UniProtKB - Q61527 (ERBB4_MOUSE)
Receptor tyrosine-protein kinase erbB-4
Erbb4
Functioni
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 751 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 843 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 724 – 732 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 797 – 799 | ATPPROSITE-ProRule annotation | 3 | |
Nucleotide bindingi | 843 – 848 | ATPPROSITE-ProRule annotation | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- epidermal growth factor receptor binding Source: MGI
- neuregulin binding Source: MGI
- protein homodimerization activity Source: MGI
- protein tyrosine kinase activity Source: MGI
- transcription regulatory region sequence-specific DNA binding Source: MGI
- transmembrane receptor protein tyrosine kinase activity Source: UniProtKB
GO - Biological processi
- cardiac muscle tissue regeneration Source: UniProtKB
- cell fate commitment Source: MGI
- cell migration Source: UniProtKB
- cellular response to epidermal growth factor stimulus Source: MGI
- central nervous system morphogenesis Source: UniProtKB
- embryonic pattern specification Source: UniProtKB
- heart development Source: MGI
- lactation Source: UniProtKB
- mammary gland alveolus development Source: UniProtKB
- mammary gland epithelial cell differentiation Source: UniProtKB
- mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
- multicellular organism development Source: GO_Central
- negative regulation of apoptotic process Source: MGI
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of muscle cell apoptotic process Source: MGI
- negative regulation of neuron migration Source: MGI
- nervous system development Source: MGI
- neural crest cell migration Source: UniProtKB
- olfactory bulb interneuron differentiation Source: UniProtKB
- peptidyl-tyrosine autophosphorylation Source: MGI
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of apoptotic process Source: MGI
- positive regulation of cardiac muscle cell proliferation Source: UniProtKB
- positive regulation of cell migration Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of epithelial cell proliferation Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of glucose import Source: MGI
- positive regulation of kinase activity Source: GO_Central
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
- positive regulation of protein localization to cell surface Source: MGI
- positive regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
- positive regulation of synaptic transmission, GABAergic Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- regulation of cell migration Source: UniProtKB
- signal transduction Source: MGI
- surfactant homeostasis Source: MGI
- synapse assembly Source: SynGO
- synapse maturation Source: MGI
- transmembrane receptor protein tyrosine kinase signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Activator, Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Apoptosis, Lactation, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-1227986, Signaling by ERBB2 R-MMU-1236394, Signaling by ERBB4 R-MMU-1250196, SHC1 events in ERBB2 signaling R-MMU-1250342, PI3K events in ERBB4 signaling R-MMU-1250347, SHC1 events in ERBB4 signaling R-MMU-1251985, Nuclear signaling by ERBB4 R-MMU-1253288, Downregulation of ERBB4 signaling R-MMU-1257604, PIP3 activates AKT signaling R-MMU-1963640, GRB2 events in ERBB2 signaling R-MMU-1963642, PI3K events in ERBB2 signaling R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6785631, ERBB2 Regulates Cell Motility R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8847993, ERBB2 Activates PTK6 Signaling R-MMU-8863795, Downregulation of ERBB2 signaling R-MMU-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor tyrosine-protein kinase erbB-4 (EC:2.7.10.1)Alternative name(s): Proto-oncogene-like protein c-ErbB-4 Cleaved into the following chain: Alternative name(s): s80HER4 |
Gene namesi | Name:Erbb4 Synonyms:Mer4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104771, Erbb4 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: In response to NRG1 treatment, the activated receptor is internalized.
Mitochondrion
- Mitochondrion By similarity
Nucleus
Note: Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD2 colocalizes with YAP1 in the nucleus (By similarity).By similarity
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- basal plasma membrane Source: GO_Central
- basolateral plasma membrane Source: MGI
- caveola Source: MGI
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic density membrane Source: SynGO
- integral component of presynaptic membrane Source: SynGO
- plasma membrane Source: MGI
- postsynaptic membrane Source: UniProtKB
Other locations
- cytoplasm Source: MGI
- GABA-ergic synapse Source: SynGO
- glutamatergic synapse Source: SynGO
- membrane raft Source: MGI
- postsynaptic density Source: MGI
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 652 | ExtracellularSequence analysisAdd BLAST | 627 | |
Transmembranei | 653 – 673 | Sequence analysisAdd BLAST | 21 | |
Topological domaini | 674 – 1308 | CytoplasmicSequence analysisAdd BLAST | 635 |
Keywords - Cellular componenti
Cell membrane, Membrane, Mitochondrion, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000270146 | 26 – 1308 | Receptor tyrosine-protein kinase erbB-4Add BLAST | 1283 | |
ChainiPRO_0000396798 | 676 – 1308 | ERBB4 intracellular domainAdd BLAST | 633 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 56 | By similarity | ||
Glycosylationi | 138 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 156 ↔ 186 | By similarity | ||
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 181 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 189 ↔ 197 | By similarity | ||
Disulfide bondi | 193 ↔ 205 | By similarity | ||
Disulfide bondi | 213 ↔ 221 | By similarity | ||
Disulfide bondi | 217 ↔ 229 | By similarity | ||
Disulfide bondi | 230 ↔ 238 | By similarity | ||
Disulfide bondi | 234 ↔ 246 | By similarity | ||
Disulfide bondi | 249 ↔ 258 | By similarity | ||
Glycosylationi | 253 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 262 ↔ 289 | By similarity | ||
Disulfide bondi | 293 ↔ 304 | By similarity | ||
Disulfide bondi | 308 ↔ 323 | By similarity | ||
Disulfide bondi | 326 ↔ 330 | By similarity | ||
Glycosylationi | 410 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 473 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 495 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 503 ↔ 512 | By similarity | ||
Disulfide bondi | 507 ↔ 520 | By similarity | ||
Disulfide bondi | 523 ↔ 532 | By similarity | ||
Disulfide bondi | 536 ↔ 552 | By similarity | ||
Glycosylationi | 548 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 555 ↔ 569 | By similarity | ||
Disulfide bondi | 559 ↔ 577 | By similarity | ||
Glycosylationi | 576 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 580 ↔ 589 | By similarity | ||
Disulfide bondi | 593 ↔ 614 | By similarity | ||
Disulfide bondi | 617 ↔ 625 | By similarity | ||
Glycosylationi | 620 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 621 ↔ 633 | By similarity | ||
Modified residuei | 875 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1035 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1056 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1150 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1162 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1188 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1202 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1242 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1258 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1284 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q61527 |
PaxDbi | Q61527 |
PeptideAtlasi | Q61527 |
PRIDEi | Q61527 |
PTM databases
GlyConnecti | 2677, 1 N-Linked glycan (1 site) |
GlyGeni | Q61527, 11 sites |
iPTMneti | Q61527 |
PhosphoSitePlusi | Q61527 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000062209, Expressed in rest of cerebellum marginal layer (mouse) and 251 other tissues |
Genevisiblei | Q61527, MM |
Interactioni
Subunit structurei
Monomer in the absence of bound ligand. Homodimer or heterodimer with another ERBB family member upon ligand binding, thus forming heterotetramers.
Interacts with EGFR and ERBB2.
Interacts with DLG2 (via its PDZ domain), DLG3 (via its PDZ domain), DLG4 (via its PDZ domain) and SNTB2 (via its PDZ domain).
Interacts with MUC1.
Interacts (via its PPxy motifs) with WWOX.
Interacts (via the PPxY motif 3 of isoform JM-A CYT-2) with YAP1 (via the WW domain 1 of isoform 1).
Interacts (isoform JM-A CYT-1 and isoform JM-B CYT-1) with WWP1.
Interacts (via its intracellular domain) with TRIM28.
Interacts (via the intracellular domains of both CYT-1 and CYT-2 isoforms) with KAP1; the interaction does not phosphorylate KAP1 but represses ERBB4-mediated transcriptional activity.
Interacts with PRPU, DDX23, MATR3, RBM15, ILF3, KAP1, U5S1, U2SURP, ITCH, HNRNPU, AP2A1, NULC, LEO1, WWP2, IGHG1, HXK1, GRB7 AND ARS2.
Interacts (phosphorylated isoform JM-A CYT-1 and isoform JM-B CYT-1) with PIK3R1.
Interacts with SHC1.
Interacts with GRB2.
Interacts (soluble intracellular domain) with BCL2.
Interacts (phosphorylated) with STAT1 (By similarity).
Interacts with CBFA2T3.
Interacts (soluble intracellular domain) with STAT5A.
By similarity2 PublicationsBinary interactionsi
Q61527
With | #Exp. | IntAct |
---|---|---|
WWOX [Q9NZC7] from Homo sapiens. | 3 | EBI-4398741,EBI-4320739 |
GO - Molecular functioni
- epidermal growth factor receptor binding Source: MGI
- neuregulin binding Source: MGI
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 199498, 5 interactors |
DIPi | DIP-29887N |
IntActi | Q61527, 3 interactors |
STRINGi | 10090.ENSMUSP00000114123 |
Miscellaneous databases
RNActi | Q61527, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 718 – 985 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 268 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 676 – 684 | Nuclear localization signalBy similarity | 9 | |
Motifi | 1032 – 1035 | PPxy motif 1By similarity | 4 | |
Motifi | 1282 – 1285 | PPxY motif 2By similarity | 4 | |
Motifi | 1290 – 1292 | PDZ-bindingBy similarity | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 186 – 262 | Cys-richAdd BLAST | 77 | |
Compositional biasi | 496 – 593 | Cys-richAdd BLAST | 98 | |
Compositional biasi | 1281 – 1284 | Poly-Pro | 4 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1025, Eukaryota |
GeneTreei | ENSGT00940000154695 |
HOGENOMi | CLU_003384_1_1_1 |
InParanoidi | Q61527 |
OMAi | GRCWGPQ |
OrthoDBi | 81952at2759 |
PhylomeDBi | Q61527 |
TreeFami | TF106002 |
Family and domain databases
CDDi | cd00064, FU, 3 hits |
Gene3Di | 3.80.20.20, 2 hits |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016245, Tyr_kinase_EGF/ERB/XmrK_rcpt |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF01030, Recep_L_domain, 2 hits |
PIRSFi | PIRSF000619, TyrPK_EGF-R, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00261, FU, 5 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLATGLWVW GSLLMAAGTV QPSASQSVCA GTENKLSSLS DLEQQYRALR
60 70 80 90 100
KYYENCEVVM GNLEITSIEH NRDLSFLRSI REVTGYVLVA LNQFRYLPLE
110 120 130 140 150
NLRIIRGTKL YEDRYALAIF LNYRKDGNFG LQELGLKNLT EILNGGVYVD
160 170 180 190 200
QNKFLCYADT IHWQDIVRNP WPSNMTLVST NGSSGCGRCH KSCTGRCWGP
210 220 230 240 250
TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG PKDTDCFACM
260 270 280 290 300
NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD
310 320 330 340 350
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS
360 370 380 390 400
SNIDKFINCT KINGNLIFLV TGIHGDPYNA IDAIDPEKLN VFRTVREITG
410 420 430 440 450
FLNIQSWPPN MTDFSVFSNL VTIGGRVLYS GLSLLILKQQ GITSLQFQSL
460 470 480 490 500
KEISAGNIYI TDNSNLCYYH TINWTTLFST INQRIVIRDN RRAENCTAEG
510 520 530 540 550
MVCNHLCSND GCWGPGPDQC LSCRRFSRGK ICIESCNLYD GEFREFENGS
560 570 580 590 600
ICVECDSQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA
610 620 630 640 650
NSFIFKYADQ DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART
660 670 680 690 700
PLIAAGVIGG LFILVIMALT FAVYVRRKSI KKKRALRRFL ETELVEPLTP
710 720 730 740 750
SGTAPNQAQL RILKETELKR VKVLGSGAFG TVYKGIWVPE GETVKIPVAI
760 770 780 790 800
KILNETTGPK ANVEFMDEAL IMASMDHPHL VRLLGVCLSP TIQLVTQLMP
810 820 830 840 850
HGCLLDYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV HRDLAARNVL
860 870 880 890 900
VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ
910 920 930 940 950
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY
960 970 980 990 1000
MVMVKCWMID ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND
1010 1020 1030 1040 1050
SKFFQNLLDE EDLEDMMDAE EYLVPQAFNI PPPIYTSRTR IDSNRSEIGH
1060 1070 1080 1090 1100
SPPPAYTPMS GNQFVYQDGG FATQQGMPMP YRATTSTIPE APVAQGATAE
1110 1120 1130 1140 1150
MFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERN PRGELDEEGY
1160 1170 1180 1190 1200
MTPMHDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHS ASSGPPKAED
1210 1220 1230 1240 1250
EYVNEPLYLN TFANALGSAE YMKNSVLSVP EKAKKAFDNP DYWNHSLPPR
1260 1270 1280 1290 1300
STLQHPDYLQ EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTMLPPPP
YRHRNTVV
The sequence of this isoform differs from the canonical sequence as follows:
626-648: NGPTSHDCIYYPWTGHSTLPQHA → IGSSIEDCIGLTD
The sequence of this isoform differs from the canonical sequence as follows:
