UniProtKB - Q61391 (NEP_MOUSE)

BLAST

>sp|Q61391|NEP_MOUSE Neprilysin OS=Mus musculus OX=10090 GN=Mme PE=1 SV=3
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKD
VLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLKLLPDIYGWPVASDNWDQTYGT
SWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLY
NKMTLAKLQNNFSLEVNGKSFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILT
KYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERI
GYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYR
AYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFADAFHCRKNSYMNPERKCRVW

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History
Entry version 163 (07 Nov 2018)
Sequence version 3 (23 Jan 2007)
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Protein

Neprilysin

Gene

Mme

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) (By similarity). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).By similarity1 Publication

Catalytic activityⁱ

Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.By similarity

Cofactorⁱ

Zn²⁺Note: Binds 1 zinc ion per subunit.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	103	Substrate carboxylBy similarity	1
Metal bindingⁱ	584	Zinc; catalyticPROSITE-ProRule annotation	1
Active siteⁱ	585	PROSITE-ProRule annotation	1
Metal bindingⁱ	588	Zinc; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	647	Zinc; catalyticPROSITE-ProRule annotation	1
Active siteⁱ	651	Proton donorPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

endopeptidase activity Source: MGI
exopeptidase activity Source: MGI
metalloendopeptidase activity Source: UniProtKB
metallopeptidase activity Source: MGI
peptidase activity
Source: MGI
Inferred from direct assayⁱ
- 15944124
peptide binding Source: UniProtKB
zinc ion binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amyloid-beta clearance Source: MGI
amyloid-beta metabolic process
Source: MGI
Inferred from direct assayⁱ
- 12074840
cellular response to cytokine stimulus Source: UniProtKB
cellular response to UV-A Source: UniProtKB
cellular response to UV-B Source: UniProtKB
creatinine metabolic process Source: UniProtKB
kidney development Source: UniProtKB
peptide metabolic process Source: UniProtKB
proteolysis Source: UniProtKB
replicative senescence Source: UniProtKB
sensory perception of pain
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9751784

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Metalloprotease, Protease
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins
R-MMU-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M13.001

MEROPSⁱ

M13.001

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neprilysin (EC:3.4.24.11By similarity) Alternative name(s): Atriopeptidase Enkephalinase Neutral endopeptidase 24.11 Short name: NEP Short name: Neutral endopeptidase Skin fibroblast elastase Short name: SFE CD_antigen: CD10
Gene namesⁱ	Name:Mme
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:97004 Mme

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 28	CytoplasmicSequence analysisAdd BLAST	27
Transmembraneⁱ	29 – 51	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	23
Topological domainⁱ	52 – 750	ExtracellularSequence analysisAdd BLAST	699

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are overtly normal in appearance and size and do not show obvious abnormalities in motor performance or coordination. Nerve conduction studies reveal no significant differences between mutant and control animals.1 Publication

Chemistry databases

ChEMBLⁱ	CHEMBL2642

ChEMBLⁱ

CHEMBL2642

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000078214	2 – 750	NeprilysinAdd BLAST		749

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycineBy similarity	1
Modified residueⁱ	4	PhosphoserineCombined sources	1
Modified residueⁱ	6	PhosphoserineCombined sources	1
Disulfide bondⁱ	57 ↔ 62	By similarity
Disulfide bondⁱ	80 ↔ 735	By similarity
Disulfide bondⁱ	88 ↔ 695	By similarity
Disulfide bondⁱ	143 ↔ 411	By similarity
Glycosylationⁱ	145	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	211	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	234 ↔ 242	By similarity
Glycosylationⁱ	285	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	311	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	325	N-linked (GlcNAc...) asparagineBy similarity	1
Disulfide bondⁱ	621 ↔ 747	By similarity
Glycosylationⁱ	628	N-linked (GlcNAc...) asparagineBy similarity	1

Post-translational modificationⁱ

Myristoylation is a determinant of membrane targeting.By similarity

Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61391
PaxDbⁱ	Q61391
PeptideAtlas More...PeptideAtlasⁱ	Q61391
PRIDEⁱ	Q61391

PTM databases

iPTMnetⁱ	Q61391
PhosphoSitePlusⁱ	Q61391

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027820 Expressed in 236 organ(s), highest expression level in epithelium of lens
CleanExⁱ	MM_MME
ExpressionAtlasⁱ	Q61391 baseline and differential
Genevisibleⁱ	Q61391 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	201441, 2 interactors
IntActⁱ	Q61391, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q61391
STRINGⁱ	10090.ENSMUSP00000029400

