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Protein

Transcription factor SOX-17

Gene

Sox17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Isoform 2 (T-SOX17) shows no DNA-binding activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi68 – 136HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-17
Gene namesi
Name:Sox17
Synonyms:Sox-17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107543 Sox17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal due to defects in the development of the definite gut endoderm and aberrant heart looping. Embryos die at about 10.5 dpc.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487661 – 419Transcription factor SOX-17Add BLAST419

Proteomic databases

PaxDbiQ61473
PRIDEiQ61473

PTM databases

iPTMnetiQ61473
PhosphoSitePlusiQ61473

Expressioni

Tissue specificityi

Testis. Detected in lung.

Developmental stagei

Detected in the extraembryonic region of the visceral endoderm of pre-streak and early-streak embryos. Detected in the extraembryonic region of the visceral endoderm and in the definitive endoderm at 7.5 dpc. By the seven to eight somite stage, detected in the posterior endoderm, mainly in the endoderm of the midgut and hindgut invagination. Expressed in spermatogonia. The expression clearly declines from the early pachytene spermatocyte stage onward. In contrast, expression of isoform 2 (T-SOX17) begins at the pachytene spermatocyte stage and is highly accumulated in round spermatids.1 Publication

Gene expression databases

BgeeiENSMUSG00000025902 Expressed in 226 organ(s), highest expression level in brain blood vessel
CleanExiMM_SOX17
ExpressionAtlasiQ61473 baseline and differential
GenevisibleiQ61473 MM

Interactioni

Subunit structurei

Interacts with CTNNB1, LEF1 and TCF4.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203403, 1 interactor
IntActiQ61473, 7 interactors
STRINGi10090.ENSMUSP00000027035

Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ61473
SMRiQ61473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini278 – 418Sox C-terminalPROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi312 – 346Gln/Pro-richAdd BLAST35
Compositional biasi322 – 326Poly-Pro5

Phylogenomic databases

eggNOGiENOG410IPZH Eukaryota
ENOG41114B8 LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000069999
HOVERGENiHBG000517
InParanoidiQ61473
KOiK04495
OrthoDBiEOG091G0CYU
PhylomeDBiQ61473

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR033392 Sox7/17/18_central
IPR021934 Sox_C
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12067 Sox17_18_mid, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS51516 SOX_C, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61473-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSPDAGYAS DDQSQPRSAQ PAVMAGLGPC PWAESLSPLG DVKVKGEVVA
60 70 80 90 100
SSGAPAGTSG RAKAESRIRR PMNAFMVWAK DERKRLAQQN PDLHNAELSK
110 120 130 140 150
MLGKSWKALT LAEKRPFVEE AERLRVQHMQ DHPNYKYRPR RRKQVKRMKR
160 170 180 190 200
VEGGFLHALV EPQAGALGPE GGRVAMDGLG LPFPEPGYPA GPPLMSPHMG
210 220 230 240 250
PHYRDCQGLG APALDGYPLP TPDTSPLDGV EQDPAFFAAP LPGDCPAAGT
260 270 280 290 300
YTYAPVSDYA VSVEPPAGPM RVGPDPSGPA MPGILAPPSA LHLYYGAMGS
310 320 330 340 350
PAASAGRGFH AQPQQPLQPQ APPPPPQQQH PAHGPGQPSP PPEALPCRDG
360 370 380 390 400
TESNQPTELL GEVDRTEFEQ YLPFVYKPEM GLPYQGHDCG VNLSDSHGAI
410
SSVVSDASSA VYYCNYPDI
Length:419
Mass (Da):44,646
Last modified:November 1, 1997 - v1
Checksum:i14233EED2CCDD69D
GO
Isoform 2 (identifier: Q61473-2) [UniParc]FASTAAdd to basket
Also known as: T-SOX17

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Show »
Length:291
Mass (Da):30,782
Checksum:i2298C8A3EC02F44C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YXS3A0A0A6YXS3_MOUSE
Transcription factor SOX-17
Sox17
354Annotation score:
A0A0A6YWS4A0A0A6YWS4_MOUSE
Transcription factor SOX-17
Sox17
169Annotation score:
A0A0A6YXV3A0A0A6YXV3_MOUSE
Transcription factor SOX-17
Sox17
170Annotation score:
A0A0A6YXZ2A0A0A6YXZ2_MOUSE
Transcription factor SOX-17
Sox17
107Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0022041 – 128Missing in isoform 2. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49474 mRNA Translation: BAA08444.1
D49473 mRNA Translation: BAA08443.1
AK004781 mRNA Translation: BAB23559.1
L29085 mRNA Translation: AAA56843.1
CCDSiCCDS14805.1 [Q61473-1]
CCDS78538.1 [Q61473-2]
RefSeqiNP_001276393.1, NM_001289464.1 [Q61473-1]
NP_001276394.1, NM_001289465.1
NP_001276396.1, NM_001289467.1 [Q61473-2]
NP_035571.1, NM_011441.5 [Q61473-1]
XP_006495537.1, XM_006495474.2 [Q61473-1]
XP_006495538.1, XM_006495475.3 [Q61473-1]
XP_011236666.1, XM_011238364.2 [Q61473-1]
UniGeneiMm.279103

Genome annotation databases

EnsembliENSMUST00000027035; ENSMUSP00000027035; ENSMUSG00000025902 [Q61473-1]
ENSMUST00000116652; ENSMUSP00000112351; ENSMUSG00000025902 [Q61473-1]
ENSMUST00000195555; ENSMUSP00000141894; ENSMUSG00000025902 [Q61473-2]
GeneIDi20671
KEGGimmu:20671
UCSCiuc007aey.1 mouse [Q61473-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49474 mRNA Translation: BAA08444.1
D49473 mRNA Translation: BAA08443.1
AK004781 mRNA Translation: BAB23559.1
L29085 mRNA Translation: AAA56843.1
CCDSiCCDS14805.1 [Q61473-1]
CCDS78538.1 [Q61473-2]
RefSeqiNP_001276393.1, NM_001289464.1 [Q61473-1]
NP_001276394.1, NM_001289465.1
NP_001276396.1, NM_001289467.1 [Q61473-2]
NP_035571.1, NM_011441.5 [Q61473-1]
XP_006495537.1, XM_006495474.2 [Q61473-1]
XP_006495538.1, XM_006495475.3 [Q61473-1]
XP_011236666.1, XM_011238364.2 [Q61473-1]
UniGeneiMm.279103

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F27X-ray2.75D66-144[»]
ProteinModelPortaliQ61473
SMRiQ61473
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203403, 1 interactor
IntActiQ61473, 7 interactors
STRINGi10090.ENSMUSP00000027035

PTM databases

iPTMnetiQ61473
PhosphoSitePlusiQ61473

Proteomic databases

PaxDbiQ61473
PRIDEiQ61473

Protocols and materials databases

DNASUi20671
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027035; ENSMUSP00000027035; ENSMUSG00000025902 [Q61473-1]
ENSMUST00000116652; ENSMUSP00000112351; ENSMUSG00000025902 [Q61473-1]
ENSMUST00000195555; ENSMUSP00000141894; ENSMUSG00000025902 [Q61473-2]
GeneIDi20671
KEGGimmu:20671
UCSCiuc007aey.1 mouse [Q61473-1]

Organism-specific databases

CTDi64321
MGIiMGI:107543 Sox17

Phylogenomic databases

eggNOGiENOG410IPZH Eukaryota
ENOG41114B8 LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000069999
HOVERGENiHBG000517
InParanoidiQ61473
KOiK04495
OrthoDBiEOG091G0CYU
PhylomeDBiQ61473

Enzyme and pathway databases

ReactomeiR-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

PROiPR:Q61473
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025902 Expressed in 226 organ(s), highest expression level in brain blood vessel
CleanExiMM_SOX17
ExpressionAtlasiQ61473 baseline and differential
GenevisibleiQ61473 MM

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR033392 Sox7/17/18_central
IPR021934 Sox_C
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12067 Sox17_18_mid, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
PS51516 SOX_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX17_MOUSE
AccessioniPrimary (citable) accession number: Q61473
Secondary accession number(s): Q61472, Q62248
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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