Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proepiregulin

Gene

Ereg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (By similarity). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).1 PublicationBy similarity

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • growth factor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-1227986 Signaling by ERBB2
R-MMU-1236394 Signaling by ERBB4
R-MMU-1250196 SHC1 events in ERBB2 signaling
R-MMU-1250342 PI3K events in ERBB4 signaling
R-MMU-1250347 SHC1 events in ERBB4 signaling
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1963640 GRB2 events in ERBB2 signaling
R-MMU-1963642 PI3K events in ERBB2 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6785631 ERBB2 Regulates Cell Motility
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847993 ERBB2 Activates PTK6 Signaling
R-MMU-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Proepiregulin
Cleaved into the following chain:
Epiregulin
Short name:
EPR
Gene namesi
Name:Ereg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107508 Ereg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini53 – 112ExtracellularSequence analysisAdd BLAST60
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 162CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000030280123 – 162ProepiregulinAdd BLAST140
PropeptideiPRO_000000755923 – 551 PublicationAdd BLAST33
ChainiPRO_000000756056 – 101EpiregulinAdd BLAST46
PropeptideiPRO_0000007561102 – 162Removed in mature formBy similarityAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi61 ↔ 74PROSITE-ProRule annotation
Disulfide bondi69 ↔ 85PROSITE-ProRule annotation
Disulfide bondi87 ↔ 96PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61521
PRIDEiQ61521

PTM databases

PhosphoSitePlusiQ61521

Miscellaneous databases

PMAP-CutDBiQ61521

Expressioni

Developmental stagei

Expressed in 7-day-old embryos with levels then falling to very low or undetectable amounts. Not detected in adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000029377 Expressed in 75 organ(s), highest expression level in cumulus cell
CleanExiMM_EREG
GenevisibleiQ61521 MM

Interactioni

Subunit structurei

Interacts with EGFR and ERBB4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031324

Structurei

3D structure databases

ProteinModelPortaliQ61521
SMRiQ61521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 97EGF-likePROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi138 – 145Arg/Lys-rich (basic)8

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXV0 Eukaryota
ENOG410YNFA LUCA
GeneTreeiENSGT00510000048748
HOGENOMiHOG000059635
HOVERGENiHBG005601
InParanoidiQ61521
KOiK09784
OMAiCTALVQM
OrthoDBiEOG091G0SX3
PhylomeDBiQ61521
TreeFamiTF336145

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61521-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METLPASWVL TLLCLGSHLL QAVISTTVIP SCIPGESEDN CTALVQMEDD
60 70 80 90 100
PRVAQVQITK CSSDMDGYCL HGQCIYLVDM REKFCRCEVG YTGLRCEHFF
110 120 130 140 150
LTVHQPLSKE YVALTVILIF LFLIITAGCI YYFCRWYKNR KSKKSREEYE
160
RVTSGDPVLP QV
Length:162
Mass (Da):18,474
Last modified:November 1, 1996 - v1
Checksum:iDA50A10C9386B97D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30782 mRNA Translation: BAA06446.1
BC027838 mRNA Translation: AAH27838.1
CCDSiCCDS19420.1
PIRiJT0747
S68401
RefSeqiNP_031976.1, NM_007950.2
UniGeneiMm.4791

Genome annotation databases

EnsembliENSMUST00000031324; ENSMUSP00000031324; ENSMUSG00000029377
GeneIDi13874
KEGGimmu:13874
UCSCiuc008ybs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30782 mRNA Translation: BAA06446.1
BC027838 mRNA Translation: AAH27838.1
CCDSiCCDS19420.1
PIRiJT0747
S68401
RefSeqiNP_031976.1, NM_007950.2
UniGeneiMm.4791

3D structure databases

ProteinModelPortaliQ61521
SMRiQ61521
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031324

PTM databases

PhosphoSitePlusiQ61521

Proteomic databases

PaxDbiQ61521
PRIDEiQ61521

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031324; ENSMUSP00000031324; ENSMUSG00000029377
GeneIDi13874
KEGGimmu:13874
UCSCiuc008ybs.1 mouse

Organism-specific databases

CTDi2069
MGIiMGI:107508 Ereg

Phylogenomic databases

eggNOGiENOG410IXV0 Eukaryota
ENOG410YNFA LUCA
GeneTreeiENSGT00510000048748
HOGENOMiHOG000059635
HOVERGENiHBG005601
InParanoidiQ61521
KOiK09784
OMAiCTALVQM
OrthoDBiEOG091G0SX3
PhylomeDBiQ61521
TreeFamiTF336145

Enzyme and pathway databases

ReactomeiR-MMU-1227986 Signaling by ERBB2
R-MMU-1236394 Signaling by ERBB4
R-MMU-1250196 SHC1 events in ERBB2 signaling
R-MMU-1250342 PI3K events in ERBB4 signaling
R-MMU-1250347 SHC1 events in ERBB4 signaling
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1963640 GRB2 events in ERBB2 signaling
R-MMU-1963642 PI3K events in ERBB2 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6785631 ERBB2 Regulates Cell Motility
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847993 ERBB2 Activates PTK6 Signaling
R-MMU-8863795 Downregulation of ERBB2 signaling

Miscellaneous databases

PMAP-CutDBiQ61521
PROiPR:Q61521
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029377 Expressed in 75 organ(s), highest expression level in cumulus cell
CleanExiMM_EREG
GenevisibleiQ61521 MM

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEREG_MOUSE
AccessioniPrimary (citable) accession number: Q61521
Secondary accession number(s): Q7M0A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again