UniProtKB - Q61477 (NBL1_MOUSE)
Protein
Neuroblastoma suppressor of tumorigenicity 1
Gene
Nbl1
Organism
Mus musculus (Mouse)
Status
Functioni
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
GO - Molecular functioni
- BMP binding Source: BHF-UCL
- identical protein binding Source: MGI
- morphogen activity Source: BHF-UCL
- receptor ligand activity Source: GO_Central
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- determination of dorsal identity Source: BHF-UCL
- negative regulation of BMP signaling pathway Source: MGI
- negative regulation of monocyte chemotaxis Source: BHF-UCL
- nervous system development Source: BHF-UCL
- neuron projection morphogenesis Source: MGI
- positive regulation of neuron differentiation Source: MGI
- sequestering of BMP from receptor via BMP binding Source: GO_Central
- sequestering of BMP in extracellular matrix Source: BHF-UCL
Names & Taxonomyi
Protein namesi | Recommended name: Neuroblastoma suppressor of tumorigenicity 1Alternative name(s): N03 Zinc finger protein DAN |
Gene namesi | Name:Nbl1 Synonyms:Dan, Dana |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104591, Nbl1 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000006723 | 17 – 178 | Neuroblastoma suppressor of tumorigenicity 1Add BLAST | 162 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 84 | By similarity | ||
Disulfide bondi | 48 ↔ 98 | By similarity | ||
Disulfide bondi | 58 ↔ 117 | By similarity | ||
Disulfide bondi | 62 ↔ 119 | By similarity | ||
Disulfide bondi | 81 ↔ 122 | Sequence analysis |
Keywords - PTMi
Disulfide bondProteomic databases
CPTACi | non-CPTAC-3393 |
MaxQBi | Q61477 |
PaxDbi | Q61477 |
PeptideAtlasi | Q61477 |
PRIDEi | Q61477 |
PTM databases
GlyConnecti | 2544, 1 N-Linked glycan (1 site) |
GlyGeni | Q61477, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041120, Expressed in esophagus and 267 other tissues |
Genevisiblei | Q61477, MM |
Interactioni
Subunit structurei
Homodimer.
1 PublicationGO - Molecular functioni
- BMP binding Source: BHF-UCL
- identical protein binding Source: MGI
- morphogen activity Source: BHF-UCL
- receptor ligand activity Source: GO_Central
Protein-protein interaction databases
MINTi | Q61477 |
STRINGi | 10090.ENSMUSP00000045608 |
Miscellaneous databases
RNActi | Q61477, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 123 | CTCKAdd BLAST | 90 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 141 – 169 | Pro-richAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the DAN family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RYP0, Eukaryota |
GeneTreei | ENSGT00940000154209 |
HOGENOMi | CLU_115450_0_0_1 |
InParanoidi | Q61477 |
OMAi | GLNVYVQ |
OrthoDBi | 1517793at2759 |
PhylomeDBi | Q61477 |
TreeFami | TF106445 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR029034, Cystine-knot_cytokine IPR004133, DAN IPR016728, Neuroblast_suppress_tumour_1 |
Pfami | View protein in Pfam PF03045, DAN, 1 hit |
PIRSFi | PIRSF018557, DAN_sub, 1 hit |
SMARTi | View protein in SMART SM00041, CT, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q61477-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLWVLVGAVL PVMLLAAPPP INKLALFPDK SAWCEAKNIT QIVGHSGCEA
60 70 80 90 100
KSIQNRACLG QCFSYSVPNT FPQSTESLVH CDSCMPAQSM WEIVTLECPG
110 120 130 140 150
HEEVPRVDKL VEKIVHCSCQ ACGKEPSHEG LNVYVQGEDS PGSQPGPHSH
160 170
AHPHPGGQTP EPEEPPGAPQ VEEEGAED
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 100 | G → D in BAA08817 (PubMed:8609050).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50263 mRNA Translation: BAA08817.1 AK133787 mRNA Translation: BAE21841.1 AK146535 mRNA Translation: BAE27241.1 AK158008 mRNA Translation: BAE34315.1 AL805923 Genomic DNA No translation available. CH466615 Genomic DNA Translation: EDL13294.1 BC099856 mRNA Translation: AAH99856.1 BC099857 mRNA Translation: AAH99857.1 BC099858 mRNA Translation: AAH99858.1 BC107810 mRNA Translation: AAI07811.1 |
CCDSi | CCDS18839.1 |
RefSeqi | NP_032701.2, NM_008675.2 XP_006538688.1, XM_006538625.3 XP_006538689.1, XM_006538626.3 |
Genome annotation databases
Ensembli | ENSMUST00000042844; ENSMUSP00000045608; ENSMUSG00000041120 |
GeneIDi | 17965 |
KEGGi | mmu:17965 |
UCSCi | uc008vls.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50263 mRNA Translation: BAA08817.1 AK133787 mRNA Translation: BAE21841.1 AK146535 mRNA Translation: BAE27241.1 AK158008 mRNA Translation: BAE34315.1 AL805923 Genomic DNA No translation available. CH466615 Genomic DNA Translation: EDL13294.1 BC099856 mRNA Translation: AAH99856.1 BC099857 mRNA Translation: AAH99857.1 BC099858 mRNA Translation: AAH99858.1 BC107810 mRNA Translation: AAI07811.1 |
CCDSi | CCDS18839.1 |
RefSeqi | NP_032701.2, NM_008675.2 XP_006538688.1, XM_006538625.3 XP_006538689.1, XM_006538626.3 |
3D structure databases
SMRi | Q61477 |
ModBasei | Search... |
Protein-protein interaction databases
MINTi | Q61477 |
STRINGi | 10090.ENSMUSP00000045608 |
PTM databases
GlyConnecti | 2544, 1 N-Linked glycan (1 site) |
GlyGeni | Q61477, 1 site |
Proteomic databases
CPTACi | non-CPTAC-3393 |
MaxQBi | Q61477 |
PaxDbi | Q61477 |
PeptideAtlasi | Q61477 |
PRIDEi | Q61477 |
Protocols and materials databases
Antibodypediai | 29695, 300 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042844; ENSMUSP00000045608; ENSMUSG00000041120 |
GeneIDi | 17965 |
KEGGi | mmu:17965 |
UCSCi | uc008vls.1, mouse |
Organism-specific databases
CTDi | 4681 |
MGIi | MGI:104591, Nbl1 |
Phylogenomic databases
eggNOGi | ENOG502RYP0, Eukaryota |
GeneTreei | ENSGT00940000154209 |
HOGENOMi | CLU_115450_0_0_1 |
InParanoidi | Q61477 |
OMAi | GLNVYVQ |
OrthoDBi | 1517793at2759 |
PhylomeDBi | Q61477 |
TreeFami | TF106445 |
Miscellaneous databases
BioGRID-ORCSi | 17965, 0 hits in 17 CRISPR screens |
ChiTaRSi | Nbl1, mouse |
PROi | PR:Q61477 |
RNActi | Q61477, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041120, Expressed in esophagus and 267 other tissues |
Genevisiblei | Q61477, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR029034, Cystine-knot_cytokine IPR004133, DAN IPR016728, Neuroblast_suppress_tumour_1 |
Pfami | View protein in Pfam PF03045, DAN, 1 hit |
PIRSFi | PIRSF018557, DAN_sub, 1 hit |
SMARTi | View protein in SMART SM00041, CT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NBL1_MOUSE | |
Accessioni | Q61477Primary (citable) accession number: Q61477 Secondary accession number(s): Q499K5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families