UniProtKB - Q61526 (ERBB3_MOUSE)
Protein
Receptor tyrosine-protein kinase erbB-3
Gene
Erbb3
Organism
Mus musculus (Mouse)
Status
Functioni
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5.By similarity
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 740 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 832 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 713 – 721 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 786 – 788 | ATPPROSITE-ProRule annotation | 3 | |
Nucleotide bindingi | 832 – 837 | ATPPROSITE-ProRule annotation | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- growth factor binding Source: MGI
- identical protein binding Source: MGI
- neuregulin binding Source: UniProtKB
- neuregulin receptor activity Source: MGI
- protein heterodimerization activity Source: MGI
- protein tyrosine kinase activator activity Source: MGI
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
- ubiquitin protein ligase binding Source: MGI
GO - Biological processi
- cranial nerve development Source: MGI
- endocardial cushion development Source: MGI
- epidermal growth factor receptor signaling pathway Source: MGI
- extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- negative regulation of cell adhesion Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of secretion Source: MGI
- negative regulation of signal transduction Source: MGI
- nervous system development Source: GO_Central
- neuron apoptotic process Source: MGI
- peripheral nervous system development Source: MGI
- phosphatidylinositol 3-kinase signaling Source: MGI
- positive regulation of calcineurin-NFAT signaling cascade Source: MGI
- positive regulation of cardiac muscle tissue development Source: MGI
- positive regulation of cell population proliferation Source: GO_Central
- positive regulation of gene expression Source: MGI
- positive regulation of glucose import Source: MGI
- positive regulation of protein tyrosine kinase activity Source: MGI
- regulation of cell population proliferation Source: MGI
- Schwann cell differentiation Source: MGI
- signal transduction Source: MGI
- transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Keywordsi
Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1 3474 |
Reactomei | R-MMU-1227986 Signaling by ERBB2 R-MMU-1236394 Signaling by ERBB4 R-MMU-1250196 SHC1 events in ERBB2 signaling R-MMU-1257604 PIP3 activates AKT signaling R-MMU-1306955 GRB7 events in ERBB2 signaling R-MMU-1358803 Downregulation of ERBB2:ERBB3 signaling R-MMU-1963642 PI3K events in ERBB2 signaling R-MMU-5673001 RAF/MAP kinase cascade R-MMU-6785631 ERBB2 Regulates Cell Motility R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8847993 ERBB2 Activates PTK6 Signaling R-MMU-8863795 Downregulation of ERBB2 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor tyrosine-protein kinase erbB-3 (EC:2.7.10.1)Alternative name(s): Glial growth factor receptor Proto-oncogene-like protein c-ErbB-3 |
Gene namesi | Name:Erbb3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95411 Erbb3 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein By similarity
Extracellular region or secreted
- extracellular space Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- basal plasma membrane Source: GO_Central
- basolateral plasma membrane Source: MGI
- integral component of plasma membrane Source: GO_Central
- lateral plasma membrane Source: MGI
- postsynaptic membrane Source: MGI
Other locations
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 641 | ExtracellularSequence analysisAdd BLAST | 622 | |
Transmembranei | 642 – 662 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 663 – 1339 | CytoplasmicSequence analysisAdd BLAST | 677 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000042231 | 20 – 1339 | Receptor tyrosine-protein kinase erbB-3Add BLAST | 1320 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 186 ↔ 194 | By similarity | ||
Disulfide bondi | 190 ↔ 202 | By similarity | ||
Disulfide bondi | 210 ↔ 218 | By similarity | ||
Disulfide bondi | 214 ↔ 226 | By similarity | ||
Disulfide bondi | 227 ↔ 235 | By similarity | ||
Disulfide bondi | 231 ↔ 243 | By similarity | ||
Disulfide bondi | 246 ↔ 255 | By similarity | ||
Glycosylationi | 250 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 259 ↔ 286 | By similarity | ||
Disulfide bondi | 290 ↔ 301 | By similarity | ||
Disulfide bondi | 305 ↔ 320 | By similarity | ||
Disulfide bondi | 323 ↔ 327 | By similarity | ||
Glycosylationi | 353 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 408 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 414 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 437 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 469 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 500 ↔ 509 | By similarity | ||
Disulfide bondi | 504 ↔ 517 | By similarity | ||
Disulfide bondi | 520 ↔ 529 | By similarity | ||
Glycosylationi | 522 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 533 ↔ 549 | By similarity | ||
Disulfide bondi | 552 ↔ 565 | By similarity | ||
Disulfide bondi | 556 ↔ 573 | By similarity | ||
Glycosylationi | 566 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 576 ↔ 585 | By similarity | ||
Disulfide bondi | 589 ↔ 610 | By similarity | ||
Disulfide bondi | 613 ↔ 621 | By similarity | ||
Glycosylationi | 616 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 617 ↔ 629 | By similarity | ||
Modified residuei | 684 | PhosphoserineBy similarity | 1 | |
Modified residuei | 980 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q61526 |
PaxDbi | Q61526 |
PeptideAtlasi | Q61526 |
PRIDEi | Q61526 |
PTM databases
iPTMneti | Q61526 |
PhosphoSitePlusi | Q61526 |
Expressioni
Tissue specificityi
In the muscle, expression localizes to the synaptic sites of muscle fibers.
Gene expression databases
Bgeei | ENSMUSG00000018166 Expressed in 293 organ(s), highest expression level in ileum |
Genevisiblei | Q61526 MM |
Interactioni
Subunit structurei
Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4, GRB7 and MUC1 (By similarity). Interacts with MYOC (PubMed:23897819). Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (By similarity).By similarityCurated1 Publication
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Erbb2 | P70424 | 2 | EBI-931878,EBI-2945468 |
GO - Molecular functioni
- growth factor binding Source: MGI
- identical protein binding Source: MGI
- neuregulin binding Source: UniProtKB
- protein heterodimerization activity Source: MGI
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGridi | 199497, 1 interactor |
IntActi | Q61526, 2 interactors |
STRINGi | 10090.ENSMUSP00000080716 |
Structurei
3D structure databases
ProteinModelPortali | Q61526 |
SMRi | Q61526 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 707 – 964 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 258 |
Domaini
The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1025 Eukaryota ENOG410XNSR LUCA |
GeneTreei | ENSGT00940000156107 |
HOGENOMi | HOG000230982 |
HOVERGENi | HBG000490 |
InParanoidi | Q61526 |
KOi | K05084 |
OMAi | SKTHLAM |
OrthoDBi | 81952at2759 |
PhylomeDBi | Q61526 |
TreeFami | TF106002 |
Family and domain databases
CDDi | cd00064 FU, 3 hits |
Gene3Di | 3.80.20.20, 2 hits |
InterProi | View protein in InterPro IPR006211 Furin-like_Cys-rich_dom IPR006212 Furin_repeat IPR032778 GF_recep_IV IPR009030 Growth_fac_rcpt_cys_sf IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR000494 Rcpt_L-dom IPR036941 Rcpt_L-dom_sf IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt |
Pfami | View protein in Pfam PF00757 Furin-like, 1 hit PF14843 GF_recep_IV, 1 hit PF07714 Pkinase_Tyr, 1 hit PF01030 Recep_L_domain, 2 hits |
PIRSFi | PIRSF000619 TyrPK_EGF-R, 1 hit |
PRINTSi | PR00109 TYRKINASE |
SMARTi | View protein in SMART SM00261 FU, 5 hits SM00219 TyrKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit SSF57184 SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q61526-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAIGTLQVL GFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY
60 70 80 90 100
KLYEKCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP
110 120 130 140 150
NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRFTQLT EILLGGVYIE
160 170 180 190 200
KNDKLCHMDT IDWRDIVRVP DAEIVVKNNG GNCPPCHEVC KGRCWGPGPE
210 220 230 240 250
DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD TDCFACRHFN
260 270 280 290 300
DSGACVPRCP APLVYNKLTF QLEPNPHIKY QYGGVCVASC PHNFVVDQTF
310 320 330 340 350
CVRACPADKM EVDKNGLKMC EPCRGLCPKA CEGTGSGSRY QTVDSSNIDG
360 370 380 390 400
FVNCTKILGN LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ
410 420 430 440 450
SWPPHMHNFS VFSNLTTIGG RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS
460 470 480 490 500
AGRVYISANQ QLCYHHSLNW TRLLRGPAEE RLDIKYNRPL GECVAEGKVC
510 520 530 540 550
DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNVLQGEP REFVHEAHCF
560 570 580 590 600
SCHPECQPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI
610 620 630 640 650
YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQAEVLMSKP HLVIAVTVGL
660 670 680 690 700
TVIFLILGGS FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR
710 720 730 740 750
IFKETELRKL KVLGSGVFGT VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS
760 770 780 790 800
FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS LQLVTQYLPL GSLLDHVRQH
810 820 830 840 850
RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML KSPSQVQVAD
860 870 880 890 900
FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW
910 920 930 940 950
ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE
960 970 980 990 1000
NIRPTFKELA NEFTRMARDP PRYLVIKRAS GPGIPPAAEP SALSTKELQD
1010 1020 1030 1040 1050
AELEPDLDLD LDVEVEEEGL ATTLGSALSL PTGTLTRPRG SQSLLSPSSG
1060 1070 1080 1090 1100
YMPMNQSNLG EACLDSAVLG GREQFSRPIS LHPIPRGRQT SESSEGHVTG
1110 1120 1130 1140 1150
