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Protein

DNA polymerase zeta catalytic subunit

Gene

Rev3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3034ZincBy similarity1
Metal bindingi3037ZincBy similarity1
Metal bindingi3046ZincBy similarity1
Metal bindingi3049ZincBy similarity1
Metal bindingi3078Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi3081Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi3091Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi3096Iron-sulfur (4Fe-4S)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri3034 – 3049CysA-typeAdd BLAST16

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • DNA repair Source: MGI
  • DNA replication Source: UniProtKB-KW
  • error-prone translesion synthesis Source: GO_Central
  • nucleic acid phosphodiester bond hydrolysis Source: GOC

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-110312 Translesion synthesis by REV1
R-MMU-5655862 Translesion synthesis by POLK
R-MMU-5656121 Translesion synthesis by POLI

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase zeta catalytic subunit (EC:2.7.7.7)
Alternative name(s):
Protein reversionless 3-like
Short name:
REV3-like
Seizure-related protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rev3l
Synonyms:Polz, Sez4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1337131 Rev3l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000464691 – 3122DNA polymerase zeta catalytic subunitAdd BLAST3122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1029PhosphoserineCombined sources1
Modified residuei1040PhosphothreonineCombined sources1
Modified residuei1964PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q61493

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q61493

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61493

PeptideAtlas

More...
PeptideAtlasi
Q61493

PRoteomics IDEntifications database

More...
PRIDEi
Q61493

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61493

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61493

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019841 Expressed in 297 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q61493 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q61493 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
202866, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000019986

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q61493

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q61493

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1844 – 1895Mediates interaction with MAD2L2By similarityAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3078 – 3096CysB motifAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3034 – 3049CysA-typeAdd BLAST16

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0968 Eukaryota
COG0417 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156226

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112263

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000426

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q61493

KEGG Orthology (KO)

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KOi
K02350

Identification of Orthologs from Complete Genome Data

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OMAi
CSKCRSQ

Database of Orthologous Groups

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OrthoDBi
EOG091G01N0

TreeFam database of animal gene trees

More...
TreeFami
TF101072

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit
3.90.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR032757 DUF4683
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR025687 Znf-C4pol

The PANTHER Classification System

More...
PANTHERi
PTHR10322:SF26 PTHR10322:SF26, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PF15735 DUF4683, 1 hit
PF14260 zf-C4pol, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00106 DNAPOLB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00486 POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61493-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSVRIVTAD YYMASPLPGL DTCQSPLTQL PVKKVPVVRV FGATPAGQKT
60 70 80 90 100
CLHLHGIFPY LYVPYDGYGQ QPESYLSQMA FSIDRALNVA LGNPSSTAQH
110 120 130 140 150
VFKVSLVSGM PFYGYHEKER HFMKIYLYNP AMVKRICELL QSGAIMNKCY
160 170 180 190 200
QPHEAHIPYL LQLFIDYNLY GMNLINLAAV KFRKARRKGN ASHATGLFKH
210 220 230 240 250
QLSGNSPAGT LFRWEEDEIP SSLLLEGVEP LSTCELEVDA VAADILNRLD
260 270 280 290 300
IEAQIGGNPG LQAIWEDEKQ RRRNRNESSQ ISQPESQDCR FVPATESEKQ
310 320 330 340 350
FQKRLQEVLK QNDFSVTLSG SVDYSNGSQE FSAELTLHSE ILSPEMLPCS
360 370 380 390 400
PANMIEVHKD TDLSKGNTKH KVEEALINEE AILNLIENSQ TFQPLTQRLS
410 420 430 440 450
ETPVFMGSSP DESLVHLLAG LESDGYQGEK NRMPLPCHSF GESQNPQNSD
460 470 480 490 500
DEENEPQIEK EEMELSVVMS QRWDSDIEEH CAKKRSLCRN AHRSSTEEDD
510 520 530 540 550
SSSEEEMEWT DNSLLFANLS IPQLDGTADE NSDNPLNNEN SRAHSSVIAT
560 570 580 590 600
SKLSVRPSIF HKDAATLEPP SSAKITFQCK HTSALSSHVL NKDGLTEDLS
610 620 630 640 650
QPNSTEKGRD NSVTFTKEST YSMKYSGSLS STVHSDNSHK EICKKDKSLP
660 670 680 690 700
VSSCESSVFD YEEDIPSVTR QVPSRKYSNM RKIEKDASCI HVNRHISETI
710 720 730 740 750
LGKNSFNFAD LNHSKRKLSS EGNEKGNSTS LSGVFPSSLT ENCDLLPSSG
760 770 780 790 800
ENRSMAHSLE SITDESGLNK LKIRYEEFQE HKMEKPSLSQ QAAHYMFFPS
810 820 830 840 850
VVLSNCLTRP QKLSPVTYKL QSGNKPSRLK LNKKKLIGLQ ETSTKSTETG
860 870 880 890 900
ATKDSCTHND LYTGASEKEN GLSSDSAKAT HGTFENKPPT EHFIDCHFGD
910 920 930 940 950
GSLEAEQSFG LYGNKYTLRA KRKVNYETED SESSFVTQNS KISLPHPMEI
960 970 980 990 1000
GENLDGTLKS RKRRKMSKKL PPVIIKYIII NRFRGRKNML VKLGKIDSKE
1010 1020 1030 1040 1050
KQVILTEEKM ELYKKLAPLK DFWPKVPDSP ATKYPIYPLT PKKSHRRKSK
1060 1070 1080 1090 1100
HKSAKKKPGK QHRTNSENIK RTLSFRKKRT HAVLSPPSPS YIAETEDCDL
1110 1120 1130 1140 1150
SYSDVMSKLG FLSERSTSPI NSSPPRCWSP TDPRAEEIMA AAEKESMLFK
1160 1170 1180 1190 1200
GPNVYNTKTV SPRVGKASRA RAQVKKSKAR LANSSVVTNK RNKRNQTTKL
1210 1220 1230 1240 1250
VDDGKKKPRA KQKQRANEKS LSRKHAIPAD EKMKPHSEAE LTPNHQSVSE
1260 1270 1280 1290 1300
LTSSSGAQAL SKQKEMSQTG PAVDHPLPPA QPTGISAQQR LSNCFSSFLE
1310 1320 1330 1340 1350
SKKSVDLRTF PSSRDDSHSS VVYSSIGPGI SKINIQRSHN QSAMFTRKET
1360 1370 1380 1390 1400
TLIQKSIFDL SNHLSQVAQS TQVCSGIISP KTEESSSTQK NCGSSMGKLN
1410 1420 1430 1440 1450
EYRSSLESKP EQVCAPNFLH CKDSQQQTVS VSEQSKTSET CSPGNAASEE
1460 1470 1480 1490 1500
SQTPNCFVTS LKSPIKQIAW EQKQRGFILD MSNFKPEKVK QRSLSEAISQ
1510 1520 1530 1540 1550
TKALSQCKNQ NVSTPSVFGE GQSGLAVLKE LLQKRQQKAQ STNVVQDSTS
1560 1570 1580 1590 1600
THQPDKNISV SNEHKKANKR TRPVTSPRKP RTPRRTKPKE QTPRRLKVDP
1610 1620 1630 1640 1650
LNLQTSGHLD NSLSDDSPIL FSDPGFESCY SLEDSLSPEH NYNFDINTIG
1660 1670 1680 1690 1700
QTGFCSFYSG SQFVPADQNL PQKFLSDAVQ DLFPGQAIDK SELLSHDRQS
1710 1720 1730 1740 1750
CSEEKHHVSD SSPWIRASTL NPELFEKVAM DNNENHRHSQ WKNSFHPLTS
1760 1770 1780 1790 1800
HSNSIMESFC VQQAENCLTE KSRLNRSSVS KEVFLSLPQA NSSDWIQGHN
1810 1820 1830 1840 1850
RKEADQSLHS ANTSFTTILS SPDGELVDAA SEDLELYVSR NNDVLTPTPD
1860 1870 1880 1890 1900
SSPRSTSSPL QSKNGSFTPR TAHILKPLMS PPSREEIVAT LLDHDLSEAI
1910 1920 1930 1940 1950
YQEPFCSNPS DVPEKPREIG GRLLMVETRL PNDLIEFEGD FSLEGLRLWK
1960 1970 1980 1990 2000
TAFSAMTQNP RPGSPLRNGQ AVVNKESSNS HKMVEDKKIV IMPCKYAPSR
2010 2020 2030 2040 2050
QLVQAWLQAK EEYERSKKLP KTELTPVTKS AENVSPSLNP GDTCAVSPQV
2060 2070 2080 2090 2100
DKCPHTLSSS AHTKEEVSKS QIALQTSTTG CSQTLLAAAS AAVPEEDEDD
2110 2120 2130 2140 2150
NDNCYVSYSS PDSPGIPPWQ QAASPDFRSL NGDDRHSSPG KELCSLAVEN
2160 2170 2180 2190 2200
FLKPIKDGIQ KSSCSESWEP QVISPIHARA RTGKWDPLCL HSTPVMQRKF
2210 2220 2230 2240 2250
LEKLPEATGL SPLSVEPKTQ KLYNKKGSDA DGLRRVLLTT QVENQFAAVN
2260 2270 2280 2290 2300
TPKKETSQID GPSLNNTYGF KVSIQNLQEA KALHEIQNLT LISVELHART
2310 2320 2330 2340 2350
RRDLQPDPEF DPICALFYCI SSDTPLPDTE KTELTGVIVI DKDKTVTHQD
2360 2370 2380 2390 2400
IRSQTPLLIR SGITGLEVTY AADEKALFQE ITNIIKRYDP DILLGYEIQM
2410 2420 2430 2440 2450
HSWGYLLQRA AALSVDLCQM ISRVPDDKIE NRFAAERDDY GSDTMSEINI
2460 2470 2480 2490 2500
VGRITLNLWR IMRNEVALTN YTFENVSFHV LHQRFPLFTF RVLSDWFDNK
2510 2520 2530 2540 2550
TDLYRWKMVD HYVSRVRGNL QMLEQLDLIG KTSEMARLFG IQFLHVLTRG
2560 2570 2580 2590 2600
SQYRVESMML RIAKPMNYIP VTPSIQQRSQ MRAPQCVPLI MEPESRFYSN
2610 2620 2630 2640 2650
SVLVLDFQSL YPSIVIAYNY CFSTCLGHVE NLGKYDEFKF GCTSLRVPPD
2660 2670 2680 2690 2700
LLYQIRHDVT VSPNGVAFVK PSVRKGVLPR MLEEILKTRL MVKQSMKSYK
2710 2720 2730 2740 2750
QDRALSRMLN ARQLGLKLIA NVTFGYTAAN FSGRMPCIEV GDSIVHKARE
2760 2770 2780 2790 2800
TLERAIKLVN DTKKWGARVV YGDTDSMFVL LKGATKEQSF KIGQEIAEAV
2810 2820 2830 2840 2850
TATNPRPVKL KFEKVYLPCV LQTKKRYVGY MYETLDQKEP VFDAKGIETV
2860 2870 2880 2890 2900
RRDSCPAVSK ILERSLKLLF ETRDISLIKQ YVQRQCMKLV EGKASIQDFI
2910 2920 2930 2940 2950
FAKEYRGSFS YRPGACVPAL ELTRKMLAYD RRSEPRVGER VPYVIIYGTP
2960 2970 2980 2990 3000
GLPLIQLIRR PAEVLQDPTL RLNATYYITK QILPPLARIF SLIGIDVFSW
3010 3020 3030 3040 3050
YQELPRIQKA TSSSRSELEG RKGTISQYFT TLHCPVCDDL TQHGICSKCR
3060 3070 3080 3090 3100
SQPQHVAIIL NQEIRELERK QEQLIKICRN CTGSFDRHIP CVSLNCPVLF
3110 3120
KLSRVNRELS KAPYLRQLLD QF
Length:3,122
Mass (Da):350,711
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D365BD1CD5548C2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6T1D2F6T1D2_MOUSE
DNA polymerase zeta catalytic subun...
Rev3l
807Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9Z281Q9Z281_MOUSE
DNA polymerase zeta catalytic subun...
Rev3l
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti92G → A in BAA90768 (Ref. 2) Curated1
Sequence conflicti294A → T in BAA90768 (Ref. 2) Curated1
Sequence conflicti578Q → E in AAC98785 (PubMed:10102037).Curated1
Sequence conflicti609R → Q in BAA90768 (Ref. 2) Curated1
Sequence conflicti1278P → L in AAC98785 (PubMed:10102037).Curated1
Sequence conflicti1298F → L in AAC98785 (PubMed:10102037).Curated1
Sequence conflicti1416P → L in BAA90768 (Ref. 2) Curated1
Sequence conflicti1848T → A in AAC98785 (PubMed:10102037).Curated1
Sequence conflicti2368V → G in BAA11461 (PubMed:8645260).Curated1
Sequence conflicti2467A → G in AAC98785 (PubMed:10102037).Curated1
Sequence conflicti2467A → G in BAA90768 (Ref. 2) Curated1
Sequence conflicti2467A → G in BAA11461 (PubMed:8645260).Curated1
Sequence conflicti2883Q → H in AAC98785 (PubMed:10102037).Curated1
Sequence conflicti2883Q → H in BAA90768 (Ref. 2) Curated1
Sequence conflicti2883Q → H in BAA11461 (PubMed:8645260).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF083464 mRNA Translation: AAC98785.1
AB031049 mRNA Translation: BAA90768.1
AC118733 Genomic DNA No translation available.
AC119943 Genomic DNA No translation available.
D78644 mRNA Translation: BAA11461.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS23790.1

Protein sequence database of the Protein Information Resource

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PIRi
T17202

NCBI Reference Sequences

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RefSeqi
NP_035394.2, NM_011264.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.439723

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000019986; ENSMUSP00000019986; ENSMUSG00000019841
ENSMUST00000164763; ENSMUSP00000131519; ENSMUSG00000019841

Database of genes from NCBI RefSeq genomes

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GeneIDi
19714

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:19714

UCSC genome browser

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UCSCi
uc007ewc.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083464 mRNA Translation: AAC98785.1
AB031049 mRNA Translation: BAA90768.1
AC118733 Genomic DNA No translation available.
AC119943 Genomic DNA No translation available.
D78644 mRNA Translation: BAA11461.1
CCDSiCCDS23790.1
PIRiT17202
RefSeqiNP_035394.2, NM_011264.3
UniGeneiMm.439723

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FJOX-ray2.72D1865-1894[»]
ProteinModelPortaliQ61493
SMRiQ61493
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202866, 1 interactor
STRINGi10090.ENSMUSP00000019986

PTM databases

iPTMnetiQ61493
PhosphoSitePlusiQ61493

Proteomic databases

EPDiQ61493
MaxQBiQ61493
PaxDbiQ61493
PeptideAtlasiQ61493
PRIDEiQ61493

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019986; ENSMUSP00000019986; ENSMUSG00000019841
ENSMUST00000164763; ENSMUSP00000131519; ENSMUSG00000019841
GeneIDi19714
KEGGimmu:19714
UCSCiuc007ewc.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5980
MGIiMGI:1337131 Rev3l

Phylogenomic databases

eggNOGiKOG0968 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00940000156226
HOGENOMiHOG000112263
HOVERGENiHBG000426
InParanoidiQ61493
KOiK02350
OMAiCSKCRSQ
OrthoDBiEOG091G01N0
TreeFamiTF101072

Enzyme and pathway databases

ReactomeiR-MMU-110312 Translesion synthesis by REV1
R-MMU-5655862 Translesion synthesis by POLK
R-MMU-5656121 Translesion synthesis by POLI

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rev3l mouse

Protein Ontology

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PROi
PR:Q61493

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019841 Expressed in 297 organ(s), highest expression level in forebrain
ExpressionAtlasiQ61493 baseline and differential
GenevisibleiQ61493 MM

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR032757 DUF4683
IPR030559 PolZ_Rev3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR025687 Znf-C4pol
PANTHERiPTHR10322:SF26 PTHR10322:SF26, 1 hit
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 2 hits
PF15735 DUF4683, 1 hit
PF14260 zf-C4pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiREV3L_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61493
Secondary accession number(s): E9Q1X0, Q9JMD6, Q9QWX6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: December 5, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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