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Protein

Cyclin-A1

Gene

Ccna1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.2 Publications

Miscellaneous

CCNA1 -/- males are sterile due to a block of spermatogenesis before the first meiotic division, whereas females are normal.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCyclin, Developmental protein
Biological processCell cycle, Cell division, Differentiation, Meiosis, Mitosis, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-MMU-1538133 G0 and Early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-5689880 Ub-specific processing proteases
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6804757 Regulation of TP53 Degradation
R-MMU-68911 G2 Phase
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-MMU-69563 p53-Dependent G1 DNA Damage Response
R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A1
Gene namesi
Name:Ccna1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:108042 Ccna1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803341 – 421Cyclin-A1Add BLAST421

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ61456
PRIDEiQ61456

PTM databases

iPTMnetiQ61456
PhosphoSitePlusiQ61456

Expressioni

Tissue specificityi

Testis and ovaries.

Developmental stagei

In male germ cells just prior to or during the first, but not the second meiotic division.

Gene expression databases

BgeeiENSMUSG00000027793 Expressed in 40 organ(s), highest expression level in testis
CleanExiMM_CCNA1
ExpressionAtlasiQ61456 baseline and differential
GenevisibleiQ61456 MM

Interactioni

Subunit structurei

Interacts with INCA1 and KLHDC9 (By similarity). Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNE1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198544, 3 interactors
ComplexPortaliCPX-2061 Cyclin A1-CDK1 complex
CPX-2065 Cyclin A1-CDK2 complex
CORUMiQ61456
STRINGi10090.ENSMUSP00000029368

Structurei

3D structure databases

ProteinModelPortaliQ61456
SMRiQ61456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
HOVERGENiHBG106244
InParanoidiQ61456
KOiK06627
OrthoDBiEOG091G090I
PhylomeDBiQ61456
TreeFamiTF101002

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q61456-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRQSSKSGV ALPPVGQGPD ACQMLSRAQL GQDPPQRTVL GVLTENEQYR
60 70 80 90 100
RTCGQEITAI RCFSGSENVF PAAGKKVLSD HGVNEPAKRG FDIYMDDPEQ
110 120 130 140 150
GDRDTCSGKE GIIFEDVYEV DTSMLKSDLH FLLDFNTVSP MLVDPTTHAQ
160 170 180 190 200
SEEATDFGSD VINVTEYAEE IHRYLREAEV RHRPKAHYMR KQPDITEGMR
210 220 230 240 250
AILVDWLVEV GEEYKLRTET LYLAVNFLDR FLSCMSVLRG KLQLVGTAAI
260 270 280 290 300
LLASKYEEIY PPDVDEFVYI TDDTYTKRQL LRMEHLLLKV LAFDLTVPTT
310 320 330 340 350
NQFLLQYLRR QGVCIRTENL AKYVAELSLL EADPFLKYLP SLVAAAAYCL
360 370 380 390 400
ANYIVNRHFW PETLAAFTGY SLNEIVPCLS ELHKACLSIP HRPQQAIREK
410 420
YKASKYLHVS LMEPPVVLPL Q
Length:421
Mass (Da):47,772
Last modified:July 1, 2008 - v2
Checksum:iFF717D0065B954E9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JEB5A0A0G2JEB5_MOUSE
Cyclin-A1
Ccna1
250Annotation score:
A0A0G2JFR4A0A0G2JFR4_MOUSE
Cyclin-A1
Ccna1
165Annotation score:
A0A0G2JGG4A0A0G2JGG4_MOUSE
Cyclin-A1
Ccna1
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176R → P in CAA59053 (PubMed:8565853).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84311 mRNA Translation: CAA59053.1
AK077114 mRNA Translation: BAC36619.1
BC120518 mRNA Translation: AAI20519.1
BC125436 mRNA Translation: AAI25437.1
CCDSiCCDS17356.1
RefSeqiNP_001292150.1, NM_001305221.1
NP_031654.2, NM_007628.3
XP_006501012.1, XM_006500949.2
XP_006501013.1, XM_006500950.3
XP_006501014.1, XM_006500951.2
XP_006501015.1, XM_006500952.2
XP_011238305.1, XM_011240003.2
UniGeneiMm.4815

Genome annotation databases

EnsembliENSMUST00000029368; ENSMUSP00000029368; ENSMUSG00000027793
ENSMUST00000197238; ENSMUSP00000142692; ENSMUSG00000027793
ENSMUST00000198320; ENSMUSP00000143447; ENSMUSG00000027793
GeneIDi12427
KEGGimmu:12427
UCSCiuc008pfy.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84311 mRNA Translation: CAA59053.1
AK077114 mRNA Translation: BAC36619.1
BC120518 mRNA Translation: AAI20519.1
BC125436 mRNA Translation: AAI25437.1
CCDSiCCDS17356.1
RefSeqiNP_001292150.1, NM_001305221.1
NP_031654.2, NM_007628.3
XP_006501012.1, XM_006500949.2
XP_006501013.1, XM_006500950.3
XP_006501014.1, XM_006500951.2
XP_006501015.1, XM_006500952.2
XP_011238305.1, XM_011240003.2
UniGeneiMm.4815

3D structure databases

ProteinModelPortaliQ61456
SMRiQ61456
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198544, 3 interactors
ComplexPortaliCPX-2061 Cyclin A1-CDK1 complex
CPX-2065 Cyclin A1-CDK2 complex
CORUMiQ61456
STRINGi10090.ENSMUSP00000029368

PTM databases

iPTMnetiQ61456
PhosphoSitePlusiQ61456

Proteomic databases

PaxDbiQ61456
PRIDEiQ61456

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029368; ENSMUSP00000029368; ENSMUSG00000027793
ENSMUST00000197238; ENSMUSP00000142692; ENSMUSG00000027793
ENSMUST00000198320; ENSMUSP00000143447; ENSMUSG00000027793
GeneIDi12427
KEGGimmu:12427
UCSCiuc008pfy.3 mouse

Organism-specific databases

CTDi8900
MGIiMGI:108042 Ccna1

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000167672
HOVERGENiHBG106244
InParanoidiQ61456
KOiK06627
OrthoDBiEOG091G090I
PhylomeDBiQ61456
TreeFamiTF101002

Enzyme and pathway databases

ReactomeiR-MMU-1538133 G0 and Early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-176408 Regulation of APC/C activators between G1/S and early anaphase
R-MMU-187577 SCF(Skp2)-mediated degradation of p27/p21
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-5689880 Ub-specific processing proteases
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6804757 Regulation of TP53 Degradation
R-MMU-68911 G2 Phase
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-MMU-69563 p53-Dependent G1 DNA Damage Response
R-MMU-69656 Cyclin A:Cdk2-associated events at S phase entry

Miscellaneous databases

PROiPR:Q61456
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027793 Expressed in 40 organ(s), highest expression level in testis
CleanExiMM_CCNA1
ExpressionAtlasiQ61456 baseline and differential
GenevisibleiQ61456 MM

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCNA1_MOUSE
AccessioniPrimary (citable) accession number: Q61456
Secondary accession number(s): Q8C5U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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