Cd37

Functionⁱ

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to protozoan
Source: MGI
Inferred from genetic interactionⁱ
- 20709950
negative regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 20709950
negative regulation of myeloid dendritic cell activation
Source: MGI
Inferred from genetic interactionⁱ
- 20709950
positive regulation of immunoglobulin production
Source: MGI
Inferred from mutant phenotypeⁱ
- 10891477
regulation of defense response to virus
Source: MGI
Inferred from genetic interactionⁱ
- 20709950
regulation of humoral immune response
Source: MGI
Inferred from mutant phenotypeⁱ
- 10891477
- 20709950

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leukocyte antigen CD37 Alternative name(s): CD_antigen: CD37
Gene namesⁱ	Name:Cd37
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:88330 Cd37

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 17	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	18 – 38	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	39 – 59	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	60 – 74	HelicalSequence analysisAdd BLAST	15
Topological domainⁱ	75 – 85	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	86 – 111	HelicalSequence analysisAdd BLAST	26
Topological domainⁱ	112 – 241	ExtracellularSequence analysisAdd BLAST	130
Transmembraneⁱ	242 – 266	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	267 – 281	CytoplasmicSequence analysisAdd BLAST	15

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219210	1 – 281	Leukocyte antigen CD37Add BLAST		281

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	170	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	183	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	188	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q61470
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61470
PaxDbⁱ	Q61470
PRIDEⁱ	Q61470

PTM databases

iPTMnetⁱ	Q61470
PhosphoSitePlusⁱ	Q61470
SwissPalmⁱ	Q61470

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030798 Expressed in 17 organ(s), highest expression level in spleen
CleanExⁱ	MM_CD37
ExpressionAtlasⁱ	Q61470 baseline and differential
Genevisibleⁱ	Q61470 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SCIMP.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000096061

STRINGⁱ

10090.ENSMUSP00000096061

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61470
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137858
HOGENOMⁱ	HOG000230651
HOVERGENⁱ	HBG002324
InParanoidⁱ	Q61470
KEGG Orthology (KO) More...KOⁱ	K06475
PhylomeDBⁱ	Q61470
TreeFamⁱ	TF352892

Family and domain databases

Gene3Dⁱ	1.10.1450.10, 1 hit
InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
SUPFAMⁱ	SSF48652 SSF48652, 1 hit
PROSITEⁱ	View protein in PROSITE PS00421 TM4_1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

Q61470-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAQESCLSL IKYFLFVFNL FFFVLGGLIF CFGTWILIDK TSFVSFVGLS 
        60         70         80         90        100
FVPLQTWSKV LAVSGVLTMA LALLGCVGAL KELRCLLGLY FGMLLLLFAT 
       110        120        130        140        150
QITLGILIST QRVRLERRVQ ELVLRTIQSY RTNPDETAAE ESWDYAQFQL 
       160        170        180        190        200
RCCGWQSPRD WNKAQMLKAN ESEEPFVPCS CYNSTATNDS TVFDKLFFSQ 
       210        220        230        240        250
LSRLGPRAKL RQTADICALP AKAHIYREGC AQSLQKWLHN NIISIVGICL 
       260        270        280 
GVGLLELGFM TLSIFLCRNL DHVYDRLARY R

Length:281

Mass (Da):31,852

Last modified:November 1, 1996 - v1

Checksum:ⁱ5B0E11B3B9CCA22D

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q3U1W9	Q3U1W9_MOUSE	Tetraspanin Tetraspanin	Cd37	252	Annotation score:
A0A1B0GS72	A0A1B0GS72_MOUSE	Tetraspanin Tetraspanin	Cd37	235	Annotation score:
A0A1B0GSZ7	A0A1B0GSZ7_MOUSE	Tetraspanin Tetraspanin	Cd37	258	Annotation score:
Q3U429	Q3U429_MOUSE	Tetraspanin Tetraspanin	Cd37	303	Annotation score:
A0A1B0GSS0	A0A1B0GSS0_MOUSE	Leukocyte antigen CD37 Leukocyte antigen CD37	Cd37	60	Annotation score:
A0A1B0GST6	A0A1B0GST6_MOUSE	Leukocyte antigen CD37 Leukocyte antigen CD37	Cd37	61	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18372 U18371 Genomic DNA Translation: AAB39500.1 BC019402 mRNA Translation: AAH19402.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21237.1
NCBI Reference Sequences More...RefSeqⁱ	NP_031671.1, NM_007645.4
UniGeneⁱ	Mm.3689

Genome annotation databases

Ensemblⁱ	ENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798
GeneIDⁱ	12493
KEGGⁱ	mmu:12493
UCSC genome browser More...UCSCⁱ	uc009guh.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61470	Tetraspanin		MOUSE		303	UniRef100_Q61470
Tetraspanin		MOUSE		281

Protein	Similar proteins		Species	Score	Length	Source
Q61470	Leukocyte antigen CD37		RAT		281	UniRef90_Q61470
Tetraspanin		MOUSE		303
Tetraspanin		NEOLE		304
UPI0004545481		CRIGR		304
UPI00077DA381		PERMB		304
+12

Protein	Similar proteins		Species	Score	Length	Source
Q61470	Leukocyte antigen CD37		HUMAN		281	UniRef50_P11049
Leukocyte antigen CD37		RAT		281
Tetraspanin		NOMLE		281
Tetraspanin		AOTNA		281
Tetraspanin		Cebus capucinus imitator		281
+167

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U18372 U18371 Genomic DNA Translation: AAB39500.1 BC019402 mRNA Translation: AAH19402.1
CCDSⁱ	CCDS21237.1
RefSeqⁱ	NP_031671.1, NM_007645.4
UniGeneⁱ	Mm.3689

3D structure databases

ProteinModelPortalⁱ	Q61470
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000096061

STRINGⁱ

10090.ENSMUSP00000096061

PTM databases

iPTMnetⁱ	Q61470
PhosphoSitePlusⁱ	Q61470
SwissPalmⁱ	Q61470

Proteomic databases

EPDⁱ	Q61470
MaxQBⁱ	Q61470
PaxDbⁱ	Q61470
PRIDEⁱ	Q61470

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798
GeneIDⁱ	12493
KEGGⁱ	mmu:12493
UCSCⁱ	uc009guh.1 mouse

Organism-specific databases

CTDⁱ	951
MGIⁱ	MGI:88330 Cd37

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
GeneTreeⁱ	ENSGT00880000137858
HOGENOMⁱ	HOG000230651
HOVERGENⁱ	HBG002324
InParanoidⁱ	Q61470
KOⁱ	K06475
PhylomeDBⁱ	Q61470
TreeFamⁱ	TF352892

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q61470
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030798 Expressed in 17 organ(s), highest expression level in spleen
CleanExⁱ	MM_CD37
ExpressionAtlasⁱ	Q61470 baseline and differential
Genevisibleⁱ	Q61470 MM

Family and domain databases

Gene3Dⁱ	1.10.1450.10, 1 hit
InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf
Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
SUPFAMⁱ	SSF48652 SSF48652, 1 hit
PROSITEⁱ	View protein in PROSITE PS00421 TM4_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD37_MOUSE
Accessionⁱ	Q61470Primary (citable) accession number: Q61470
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61470 (CD37_MOUSE)

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Leukocyte antigen CD37

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