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Protein

Leukocyte antigen CD37

Gene

Cd37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • defense response to protozoan Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of myeloid dendritic cell activation Source: MGI
  • positive regulation of immunoglobulin production Source: MGI
  • regulation of defense response to virus Source: MGI
  • regulation of humoral immune response Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte antigen CD37
Alternative name(s):
CD_antigen: CD37
Gene namesi
Name:Cd37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88330 Cd37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 59ExtracellularSequence analysisAdd BLAST21
Transmembranei60 – 74HelicalSequence analysisAdd BLAST15
Topological domaini75 – 85CytoplasmicSequence analysisAdd BLAST11
Transmembranei86 – 111HelicalSequence analysisAdd BLAST26
Topological domaini112 – 241ExtracellularSequence analysisAdd BLAST130
Transmembranei242 – 266HelicalSequence analysisAdd BLAST25
Topological domaini267 – 281CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192101 – 281Leukocyte antigen CD37Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ61470
MaxQBiQ61470
PaxDbiQ61470
PRIDEiQ61470

PTM databases

iPTMnetiQ61470
PhosphoSitePlusiQ61470
SwissPalmiQ61470

Expressioni

Gene expression databases

BgeeiENSMUSG00000030798 Expressed in 17 organ(s), highest expression level in spleen
CleanExiMM_CD37
ExpressionAtlasiQ61470 baseline and differential
GenevisibleiQ61470 MM

Interactioni

Subunit structurei

Interacts with SCIMP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096061

Structurei

3D structure databases

ProteinModelPortaliQ61470
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ61470
KOiK06475
PhylomeDBiQ61470
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q61470-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAQESCLSL IKYFLFVFNL FFFVLGGLIF CFGTWILIDK TSFVSFVGLS
60 70 80 90 100
FVPLQTWSKV LAVSGVLTMA LALLGCVGAL KELRCLLGLY FGMLLLLFAT
110 120 130 140 150
QITLGILIST QRVRLERRVQ ELVLRTIQSY RTNPDETAAE ESWDYAQFQL
160 170 180 190 200
RCCGWQSPRD WNKAQMLKAN ESEEPFVPCS CYNSTATNDS TVFDKLFFSQ
210 220 230 240 250
LSRLGPRAKL RQTADICALP AKAHIYREGC AQSLQKWLHN NIISIVGICL
260 270 280
GVGLLELGFM TLSIFLCRNL DHVYDRLARY R
Length:281
Mass (Da):31,852
Last modified:November 1, 1996 - v1
Checksum:i5B0E11B3B9CCA22D
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U1W9Q3U1W9_MOUSE
Tetraspanin
Cd37
252Annotation score:
A0A1B0GS72A0A1B0GS72_MOUSE
Tetraspanin
Cd37
235Annotation score:
A0A1B0GSZ7A0A1B0GSZ7_MOUSE
Tetraspanin
Cd37
258Annotation score:
Q3U429Q3U429_MOUSE
Tetraspanin
Cd37
303Annotation score:
A0A1B0GSS0A0A1B0GSS0_MOUSE
Leukocyte antigen CD37
Cd37
60Annotation score:
A0A1B0GST6A0A1B0GST6_MOUSE
Leukocyte antigen CD37
Cd37
61Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18372
, U18367, U18368, U18369, U18370, U18371 Genomic DNA Translation: AAB39500.1
BC019402 mRNA Translation: AAH19402.1
CCDSiCCDS21237.1
RefSeqiNP_031671.1, NM_007645.4
UniGeneiMm.3689

Genome annotation databases

EnsembliENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798
GeneIDi12493
KEGGimmu:12493
UCSCiuc009guh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18372
, U18367, U18368, U18369, U18370, U18371 Genomic DNA Translation: AAB39500.1
BC019402 mRNA Translation: AAH19402.1
CCDSiCCDS21237.1
RefSeqiNP_031671.1, NM_007645.4
UniGeneiMm.3689

3D structure databases

ProteinModelPortaliQ61470
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096061

PTM databases

iPTMnetiQ61470
PhosphoSitePlusiQ61470
SwissPalmiQ61470

Proteomic databases

EPDiQ61470
MaxQBiQ61470
PaxDbiQ61470
PRIDEiQ61470

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798
GeneIDi12493
KEGGimmu:12493
UCSCiuc009guh.1 mouse

Organism-specific databases

CTDi951
MGIiMGI:88330 Cd37

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ61470
KOiK06475
PhylomeDBiQ61470
TreeFamiTF352892

Miscellaneous databases

PROiPR:Q61470
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030798 Expressed in 17 organ(s), highest expression level in spleen
CleanExiMM_CD37
ExpressionAtlasiQ61470 baseline and differential
GenevisibleiQ61470 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD37_MOUSE
AccessioniPrimary (citable) accession number: Q61470
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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