Smarcd1

Functionⁱ

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (PubMed:17640523). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

chromatin binding Source: MGI
protein-containing complex scaffold activity Source: MGI
signaling receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to fatty acid Source: Ensembl
chromatin-mediated maintenance of transcription Source: MGI
chromatin remodeling Source: MGI
nervous system development Source: UniProtKB-KW
nucleosome disassembly Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator
Biological process	Neurogenesis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214858 RMTs methylate histone arginines R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Reactomeⁱ

R-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Alternative name(s): 60 kDa BRG-1/Brm-associated factor subunit A BRG1-associated factor 60A Short name: BAF60A Protein D15KZ1 SWI/SNF complex 60 kDa subunit
Gene namesⁱ	Name:Smarcd1 Synonyms:Baf60a, D15Kz1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1933623 Smarcd1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000071984	1 – 515	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1Add BLAST		515

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	68	Asymmetric dimethylarginineBy similarity	1
Modified residueⁱ	88	Asymmetric dimethylarginineCombined sources	1
Cross-linkⁱ	101	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	203	PhosphothreonineBy similarity	1
Modified residueⁱ	223	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q61466
PeptideAtlas More...PeptideAtlasⁱ	Q61466
PRIDEⁱ	Q61466

PTM databases

iPTMnetⁱ	Q61466
PhosphoSitePlusⁱ	Q61466

Expressionⁱ

Tissue specificityⁱ

Developmental stageⁱ

Expressed ubiquitously throughout the developing spinal cord, brain and other embryonic tissues at E10.5-E16.5.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000023018 Expressed in 250 organ(s), highest expression level in ear
Genevisibleⁱ	Q61466 MM

Interactionⁱ

Subunit structureⁱ

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (PubMed:8804307, PubMed:8895581). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (PubMed:17640523). Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (ACTB) (By similarity). Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Specifically interacts with the VDR heterodimer complex. Interacts with ESR1, NR3C1, NR1H4, PGR, SMARCA4, SMARCC1 and SMARCC2 (By similarity). Interacts with DPF2.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Akirin2	B1AXD8	2	EBI-371529,EBI-10107866
Smarcc1	P97496	3	EBI-371529,EBI-648047
Tbx1	P70323	3	EBI-371529,EBI-13635846
Tp53	P02340	4	EBI-371529,EBI-474016

GO - Molecular functionⁱ

protein-containing complex scaffold activity Source: MGI
signaling receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	219977, 15 interactors
ComplexPortalⁱ	CPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1234 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1235 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1238 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1239 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1242 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1243 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1246 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1247 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1254 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1255 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1258 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1259 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CORUMⁱ	Q61466
Database of interacting proteins More...DIPⁱ	DIP-33019N
IntActⁱ	Q61466, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q61466
STRINGⁱ	10090.ENSMUSP00000023759

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	294 – 297	Combined sources	4
Helixⁱ	301 – 304	Combined sources	4
Beta strandⁱ	308 – 311	Combined sources	4
Helixⁱ	312 – 325	Combined sources	14
Beta strandⁱ	334 – 337	Combined sources	4
Helixⁱ	343 – 346	Combined sources	4
Beta strandⁱ	350 – 353	Combined sources	4
Helixⁱ	354 – 356	Combined sources	3
Helixⁱ	358 – 364	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q61466
SMRⁱ	Q61466
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q61466

EvolutionaryTraceⁱ

Q61466

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	291 – 390	SWIBAdd BLAST		100

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	43 – 167	Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4By similarityAdd BLAST	125
Regionⁱ	168 – 474	Interaction with SMARCC1 and SMARCC2By similarityAdd BLAST	307
Regionⁱ	180 – 515	Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin; required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivoBy similarityAdd BLAST	336

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	412 – 440	Sequence analysisAdd BLAST		29

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	124 – 127	Poly-Lys		4

Sequence similaritiesⁱ

Belongs to the SMARCD family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2570 Eukaryota COG5531 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017809
HOGENOMⁱ	HOG000240746
HOVERGENⁱ	HBG054046
InParanoidⁱ	Q61466
KEGG Orthology (KO) More...KOⁱ	K11650
OMAⁱ	MNITINL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06WW
PhylomeDBⁱ	Q61466
TreeFamⁱ	TF106486

Family and domain databases

Gene3Dⁱ	1.10.245.10, 1 hit
InterProⁱ	View protein in InterPro IPR038041 SMARCD1 IPR019835 SWIB_domain IPR036885 SWIB_MDM2_dom_sf IPR003121 SWIB_MDM2_domain
PANTHERⁱ	PTHR13844:SF1 PTHR13844:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02201 SWIB, 1 hit
SMARTⁱ	View protein in SMART SM00151 SWIB, 1 hit
SUPFAMⁱ	SSF47592 SSF47592, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q61466-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAARAGFQSV APSGGAGASG GAGVAAALGP GGTPGPPVRM GPAPGQGLYR 
        60         70         80         90        100
SPMPGAAYPR PGMLPGSRMT PQGPSMGPPG YGGNPSVRPG LAQSGMDQSR 
       110        120        130        140        150
KRPAPQQIQQ VQQQAVQNRN HNAKKKKMAD KILPQRIREL VPESQAYMDL 
       160        170        180        190        200
LAFERKLDQT IMRKRLDIQE ALKRPIKQKR KLRIFISNTF NPAKSDAEDG 
       210        220        230        240        250
EGTVASWELR VEGRLLEDAA LSKYDATKQK RKFSSFFKSL VIELDKDLYG 
       260        270        280        290        300
PDNHLVEWHR TATTQETDGF QVKRPGDVNV RCTVLLMLDY QPPQFKLDPR 
       310        320        330        340        350
LARLLGIHTQ TRPVIIQALW QYIKTHKLQD PHEREFVLCD KYLQQIFESQ 
       360        370        380        390        400
RMKFSEIPQR LHALLMPPEP IIINHVISVD PNDQKKTACY DIDVEVDDTL 
       410        420        430        440        450
KTQMNSFLLS TASQQEIATL DNKIHETIET INQLKTQREF MLSFARDPQG 
       460        470        480        490        500
FINDWLQSQC RDLKTMTDVV GNPEEERRAE FYFQPWAQEA VCRYFYSKVQ 
       510 
QRRQELEQAL GIRNT

Length:515

Mass (Da):58,245

Last modified:May 26, 2009 - v3

Checksum:ⁱ166D88566C856A0F

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2R8VKP3	A0A2R8VKP3_MOUSE	SWI/SNF-related matrix-associated a... SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	Smarcd1	474	Annotation score:
A0A2R8VI06	A0A2R8VI06_MOUSE	SWI/SNF-related matrix-associated a... SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	Smarcd1	175	Annotation score:
A0A2R8VI28	A0A2R8VI28_MOUSE	SWI/SNF-related matrix-associated a... SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	Smarcd1	98	Annotation score:
A0A2R8VHB7	A0A2R8VHB7_MOUSE	SWI/SNF-related matrix-associated a... SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1	Smarcd1	95	Annotation score:

Sequence cautionⁱ

The sequence AAA53377 differs from that shown. Reason: Frameshift at positions 29, 445, 447, 462 and 473.Curated

The sequence AAA53377 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAC52794 differs from that shown. Reason: Frameshift at positions 29, 445 and 447.Curated

The sequence AAC52794 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH26783 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15	G → A in AAA53377 (PubMed:2725507).Curated	1
Sequence conflictⁱ	15	G → A in AAC52794 (PubMed:8804307).Curated	1
Sequence conflictⁱ	215	L → I in BAC35856 (PubMed:16141072).Curated	1
Sequence conflictⁱ	218	D → E in BAC35856 (PubMed:16141072).Curated	1
Sequence conflictⁱ	449	Q → S in AAA53377 (PubMed:2725507).Curated	1
Sequence conflictⁱ	449	Q → S in AAC52794 (PubMed:8804307).Curated	1
Sequence conflictⁱ	462	D → G in AAA53377 (PubMed:2725507).Curated	1
Sequence conflictⁱ	462	D → G in AAC52794 (PubMed:8804307).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC026783 mRNA Translation: AAH26783.3 Different initiation. BC059921 mRNA No translation available. M25773 mRNA Translation: AAA53377.1 Sequence problems. U66620 mRNA Translation: AAC52794.1 Sequence problems. AK075611 mRNA Translation: BAC35856.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37204.1
PIRⁱ	A30222
NCBI Reference Sequences More...RefSeqⁱ	NP_114030.2, NM_031842.2
UniGeneⁱ	Mm.273756

Genome annotation databases

Ensemblⁱ	ENSMUST00000023759; ENSMUSP00000023759; ENSMUSG00000023018
GeneIDⁱ	83797
KEGGⁱ	mmu:83797
UCSC genome browser More...UCSCⁱ	uc007xqb.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61466	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (Fragment)		MOUSE		175	UniRef100_Q61466

Protein	Similar proteins		Species	Score	Length	Source
Q61466	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1		BOVIN		515	UniRef90_Q61466
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (Fragment)		MOUSE		175
Uncharacterized protein		MYOLU		515
Uncharacterized protein		RABIT		515
Uncharacterized protein		CAVPO		515
+71

Protein	Similar proteins		Species	Score	Length	Source
Q61466	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1		BOVIN		515	UniRef50_Q61466
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (Fragment)		MOUSE		175
Uncharacterized protein		MYOLU		515
Uncharacterized protein		RABIT		515
Uncharacterized protein		LOXAF		515
+232

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC026783 mRNA Translation: AAH26783.3 Different initiation. BC059921 mRNA No translation available. M25773 mRNA Translation: AAA53377.1 Sequence problems. U66620 mRNA Translation: AAC52794.1 Sequence problems. AK075611 mRNA Translation: BAC35856.1
CCDSⁱ	CCDS37204.1
PIRⁱ	A30222
RefSeqⁱ	NP_114030.2, NM_031842.2
UniGeneⁱ	Mm.273756

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1UHR	NMR	-	A	291-370	[»]
ProteinModelPortalⁱ	Q61466
SMRⁱ	Q61466
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	219977, 15 interactors
ComplexPortalⁱ	CPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1234 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1235 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1238 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1239 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1242 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1243 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1246 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1247 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1254 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1255 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1258 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1259 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CORUMⁱ	Q61466
DIPⁱ	DIP-33019N
IntActⁱ	Q61466, 14 interactors
MINTⁱ	Q61466
STRINGⁱ	10090.ENSMUSP00000023759

PTM databases

iPTMnetⁱ	Q61466
PhosphoSitePlusⁱ	Q61466

Proteomic databases

PaxDbⁱ	Q61466
PeptideAtlasⁱ	Q61466
PRIDEⁱ	Q61466

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023759; ENSMUSP00000023759; ENSMUSG00000023018
GeneIDⁱ	83797
KEGGⁱ	mmu:83797
UCSCⁱ	uc007xqb.1 mouse

Organism-specific databases

CTDⁱ	6602
MGIⁱ	MGI:1933623 Smarcd1

Phylogenomic databases

eggNOGⁱ	KOG2570 Eukaryota COG5531 LUCA
GeneTreeⁱ	ENSGT00390000017809
HOGENOMⁱ	HOG000240746
HOVERGENⁱ	HBG054046
InParanoidⁱ	Q61466
KOⁱ	K11650
OMAⁱ	MNITINL
OrthoDBⁱ	EOG091G06WW
PhylomeDBⁱ	Q61466
TreeFamⁱ	TF106486

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214858 RMTs methylate histone arginines R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Reactomeⁱ

R-MMU-3214858 RMTs methylate histone arginines
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

ChiTaRSⁱ	Smarcd1 mouse
EvolutionaryTraceⁱ	Q61466
Protein Ontology More...PROⁱ	PR:Q61466
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000023018 Expressed in 250 organ(s), highest expression level in ear
Genevisibleⁱ	Q61466 MM

Family and domain databases

Gene3Dⁱ	1.10.245.10, 1 hit
InterProⁱ	View protein in InterPro IPR038041 SMARCD1 IPR019835 SWIB_domain IPR036885 SWIB_MDM2_dom_sf IPR003121 SWIB_MDM2_domain
PANTHERⁱ	PTHR13844:SF1 PTHR13844:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF02201 SWIB, 1 hit
SMARTⁱ	View protein in SMART SM00151 SWIB, 1 hit
SUPFAMⁱ	SSF47592 SSF47592, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMRD1_MOUSE
Accessionⁱ	Q61466Primary (citable) accession number: Q61466 Secondary accession number(s): P70384, Q8R0I7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 26, 2009
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q61466 (SMRD1_MOUSE)

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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Amino acid modifications

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Proteomic databases

PTM databases

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Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