UniProtKB - Q61483 (DLL1_MOUSE)
Delta-like protein 1
Dll1
Functioni
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:21985982, PubMed:10958687).
Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (PubMed:10958687, PubMed:18676613).
Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:17194759, PubMed:19562077, PubMed:18997111, PubMed:23695674, PubMed:16495313, PubMed:21238454, PubMed:22282195, PubMed:7671806, PubMed:17960184, PubMed:22529374, PubMed:19389377, PubMed:23699523, PubMed:19144989, PubMed:23688253, PubMed:23806616, PubMed:26114479, PubMed:22940113, PubMed:25220152, PubMed:20081190, PubMed:21572390, PubMed:22096075).
Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner (PubMed:7671806, PubMed:18997111).
During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries (PubMed:23699523).
During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway (PubMed:23688253).
At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway (PubMed:19389377, PubMed:26114479).
Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis (PubMed:20081190).
Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell (PubMed:23695674).
Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B cells (PubMed:15146182, PubMed:19217325).
Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (By similarity).
Upon MMP14 cleavage, negatively regulates Notch signaling in haematopoietic progenitor cells to specifically maintain normal B-cell development in bone marrow (PubMed:21572390).
Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation (PubMed:17194759).
Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression (PubMed:22940113).
During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression (PubMed:25220152).
Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium (PubMed:22529374).
Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels (PubMed:22096075).
During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression (PubMed:19144989).
Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation (PubMed:22282195).
Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine (PubMed:21238454, PubMed:21915337).
Plays a role during inner ear development; negatively regulates auditory hair cell differentiation (PubMed:16495313).
Plays a role during nephron development through Notch signaling pathway (PubMed:23806616).
Regulates growth, blood pressure and energy homeostasis (PubMed:19562077).
By similarity27 PublicationsGO - Molecular functioni
- calcium ion binding Source: InterPro
- Notch binding Source: UniProtKB
- scaffold protein binding Source: UniProtKB
- Tat protein binding Source: MGI
GO - Biological processi
- animal organ morphogenesis Source: UniProtKB
- astrocyte development Source: UniProtKB
- auditory receptor cell fate commitment Source: UniProtKB
- cell-cell signaling Source: MGI
- cerebellar molecular layer formation Source: UniProtKB
- cerebellar Purkinje cell layer structural organization Source: UniProtKB
- clathrin-dependent endocytosis Source: UniProtKB
- compartment pattern specification Source: MGI
- determination of left/right symmetry Source: MGI
- endothelial tip cell fate specification Source: UniProtKB
- energy homeostasis Source: UniProtKB
- heart looping Source: BHF-UCL
- inner ear auditory receptor cell differentiation Source: UniProtKB
- inner ear development Source: MGI
- inner ear morphogenesis Source: UniProtKB
- in utero embryonic development Source: UniProtKB
- lateral inhibition Source: UniProtKB
- left/right axis specification Source: BHF-UCL
- loop of Henle development Source: UniProtKB
- marginal zone B cell differentiation Source: UniProtKB
- negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
- negative regulation of cell differentiation Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of epidermal cell differentiation Source: UniProtKB
- negative regulation of epithelial cell differentiation Source: UniProtKB
- negative regulation of glial cell apoptotic process Source: UniProtKB
- negative regulation of inner ear auditory receptor cell differentiation Source: MGI
- negative regulation of interleukin-10 production Source: MGI
- negative regulation of myeloid cell differentiation Source: MGI
- negative regulation of myoblast differentiation Source: UniProtKB
- negative regulation of neuron differentiation Source: UniProtKB
- negative regulation of Notch signaling pathway Source: GO_Central
- nephron development Source: UniProtKB
- nervous system development Source: UniProtKB
- neuronal stem cell population maintenance Source: UniProtKB
- neuron fate specification Source: UniProtKB
- Notch signaling involved in heart development Source: BHF-UCL
- Notch signaling pathway Source: UniProtKB
- Notch signaling pathway involved in arterial endothelial cell fate commitment Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: UniProtKB
- organ growth Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of endocytosis Source: UniProtKB
- positive regulation of gene expression Source: MGI
- positive regulation of Notch signaling pathway Source: UniProtKB
- positive regulation of skeletal muscle tissue growth Source: UniProtKB
- positive regulation of sprouting angiogenesis Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- proximal/distal pattern formation Source: UniProtKB
- proximal tubule development Source: UniProtKB
- regulation of blood pressure Source: UniProtKB
- regulation of cell adhesion Source: UniProtKB
- regulation of cell division Source: UniProtKB
- regulation of growth Source: UniProtKB
- regulation of neurogenesis Source: UniProtKB
- regulation of skeletal muscle tissue growth Source: UniProtKB
- regulation of somitogenesis Source: UniProtKB
- regulation of vascular endothelial growth factor signaling pathway Source: UniProtKB
- retina development in camera-type eye Source: UniProtKB
- retina morphogenesis in camera-type eye Source: UniProtKB
- skeletal muscle tissue growth Source: UniProtKB
- skin epidermis development Source: UniProtKB
- somite specification Source: MGI
- somitogenesis Source: UniProtKB
- spinal cord development Source: UniProtKB
- type B pancreatic cell development Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Notch signaling pathway |
Enzyme and pathway databases
Reactomei | R-MMU-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus |
Names & Taxonomyi
Protein namesi | Recommended name: Delta-like protein 1CuratedAlternative name(s): Drosophila Delta homolog 1 Short name: Delta11 Publication Cleaved into the following 3 chains: Dll1-derived cell-associated form1 Publication Short name: Dll1-TMIC1 Publication Short name: Membrane-associated fragment1 Publication |
Gene namesi | Name:Dll1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104659, Dll1 |
VEuPathDBi | HostDB:ENSMUSG00000014773 |
Subcellular locationi
Plasma membrane
- Apical cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Other locations
- adherens junction 2 Publications
- Membrane raft 2 Publications
Note: Distributed around adherens junction in the apical endfeet through interactions with MAGI1.2 Publications
Plasma membrane
- Cell membrane 1 Publication
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- adherens junction Source: UniProtKB
- cytoplasmic vesicle Source: MGI
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 545 | ExtracellularSequence analysisAdd BLAST | 528 | |
Transmembranei | 546 – 568 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 569 – 722 | CytoplasmicSequence analysisAdd BLAST | 154 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 613 – 618 | KNTNKK → RNTNRR: Highly decreases Notch signaling pathway. Multi-ubiquitination pattern is reduced, although it does appear to be mono-ubiquitinated. Interacts with MIB1. Loss of cis interaction with NOTCH1. 1 Publication | 6 | |
Mutagenesisi | 613 | K → R: Highly decreases Notch signaling pathway. Multi-ubiquitination pattern is reduced, although it does appear to be mono-ubiquitinated. Interacts with MIB1. Loss of cis and trans interaction with NOTCH1. Increases its association with lipid raft microdomains. 1 Publication | 1 | |
Mutagenesisi | 638 | T → V: Not phosphorylated; when associated with A-693 and A-696. Not phosphorylated and doesn't prevent phosphorylation at S-693 and S-696. Reduces NOTCH1 transactivation; when associated with A-693 and A-696. Reduces cell surface levels of proteins; when associated with A-693 and A-696. Increases ectodomain shedding; when associated with A-693 and A-696. 1 Publication | 1 | |
Mutagenesisi | 689 | K → R: Decreases Notch signaling pathway. 1 Publication | 1 | |
Mutagenesisi | 693 | S → A: Not phosphorylated; when associated with V-638 and A-696. Not phosphorylated and prevents phosphorylation at S-696. Reduces NOTCH1 transactivation; when associated with V-638 and A-696. Reduces cell surface levels of proteins; when associated with V-638 and A-696. Increases ectodomain shedding; when associated with V-638 and A-696. 1 Publication | 1 | |
Mutagenesisi | 696 | S → A: Not phosphorylated; when associated with V-638 and A-693. Not phosphorylated and doesn't prevent phosphorylation at T-638 and S-693, Reduces NOTCH1 transactivation; when associated with V-638 and A-693. Reduces cell surface levels of proteins; when associated with V-638 and A-693. Increases ectodomain shedding; when associated with V-638 and A-693. 1 Publication | 1 | |
Mutagenesisi | 699 | K → R: Decreases Notch signaling pathway. 1 Publication | 1 | |
Mutagenesisi | 713 | K → R: Decreases Notch signaling pathway. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000007507 | 18 – 722 | Delta-like protein 1Add BLAST | 705 | |
ChainiPRO_0000434830 | 18 – 535 | Dll1-soluble form1 PublicationAdd BLAST | 518 | |
ChainiPRO_0000434831 | 536 – 722 | Dll1-derived cell-associated form1 PublicationAdd BLAST | 187 | |
ChainiPRO_0000434832 | ? – 722 | Dll1-intracellular form1 Publication |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 178 ↔ 187 | By similarity | ||
Disulfide bondi | 191 ↔ 203 | By similarity | ||
Disulfide bondi | 211 ↔ 220 | By similarity | ||
Disulfide bondi | 225 ↔ 236 | By similarity | ||
Disulfide bondi | 229 ↔ 242 | By similarity | ||
Disulfide bondi | 244 ↔ 253 | By similarity | ||
Disulfide bondi | 256 ↔ 267 | By similarity | ||
Disulfide bondi | 262 ↔ 273 | By similarity | ||
Disulfide bondi | 275 ↔ 284 | By similarity | ||
Disulfide bondi | 291 ↔ 303 | By similarity | ||
Disulfide bondi | 297 ↔ 313 | By similarity | ||
Disulfide bondi | 315 ↔ 324 | By similarity | ||
Disulfide bondi | 331 ↔ 342 | By similarity | ||
Disulfide bondi | 336 ↔ 351 | By similarity | ||
Disulfide bondi | 353 ↔ 362 | By similarity | ||
Disulfide bondi | 369 ↔ 380 | By similarity | ||
Disulfide bondi | 374 ↔ 390 | By similarity | ||
Disulfide bondi | 392 ↔ 401 | By similarity | ||
Disulfide bondi | 408 ↔ 419 | By similarity | ||
Disulfide bondi | 413 ↔ 428 | By similarity | ||
Disulfide bondi | 430 ↔ 439 | By similarity | ||
Disulfide bondi | 446 ↔ 457 | By similarity | ||
Disulfide bondi | 451 ↔ 466 | By similarity | ||
Disulfide bondi | 468 ↔ 477 | By similarity | ||
Glycosylationi | 476 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 484 ↔ 495 | By similarity | ||
Disulfide bondi | 489 ↔ 504 | By similarity | ||
Disulfide bondi | 506 ↔ 515 | By similarity | ||
Cross-linki | 613 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 638 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 693 | Phosphoserine; by PKB1 Publication | 1 | |
Modified residuei | 696 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 527 – 528 | Cleavage; by MMP141 Publication | 2 | |
Sitei | 535 – 536 | Cleavage; by ADAM protease1 Publication | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q61483 |
PRIDEi | Q61483 |
ProteomicsDBi | 279687 |
PTM databases
GlyGeni | Q61483, 1 site |
iPTMneti | Q61483 |
PhosphoSitePlusi | Q61483 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000014773, Expressed in presomitic mesoderm and 342 other tissues |
ExpressionAtlasi | Q61483, baseline and differential |
Genevisiblei | Q61483, MM |
Interactioni
Subunit structurei
Homodimer (PubMed:12794186).
Interacts with TJP1 (PubMed:24715457).
Interacts with MMP14; inhibits DLL1-induced Notch signaling (PubMed:21572390).
Interacts with MAGI1 (via PDZ domain); forms a complex with CTNNB1 and CDH2 and promotes recruitment to the adherens junction and stabilization on the cell surface (PubMed:15908431).
Interacts with PSEN1; undergoes a presenilin-dependent gamma-secretase cleavage that releases a Dll1-intracellular form (PubMed:12794186).
Interacts with MFAP5 (PubMed:15788413).
Interacts with MIB1 (PubMed:21985982).
Interacts with NEURL1B; leads to ubiquitination (PubMed:17003037, PubMed:19723503).
Interacts with NEURL1 (PubMed:19723503).
Interacts with SYNJ2BP; enhances DLL1 protein stability, and promotes Notch signaling in endothelial cells (By similarity).
Interacts with MAGI1, MAGI2, MAGI3 and MPDZ (By similarity).
Interacts (via ubiquitin) with EPN1 (via IUM domain); binding with NOTCH1 attached to neighboring cell, promotes ligand ubiquitination and EPN1 interaction, leading to NECD transendocytosis and Notch signaling.
Interacts with NOTCH1 (By similarity).
By similarity8 PublicationsBinary interactionsi
Q61483
With | #Exp. | IntAct |
---|---|---|
Magi2 [Q9WVQ1] | 3 | EBI-297125,EBI-297151 |
GO - Molecular functioni
- Notch binding Source: UniProtKB
- scaffold protein binding Source: UniProtKB
- Tat protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199232, 7 interactors |
DIPi | DIP-32600N |
IntActi | Q61483, 8 interactors |
MINTi | Q61483 |
STRINGi | 10090.ENSMUSP00000014917 |
Miscellaneous databases
RNActi | Q61483, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 176 – 220 | DSLPROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 225 – 253 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Domaini | 256 – 284 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 29 | |
Domaini | 291 – 324 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 331 – 362 | EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 32 | |
Domaini | 369 – 401 | EGF-like 5PROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 408 – 439 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 32 | |
Domaini | 446 – 477 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 32 | |
Domaini | 484 – 515 | EGF-like 8PROSITE-ProRule annotationAdd BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 655 – 697 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 719 – 722 | Interaction with MAGI11 Publication | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 680 – 696 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000159781 |
HOGENOMi | CLU_012574_1_0_1 |
InParanoidi | Q61483 |
OMAi | DKPCHQG |
OrthoDBi | 406049at2759 |
PhylomeDBi | Q61483 |
TreeFami | TF351835 |
Family and domain databases
InterProi | View protein in InterPro IPR001774, DSL IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR011651, Notch_ligand_N |
Pfami | View protein in Pfam PF01414, DSL, 1 hit PF00008, EGF, 4 hits PF07645, EGF_CA, 1 hit PF12661, hEGF, 1 hit PF07657, MNNL, 1 hit |
SMARTi | View protein in SMART SM00051, DSL, 1 hit SM00181, EGF, 8 hits SM00179, EGF_CA, 6 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 3 hits PS51051, DSL, 1 hit PS00022, EGF_1, 8 hits PS01186, EGF_2, 8 hits PS50026, EGF_3, 7 hits PS01187, EGF_CA, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGRRSALALA VVSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGSG
60 70 80 90 100
PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGAGID
110 120 130 140 150
PAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLTTQR
160 170 180 190 200
HLTVGEEWSQ DLHSSGRTDL RYSYRFVCDE HYYGEGCSVF CRPRDDAFGH
210 220 230 240 250
FTCGDRGEKM CDPGWKGQYC TDPICLPGCD DQHGYCDKPG ECKCRVGWQG
260 270 280 290 300
RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCRNG
310 320 330 340 350
ATCTNTGQGS YTCSCRPGYT GANCELEVDE CAPSPCKNGA SCTDLEDSFS
360 370 380 390 400
CTCPPGFYGK VCELSAMTCA DGPCFNGGRC SDNPDGGYTC HCPLGFSGFN
410 420 430 440 450
CEKKMDLCGS SPCSNGAKCV DLGNSYLCRC QAGFSGRYCE DNVDDCASSP
460 470 480 490 500
CANGGTCRDS VNDFSCTCPP GYTGKNCSAP VSRCEHAPCH NGATCHQRGQ
510 520 530 540 550
RYMCECAQGY GGPNCQFLLP EPPPGPMVVD LSERHMESQG GPFPWVAVCA
560 570 580 590 600
GVVLVLLLLL GCAAVVVCVR LKLQKHQPPP EPCGGETETM NNLANCQREK
610 620 630 640 650
DVSVSIIGAT QIKNTNKKAD FHGDHGAEKS SFKVRYPTVD YNLVRDLKGD
660 670 680 690 700
EATVRDTHSK RDTKCQSQSS AGEEKIAPTL RGGEIPDRKR PESVYSTSKD
710 720
TKYQSVYVLS AEKDECVIAT EV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A338P7A6 | A0A338P7A6_MOUSE | Delta-like protein 1 | Dll1 | 73 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 628 | E → K in CAA56865 (PubMed:7671806).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80903 mRNA Translation: CAA56865.1 AY497019 Genomic DNA Translation: AAR30869.1 CH466630 Genomic DNA Translation: EDL20466.1 BC057400 mRNA Translation: AAH57400.1 BC065063 mRNA Translation: AAH65063.1 |
CCDSi | CCDS37452.1 |
PIRi | I48324 |
RefSeqi | NP_031891.2, NM_007865.3 |
Genome annotation databases
Ensembli | ENSMUST00000014917; ENSMUSP00000014917; ENSMUSG00000014773 |
GeneIDi | 13388 |
KEGGi | mmu:13388 |
UCSCi | uc008aoi.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80903 mRNA Translation: CAA56865.1 AY497019 Genomic DNA Translation: AAR30869.1 CH466630 Genomic DNA Translation: EDL20466.1 BC057400 mRNA Translation: AAH57400.1 BC065063 mRNA Translation: AAH65063.1 |
CCDSi | CCDS37452.1 |
PIRi | I48324 |
RefSeqi | NP_031891.2, NM_007865.3 |
3D structure databases
SMRi | Q61483 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199232, 7 interactors |
DIPi | DIP-32600N |
IntActi | Q61483, 8 interactors |
MINTi | Q61483 |
STRINGi | 10090.ENSMUSP00000014917 |
PTM databases
GlyGeni | Q61483, 1 site |
iPTMneti | Q61483 |
PhosphoSitePlusi | Q61483 |
Proteomic databases
PaxDbi | Q61483 |
PRIDEi | Q61483 |
ProteomicsDBi | 279687 |
Protocols and materials databases
Antibodypediai | 20091, 562 antibodies from 41 providers |
DNASUi | 13388 |
Genome annotation databases
Ensembli | ENSMUST00000014917; ENSMUSP00000014917; ENSMUSG00000014773 |
GeneIDi | 13388 |
KEGGi | mmu:13388 |
UCSCi | uc008aoi.2, mouse |
Organism-specific databases
CTDi | 28514 |
MGIi | MGI:104659, Dll1 |
VEuPathDBi | HostDB:ENSMUSG00000014773 |
Phylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00940000159781 |
HOGENOMi | CLU_012574_1_0_1 |
InParanoidi | Q61483 |
OMAi | DKPCHQG |
OrthoDBi | 406049at2759 |
PhylomeDBi | Q61483 |
TreeFami | TF351835 |
Enzyme and pathway databases
Reactomei | R-MMU-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus |
Miscellaneous databases
BioGRID-ORCSi | 13388, 3 hits in 63 CRISPR screens |
ChiTaRSi | Dll1, mouse |
PROi | PR:Q61483 |
RNActi | Q61483, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000014773, Expressed in presomitic mesoderm and 342 other tissues |
ExpressionAtlasi | Q61483, baseline and differential |
Genevisiblei | Q61483, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001774, DSL IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR011651, Notch_ligand_N |
Pfami | View protein in Pfam PF01414, DSL, 1 hit PF00008, EGF, 4 hits PF07645, EGF_CA, 1 hit PF12661, hEGF, 1 hit PF07657, MNNL, 1 hit |
SMARTi | View protein in SMART SM00051, DSL, 1 hit SM00181, EGF, 8 hits SM00179, EGF_CA, 6 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 3 hits PS51051, DSL, 1 hit PS00022, EGF_1, 8 hits PS01186, EGF_2, 8 hits PS50026, EGF_3, 7 hits PS01187, EGF_CA, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DLL1_MOUSE | |
Accessioni | Q61483Primary (citable) accession number: Q61483 Secondary accession number(s): Q6PFV7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot