E2f1

Functionⁱ

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:11672531, PubMed:20176812). Positively regulates transcription of RRP1B (By similarity).By similarity3 Publications

Activity regulationⁱ

BIRC2/c-IAP1 stimulates its transcriptional activity.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	105 – 189	Sequence analysisAdd BLAST		85

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from sequence orthologyⁱ
- 15073182
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
protein dimerization activity Source: InterPro
protein kinase binding Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter sequence-specific DNA binding Source: MGI
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11672531
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10597240
transcription regulatory region DNA binding
Source: MGI
Inferred from direct assayⁱ
- 24014029

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anoikis
Source: MGI
Inferred from direct assayⁱ
- 14667810
cellular response to fatty acid Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to nerve growth factor stimulus Source: MGI
cellular response to xenobiotic stimulus
Source: MGI
Inferred from direct assayⁱ
- 24726645
DNA damage checkpoint Source: UniProtKB
forebrain development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15525772
intrinsic apoptotic signaling pathway by p53 class mediator
Source: MGI
Inferred from direct assayⁱ
- 11095619
intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
lens fiber cell apoptotic process
Source: MGI
Inferred from direct assayⁱ
- 11095619
mRNA stabilization Source: MGI
negative regulation of DNA binding Source: MGI
negative regulation of fat cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 11672531
negative regulation of fat cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20176812
negative regulation of transcription, DNA-templated Source: MGI
negative regulation of transcription by RNA polymerase II Source: MGI
negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: MGI
positive regulation of apoptotic process Source: MGI
positive regulation of fibroblast proliferation Source: MGI
positive regulation of gene expression Source: MGI
positive regulation of glial cell proliferation Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 11004506
- 24014029
regulation of cell cycle
Source: MGI
Inferred from direct assayⁱ
- 11095619
regulation of G1/S transition of mitotic cell cycle Source: MGI
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
spermatogenesis Source: Ensembl
transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 11672531

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Apoptosis, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-68689 CDC6 association with the ORC:origin complex R-MMU-68911 G2 Phase R-MMU-69231 Cyclin D associated events in G1

Reactomeⁱ

R-MMU-68689 CDC6 association with the ORC:origin complex
R-MMU-68911 G2 Phase
R-MMU-69231 Cyclin D associated events in G1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor E2F1 Short name: E2F-1
Gene namesⁱ	Name:E2f1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:101941 E2f1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219462	1 – 430	Transcription factor E2F1Add BLAST		430

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	112	N6-acetyllysineBy similarity	1
Modified residueⁱ	115	N6-acetyllysineBy similarity	1
Modified residueⁱ	120	N6-acetyllysineBy similarity	1
Modified residueⁱ	368	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis (By similarity).By similarity

Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1. Regulated by KAP1/TRIM28 which recruits HDAC1 to E2F1 resulting in deacetylation. Acetylated by P/CAF/KAT2B (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q61501
PRIDEⁱ	Q61501

PTM databases

iPTMnetⁱ	Q61501
PhosphoSitePlusⁱ	Q61501

Expressionⁱ

Developmental stageⁱ

In the developing nervous system, first detected in the neural tube at day 9.5 dpc. By day 10.5, levels increase throughout the brain, with highest levels in the hindbrain and in the spinal cord, expressed only in the rostral half. By day 11.5, expression found throughout the brain and spinal cord. From day 12.5, expression restricted to the ventricular regions of the brain, peaks at day 13.5 and declines thereafter. Only weak expression in the developing spinal cord from day 11.5-16.5. In the developing retina, expression is confined to the undifferentiated retinoblastic cell layer. In other developing tissues, E2F1 is expressed in kidney, lung, liver hepatocytes, heart and thymus. Highest levels in liver. Absent in choroid plexus.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000027490 Expressed in 236 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_E2F1
ExpressionAtlasⁱ	Q61501 baseline and differential
Genevisibleⁱ	Q61501 MM

Interactionⁱ

Subunit structureⁱ

Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with TRIM28; the interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional activity. Interaction with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional activity. Interacts with BIRC2/c-IAP1 (via BIR domains). The complex TFDP1:E2F1 interacts with CEBPA; the interaction prevents CEBPA binding to target genes promoters and represses its transcriptional activity. Interacts with RRP1B (By similarity). Interacts with HCFC1 (By similarity). Interacts with KMT2E; the interaction is probably indirect and is mediated via HCFC1 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Ndn	P25233	5	EBI-1025536,EBI-1801080
Nsmce3	Q9CPR8	5	EBI-1025536,EBI-5529102

