
CCDSi | CCDS50160.1 |
RefSeqi | NP_034260.1, NM_010130.4 XP_006523664.1, XM_006523601.1 |
3D structure databases
AlphaFoldDBi | Q61549 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 199441, 1 interactor |
IntActi | Q61549, 1 interactor |
MINTi | Q61549 |
STRINGi | 10090.ENSMUSP00000083971 |
Protein family/group databases
MEROPSi | P02.951 |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q61549, 10 sites |
iPTMneti | Q61549 |
PhosphoSitePlusi | Q61549 |
Proteomic databases
MaxQBi | Q61549 |
PaxDbi | Q61549 |
PRIDEi | Q61549 |
ProteomicsDBi | 296129 |
Protocols and materials databases
Antibodypediai | 11973, 731 antibodies from 41 providers |
DNASUi | 13733 |
Genome annotation databases
Ensembli | ENSMUST00000004850; ENSMUSP00000004850; ENSMUSG00000004730 ENSMUST00000086763; ENSMUSP00000083971; ENSMUSG00000004730 |
GeneIDi | 13733 |
KEGGi | mmu:13733 |
UCSCi | uc008det.2, mouse |
Organism-specific databases
CTDi | 2015 |
MGIi | MGI:106912, Adgre1 |
VEuPathDBi | HostDB:ENSMUSG00000004730 |
Phylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000161354 |
HOGENOMi | CLU_002753_3_7_1 |
InParanoidi | Q61549 |
OMAi | PGRFICT |
OrthoDBi | 124090at2759 |
PhylomeDBi | Q61549 |
TreeFami | TF316380 |
Enzyme and pathway databases
Reactomei | R-MMU-373080, Class B/2 (Secretin family receptors) |
Miscellaneous databases
BioGRID-ORCSi | 13733, 0 hits in 71 CRISPR screens |
ChiTaRSi | Adgre1, mouse |
PROi | PR:Q61549 |
RNActi | Q61549, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004730, Expressed in bone marrow macrophage and 289 other tissues |
ExpressionAtlasi | Q61549, baseline and differential |
Genevisiblei | Q61549, MM |
Family and domain databases
Gene3Di | 2.60.220.50, 1 hit |
InterProi | View protein in InterPro IPR026823, cEGF IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR046338, GAIN_dom_sf IPR017981, GPCR_2-like IPR001740, GPCR_2_EMR1-like_rcpt IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR009030, Growth_fac_rcpt_cys_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF12662, cEGF, 1 hit PF07645, EGF_CA, 5 hits PF01825, GPS, 1 hit |
PRINTSi | PR01128, EMR1HORMONER PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00181, EGF, 7 hits SM00179, EGF_CA, 7 hits SM00303, GPS, 1 hit |
SUPFAMi | SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 6 hits PS01186, EGF_2, 1 hit PS50026, EGF_3, 7 hits PS01187, EGF_CA, 5 hits PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRE1_MOUSE | |
Accessioni | Q61549Primary (citable) accession number: Q61549 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families