UniProtKB - Q61470 (CD37_MOUSE)
Protein
Leukocyte antigen CD37
Gene
Cd37
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- defense response to protozoan Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of myeloid dendritic cell activation Source: MGI
- positive regulation of immunoglobulin production Source: MGI
- regulation of defense response to virus Source: MGI
- regulation of humoral immune response Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte antigen CD37Alternative name(s): CD_antigen: CD37 |
Gene namesi | Name:Cd37 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88330, Cd37 |
Subcellular locationi
Other locations
Plasma Membrane
- immunological synapse Source: MGI
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 39 – 59 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 60 – 74 | HelicalSequence analysisAdd BLAST | 15 | |
Topological domaini | 75 – 85 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 86 – 111 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 112 – 241 | ExtracellularSequence analysisAdd BLAST | 130 | |
Transmembranei | 242 – 266 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 267 – 281 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219210 | 1 – 281 | Leukocyte antigen CD37Add BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 170 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 183 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q61470 |
MaxQBi | Q61470 |
PaxDbi | Q61470 |
PRIDEi | Q61470 |
PTM databases
GlyGeni | Q61470, 3 sites |
iPTMneti | Q61470 |
PhosphoSitePlusi | Q61470 |
SwissPalmi | Q61470 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030798, Expressed in spleen and 46 other tissues |
Genevisiblei | Q61470, MM |
Interactioni
Subunit structurei
Interacts with SCIMP.
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000096061 |
Miscellaneous databases
RNActi | Q61470, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000161485 |
HOGENOMi | CLU_055524_2_0_1 |
InParanoidi | Q61470 |
OrthoDBi | 1207549at2759 |
PhylomeDBi | Q61470 |
TreeFami | TF352892 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q61470-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAQESCLSL IKYFLFVFNL FFFVLGGLIF CFGTWILIDK TSFVSFVGLS
60 70 80 90 100
FVPLQTWSKV LAVSGVLTMA LALLGCVGAL KELRCLLGLY FGMLLLLFAT
110 120 130 140 150
QITLGILIST QRVRLERRVQ ELVLRTIQSY RTNPDETAAE ESWDYAQFQL
160 170 180 190 200
RCCGWQSPRD WNKAQMLKAN ESEEPFVPCS CYNSTATNDS TVFDKLFFSQ
210 220 230 240 250
LSRLGPRAKL RQTADICALP AKAHIYREGC AQSLQKWLHN NIISIVGICL
260 270 280
GVGLLELGFM TLSIFLCRNL DHVYDRLARY R
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3U1W9 | Q3U1W9_MOUSE | Tetraspanin | Cd37 | 252 | Annotation score: | ||
A0A1B0GS72 | A0A1B0GS72_MOUSE | Tetraspanin | Cd37 | 235 | Annotation score: | ||
A0A1B0GSZ7 | A0A1B0GSZ7_MOUSE | Tetraspanin | Cd37 | 258 | Annotation score: | ||
Q3U429 | Q3U429_MOUSE | Tetraspanin | Cd37 | 303 | Annotation score: | ||
A0A1B0GSS0 | A0A1B0GSS0_MOUSE | Leukocyte antigen CD37 | Cd37 | 60 | Annotation score: | ||
A0A1B0GST6 | A0A1B0GST6_MOUSE | Leukocyte antigen CD37 | Cd37 | 61 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18372 , U18367, U18368, U18369, U18370, U18371 Genomic DNA Translation: AAB39500.1 BC019402 mRNA Translation: AAH19402.1 |
CCDSi | CCDS21237.1 |
RefSeqi | NP_031671.1, NM_007645.4 |
Genome annotation databases
Ensembli | ENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798 |
GeneIDi | 12493 |
KEGGi | mmu:12493 |
UCSCi | uc009guh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18372 , U18367, U18368, U18369, U18370, U18371 Genomic DNA Translation: AAB39500.1 BC019402 mRNA Translation: AAH19402.1 |
CCDSi | CCDS21237.1 |
RefSeqi | NP_031671.1, NM_007645.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000096061 |
PTM databases
GlyGeni | Q61470, 3 sites |
iPTMneti | Q61470 |
PhosphoSitePlusi | Q61470 |
SwissPalmi | Q61470 |
Proteomic databases
EPDi | Q61470 |
MaxQBi | Q61470 |
PaxDbi | Q61470 |
PRIDEi | Q61470 |
Protocols and materials databases
ABCDi | Q61470, 1 sequenced antibody |
Antibodypediai | 3735, 529 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798 |
GeneIDi | 12493 |
KEGGi | mmu:12493 |
UCSCi | uc009guh.1, mouse |
Organism-specific databases
CTDi | 951 |
MGIi | MGI:88330, Cd37 |
Phylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000161485 |
HOGENOMi | CLU_055524_2_0_1 |
InParanoidi | Q61470 |
OrthoDBi | 1207549at2759 |
PhylomeDBi | Q61470 |
TreeFami | TF352892 |
Miscellaneous databases
BioGRID-ORCSi | 12493, 0 hits in 17 CRISPR screens |
ChiTaRSi | Cd37, mouse |
PROi | PR:Q61470 |
RNActi | Q61470, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030798, Expressed in spleen and 46 other tissues |
Genevisiblei | Q61470, MM |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD37_MOUSE | |
Accessioni | Q61470Primary (citable) accession number: Q61470 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families