1046-1061: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB2KGF7 | B2KGF7_MOUSE | Receptor protein-tyrosine kinase | Erbb4 | 732 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1019 | A → V in AAC28334 (Ref. 5) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002896 | 626 – 648 | NGPTS…LPQHA → IGSSIEDCIGLTD in isoform JM-B CYT-2. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_042131 | 1046 – 1061 | Missing in isoform JM-A CYT-2. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU368746 Genomic DNA No translation available. CU372923 Genomic DNA No translation available. CU392849 Genomic DNA No translation available. CU405881 Genomic DNA No translation available. CU407006 Genomic DNA No translation available. CU459008 Genomic DNA No translation available. CU459207 Genomic DNA No translation available. AK144050 mRNA Translation: BAE25671.1 L47241 mRNA Translation: AAA93534.1 AF059177 mRNA Translation: AAC28334.1 |
CCDSi | CCDS48285.1 [Q61527-3] |
RefSeqi | NP_034284.1, NM_010154.2 [Q61527-3] XP_006495755.1, XM_006495692.3 [Q61527-1] XP_006495756.1, XM_006495693.3 [Q61527-2] |
Genome annotation databases
Ensembli | ENSMUST00000119142; ENSMUSP00000112713; ENSMUSG00000062209 [Q61527-1] ENSMUST00000121473; ENSMUSP00000114123; ENSMUSG00000062209 [Q61527-3] |
GeneIDi | 13869 |
KEGGi | mmu:13869 |
UCSCi | uc007bjb.1, mouse [Q61527-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU368746 Genomic DNA No translation available. CU372923 Genomic DNA No translation available. CU392849 Genomic DNA No translation available. CU405881 Genomic DNA No translation available. CU407006 Genomic DNA No translation available. CU459008 Genomic DNA No translation available. CU459207 Genomic DNA No translation available. AK144050 mRNA Translation: BAE25671.1 L47241 mRNA Translation: AAA93534.1 AF059177 mRNA Translation: AAC28334.1 |
CCDSi | CCDS48285.1 [Q61527-3] |
RefSeqi | NP_034284.1, NM_010154.2 [Q61527-3] XP_006495755.1, XM_006495692.3 [Q61527-1] XP_006495756.1, XM_006495693.3 [Q61527-2] |
3D structure databases
SMRi | Q61527 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199498, 5 interactors |
DIPi | DIP-29887N |
IntActi | Q61527, 3 interactors |
STRINGi | 10090.ENSMUSP00000114123 |
PTM databases
GlyConnecti | 2677, 1 N-Linked glycan (1 site) |
GlyGeni | Q61527, 11 sites |
iPTMneti | Q61527 |
PhosphoSitePlusi | Q61527 |
Proteomic databases
jPOSTi | Q61527 |
PaxDbi | Q61527 |
PeptideAtlasi | Q61527 |
PRIDEi | Q61527 |
Protocols and materials databases
Antibodypediai | 1602, 1394 antibodies |
DNASUi | 13869 |
Genome annotation databases
Ensembli | ENSMUST00000119142; ENSMUSP00000112713; ENSMUSG00000062209 [Q61527-1] ENSMUST00000121473; ENSMUSP00000114123; ENSMUSG00000062209 [Q61527-3] |
GeneIDi | 13869 |
KEGGi | mmu:13869 |
UCSCi | uc007bjb.1, mouse [Q61527-3] |
Organism-specific databases
CTDi | 2066 |
MGIi | MGI:104771, Erbb4 |
Phylogenomic databases
eggNOGi | KOG1025, Eukaryota |
GeneTreei | ENSGT00940000154695 |
HOGENOMi | CLU_003384_1_1_1 |
InParanoidi | Q61527 |
OMAi | GRCWGPQ |
OrthoDBi | 81952at2759 |
PhylomeDBi | Q61527 |
TreeFami | TF106002 |
Enzyme and pathway databases
Reactomei | R-MMU-1227986, Signaling by ERBB2 R-MMU-1236394, Signaling by ERBB4 R-MMU-1250196, SHC1 events in ERBB2 signaling R-MMU-1250342, PI3K events in ERBB4 signaling R-MMU-1250347, SHC1 events in ERBB4 signaling R-MMU-1251985, Nuclear signaling by ERBB4 R-MMU-1253288, Downregulation of ERBB4 signaling R-MMU-1257604, PIP3 activates AKT signaling R-MMU-1963640, GRB2 events in ERBB2 signaling R-MMU-1963642, PI3K events in ERBB2 signaling R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6785631, ERBB2 Regulates Cell Motility R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8847993, ERBB2 Activates PTK6 Signaling R-MMU-8863795, Downregulation of ERBB2 signaling R-MMU-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
BioGRID-ORCSi | 13869, 1 hit in 17 CRISPR screens |
ChiTaRSi | Erbb4, mouse |
PROi | PR:Q61527 |
RNActi | Q61527, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000062209, Expressed in rest of cerebellum marginal layer (mouse) and 251 other tissues |
Genevisiblei | Q61527, MM |
Family and domain databases
CDDi | cd00064, FU, 3 hits |
Gene3Di | 3.80.20.20, 2 hits |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016245, Tyr_kinase_EGF/ERB/XmrK_rcpt |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF01030, Recep_L_domain, 2 hits |
PIRSFi | PIRSF000619, TyrPK_EGF-R, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00261, FU, 5 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57184, SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERBB4_MOUSE | |
Accessioni | Q61527Primary (citable) accession number: Q61527 Secondary accession number(s): B2KGF5 Q3UNS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 25, 2012 | |
Last modified: | December 2, 2020 | |
This is version 186 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index