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
protein kinase binding Source: MGI
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10597240

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199350, 18 interactors
ComplexPortalⁱ	CPX-159 E2F1-DP1 transcription factor complex CPX-160 RB1-E2F1-TFDP1 transcription repressor complex
CORUMⁱ	Q61501
IntActⁱ	Q61501, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q61501
STRINGⁱ	10090.ENSMUSP00000099434

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61501
SMRⁱ	Q61501
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	62 – 103	Cyclin A:CDK2 bindingBy similarityAdd BLAST	42
Regionⁱ	84 – 186	Interaction with BIRC2/c-IAP1By similarityAdd BLAST	103
Regionⁱ	148 – 169	Leucine-zipperAdd BLAST	22
Regionⁱ	187 – 375	Required for interaction with TRIM28By similarityAdd BLAST	189
Regionⁱ	190 – 279	DimerizationSequence analysisAdd BLAST	90
Regionⁱ	361 – 430	TransactivationBy similarityAdd BLAST	70
Regionⁱ	402 – 419	RB1 bindingBy similarityAdd BLAST	18

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	153 – 189	DEF boxAdd BLAST		37

Sequence similaritiesⁱ

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2577 Eukaryota ENOG410XNYI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074403
HOGENOMⁱ	HOG000232045
HOVERGENⁱ	HBG002227
InParanoidⁱ	Q61501
KEGG Orthology (KO) More...KOⁱ	K17454
OMAⁱ	VRCQDLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G087U
PhylomeDBⁱ	Q61501
TreeFamⁱ	TF105566

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14660 E2F_DD, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR015633 E2F IPR037241 E2F-DP_heterodim IPR032198 E2F_CC-MB IPR003316 E2F_WHTH_DNA-bd_dom IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR12081 PTHR12081, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16421 E2F_CC-MB, 1 hit PF02319 E2F_TDP, 1 hit
SMARTⁱ	View protein in SMART SM01372 E2F_TDP, 1 hit
SUPFAMⁱ	SSF144074 SSF144074, 1 hit SSF46785 SSF46785, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q61501-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVAPAGGQH APALEALLGA GALRLLDSSQ IVIISTAPDV GAPQLPAAPP 
        60         70         80         90        100
TGPRDSDVLL FATPQAPRPA PSAPRPALGR PPVKRRLDLE TDHQYLAGSS 
       110        120        130        140        150
GPFRGRGRHP GKGVKSPGEK SRYETSLNLT TKRFLELLSR SADGVVDLNW 
       160        170        180        190        200
AAEVLKVQKR RIYDITNVLE GIQLIAKKSK NHIQWLGSHT MVGIGKRLEG 
       210        220        230        240        250
LTQDLQQLQE SEQQLDHLMH ICTTQLQLLS EDSDTQRLAY VTCQDLRSIA 
       260        270        280        290        300
DPAEQMVIVI KAPPETQLQA VDSSETFQIS LKSKQGPIDV FLCPEESADG 
       310        320        330        340        350
ISPGKTSCQE TSSGEDRTAD SGPAGPPPSP PSTSPALDPS QSLLGLEQEA 
       360        370        380        390        400
VLPRMGHLRV PMEEDQLSPL VAADSLLEHV KEDFSGLLPG EFISLSPPHE 
       410        420        430
ALDYHFGLEE GEGIRDLFDC DFGDLTPLDF

Length:430

Mass (Da):46,323

Last modified:November 1, 1996 - v1

Checksum:ⁱC5DF18AD3B4DFEFA

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q9CYB4	Q9CYB4_MOUSE		E2F transcription factor 1, isoform... E2F transcription factor 1, isoform CRA_b (Transcription factor E2F1)	E2f1 mCG_3689	385	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L21973 mRNA Translation: AAA83217.1 BC052160 mRNA Translation: AAH52160.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16935.1
PIRⁱ	A56209
NCBI Reference Sequences More...RefSeqⁱ	NP_031917.1, NM_007891.5
UniGeneⁱ	Mm.18036 Mm.441323

