Neuroblastoma suppressor of tumorigenicity 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• BMP binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."
    Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.
    Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]
• morphogen activity Source: BHF-UCLInferred from direct assayⁱ
  • "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."
    Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.
    Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: MGI

GO - Biological processⁱ

• determination of dorsal identity Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."
    Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.
    Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of BMP signaling pathway Source: MGIInferred from direct assayⁱ
  • "Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye."
    Zhou Y., Tanzie C., Yan Z., Chen S., Duncan M., Gaudenz K., Li H., Seidel C., Lewis B., Moran A., Libby R.T., Kiernan A.E., Xie T.
    Proc. Natl. Acad. Sci. U.S.A. 110:8966-8971(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of monocyte chemotaxis Source: BHF-UCLInferred from direct assayⁱ
  • "Bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis."
    Chen B., Blair D.G., Plisov S., Vasiliev G., Perantoni A.O., Chen Q., Athanasiou M., Wu J.Y., Oppenheim J.J., Yang D.
    J. Immunol. 173:5914-5917(2004) [PubMed] [Europe PMC] [Abstract]
• nervous system development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."
    Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.
    Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]
• neuron projection morphogenesis Source: MGIInferred from direct assayⁱ
  • "A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors."
    Krizhanovsky V., Ben-Arie N.
    Mech. Dev. 123:67-75(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron differentiation Source: MGIInferred from direct assayⁱ
  • "A novel role for the choroid plexus in BMP-mediated inhibition of differentiation of cerebellar neural progenitors."
    Krizhanovsky V., Ben-Arie N.
    Mech. Dev. 123:67-75(2006) [PubMed] [Europe PMC] [Abstract]
• sequestering of BMP from receptor via BMP binding Source: Ensembl
• sequestering of BMP in extracellular matrix Source: BHF-UCLInferred from direct assayⁱ
  • "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."
    Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.
    Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• BMP binding Source: BHF-UCLInferred from direct assayⁱ
  • "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."
    Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.
    Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]
• morphogen activity Source: BHF-UCLInferred from direct assayⁱ
  • "The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."
    Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M.
    Mol. Cell 1:673-683(1998) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MLWVLVGAVL PVMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA 
        60         70         80         90        100
KSIQNRACLG QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG 
       110        120        130        140        150
HEEVPRVDKL VEKIVHCSCQ ACGKEPSHEG LNVYVQGEDS PGSQPGPHSH 
       160        170 
AHPHPGGQTP EPEEPPGAPQ VEEEGAED                         

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot