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Protein

Complement decay-accelerating factor transmembrane isoform

Gene

Cd55b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processComplement pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement decay-accelerating factor transmembrane isoform
Short name:
DAF-TM
Alternative name(s):
CD_antigen: CD55
Gene namesi
Name:Cd55b
Synonyms:Daf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104849 Cd55b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini40 – 368ExtracellularSequence analysisAdd BLAST329
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 407CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000000600640 – 407Complement decay-accelerating factor transmembrane isoformAdd BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 86PROSITE-ProRule annotation
Disulfide bondi70 ↔ 99PROSITE-ProRule annotation
Disulfide bondi103 ↔ 150PROSITE-ProRule annotation
Disulfide bondi134 ↔ 163PROSITE-ProRule annotation
Disulfide bondi168 ↔ 209PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi195 ↔ 225PROSITE-ProRule annotation
Disulfide bondi230 ↔ 272PROSITE-ProRule annotation
Disulfide bondi258 ↔ 289PROSITE-ProRule annotation
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61476
PaxDbiQ61476
PRIDEiQ61476

Expressioni

Tissue specificityi

Testis, spleen and lymph node.

Gene expression databases

CleanExiMM_DAF2

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108107

Structurei

3D structure databases

ProteinModelPortaliQ61476
SMRiQ61476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 101Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini102 – 165Sushi 2PROSITE-ProRule annotationAdd BLAST64
Domaini166 – 227Sushi 3PROSITE-ProRule annotationAdd BLAST62
Domaini228 – 291Sushi 4PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi291 – 363Ser/Thr-richAdd BLAST73

Domaini

The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGQ Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000237360
HOVERGENiHBG001406
InParanoidiQ61476
KOiK04006

Family and domain databases

CDDicd00033 CCP, 4 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 4 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SUPFAMiSSF57535 SSF57535, 4 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61476-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSSTWGYDP RAGAGDLVIT TTAAGAVTIA VLLFQTVCGD CGPPPDIPNA
60 70 80 90 100
RPILGRHSKF AEQSKVAYSC NNGFKQVPDK SNIVVCLENG QWSSHETFCE
110 120 130 140 150
KSCDTPERLS FASLKKEYFN MNFFPVGTIV EYECRPGFRK QPSLSGKSTC
160 170 180 190 200
LEDLVWSPVA QFCKKKSCPN PKDLDNGHIN IPTGILFGSE INFSCNPGYR
210 220 230 240 250
LVGITSILCT IIGNTVDWDD EFPVCTEIFC PDPPKINNGI MRGESDSYKY
260 270 280 290 300
SQVVIYSCDK GFILFGNSTI YCTVSKSDVG QWSSPPPQCI EESKVPIKKP
310 320 330 340 350
VVNVPSTGIP STPQKPTTES VPNPGDQPTP QKPSTVKVPA TQHEPDTTTR
360 370 380 390 400
TSTDKGESNS GGDRYIYGFV AVIAMIDSLI IVKTLWTILS PNRRSDFQGK

ERKDVSK
Length:407
Mass (Da):44,511
Last modified:July 27, 2011 - v2
Checksum:i12C461C9A69A9C76
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QAP4E9QAP4_MOUSE
Complement decay-accelerating facto...
Cd55b Daf2
400Annotation score:
E9Q731E9Q731_MOUSE
Complement decay-accelerating facto...
Cd55b Daf2
287Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti212I → T in AAB00092 (PubMed:7545711).Curated1
Sequence conflicti215T → A in AAB00092 (PubMed:7545711).Curated1
Sequence conflicti238N → D in AAB00092 (PubMed:7545711).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41365 mRNA Translation: AAB00092.1
AC111067 Genomic DNA No translation available.
AC116692 Genomic DNA No translation available.
RefSeqiNP_001304290.1, NM_001317361.1
NP_031853.2, NM_007827.3
UniGeneiMm.436759

Genome annotation databases

GeneIDi13137
KEGGimmu:13137

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41365 mRNA Translation: AAB00092.1
AC111067 Genomic DNA No translation available.
AC116692 Genomic DNA No translation available.
RefSeqiNP_001304290.1, NM_001317361.1
NP_031853.2, NM_007827.3
UniGeneiMm.436759

3D structure databases

ProteinModelPortaliQ61476
SMRiQ61476
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108107

Proteomic databases

MaxQBiQ61476
PaxDbiQ61476
PRIDEiQ61476

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13137
KEGGimmu:13137

Organism-specific databases

CTDi13137
MGIiMGI:104849 Cd55b

Phylogenomic databases

eggNOGiENOG410IEGQ Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000237360
HOVERGENiHBG001406
InParanoidiQ61476
KOiK04006

Miscellaneous databases

PROiPR:Q61476
SOURCEiSearch...

Gene expression databases

CleanExiMM_DAF2

Family and domain databases

CDDicd00033 CCP, 4 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 4 hits
SMARTiView protein in SMART
SM00032 CCP, 4 hits
SUPFAMiSSF57535 SSF57535, 4 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDAF2_MOUSE
AccessioniPrimary (citable) accession number: Q61476
Secondary accession number(s): E9QLT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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