Genome annotation databases

Ensemblⁱ	ENSMUST00000103145; ENSMUSP00000099434; ENSMUSG00000027490
GeneIDⁱ	13555
KEGGⁱ	mmu:13555
UCSC genome browser More...UCSCⁱ	uc008njk.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61501	E2F transcription factor 1, isoform CRA_a		MOUSE		430	UniRef100_Q61501

Protein	Similar proteins		Species	Score	Length	Source
Q61501	Transcription factor E2F1 (Fragment)		RAT		432	UniRef90_Q61501
E2F transcription factor 1, isoform CRA_a		MOUSE		430
UPI000A308471		MUSPA		433
UPI000A31589B		MUSCR		433
UPI000A327FDD		MESAU		433
+3

Protein	Similar proteins		Species	Score	Length	Source
Q61501	Transcription factor E2F1 (Fragment)		RAT		432	UniRef50_Q61501
Transcription factor E2F1		CHICK		403
E2F transcription factor 1, isoform CRA_a		MOUSE		430
E2F transcription factor 1		ICTTR		392
Transcription factor E2F1		PTEAL		373
+152

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L21973 mRNA Translation: AAA83217.1 BC052160 mRNA Translation: AAH52160.2
CCDSⁱ	CCDS16935.1
PIRⁱ	A56209
RefSeqⁱ	NP_031917.1, NM_007891.5
UniGeneⁱ	Mm.18036 Mm.441323

3D structure databases

ProteinModelPortalⁱ	Q61501
SMRⁱ	Q61501
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199350, 18 interactors
ComplexPortalⁱ	CPX-159 E2F1-DP1 transcription factor complex CPX-160 RB1-E2F1-TFDP1 transcription repressor complex
CORUMⁱ	Q61501
IntActⁱ	Q61501, 6 interactors
MINTⁱ	Q61501
STRINGⁱ	10090.ENSMUSP00000099434

PTM databases

iPTMnetⁱ	Q61501
PhosphoSitePlusⁱ	Q61501

Proteomic databases

PaxDbⁱ	Q61501
PRIDEⁱ	Q61501

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000103145; ENSMUSP00000099434; ENSMUSG00000027490
GeneIDⁱ	13555
KEGGⁱ	mmu:13555
UCSCⁱ	uc008njk.2 mouse

Organism-specific databases

CTDⁱ	1869
MGIⁱ	MGI:101941 E2f1

Phylogenomic databases

eggNOGⁱ	KOG2577 Eukaryota ENOG410XNYI LUCA
GeneTreeⁱ	ENSGT00550000074403
HOGENOMⁱ	HOG000232045
HOVERGENⁱ	HBG002227
InParanoidⁱ	Q61501
KOⁱ	K17454
OMAⁱ	VRCQDLR
OrthoDBⁱ	EOG091G087U
PhylomeDBⁱ	Q61501
TreeFamⁱ	TF105566

Enzyme and pathway databases

Reactomeⁱ	R-MMU-68689 CDC6 association with the ORC:origin complex R-MMU-68911 G2 Phase R-MMU-69231 Cyclin D associated events in G1

Reactomeⁱ

R-MMU-68689 CDC6 association with the ORC:origin complex
R-MMU-68911 G2 Phase
R-MMU-69231 Cyclin D associated events in G1

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q61501
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027490 Expressed in 236 organ(s), highest expression level in secondary oocyte
CleanExⁱ	MM_E2F1
ExpressionAtlasⁱ	Q61501 baseline and differential
Genevisibleⁱ	Q61501 MM

Family and domain databases

CDDⁱ	cd14660 E2F_DD, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR015633 E2F IPR037241 E2F-DP_heterodim IPR032198 E2F_CC-MB IPR003316 E2F_WHTH_DNA-bd_dom IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR12081 PTHR12081, 1 hit
Pfamⁱ	View protein in Pfam PF16421 E2F_CC-MB, 1 hit PF02319 E2F_TDP, 1 hit
SMARTⁱ	View protein in SMART SM01372 E2F_TDP, 1 hit
SUPFAMⁱ	SSF144074 SSF144074, 1 hit SSF46785 SSF46785, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E2F1_MOUSE
Accessionⁱ	Q61501Primary (citable) accession number: Q61501 Secondary accession number(s): Q80VZ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61501 (E2F1_MOUSE)

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Transcription factor E2F1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