UniProtKB - Q61502 (E2F5_MOUSE)
Transcription factor E2F5
E2f5
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 37 – 108 | Sequence analysisAdd BLAST | 72 |
GO - Molecular functioni
- DNA binding Source: GO_Central
- DNA-binding transcription activator activity Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- sequence-specific DNA binding Source: MGI
- transcription factor binding Source: MGI
GO - Biological processi
- animal organ morphogenesis Source: MGI
- cell projection organization Source: UniProtKB-KW
- G1/S transition of mitotic cell cycle Source: MGI
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of cell cycle Source: GO_Central
- regulation of transcription, DNA-templated Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Cilium biogenesis/degradation, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-1538133, G0 and Early G1 R-MMU-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-MMU-69231, Cyclin D associated events in G1 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor E2F5Short name: E2F-5 |
Gene namesi | Name:E2f5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105091, E2f5 |
Subcellular locationi
Nucleus
Nucleus
- fibrillar center Source: MGI
- nuclear envelope Source: MGI
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
- RNA polymerase II transcription regulator complex Source: GO_Central
- sarcoplasm Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219470 | 1 – 335 | Transcription factor E2F5Add BLAST | 335 |
Proteomic databases
MaxQBi | Q61502 |
PaxDbi | Q61502 |
PeptideAtlasi | Q61502 |
PRIDEi | Q61502 |
PTM databases
iPTMneti | Q61502 |
PhosphoSitePlusi | Q61502 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000027552, Expressed in zygote and 304 other tissues |
Genevisiblei | Q61502, MM |
Interactioni
Subunit structurei
Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (By similarity).
By similarityBinary interactionsi
Q61502
With | #Exp. | IntAct |
---|---|---|
Tfdp2 - isoform Delta [Q64163-4] | 2 | EBI-7225685,EBI-8077763 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199352, 4 interactors |
CORUMi | Q61502 |
IntActi | Q61502, 3 interactors |
MINTi | Q61502 |
STRINGi | 10090.ENSMUSP00000127877 |
Miscellaneous databases
RNActi | Q61502, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 66 – 88 | Leucine-zipperAdd BLAST | 23 | |
Regioni | 109 – 205 | DimerizationSequence analysisAdd BLAST | 97 | |
Regioni | 277 – 335 | TransactivationSequence analysisAdd BLAST | 59 | |
Regioni | 312 – 329 | RBL2 associationSequence analysisAdd BLAST | 18 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 71 – 108 | DEF boxAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 223 – 226 | Poly-Ser | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2577, Eukaryota |
GeneTreei | ENSGT00940000157353 |
HOGENOMi | CLU_032091_2_0_1 |
InParanoidi | Q61502 |
OrthoDBi | 1087250at2759 |
Family and domain databases
CDDi | cd14660, E2F_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR028316, E2F5 IPR032198, E2F_CC-MB IPR003316, E2F_WHTH_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF35, PTHR12081:SF35, 1 hit |
Pfami | View protein in Pfam PF16421, E2F_CC-MB, 1 hit PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAAAEPTSSA QPTPQAQAQP PPHGAPSSQP SAALAGGSSR HEKSLGLLTT
60 70 80 90 100
KFVSLLQEAQ DGVLDLKAAA DTLAVRQKRR IYDITNVLEG IDLIEKKSKN
110 120 130 140 150
SIQWKGVGAG CNTKEVIDRL RCLKAEIEDL ELKERELDQQ KLWLQQSIKN
160 170 180 190 200
VMEDSINNRF SYVTHEDICN CFHGDTLLAI QAPSGTQLEV PIPEMGQNGQ
210 220 230 240 250
KKYQINLKSH SGPIHVLLIN KESSSSKPVV FPVPPPDDLT QPSSQSSTSV
260 270 280 290 300
TPQKSTMAAQ NLPEQHVSER SQTFQQTPAA EVSSGSISGD IIDELMSSDV
310 320 330
FPLLRLSPTP ADDYNFNLDD NEGVCDLFDV QILNY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9Q011 | E9Q011_MOUSE | Transcription factor E2F5 | E2f5 | 336 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 – 35 | AALA → RRSR in CAA60508 (PubMed:7542760).Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86925 mRNA Translation: CAA60508.1 AK156760 mRNA Translation: BAE33842.1 BC003220 mRNA Translation: AAH03220.1 |
CCDSi | CCDS38391.1 |
PIRi | I48338 |
RefSeqi | NP_031918.2, NM_007892.2 |
Genome annotation databases
Ensembli | ENSMUST00000029069; ENSMUSP00000029069; ENSMUSG00000027552 |
GeneIDi | 13559 |
KEGGi | mmu:13559 |
UCSCi | uc008oqk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X86925 mRNA Translation: CAA60508.1 AK156760 mRNA Translation: BAE33842.1 BC003220 mRNA Translation: AAH03220.1 |
CCDSi | CCDS38391.1 |
PIRi | I48338 |
RefSeqi | NP_031918.2, NM_007892.2 |
3D structure databases
SMRi | Q61502 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199352, 4 interactors |
CORUMi | Q61502 |
IntActi | Q61502, 3 interactors |
MINTi | Q61502 |
STRINGi | 10090.ENSMUSP00000127877 |
PTM databases
iPTMneti | Q61502 |
PhosphoSitePlusi | Q61502 |
Proteomic databases
MaxQBi | Q61502 |
PaxDbi | Q61502 |
PeptideAtlasi | Q61502 |
PRIDEi | Q61502 |
Protocols and materials databases
Antibodypediai | 6582, 193 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000029069; ENSMUSP00000029069; ENSMUSG00000027552 |
GeneIDi | 13559 |
KEGGi | mmu:13559 |
UCSCi | uc008oqk.1, mouse |
Organism-specific databases
CTDi | 1875 |
MGIi | MGI:105091, E2f5 |
Phylogenomic databases
eggNOGi | KOG2577, Eukaryota |
GeneTreei | ENSGT00940000157353 |
HOGENOMi | CLU_032091_2_0_1 |
InParanoidi | Q61502 |
OrthoDBi | 1087250at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-1538133, G0 and Early G1 R-MMU-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-MMU-69231, Cyclin D associated events in G1 |
Miscellaneous databases
BioGRID-ORCSi | 13559, 1 hit in 17 CRISPR screens |
ChiTaRSi | E2f5, mouse |
PROi | PR:Q61502 |
RNActi | Q61502, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027552, Expressed in zygote and 304 other tissues |
Genevisiblei | Q61502, MM |
Family and domain databases
CDDi | cd14660, E2F_DD, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR028316, E2F5 IPR032198, E2F_CC-MB IPR003316, E2F_WHTH_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF35, PTHR12081:SF35, 1 hit |
Pfami | View protein in Pfam PF16421, E2F_CC-MB, 1 hit PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E2F5_MOUSE | |
Accessioni | Q61502Primary (citable) accession number: Q61502 Secondary accession number(s): Q99LK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families