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Protein

Zinc finger protein ZIC 4

Gene

Zic4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to DNA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 169C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST35
Zinc fingeri178 – 205C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri211 – 235C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri241 – 265C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri271 – 295C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 4
Alternative name(s):
Zinc finger protein of the cerebellum 4
Gene namesi
Name:Zic4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107201 Zic4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472541 – 341Zinc finger protein ZIC 4Add BLAST341

Proteomic databases

MaxQBiQ61467
PaxDbiQ61467
PRIDEiQ61467

PTM databases

iPTMnetiQ61467
PhosphoSitePlusiQ61467

Expressioni

Tissue specificityi

Exclusively expressed in the cerebellum.1 Publication

Developmental stagei

First expressed in embryo at 9 dpc. Expressed in the dorsal midline of the forebrain at 10.5 dpc at the boundary between the diencephalon and telencephalon, the septum, and the lamina terminalis. Expressed in the choroid plexus of the third ventricle, the dorsal part of the spinal neural tube, the dorsal sclerotome and the dorsomedial lip of the dermomyotome between 10.5 and 12.5 dpc. Expressed in the midline of the forebrain and in the dorsal spinal neural tube at 12.5 dpc.2 Publications

Gene expression databases

BgeeiENSMUSG00000036972 Expressed in 116 organ(s), highest expression level in head
CleanExiMM_ZIC4
ExpressionAtlasiQ61467 baseline and differential
GenevisibleiQ61467 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133958

Structurei

3D structure databases

ProteinModelPortaliQ61467
SMRiQ61467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri135 – 169C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST35
Zinc fingeri178 – 205C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri211 – 235C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri241 – 265C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri271 – 295C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
HOGENOMiHOG000232057
HOVERGENiHBG007135
InParanoidiQ61467
KOiK09225
OrthoDBiEOG091G0M59
PhylomeDBiQ61467

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q61467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLGRVCPRG PGKVRSPRHR FSCTLFVSTT GSSCGHHGPQ LAASSNPSVL
60 70 80 90 100
PGLHEQPPQA SHSRPLNGLL RLGIPGDMYA RSEPFAPGPM ARSDTLATAT
110 120 130 140 150
ALHGYGGMNL TMNLTAPHGP GAFFRYMRQP IKQELICKWL GDDSPMSPRP
160 170 180 190 200
CSKTFSTMHE LVTHVTVEHV GGPEQANHIC FWEECPRQGK PFKAKYKLVN
210 220 230 240 250
HIRVHTGEKP FPCPFPGCGK VFARSENLKI HKRTHTGEKP FRCEFEGCER
260 270 280 290 300
RFANSSDRKK HSHVHTSDKP YMCKVRGCDK CYTHPSSLRK HMKVHGRSPP
310 320 330 340
PSSGYDSAIT SALASPSLES GREPSVACSA AVVVRGTDVS E
Length:341
Mass (Da):37,437
Last modified:January 24, 2006 - v2
Checksum:iB4BB10DE736230CF
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYE7G3UYE7_MOUSE
Zinc finger protein ZIC 4
Zic4 mCG_4264
334Annotation score:
G3UXS7G3UXS7_MOUSE
Zinc finger protein ZIC 4
Zic4
158Annotation score:
G3UZ66G3UZ66_MOUSE
Zinc finger protein ZIC 4
Zic4
181Annotation score:
G3UY76G3UY76_MOUSE
Zinc finger protein ZIC 4
Zic4
67Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78174 mRNA Translation: BAA11240.1 Different termination.
AK028305 mRNA Translation: BAC25871.1
AK035908 mRNA Translation: BAC29239.1
PIRiJC4875
RefSeqiNP_033602.2, NM_009576.2
XP_011241029.1, XM_011242727.2
UniGeneiMm.434835
Mm.8062

Genome annotation databases

EnsembliENSMUST00000066384; ENSMUSP00000069568; ENSMUSG00000036972
GeneIDi22774
KEGGimmu:22774
UCSCiuc009rak.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78174 mRNA Translation: BAA11240.1 Different termination.
AK028305 mRNA Translation: BAC25871.1
AK035908 mRNA Translation: BAC29239.1
PIRiJC4875
RefSeqiNP_033602.2, NM_009576.2
XP_011241029.1, XM_011242727.2
UniGeneiMm.434835
Mm.8062

3D structure databases

ProteinModelPortaliQ61467
SMRiQ61467
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133958

PTM databases

iPTMnetiQ61467
PhosphoSitePlusiQ61467

Proteomic databases

MaxQBiQ61467
PaxDbiQ61467
PRIDEiQ61467

Protocols and materials databases

DNASUi22774
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066384; ENSMUSP00000069568; ENSMUSG00000036972
GeneIDi22774
KEGGimmu:22774
UCSCiuc009rak.1 mouse

Organism-specific databases

CTDi84107
MGIiMGI:107201 Zic4

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
HOGENOMiHOG000232057
HOVERGENiHBG007135
InParanoidiQ61467
KOiK09225
OrthoDBiEOG091G0M59
PhylomeDBiQ61467

Miscellaneous databases

PROiPR:Q61467
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036972 Expressed in 116 organ(s), highest expression level in head
CleanExiMM_ZIC4
ExpressionAtlasiQ61467 baseline and differential
GenevisibleiQ61467 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZIC4_MOUSE
AccessioniPrimary (citable) accession number: Q61467
Secondary accession number(s): Q8BG91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 24, 2006
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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