Transcription factor SOX-17

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-catenin binding Source: MGI
• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15082719
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • 19515696
• protein heterodimerization activity Source: MGIInferred from direct assayⁱ
  • 22344693
• RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 22344693
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 8636240
• transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 25209250
• transcription coactivator activity Source: MGIInferred from direct assayⁱ
  • 8636240
• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGIInferred from direct assayⁱ
  • 15220343
• transcription factor binding Source: MGI
• transcription regulatory region DNA binding Source: BHF-UCLInferred from direct assayⁱ
  • 19328208
  • 20802155

GO - Biological processⁱ

• angiogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 16895970
• canonical Wnt signaling pathway Source: MGIInferred from direct assayⁱ
  • 17360443
• cardiac cell fate determination Source: MGI
• cardiogenic plate morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 21305474
• cell migration involved in gastrulation Source: MGIInferred from mutant phenotypeⁱ
  • 21146513
• cellular response to leukemia inhibitory factor Source: MGIInferred from direct assayⁱ
  • 20439489
• common bile duct development Source: MGIInferred from mutant phenotypeⁱ
  • 19913509
• embryonic foregut morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 21305474
• embryonic heart tube development Source: MGIInferred from genetic interactionⁱ
  • 17610846
• embryonic heart tube morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 21305474
• embryonic organ development Source: MGIInferred from mutant phenotypeⁱ
  • 19913509
• endocardial cell differentiation Source: MGIInferred from genetic interactionⁱ
  • 17610846
• endocardium formation Source: MGIInferred from genetic interactionⁱ
  • 17610846
• endodermal cell fate determination Source: MGIInferred from direct assayⁱ
  • 20308546
• endodermal digestive tract morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 21305474
• endoderm development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 11973269
• endoderm formation Source: MGI
• gall bladder development Source: MGIInferred from mutant phenotypeⁱ
  • 19913509
• gastrulation Source: MGIInferred from mutant phenotypeⁱ
  • 20123909
• heart looping Source: UniProtKBInferred from mutant phenotypeⁱ
  • 17655922
• inner cell mass cellular morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 21146513
• mRNA transcription by RNA polymerase II Source: MGI
• negative regulation of canonical Wnt signaling pathway Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 17875931
• negative regulation of cell growth Source: MGI
• negative regulation of mesodermal cell fate specification Source: MGIInferred from mutant phenotypeⁱ
  • 17360443
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • 17360443
• negative regulation of Wnt signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • 20802155
• negative regulation of Wnt signaling pathway involved in heart development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 17360443
• outflow tract morphogenesis Source: BHF-UCLInferred from genetic interactionⁱ
  • 17610846
• positive regulation of cell differentiation Source: MGIInferred from direct assayⁱ
  • 17940068
• positive regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • 17940068
  • 20123909
• positive regulation of protein catabolic process Source: UniProtKBInferred from direct assayⁱ
  • 20802155
• positive regulation of skeletal muscle tissue development Source: MGIInferred from direct assayⁱ
  • 17360443
• positive regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • 15220343
  • 19515696
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 17360443
  • 8636240
• protein destabilization Source: MGI
• protein stabilization Source: MGI
• regulation of cardiac cell fate specification Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 17360443
• regulation of cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 21146513
• regulation of embryonic development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 11973269
• regulation of mesodermal cell fate specification Source: MGIInferred from mutant phenotypeⁱ
  • 17360443
• regulation of stem cell division Source: MGIInferred from mutant phenotypeⁱ
  • 20123909
• regulation of stem cell proliferation Source: MGIInferred from direct assayⁱ
  • 20228271
• regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 20802155
• regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 21305474
• renal system development Source: MGI
• rostrocaudal neural tube patterning Source: MGIInferred from mutant phenotypeⁱ
  • 19913509
• signal transduction involved in regulation of gene expression Source: MGIInferred from direct assayⁱ
  • 18462699
• spermatogenesis Source: MGIInferred from direct assayⁱ
  • 8636240
• stem cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 20123909
• stem cell fate specification Source: MGIInferred from direct assayⁱ
  • 20228271
• vasculogenesis Source: MGIInferred from genetic interactionⁱ
  • 16895970

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• beta-catenin binding Source: MGI
• protein heterodimerization activity Source: MGIInferred from direct assayⁱ
  • 22344693
• transcription factor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSPDAGYAS DDQSQPRSAQ PAVMAGLGPC PWAESLSPLG DVKVKGEVVA 
        60         70         80         90        100
SSGAPAGTSG RAKAESRIRR PMNAFMVWAK DERKRLAQQN PDLHNAELSK 
       110        120        130        140        150
MLGKSWKALT LAEKRPFVEE AERLRVQHMQ DHPNYKYRPR RRKQVKRMKR 
       160        170        180        190        200
VEGGFLHALV EPQAGALGPE GGRVAMDGLG LPFPEPGYPA GPPLMSPHMG 
       210        220        230        240        250
PHYRDCQGLG APALDGYPLP TPDTSPLDGV EQDPAFFAAP LPGDCPAAGT 
       260        270        280        290        300
YTYAPVSDYA VSVEPPAGPM RVGPDPSGPA MPGILAPPSA LHLYYGAMGS 
       310        320        330        340        350
PAASAGRGFH AQPQQPLQPQ APPPPPQQQH PAHGPGQPSP PPEALPCRDG 
       360        370        380        390        400
TESNQPTELL GEVDRTEFEQ YLPFVYKPEM GLPYQGHDCG VNLSDSHGAI 
       410 
SSVVSDASSA VYYCNYPDI                                   

        10         20         30         40         50
MQDHPNYKYR PRRRKQVKRM KRVEGGFLHA LVEPQAGALG PEGGRVAMDG 
        60         70         80         90        100
LGLPFPEPGY PAGPPLMSPH MGPHYRDCQG LGAPALDGYP LPTPDTSPLD 
       110        120        130        140        150
GVEQDPAFFA APLPGDCPAA GTYTYAPVSD YAVSVEPPAG PMRVGPDPSG 
       160        170        180        190        200
PAMPGILAPP SALHLYYGAM GSPAASAGRG FHAQPQQPLQ PQAPPPPPQQ 
       210        220        230        240        250
QHPAHGPGQP SPPPEALPCR DGTESNQPTE LLGEVDRTEF EQYLPFVYKP 
       260        270        280        290 
EMGLPYQGHD CGVNLSDSHG AISSVVSDAS SAVYYCNYPD I          

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot