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Protein

Zinc finger protein 638

Gene

Znf638

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (PubMed:21602272). Binds to cytidine clusters in double-stranded DNA (By similarity). May also regulate alternative splicing of target genes during adipogenesis (PubMed:25024404).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1876 – 1906Matrin-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 638Imported
Alternative name(s):
Nuclear protein 2201 Publication
Zinc finger matrin-like proteinBy similarity
Gene namesi
Name:Znf638By similarity
Synonyms:Np220Imported, ZfmlImported, Zfp638Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1203484 Zfp638

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000820121 – 1960Zinc finger protein 638Add BLAST1960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Asymmetric dimethylarginineBy similarity1
Modified residuei49Asymmetric dimethylarginineBy similarity1
Modified residuei54Asymmetric dimethylarginineBy similarity1
Modified residuei128PhosphoserineCombined sources1
Modified residuei288PhosphoserineBy similarity1
Cross-linki291Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei298PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Modified residuei615PhosphoserineBy similarity1
Modified residuei637PhosphoserineBy similarity1
Cross-linki775Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1099PhosphoserineBy similarity1
Modified residuei1400PhosphoserineBy similarity1
Modified residuei1635PhosphoserineCombined sources1
Modified residuei1661PhosphoserineBy similarity1
Cross-linki1804Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1864PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61464
PaxDbiQ61464
PeptideAtlasiQ61464
PRIDEiQ61464

PTM databases

iPTMnetiQ61464
PhosphoSitePlusiQ61464

Expressioni

Developmental stagei

In an vitro adipocyte differentiation system, induced at the protein and RNA levels shortly after exposure to the induction mixture. Levels peak before PPARG induction and rapidly decrease during later stages of differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000030016
CleanExiMM_ZFML
ExpressionAtlasiQ61464 baseline and differential
GenevisibleiQ61464 MM

Interactioni

Subunit structurei

Interacts with FHL2 (By similarity). Interacts with CEBPA, CEBPD and CEBPG.By similarity1 Publication

Protein-protein interaction databases

BioGridi201815, 2 interactors
IntActiQ61464, 1 interactor
MINTiQ61464
STRINGi10090.ENSMUSP00000032088

Structurei

3D structure databases

ProteinModelPortaliQ61464
SMRiQ61464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 751RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini902 – 976RRM 2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni470 – 573Involved in localization to nuclear speckles1 PublicationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi470 – 575Arg-richAdd BLAST106
Compositional biasi1577 – 1582Poly-Lys6

Domaini

The matrin-type zinc finger domain is required for localization to nuclear speckles.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1876 – 1906Matrin-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IN3N Eukaryota
ENOG4111GCE LUCA
GeneTreeiENSGT00850000132416
HOGENOMiHOG000082488
HOVERGENiHBG094186
InParanoidiQ61464
PhylomeDBiQ61464

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR033096 ZNF638
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR15592:SF1 PTHR15592:SF1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00355 ZnF_C2H2, 2 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF54928 SSF54928, 3 hits
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61464-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPRFNPRG TFPLQRPRAP NPPGMRPPGP FVRPGSMGLP RFYPAGRARG
60 70 80 90 100
IPHRFPGHGS YQNMGPQRMN VQVTQHRTDP RLTKEKLDFP EAQQKKGKPH
110 120 130 140 150
GSRWDDESHI TPPVEVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS
160 170 180 190 200
NEDLEELSRY PDEQLTPENM PLILRDIRMR KMSRRLPNLP SHSRNKETLS
210 220 230 240 250
NETVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVKN EFQPQQSISA
260 270 280 290 300
TVSTPNVICN SVFPGGDMFR QMDFPGESSS QSFFPVESGT KMSGLHISGQ
310 320 330 340 350
SVLEPVKSIS QSISQTVSQT TSQSLNPPSM NQVPFTFELD AVLRQQERIS
360 370 380 390 400
QKSVISSADA HGGPTESKKD YQSEADLPIR SPFGIVKASW LPKFTQAGAQ
410 420 430 440 450
KMKRLPTPSM MNDYYAASPR IFPHLCSLCN VECSHLKDWI QHQNTSTHIE
460 470 480 490 500
SCRQLRQQYP DWNPEILPSR RNESNRKENE TPRRRSHSPS PRHSRRSSSG
510 520 530 540 550
HRIRRSRSPV RYIYRPRSRS PRICHRFISK YRSRSRSRSR SRSPYRSRNL
560 570 580 590 600
LRRSPKSYRS ASPERTSRKS VRSDRKKALE DGGQRSVHGT EVTKQKHTET
610 620 630 640 650
VDKGLSPAQK PKLASGTKPS AKSLSSVKSD SHLGAYSAHK SENLEDDTLP
660 670 680 690 700
EGKQESGKSA LAQRKPQKDQ SLSSNSILLV SELPEDGFTE EDIRKAFLPF
710 720 730 740 750
GKISDVLLVP CRNEAYLEME LRKAVTSIMK YIETMPLVIK GKSVKVCVPG
760 770 780 790 800
KKKPQNKEMK KKPSDIKKSS ASALKKETDA SKTMETVSSS SSAKSGQIKS
810 820 830 840 850
STVKVNKCAG KSAGSVKSVV TVAAKGKASI KTAKSGKKSL EAKKSGNIKN
860 870 880 890 900
KDSNKPVTVP ANSEIKASSE DKATGKSAEE SPSGTLEATE KEPVNKESEE
910 920 930 940 950
MSVVFISNLP NKGYSTEEIY NLAKPFGALK DILVLSSHKK AYIEINKKSA
960 970 980 990 1000
DSMVKFYTCF PISMDGNQLS ISMAPEHVDL KDEEALFTTL IQENDPEANI
1010 1020 1030 1040 1050
DKIYNRFVHL DNLPEDGLQC VLCVGHQFGK VDRYMFMSNK NKVILQLESP
1060 1070 1080 1090 1100
ESALSMYNFL KQNPQNIGEH VLTCTLSPKT DSEVQRKNDL ELGKGSTFSP
1110 1120 1130 1140 1150
DLKNSPVDES EVQTAADSSS VKPSEVEEET TSNIGTETSV HQEELGKEEP
1160 1170 1180 1190 1200
KQALCESDFA IQTLELEAQG AEVSIEIPLV ASTPANIELF SENIDESALN
1210 1220 1230 1240 1250
QQMYTSDFEK EEAEVTNPET ELAVSDSVFI EERNIKGIIE DSPSETEDIF
1260 1270 1280 1290 1300
SGIVQPMVDA IAEVDKHETV SEVLPSACNV TQAPGSYIED EKVVSKKDIA
1310 1320 1330 1340 1350
EKVILDEKEE DEFNVKETRM DLQVKTEKAE KNEAIIFKEK LEKIIAAIRE
1360 1370 1380 1390 1400
KPIESSVIKA DPTKGLDQTS KPDETGKSSV LTVSNVYSSK SSIKATVVSS
1410 1420 1430 1440 1450
PKAKSTPSKT ESHSTFPKPV LREQIKADKK VSAKEFGLLK NTRSGLAESN
1460 1470 1480 1490 1500
SKSKPTQIGV NRGCSGRISA LQCKDSKVDY KDITKQSQET ETKPPIMKRD
1510 1520 1530 1540 1550
DSNNKALALQ NTKNSKSTTD RSSKSKEEPL FTFNLDEFVT VDEVIEEVNP
1560 1570 1580 1590 1600
SQAKQNPLKG KRKEALKISP SPELNLKKKK GKTSVPHSVE GELSFVTLDE
1610 1620 1630 1640 1650
IGEEEDATVQ ALVTVDEVID EEELNMEEMV KNSNSLLTLD ELIDQDDCIP
1660 1670 1680 1690 1700
HSGPKDVTVL SMAEEQDLQQ ERLVTVDEIG EVEESADITF ATLNAKRDKR
1710 1720 1730 1740 1750
DSIGFISSQM PEDPSTLVTV DEIQDDSSDF HLMTLDEVTE EDENSLADFN
1760 1770 1780 1790 1800
NLKEELNFVT VDEVGDEEDG DNDSKVELAR GKIEHHTDKK GNRKRRAVDP
1810 1820 1830 1840 1850
KKSKLDSFSQ VGPGSETVTQ KDLKTMPERH LAAKTPMKRV RLGKSSPSQK
1860 1870 1880 1890 1900
VAEPTKGEEA FQMSEGVDDA ELKDSEPDEK RRKTQDSSVG KSMTSDVPGD
1910 1920 1930 1940 1950
LDFLVPKAGF FCPICSLFYS GEKAMANHCK STRHKQNTEK FMAKQRKEKE
1960
QNETEERSSR
Length:1,960
Mass (Da):218,134
Last modified:July 19, 2005 - v2
Checksum:i27DF6740BFE410ED
GO
Isoform 2 (identifier: Q61464-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-832: Missing.
     1147-1200: KEEPKQALCE...SENIDESALN → PGSETVTQKD...GEEAFQMSEG
     1201-1832: Missing.
     1833-1866: Missing.

Note: No experimental confirmation available.
Show »
Length:1,271
Mass (Da):142,198
Checksum:i342F546EFC525823
GO
Isoform 3 (identifier: Q61464-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-454: DWIQHQNTSTHIESCRQ → VSVFKRLLYNDAQCPGF
     456-1960: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:455
Mass (Da):50,951
Checksum:i5B605A1F5153B1C3
GO
Isoform 4 (identifier: Q61464-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1833-1866: Missing.

Show »
Length:1,926
Mass (Da):214,460
Checksum:i3B2F3A7AF4580259
GO
Isoform 5 (identifier: Q61464-5) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1832: Missing.

Show »
Length:1,274
Mass (Da):142,134
Checksum:i344E096A235A8168
GO
Isoform 6 (identifier: Q61464-7) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1866: Missing.

Show »
Length:1,240
Mass (Da):138,461
Checksum:iF2BF9C3AA2F2883B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32V → L in AAH76615 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014807438 – 454DWIQH…ESCRQ → VSVFKRLLYNDAQCPGF in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_014808456 – 1960Missing in isoform 3. 1 PublicationAdd BLAST1505
Alternative sequenceiVSP_014809810 – 832Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0148101147 – 1866Missing in isoform 6. 1 PublicationAdd BLAST720
Alternative sequenceiVSP_0148111147 – 1832Missing in isoform 5. 1 PublicationAdd BLAST686
Alternative sequenceiVSP_0148121147 – 1200KEEPK…ESALN → PGSETVTQKDLKTMPERHLA AKTPMKRVRIGKSSPSQKVA EPTKGEEAFQMSEG in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_0148131201 – 1832Missing in isoform 2. 1 PublicationAdd BLAST632
Alternative sequenceiVSP_0148141833 – 1866Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83033 mRNA Translation: BAA11749.1
AK043029 mRNA Translation: BAC31439.1
BC076615 mRNA Translation: AAH76615.1
CCDSiCCDS20288.1 [Q61464-4]
CCDS51823.1 [Q61464-2]
PIRiJC4842
RefSeqiNP_001159843.1, NM_001166371.1 [Q61464-2]
NP_032743.2, NM_008717.3
UniGeneiMm.132392

Genome annotation databases

EnsembliENSMUST00000113835; ENSMUSP00000109466; ENSMUSG00000030016 [Q61464-2]
GeneIDi18139
KEGGimmu:18139
UCSCiuc009coo.2 mouse [Q61464-3]
uc009coq.2 mouse [Q61464-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN638_MOUSE
AccessioniPrimary (citable) accession number: Q61464
Secondary accession number(s): Q6DFV9, Q8C941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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