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Protein

G1/S-specific cyclin-E1

Gene

Ccne1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: MGI
  • kinase activity Source: MGI
  • protein-containing complex binding Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome organization involved in meiotic cell cycle Source: MGI
  • DNA replication initiation Source: MGI
  • G1/S transition of mitotic cell cycle Source: InterPro
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • protein phosphorylation Source: MGI
  • regulation of cell cycle Source: MGI
  • regulation of cellular protein localization Source: MGI
  • synapsis Source: MGI
  • telomere maintenance Source: MGI
  • Wnt signaling pathway Source: MGI

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-1538133 G0 and Early G1
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
R-MMU-69202 Cyclin E associated events during G1/S transition
R-MMU-69563 p53-Dependent G1 DNA Damage Response
R-MMU-8849470 PTK6 Regulates Cell Cycle

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-E1
Gene namesi
Name:Ccne1
Synonyms:Ccne
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88316 Ccne1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804501 – 408G1/S-specific cyclin-E1Add BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphothreonineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei393PhosphothreonineBy similarity1
Modified residuei397PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation of both Thr-393 by GSK3 and Ser-397 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-74 creates a low affinity degron also recognized by FBXW7 (By similarity).By similarity
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ61457
MaxQBiQ61457
PaxDbiQ61457
PRIDEiQ61457

PTM databases

iPTMnetiQ61457
PhosphoSitePlusiQ61457

Expressioni

Tissue specificityi

Found in adult spleen, and to a lesser extent in adult testis and brain.

Gene expression databases

BgeeiENSMUSG00000002068
CleanExiMM_CCNE1
ExpressionAtlasiQ61457 baseline and differential
GenevisibleiQ61457 MM

Interactioni

Subunit structurei

Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (By similarity). Found in a complex with CDK2, CABLES1 and CCNA1.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase binding Source: MGI

Protein-protein interaction databases

BioGridi198552, 6 interactors
ComplexPortaliCPX-2081 Cyclin E1-CDK2 complex
DIPiDIP-45868N
ELMiQ61457
IntActiQ61457, 3 interactors
MINTiQ61457
STRINGi10090.ENSMUSP00000103658

Structurei

3D structure databases

ProteinModelPortaliQ61457
SMRiQ61457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

eggNOGiKOG0655 Eukaryota
ENOG410XS2J LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000231743
HOVERGENiHBG050834
InParanoidiQ61457
KOiK06626
OMAiKLHQFAY
OrthoDBiEOG091G0DAW
PhylomeDBiQ61457
TreeFamiTF101005

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR028858 Cyclin_E
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PTHR10177:SF71 PTHR10177:SF71, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

Q61457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRERDSTDH SNMKEEGGSD LSVRSRKRKA NVAVFLQDPD EEIAKIDKTV
60 70 80 90 100
KSEDSSQPWD DNSACVDPCS FIPTPNKEED NELEYPRTAF QPRKIRPPRA
110 120 130 140 150
SPLPVLNWGN REEVWRIMLN KEKTYLRDEH FLQRHPLLQA RMRAVLLDWL
160 170 180 190 200
MEVCEVYKLH RETFYLAQDF FDRYMASQHN IIKTLLQLIG ISALFIASKL
210 220 230 240 250
EEIYPPKLHQ FAYVTDGACS GDEILTMELM MMKALKWRLS PLTIVSWLNV
260 270 280 290 300
YVQVAYVNDT GEVLMPQYPQ QVFVQIAELL DLCVLDVGCL EFPYGVLAAS
310 320 330 340 350
ALYHFSSLEL MQKVSGYQWC DIEKCVKWMV PFAMVIREMG SSKLKHFRGV
360 370 380 390 400
PMEDSHNIQT HTNSLDLLDK AQAKKAILSE QNRISPPPSV VLTPPPSSKK

QSSEQETE
Length:408
Mass (Da):46,986
Last modified:November 13, 2007 - v2
Checksum:i4916B5D7117ADA69
GO

Sequence cautioni

The sequence CAA53482 differs from that shown. Reason: Frameshift at position 401.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2P → Q in AAH84588 (PubMed:15489334).Curated1
Sequence conflicti179H → Q in CAA53482 (PubMed:8003041).Curated1
Sequence conflicti179H → Q in AAH62152 (PubMed:15489334).Curated1
Sequence conflicti179H → Q in AAH84588 (PubMed:15489334).Curated1
Sequence conflicti290 – 291LE → FR in AAH62152 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75888 mRNA Translation: CAA53482.1 Frameshift.
BC062152 mRNA Translation: AAH62152.1
BC084588 mRNA Translation: AAH84588.1
BC106191 mRNA Translation: AAI06192.1
CCDSiCCDS39914.1
PIRiJC2497
RefSeqiNP_031659.2, NM_007633.2
UniGeneiMm.16110

Genome annotation databases

EnsembliENSMUST00000108023; ENSMUSP00000103658; ENSMUSG00000002068
GeneIDi12447
KEGGimmu:12447
UCSCiuc009gkr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCNE1_MOUSE
AccessioniPrimary (citable) accession number: Q61457
Secondary accession number(s): Q05BA1, Q05BA6, Q05BB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 13, 2007
Last modified: July 18, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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