Transcription factor SOX-17

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: MGI
• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "SOX7 and GATA-4 are competitive activators of Fgf-3 transcription."
    Murakami A., Shen H., Ishida S., Dickson C.
    J. Biol. Chem. 279:28564-28573(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "A regulatory network controls nephrocan expression and midgut patterning."
    Hou J., Wei W., Saund R.S., Xiang P., Cunningham T.J., Yi Y., Alder O., Lu D.Y., Savory J.G., Krentz N.A., Montpetit R., Cullum R., Hofs N., Lohnes D., Humphries R.K., Yamanaka Y., Duester G., Saijoh Y., Hoodless P.A.
    Development 141:3772-3781(2014) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis."
    Kanai Y., Kanai-Azuma M., Noce T., Saido T.C., Shiroishi T., Hayashi Y., Yazaki K.
    J. Cell Biol. 133:667-681(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice."
    Hosking B., Francois M., Wilhelm D., Orsenigo F., Caprini A., Svingen T., Tutt D., Davidson T., Browne C., Dejana E., Koopman P.
    Development 136:2385-2391(2009) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "SOX7 and SOX17 regulate the parietal endoderm-specific enhancer activity of mouse laminin alpha1 gene."
    Niimi T., Hayashi Y., Futaki S., Sekiguchi K.
    J Biol Chem 279:38055-38061(2004) [PubMed] [Europe PMC] [Abstract]
  • "Deciphering the Sox-Oct partner code by quantitative cooperativity measurements."
    Ng C.K., Li N.X., Chee S., Prabhakar S., Kolatkar P.R., Jauch R.
    Nucleic Acids Res 40:4933-4941(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis."
    Kanai Y., Kanai-Azuma M., Noce T., Saido T.C., Shiroishi T., Hayashi Y., Yazaki K.
    J. Cell Biol. 133:667-681(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• transcription factor binding Source: MGI
• transcription regulatory region sequence-specific DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • Ref.9

    "The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms."
    Palasingam P., Jauch R., Ng C.K., Kolatkar P.R.
    J. Mol. Biol. 388:619-630(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 66-144 IN COMPLEX WITH TARGET DNA, FUNCTION.
  • Ref.7

    "Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter."
    Liu X., Luo M., Xie W., Wells J.M., Goodheart M.J., Engelhardt J.F.
    Am. J. Physiol. 299:L694-L710(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CTNNB1; LEF1 AND TCF4, SUBCELLULAR LOCATION.

GO - Biological processⁱ

• anatomical structure morphogenesis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• angiogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • Ref.5

    "Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice."
    Matsui T., Kanai-Azuma M., Hara K., Matoba S., Hiramatsu R., Kawakami H., Kurohmaru M., Koopman P., Kanai Y.
    J. Cell Sci. 119:3513-3526(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• cardiac cell fate determination Source: MGI
• cardiogenic plate morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos."
    Pfister S., Jones V.J., Power M., Truisi G.L., Khoo P.L., Steiner K.A., Kanai-Azuma M., Kanai Y., Tam P.P., Loebel D.A.
    Int J Dev Biol 55:45-58(2011) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell migration involved in gastrulation Source: MGIInferred from mutant phenotypeⁱ
  • "The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17."
    Artus J., Piliszek A., Hadjantonakis A.K.
    Dev Biol 350:393-404(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to leukemia inhibitory factor Source: MGIInferred from direct assayⁱ
  • "miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells."
    Tarantino C., Paolella G., Cozzuto L., Minopoli G., Pastore L., Parisi S., Russo T.
    FASEB J 24:3255-3263(2010) [PubMed] [Europe PMC] [Abstract]
• common bile duct development Source: MGIInferred from mutant phenotypeⁱ
  • "Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis."
    Uemura M., Hara K., Shitara H., Ishii R., Tsunekawa N., Miura Y., Kurohmaru M., Taya C., Yonekawa H., Kanai-Azuma M., Kanai Y.
    Biochem Biophys Res Commun 391:357-363(2010) [PubMed] [Europe PMC] [Abstract]
• embryonic foregut morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos."
    Pfister S., Jones V.J., Power M., Truisi G.L., Khoo P.L., Steiner K.A., Kanai-Azuma M., Kanai Y., Tam P.P., Loebel D.A.
    Int J Dev Biol 55:45-58(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic heart tube development Source: MGIInferred from genetic interactionⁱ
  • "Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos."
    Sakamoto Y., Hara K., Kanai-Azuma M., Matsui T., Miura Y., Tsunekawa N., Kurohmaru M., Saijoh Y., Koopman P., Kanai Y.
    Biochem Biophys Res Commun 360:539-544(2007) [PubMed] [Europe PMC] [Abstract]
• embryonic heart tube morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos."
    Pfister S., Jones V.J., Power M., Truisi G.L., Khoo P.L., Steiner K.A., Kanai-Azuma M., Kanai Y., Tam P.P., Loebel D.A.
    Int J Dev Biol 55:45-58(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic organ development Source: MGIInferred from mutant phenotypeⁱ
  • "Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis."
    Uemura M., Hara K., Shitara H., Ishii R., Tsunekawa N., Miura Y., Kurohmaru M., Taya C., Yonekawa H., Kanai-Azuma M., Kanai Y.
    Biochem Biophys Res Commun 391:357-363(2010) [PubMed] [Europe PMC] [Abstract]
• endocardial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos."
    Sakamoto Y., Hara K., Kanai-Azuma M., Matsui T., Miura Y., Tsunekawa N., Kurohmaru M., Saijoh Y., Koopman P., Kanai Y.
    Biochem Biophys Res Commun 360:539-544(2007) [PubMed] [Europe PMC] [Abstract]
• endocardium formation Source: MGIInferred from genetic interactionⁱ
  • "Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos."
    Sakamoto Y., Hara K., Kanai-Azuma M., Matsui T., Miura Y., Tsunekawa N., Kurohmaru M., Saijoh Y., Koopman P., Kanai Y.
    Biochem Biophys Res Commun 360:539-544(2007) [PubMed] [Europe PMC] [Abstract]
• endodermal cell fate determination Source: MGIInferred from direct assayⁱ
  • "Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo."
    Morris S.A., Teo R.T., Li H., Robson P., Glover D.M., Zernicka-Goetz M.
    Proc Natl Acad Sci U S A 107:6364-6369(2010) [PubMed] [Europe PMC] [Abstract]
• endodermal cell fate specification Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos."
    Pfister S., Jones V.J., Power M., Truisi G.L., Khoo P.L., Steiner K.A., Kanai-Azuma M., Kanai Y., Tam P.P., Loebel D.A.
    Int J Dev Biol 55:45-58(2011) [PubMed] [Europe PMC] [Abstract]
• endodermal digestive tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos."
    Pfister S., Jones V.J., Power M., Truisi G.L., Khoo P.L., Steiner K.A., Kanai-Azuma M., Kanai Y., Tam P.P., Loebel D.A.
    Int J Dev Biol 55:45-58(2011) [PubMed] [Europe PMC] [Abstract]
• endoderm development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.4

    "Depletion of definitive gut endoderm in Sox17-null mutant mice."
    Kanai-Azuma M., Kanai Y., Gad J.M., Tajima Y., Taya C., Kurohmaru M., Sanai Y., Yonekawa H., Yazaki K., Tam P.P., Hayashi Y.
    Development 129:2367-2379(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
• endoderm formation Source: MGI
• gall bladder development Source: MGIInferred from mutant phenotypeⁱ
  • "Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis."
    Uemura M., Hara K., Shitara H., Ishii R., Tsunekawa N., Miura Y., Kurohmaru M., Taya C., Yonekawa H., Kanai-Azuma M., Kanai Y.
    Biochem Biophys Res Commun 391:357-363(2010) [PubMed] [Europe PMC] [Abstract]
• gastrulation Source: MGIInferred from mutant phenotypeⁱ
  • "Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal."
    Niakan K.K., Ji H., Maehr R., Vokes S.A., Rodolfa K.T., Sherwood R.I., Yamaki M., Dimos J.T., Chen A.E., Melton D.A., McMahon A.P., Eggan K.
    Genes Dev 24:312-326(2010) [PubMed] [Europe PMC] [Abstract]
• heart development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• heart looping Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.6

    "Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells."
    Kim I., Saunders T.L., Morrison S.J.
    Cell 130:470-483(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• inner cell mass cellular morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17."
    Artus J., Piliszek A., Hadjantonakis A.K.
    Dev Biol 350:393-404(2011) [PubMed] [Europe PMC] [Abstract]
• metanephros development Source: MGI
• negative regulation of canonical Wnt signaling pathway Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells."
    Sinner D., Kordich J.J., Spence J.R., Opoka R., Rankin S., Lin S.C., Jonatan D., Zorn A.M., Wells J.M.
    Mol Cell Biol 27:7802-7815(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell growth Source: MGI
• negative regulation of Wnt signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter."
    Liu X., Luo M., Xie W., Wells J.M., Goodheart M.J., Engelhardt J.F.
    Am. J. Physiol. 299:L694-L710(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CTNNB1; LEF1 AND TCF4, SUBCELLULAR LOCATION.
• negative regulation of Wnt signaling pathway involved in heart development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells."
    Liu Y., Asakura M., Inoue H., Nakamura T., Sano M., Niu Z., Chen M., Schwartz R.J., Schneider M.D.
    Proc Natl Acad Sci U S A 104:3859-3864(2007) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • "Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos."
    Sakamoto Y., Hara K., Kanai-Azuma M., Matsui T., Miura Y., Tsunekawa N., Kurohmaru M., Saijoh Y., Koopman P., Kanai Y.
    Biochem Biophys Res Commun 360:539-544(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell differentiation Source: MGIInferred from direct assayⁱ
  • "Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro."
    Shimoda M., Kanai-Azuma M., Hara K., Miyazaki S., Kanai Y., Monden M., Miyazaki J.
    J Cell Sci 120:3859-3869(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro."
    Shimoda M., Kanai-Azuma M., Hara K., Miyazaki S., Kanai Y., Monden M., Miyazaki J.
    J Cell Sci 120:3859-3869(2007) [PubMed] [Europe PMC] [Abstract]
  • "Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal."
    Niakan K.K., Ji H., Maehr R., Vokes S.A., Rodolfa K.T., Sherwood R.I., Yamaki M., Dimos J.T., Chen A.E., Melton D.A., McMahon A.P., Eggan K.
    Genes Dev 24:312-326(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein catabolic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter."
    Liu X., Luo M., Xie W., Wells J.M., Goodheart M.J., Engelhardt J.F.
    Am. J. Physiol. 299:L694-L710(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CTNNB1; LEF1 AND TCF4, SUBCELLULAR LOCATION.
• positive regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "SOX7 and SOX17 regulate the parietal endoderm-specific enhancer activity of mouse laminin alpha1 gene."
    Niimi T., Hayashi Y., Futaki S., Sekiguchi K.
    J Biol Chem 279:38055-38061(2004) [PubMed] [Europe PMC] [Abstract]
  • "Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice."
    Hosking B., Francois M., Wilhelm D., Orsenigo F., Caprini A., Svingen T., Tutt D., Davidson T., Browne C., Dejana E., Koopman P.
    Development 136:2385-2391(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis."
    Kanai Y., Kanai-Azuma M., Noce T., Saido T.C., Shiroishi T., Hayashi Y., Yazaki K.
    J. Cell Biol. 133:667-681(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• protein destabilization Source: MGI
• protein stabilization Source: MGI
• regulation of cardiac cell fate specification Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells."
    Liu Y., Asakura M., Inoue H., Nakamura T., Sano M., Niu Z., Chen M., Schwartz R.J., Schneider M.D.
    Proc Natl Acad Sci U S A 104:3859-3864(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17."
    Artus J., Piliszek A., Hadjantonakis A.K.
    Dev Biol 350:393-404(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of embryonic development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.4

    "Depletion of definitive gut endoderm in Sox17-null mutant mice."
    Kanai-Azuma M., Kanai Y., Gad J.M., Tajima Y., Taya C., Kurohmaru M., Sanai Y., Yonekawa H., Yazaki K., Tam P.P., Hayashi Y.
    Development 129:2367-2379(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
• regulation of stem cell division Source: MGIInferred from mutant phenotypeⁱ
  • "Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal."
    Niakan K.K., Ji H., Maehr R., Vokes S.A., Rodolfa K.T., Sherwood R.I., Yamaki M., Dimos J.T., Chen A.E., Melton D.A., McMahon A.P., Eggan K.
    Genes Dev 24:312-326(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of stem cell proliferation Source: MGIInferred from direct assayⁱ
  • "Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification."
    Serrano A.G., Gandillet A., Pearson S., Lacaud G., Kouskoff V.
    Blood 115:3895-3898(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter."
    Liu X., Luo M., Xie W., Wells J.M., Goodheart M.J., Engelhardt J.F.
    Am. J. Physiol. 299:L694-L710(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CTNNB1; LEF1 AND TCF4, SUBCELLULAR LOCATION.
• regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos."
    Pfister S., Jones V.J., Power M., Truisi G.L., Khoo P.L., Steiner K.A., Kanai-Azuma M., Kanai Y., Tam P.P., Loebel D.A.
    Int J Dev Biol 55:45-58(2011) [PubMed] [Europe PMC] [Abstract]
• rostrocaudal neural tube patterning Source: MGIInferred from mutant phenotypeⁱ
  • "Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis."
    Uemura M., Hara K., Shitara H., Ishii R., Tsunekawa N., Miura Y., Kurohmaru M., Taya C., Yonekawa H., Kanai-Azuma M., Kanai Y.
    Biochem Biophys Res Commun 391:357-363(2010) [PubMed] [Europe PMC] [Abstract]
• signal transduction involved in regulation of gene expression Source: MGIInferred from direct assayⁱ
  • "ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification."
    Lee D., Park C., Lee H., Lugus J.J., Kim S.H., Arentson E., Chung Y.S., Gomez G., Kyba M., Lin S., Janknecht R., Lim D.S., Choi K.
    Cell Stem Cell 2:497-507(2008) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis."
    Kanai Y., Kanai-Azuma M., Noce T., Saido T.C., Shiroishi T., Hayashi Y., Yazaki K.
    J. Cell Biol. 133:667-681(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• stem cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal."
    Niakan K.K., Ji H., Maehr R., Vokes S.A., Rodolfa K.T., Sherwood R.I., Yamaki M., Dimos J.T., Chen A.E., Melton D.A., McMahon A.P., Eggan K.
    Genes Dev 24:312-326(2010) [PubMed] [Europe PMC] [Abstract]
• stem cell fate specification Source: MGIInferred from direct assayⁱ
  • "Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification."
    Serrano A.G., Gandillet A., Pearson S., Lacaud G., Kouskoff V.
    Blood 115:3895-3898(2010) [PubMed] [Europe PMC] [Abstract]
• ureter development Source: MGI
• vasculogenesis Source: MGIInferred from genetic interactionⁱ
  • Ref.5

    "Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice."
    Matsui T., Kanai-Azuma M., Hara K., Matoba S., Hiramatsu R., Kawakami H., Kurohmaru M., Koopman P., Kanai Y.
    J. Cell Sci. 119:3513-3526(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• Wnt signaling pathway Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: MGI
• transcription factor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSPDAGYAS DDQSQPRSAQ PAVMAGLGPC PWAESLSPLG DVKVKGEVVA 
        60         70         80         90        100
SSGAPAGTSG RAKAESRIRR PMNAFMVWAK DERKRLAQQN PDLHNAELSK 
       110        120        130        140        150
MLGKSWKALT LAEKRPFVEE AERLRVQHMQ DHPNYKYRPR RRKQVKRMKR 
       160        170        180        190        200
VEGGFLHALV EPQAGALGPE GGRVAMDGLG LPFPEPGYPA GPPLMSPHMG 
       210        220        230        240        250
PHYRDCQGLG APALDGYPLP TPDTSPLDGV EQDPAFFAAP LPGDCPAAGT 
       260        270        280        290        300
YTYAPVSDYA VSVEPPAGPM RVGPDPSGPA MPGILAPPSA LHLYYGAMGS 
       310        320        330        340        350
PAASAGRGFH AQPQQPLQPQ APPPPPQQQH PAHGPGQPSP PPEALPCRDG 
       360        370        380        390        400
TESNQPTELL GEVDRTEFEQ YLPFVYKPEM GLPYQGHDCG VNLSDSHGAI 
       410 
SSVVSDASSA VYYCNYPDI                                   

        10         20         30         40         50
MQDHPNYKYR PRRRKQVKRM KRVEGGFLHA LVEPQAGALG PEGGRVAMDG 
        60         70         80         90        100
LGLPFPEPGY PAGPPLMSPH MGPHYRDCQG LGAPALDGYP LPTPDTSPLD 
       110        120        130        140        150
GVEQDPAFFA APLPGDCPAA GTYTYAPVSD YAVSVEPPAG PMRVGPDPSG 
       160        170        180        190        200
PAMPGILAPP SALHLYYGAM GSPAASAGRG FHAQPQQPLQ PQAPPPPPQQ 
       210        220        230        240        250
QHPAHGPGQP SPPPEALPCR DGTESNQPTE LLGEVDRTEF EQYLPFVYKP 
       260        270        280        290 
EMGLPYQGHD CGVNLSDSHG AISSVVSDAS SAVYYCNYPD I          

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references