SEAELQERVS MCRSRSRSRS PRPRGDSAYH SQRHSLLTPV TPLSPPGLEE
1160 1170 1180 1190 1200
EDGNGYVMPD THLRGTSSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK
1210 1220 1230 1240 1250
RRGSPARPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG
1260 1270 1280 1290 1300
TTPDEDYEYM NRRRGAGGSG GDYAAMGACP AAEQGYEEMR AFQGPGHQAP
1310 1320 1330
HVRYARLKTL RSLEATDSAF DNPDYWHSRL FPKANAQRI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1067 | A → V in AAA93533 (PubMed:7589796).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY686636 mRNA Translation: AAT95433.1 BC029028 mRNA Translation: AAH29028.1 BC049279 mRNA Translation: AAH49279.1 BC106091 mRNA Translation: AAI06092.1 L47240 mRNA Translation: AAA93533.1 |
CCDSi | CCDS24283.1 |
RefSeqi | NP_034283.1, NM_010153.1 |
UniGenei | Mm.373043 |
Genome annotation databases
Ensembli | ENSMUST00000082059; ENSMUSP00000080716; ENSMUSG00000018166 |
GeneIDi | 13867 |
KEGGi | mmu:13867 |
UCSCi | uc007hnm.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY686636 mRNA Translation: AAT95433.1 BC029028 mRNA Translation: AAH29028.1 BC049279 mRNA Translation: AAH49279.1 BC106091 mRNA Translation: AAI06092.1 L47240 mRNA Translation: AAA93533.1 |
CCDSi | CCDS24283.1 |
RefSeqi | NP_034283.1, NM_010153.1 |
UniGenei | Mm.373043 |
3D structure databases
ProteinModelPortali | Q61526 |
SMRi | Q61526 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 199497, 1 interactor |
IntActi | Q61526, 2 interactors |
STRINGi | 10090.ENSMUSP00000080716 |
PTM databases
iPTMneti | Q61526 |
PhosphoSitePlusi | Q61526 |
Proteomic databases
MaxQBi | Q61526 |
PaxDbi | Q61526 |
PeptideAtlasi | Q61526 |
PRIDEi | Q61526 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000082059; ENSMUSP00000080716; ENSMUSG00000018166 |
GeneIDi | 13867 |
KEGGi | mmu:13867 |
UCSCi | uc007hnm.1 mouse |
Organism-specific databases
CTDi | 2065 |
MGIi | MGI:95411 Erbb3 |
Phylogenomic databases
eggNOGi | KOG1025 Eukaryota ENOG410XNSR LUCA |
GeneTreei | ENSGT00940000156107 |
HOGENOMi | HOG000230982 |
HOVERGENi | HBG000490 |
InParanoidi | Q61526 |
KOi | K05084 |
OMAi | SKTHLAM |
OrthoDBi | 81952at2759 |
PhylomeDBi | Q61526 |
TreeFami | TF106002 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1 3474 |
Reactomei | R-MMU-1227986 Signaling by ERBB2 R-MMU-1236394 Signaling by ERBB4 R-MMU-1250196 SHC1 events in ERBB2 signaling R-MMU-1257604 PIP3 activates AKT signaling R-MMU-1306955 GRB7 events in ERBB2 signaling R-MMU-1358803 Downregulation of ERBB2:ERBB3 signaling R-MMU-1963642 PI3K events in ERBB2 signaling R-MMU-5673001 RAF/MAP kinase cascade R-MMU-6785631 ERBB2 Regulates Cell Motility R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-8847993 ERBB2 Activates PTK6 Signaling R-MMU-8863795 Downregulation of ERBB2 signaling |
Miscellaneous databases
ChiTaRSi | Erbb3 mouse |
PROi | PR:Q61526 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018166 Expressed in 293 organ(s), highest expression level in ileum |
Genevisiblei | Q61526 MM |
Family and domain databases
CDDi | cd00064 FU, 3 hits |
Gene3Di | 3.80.20.20, 2 hits |
InterProi | View protein in InterPro IPR006211 Furin-like_Cys-rich_dom IPR006212 Furin_repeat IPR032778 GF_recep_IV IPR009030 Growth_fac_rcpt_cys_sf IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR000494 Rcpt_L-dom IPR036941 Rcpt_L-dom_sf IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR016245 Tyr_kinase_EGF/ERB/XmrK_rcpt |
Pfami | View protein in Pfam PF00757 Furin-like, 1 hit PF14843 GF_recep_IV, 1 hit PF07714 Pkinase_Tyr, 1 hit PF01030 Recep_L_domain, 2 hits |
PIRSFi | PIRSF000619 TyrPK_EGF-R, 1 hit |
PRINTSi | PR00109 TYRKINASE |
SMARTi | View protein in SMART SM00261 FU, 5 hits SM00219 TyrKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit SSF57184 SSF57184, 2 hits |
PROSITEi | View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | ERBB3_MOUSE | |
Accessioni | Q61526Primary (citable) accession number: Q61526 Secondary accession number(s): Q3KQR1 Q8K317 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 13, 2019 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot