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Entry version 145 (05 Jun 2019)
Sequence version 2 (19 Jul 2005)
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Protein

Zinc finger protein 638

Gene

Znf638

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to cytidine clusters in double-stranded DNA (By similarity). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 (PubMed:30487602). Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (PubMed:21602272). May also regulate alternative splicing of target genes during adipogenesis (PubMed:25024404).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1876 – 1906Matrin-typePROSITE-ProRule annotationAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 6381 Publication
Alternative name(s):
Nuclear protein 2201 Publication
Zinc finger matrin-like proteinBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Znf6381 PublicationImported
Synonyms:Np2201 Publication, ZfmlImported, Zfp638Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1203484 Zfp638

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000820121 – 1960Zinc finger protein 638Add BLAST1960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47Asymmetric dimethylarginineBy similarity1
Modified residuei49Asymmetric dimethylarginineBy similarity1
Modified residuei54Asymmetric dimethylarginineBy similarity1
Modified residuei128PhosphoserineCombined sources1
Modified residuei288PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei298PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Modified residuei615PhosphoserineBy similarity1
Modified residuei637PhosphoserineBy similarity1
Cross-linki775Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1099PhosphoserineBy similarity1
Modified residuei1400PhosphoserineBy similarity1
Modified residuei1635PhosphoserineCombined sources1
Modified residuei1661PhosphoserineBy similarity1
Cross-linki1804Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1864PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q61464

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q61464

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61464

PeptideAtlas

More...
PeptideAtlasi
Q61464

PRoteomics IDEntifications database

More...
PRIDEi
Q61464

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61464

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61464

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q61464

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In an vitro adipocyte differentiation system, induced at the protein and RNA levels shortly after exposure to the induction mixture. Levels peak before PPARG induction and rapidly decrease during later stages of differentiation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030016 Expressed in 290 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q61464 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q61464 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FHL2 (By similarity).

Interacts with CEBPA, CEBPD and CEBPG (PubMed:21602272).

Interacts with MPHOSPH8 and TASOR components of the HUSH complex; leading to recruitment of the HUSH complex (By similarity).

Interacts with SETDB1 (By similarity).

Interacts with HDAC1 (By similarity).

Interacts with HDAC4 (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201815, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q61464, 1 interactor

Molecular INTeraction database

More...
MINTi
Q61464

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000032088

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q61464

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini676 – 751RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini902 – 976RRM 2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni470 – 573Involved in localization to nuclear speckles1 PublicationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi470 – 575Arg-richAdd BLAST106
Compositional biasi1577 – 1582Poly-Lys6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The matrin-type zinc finger domain is required for localization to nuclear speckles.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1876 – 1906Matrin-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IN3N Eukaryota
ENOG4111GCE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082488

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q61464

Database of Orthologous Groups

More...
OrthoDBi
301913at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q61464

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033096 ZNF638
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR15592:SF1 PTHR15592:SF1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 2 hits
SM00355 ZnF_C2H2, 2 hits
SM00451 ZnF_U1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 3 hits
SSF57667 SSF57667, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61464-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRPRFNPRG TFPLQRPRAP NPPGMRPPGP FVRPGSMGLP RFYPAGRARG
60 70 80 90 100
IPHRFPGHGS YQNMGPQRMN VQVTQHRTDP RLTKEKLDFP EAQQKKGKPH
110 120 130 140 150
GSRWDDESHI TPPVEVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS
160 170 180 190 200
NEDLEELSRY PDEQLTPENM PLILRDIRMR KMSRRLPNLP SHSRNKETLS
210 220 230 240 250
NETVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVKN EFQPQQSISA
260 270 280 290 300
TVSTPNVICN SVFPGGDMFR QMDFPGESSS QSFFPVESGT KMSGLHISGQ
310 320 330 340 350
SVLEPVKSIS QSISQTVSQT TSQSLNPPSM NQVPFTFELD AVLRQQERIS
360 370 380 390 400
QKSVISSADA HGGPTESKKD YQSEADLPIR SPFGIVKASW LPKFTQAGAQ
410 420 430 440 450
KMKRLPTPSM MNDYYAASPR IFPHLCSLCN VECSHLKDWI QHQNTSTHIE
460 470 480 490 500
SCRQLRQQYP DWNPEILPSR RNESNRKENE TPRRRSHSPS PRHSRRSSSG
510 520 530 540 550
HRIRRSRSPV RYIYRPRSRS PRICHRFISK YRSRSRSRSR SRSPYRSRNL
560 570 580 590 600
LRRSPKSYRS ASPERTSRKS VRSDRKKALE DGGQRSVHGT EVTKQKHTET
610 620 630 640 650
VDKGLSPAQK PKLASGTKPS AKSLSSVKSD SHLGAYSAHK SENLEDDTLP
660 670 680 690 700
EGKQESGKSA LAQRKPQKDQ SLSSNSILLV SELPEDGFTE EDIRKAFLPF
710 720 730 740 750
GKISDVLLVP CRNEAYLEME LRKAVTSIMK YIETMPLVIK GKSVKVCVPG
760 770 780 790 800
KKKPQNKEMK KKPSDIKKSS ASALKKETDA SKTMETVSSS SSAKSGQIKS
810 820 830 840 850
STVKVNKCAG KSAGSVKSVV TVAAKGKASI KTAKSGKKSL EAKKSGNIKN
860 870 880 890 900
KDSNKPVTVP ANSEIKASSE DKATGKSAEE SPSGTLEATE KEPVNKESEE
910 920 930 940 950
MSVVFISNLP NKGYSTEEIY NLAKPFGALK DILVLSSHKK AYIEINKKSA
960 970 980 990 1000
DSMVKFYTCF PISMDGNQLS ISMAPEHVDL KDEEALFTTL IQENDPEANI
1010 1020 1030 1040 1050
DKIYNRFVHL DNLPEDGLQC VLCVGHQFGK VDRYMFMSNK NKVILQLESP
1060 1070 1080 1090 1100
ESALSMYNFL KQNPQNIGEH VLTCTLSPKT DSEVQRKNDL ELGKGSTFSP
1110 1120 1130 1140 1150
DLKNSPVDES EVQTAADSSS VKPSEVEEET TSNIGTETSV HQEELGKEEP
1160 1170 1180 1190 1200
KQALCESDFA IQTLELEAQG AEVSIEIPLV ASTPANIELF SENIDESALN
1210 1220 1230 1240 1250
QQMYTSDFEK EEAEVTNPET ELAVSDSVFI EERNIKGIIE DSPSETEDIF
1260 1270 1280 1290 1300
SGIVQPMVDA IAEVDKHETV SEVLPSACNV TQAPGSYIED EKVVSKKDIA
1310 1320 1330 1340 1350
EKVILDEKEE DEFNVKETRM DLQVKTEKAE KNEAIIFKEK LEKIIAAIRE
1360 1370 1380 1390 1400
KPIESSVIKA DPTKGLDQTS KPDETGKSSV LTVSNVYSSK SSIKATVVSS
1410 1420 1430 1440 1450
PKAKSTPSKT ESHSTFPKPV LREQIKADKK VSAKEFGLLK NTRSGLAESN
1460 1470 1480 1490 1500
SKSKPTQIGV NRGCSGRISA LQCKDSKVDY KDITKQSQET ETKPPIMKRD
1510 1520 1530 1540 1550
DSNNKALALQ NTKNSKSTTD RSSKSKEEPL FTFNLDEFVT VDEVIEEVNP
1560 1570 1580 1590 1600
SQAKQNPLKG KRKEALKISP SPELNLKKKK GKTSVPHSVE GELSFVTLDE
1610 1620 1630 1640 1650
IGEEEDATVQ ALVTVDEVID EEELNMEEMV KNSNSLLTLD ELIDQDDCIP
1660 1670 1680 1690 1700
HSGPKDVTVL SMAEEQDLQQ ERLVTVDEIG EVEESADITF ATLNAKRDKR
1710 1720 1730 1740 1750
DSIGFISSQM PEDPSTLVTV DEIQDDSSDF HLMTLDEVTE EDENSLADFN
1760 1770 1780 1790 1800
NLKEELNFVT VDEVGDEEDG DNDSKVELAR GKIEHHTDKK GNRKRRAVDP
1810 1820 1830 1840 1850
KKSKLDSFSQ VGPGSETVTQ KDLKTMPERH LAAKTPMKRV RLGKSSPSQK
1860 1870 1880 1890 1900
VAEPTKGEEA FQMSEGVDDA ELKDSEPDEK RRKTQDSSVG KSMTSDVPGD
1910 1920 1930 1940 1950
LDFLVPKAGF FCPICSLFYS GEKAMANHCK STRHKQNTEK FMAKQRKEKE
1960
QNETEERSSR
Length:1,960
Mass (Da):218,134
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27DF6740BFE410ED
GO
Isoform 2 (identifier: Q61464-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-832: Missing.
     1147-1200: KEEPKQALCE...SENIDESALN → PGSETVTQKD...GEEAFQMSEG
     1201-1832: Missing.
     1833-1866: Missing.

Note: No experimental confirmation available.
Show »
Length:1,271
Mass (Da):142,198
Checksum:i342F546EFC525823
GO
Isoform 3 (identifier: Q61464-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-454: DWIQHQNTSTHIESCRQ → VSVFKRLLYNDAQCPGF
     456-1960: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:455
Mass (Da):50,951
Checksum:i5B605A1F5153B1C3
GO
Isoform 4 (identifier: Q61464-4) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1833-1866: Missing.

Show »
Length:1,926
Mass (Da):214,460
Checksum:i3B2F3A7AF4580259
GO
Isoform 5 (identifier: Q61464-5) [UniParc]FASTAAdd to basket
Also known as: Gamma1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1832: Missing.

Show »
Length:1,274
Mass (Da):142,134
Checksum:i344E096A235A8168
GO
Isoform 6 (identifier: Q61464-7) [UniParc]FASTAAdd to basket
Also known as: Delta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1866: Missing.

Show »
Length:1,240
Mass (Da):138,461
Checksum:iF2BF9C3AA2F2883B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QML5E9QML5_MOUSE
Zinc finger protein 638
Zfp638
1,960Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SV80A0A0N4SV80_MOUSE
Zinc finger protein 638
Zfp638
1,926Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QKZ7E9QKZ7_MOUSE
Zinc finger protein 638
Zfp638
1,275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVI8A0A0N4SVI8_MOUSE
Zinc finger protein 638
Zfp638
1,273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SV38A0A0N4SV38_MOUSE
Zinc finger protein 638
Zfp638
1,239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TZK9Q3TZK9_MOUSE
Zinc finger protein 638
Zfp638 Zfml
891Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVM8A0A0N4SVM8_MOUSE
Zinc finger protein 638
Zfp638
832Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SUP3A0A0N4SUP3_MOUSE
Zinc finger protein 638
Zfp638
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVU0A0A0N4SVU0_MOUSE
Zinc finger protein 638
Zfp638
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SWG8A0A0N4SWG8_MOUSE
Zinc finger protein 638
Zfp638
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32V → L in AAH76615 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014807438 – 454DWIQH…ESCRQ → VSVFKRLLYNDAQCPGF in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_014808456 – 1960Missing in isoform 3. 1 PublicationAdd BLAST1505
Alternative sequenceiVSP_014809810 – 832Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0148101147 – 1866Missing in isoform 6. 1 PublicationAdd BLAST720
Alternative sequenceiVSP_0148111147 – 1832Missing in isoform 5. 1 PublicationAdd BLAST686
Alternative sequenceiVSP_0148121147 – 1200KEEPK…ESALN → PGSETVTQKDLKTMPERHLA AKTPMKRVRIGKSSPSQKVA EPTKGEEAFQMSEG in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_0148131201 – 1832Missing in isoform 2. 1 PublicationAdd BLAST632
Alternative sequenceiVSP_0148141833 – 1866Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D83033 mRNA Translation: BAA11749.1
AK043029 mRNA Translation: BAC31439.1
BC076615 mRNA Translation: AAH76615.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20288.1 [Q61464-4]
CCDS51823.1 [Q61464-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4842

NCBI Reference Sequences

More...
RefSeqi
NP_001159843.1, NM_001166371.1 [Q61464-2]
NP_032743.2, NM_008717.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000113835; ENSMUSP00000109466; ENSMUSG00000030016 [Q61464-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18139

UCSC genome browser

More...
UCSCi
uc009coo.2 mouse [Q61464-3]
uc009coq.2 mouse [Q61464-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83033 mRNA Translation: BAA11749.1
AK043029 mRNA Translation: BAC31439.1
BC076615 mRNA Translation: AAH76615.1
CCDSiCCDS20288.1 [Q61464-4]
CCDS51823.1 [Q61464-2]
PIRiJC4842
RefSeqiNP_001159843.1, NM_001166371.1 [Q61464-2]
NP_032743.2, NM_008717.3

3D structure databases

SMRiQ61464
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201815, 2 interactors
IntActiQ61464, 1 interactor
MINTiQ61464
STRINGi10090.ENSMUSP00000032088

PTM databases

iPTMnetiQ61464
PhosphoSitePlusiQ61464
SwissPalmiQ61464

Proteomic databases

EPDiQ61464
jPOSTiQ61464
PaxDbiQ61464
PeptideAtlasiQ61464
PRIDEiQ61464

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113835; ENSMUSP00000109466; ENSMUSG00000030016 [Q61464-2]
GeneIDi18139
KEGGimmu:18139
UCSCiuc009coo.2 mouse [Q61464-3]
uc009coq.2 mouse [Q61464-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
18139
MGIiMGI:1203484 Zfp638

Phylogenomic databases

eggNOGiENOG410IN3N Eukaryota
ENOG4111GCE LUCA
GeneTreeiENSGT00940000153322
HOGENOMiHOG000082488
InParanoidiQ61464
OrthoDBi301913at2759
PhylomeDBiQ61464

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zfp638 mouse

Protein Ontology

More...
PROi
PR:Q61464

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030016 Expressed in 290 organ(s), highest expression level in brain
ExpressionAtlasiQ61464 baseline and differential
GenevisibleiQ61464 MM

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033096 ZNF638
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR15592:SF1 PTHR15592:SF1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00355 ZnF_C2H2, 2 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF54928 SSF54928, 3 hits
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN638_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61464
Secondary accession number(s): Q6DFV9, Q8C941
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 5, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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