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Protein

Leukocyte surface antigen CD53

Gene

Cd53

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells.1 Publication

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • positive regulation of myoblast fusion Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
CD_antigen: CD53
Gene namesi
Name:Cd53
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88341 Cd53

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 54ExtracellularSequence analysisAdd BLAST22
Transmembranei55 – 69HelicalSequence analysisAdd BLAST15
Topological domaini70 – 80CytoplasmicSequence analysisAdd BLAST11
Transmembranei81 – 106HelicalSequence analysisAdd BLAST26
Topological domaini107 – 181ExtracellularSequence analysisAdd BLAST75
Transmembranei182 – 206HelicalSequence analysisAdd BLAST25
Topological domaini207 – 219CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192131 – 219Leukocyte surface antigen CD53Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ61451
PRIDEiQ61451

Expressioni

Gene expression databases

BgeeiENSMUSG00000040747 Expressed in 226 organ(s), highest expression level in blood
CleanExiMM_CD53
ExpressionAtlasiQ61451 baseline and differential
GenevisibleiQ61451 MM

Interactioni

Subunit structurei

Interacts with SCIMP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035781

Structurei

3D structure databases

ProteinModelPortaliQ61451
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ61451
KOiK06489
OMAiVCVIQVL
OrthoDBiEOG091G0CQO
PhylomeDBiQ61451
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q61451-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMSSLKLLK YVLFIFNLLF WVCGCCILGF GIYFLVQNTY GVLFRNLPFL
60 70 80 90 100
TLGNILVIVG SIIMVVAFLG CMGSIKENKC LLMSFFVLLL IILLAEVTIA
110 120 130 140 150
ILLFVYEQKL NTLVAEGLND SIQHYHSDNS TMKAWDFIQT QLQCCGVNGS
160 170 180 190 200
SDWTSGPPSS CPSGADVQGC YNKAKSWFHS NFLYIGIITI CVCVIQVLGM
210
SFALTLNCQI DKTSQALGL
Length:219
Mass (Da):24,164
Last modified:January 23, 2007 - v2
Checksum:i7995D2E745A17AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97227 mRNA Translation: CAA65864.1
Z16078 Genomic DNA Translation: CAA78892.1
BC021310 mRNA Translation: AAH21310.1
BC052905 mRNA Translation: AAH52905.1
CCDSiCCDS17728.1
RefSeqiNP_031677.1, NM_007651.3
UniGeneiMm.316861

Genome annotation databases

EnsembliENSMUST00000038845; ENSMUSP00000035781; ENSMUSG00000040747
GeneIDi12508
KEGGimmu:12508
UCSCiuc008qwm.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97227 mRNA Translation: CAA65864.1
Z16078 Genomic DNA Translation: CAA78892.1
BC021310 mRNA Translation: AAH21310.1
BC052905 mRNA Translation: AAH52905.1
CCDSiCCDS17728.1
RefSeqiNP_031677.1, NM_007651.3
UniGeneiMm.316861

3D structure databases

ProteinModelPortaliQ61451
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035781

Proteomic databases

PaxDbiQ61451
PRIDEiQ61451

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038845; ENSMUSP00000035781; ENSMUSG00000040747
GeneIDi12508
KEGGimmu:12508
UCSCiuc008qwm.2 mouse

Organism-specific databases

CTDi963
MGIiMGI:88341 Cd53

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ61451
KOiK06489
OMAiVCVIQVL
OrthoDBiEOG091G0CQO
PhylomeDBiQ61451
TreeFamiTF352892

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:Q61451
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040747 Expressed in 226 organ(s), highest expression level in blood
CleanExiMM_CD53
ExpressionAtlasiQ61451 baseline and differential
GenevisibleiQ61451 MM

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD53_MOUSE
AccessioniPrimary (citable) accession number: Q61451
Secondary accession number(s): Q61721
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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