Chemistry databases

BindingDBⁱ

Q61391

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	9 – 12	Combined sources		4
Beta strandⁱ	19 – 21	Combined sources		3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q61391
SMRⁱ	Q61391
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q61391

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	16 – 23	Stop-transfer sequenceSequence analysis		8

Sequence similaritiesⁱ

Belongs to the peptidase M13 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3624 Eukaryota COG3590 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119162
HOGENOMⁱ	HOG000245574
HOVERGENⁱ	HBG005554
InParanoidⁱ	Q61391
KEGG Orthology (KO) More...KOⁱ	K01389
OMAⁱ	APRNHDA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G025Y
PhylomeDBⁱ	Q61391
TreeFamⁱ	TF315192

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08662 M13, 1 hit
Gene3Dⁱ	3.40.390.10, 1 hit
InterProⁱ	View protein in InterPro IPR024079 MetalloPept_cat_dom_sf IPR029727 MME/CD10/NEP IPR000718 Peptidase_M13 IPR018497 Peptidase_M13_C IPR008753 Peptidase_M13_N
PANTHERⁱ	PTHR11733 PTHR11733, 1 hit PTHR11733:SF114 PTHR11733:SF114, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01431 Peptidase_M13, 1 hit PF05649 Peptidase_M13_N, 1 hit
PRINTSⁱ	PR00786 NEPRILYSIN
PROSITEⁱ	View protein in PROSITE PS00142 ZINC_PROTEASE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q61391-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGRSESQMDI TDINAPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA 
        60         70         80         90        100
TYDDGICKSS DCIKSAARLI QNMDASVEPC TDFFKYACGG WLKRNVIPET 
       110        120        130        140        150
SSRYSNFDIL RDELEVILKD VLQEPKTEDI VAVQKAKTLY RSCINESAID 
       160        170        180        190        200
SRGGQPLLKL LPDIYGWPVA SDNWDQTYGT SWTAEKSIAQ LNSKYGKKVL 
       210        220        230        240        250
INFFVGTDDK NSTQHIIHFD QPRLGLPSRD YYECTGIYKE ACTAYVDFMI 
       260        270        280        290        300
SVARLIRQEQ SLPIDENQLS LEMNKVMELE KEIANATTKP EDRNDPMLLY 
       310        320        330        340        350
NKMTLAKLQN NFSLEVNGKS FSWSNFTNEI MSTVNINIQN EEEVVVYAPE 
       360        370        380        390        400
YLTKLKPILT KYSPRDLQNL MSWRFIMDLV SSLSRNYKES RNAFRKALYG 
       410        420        430        440        450
TTSETATWRR CANYVNGNME NAVGRLYVEA AFAGESKHVV EDLIAQIREV 
       460        470        480        490        500
FIQTLDDLTW MDAETKKKAE EKALAIKERI GYPDDIISNE NKLNNEYLEL 
       510        520        530        540        550
NYREDEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA VVNAFYSSGR 
       560        570        580        590        600
NQIVFPAGIL QPPFFSAQQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD 
       610        620        630        640        650
GDLVDWWTQQ SANNFKDQSQ CMVYQYGNFS WDLAGGQHLN GINTLGENIA 
       660        670        680        690        700
DNGGIGQAYR AYQNYVKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP 
       710        720        730        740        750
EYAVNSIKTD VHSPGNFRII GTLQNSAEFA DAFHCRKNSY MNPERKCRVW

Length:750

Mass (Da):85,702

Last modified:January 23, 2007 - v3

Checksum:ⁱ1FC39A971D98F6FE

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A6YY36	A0A0A6YY36_MOUSE	Neprilysin Neprilysin	Mme	133	Annotation score:
A0A0A6YWB9	A0A0A6YWB9_MOUSE	Neprilysin Neprilysin	Mme	178	Annotation score:
A0A0A6YW93	A0A0A6YW93_MOUSE	Neprilysin Neprilysin	Mme	187	Annotation score:
A0A0A6YWA6	A0A0A6YWA6_MOUSE	Neprilysin Neprilysin	Mme	130	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	230	D → G in AAA37386 (PubMed:1374101).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81591 mRNA Translation: AAA37386.1 AK031446 mRNA Translation: BAC27410.1 AK033824 mRNA Translation: BAC28487.1 BC034092 mRNA Translation: AAH34092.1 BC066840 mRNA Translation: AAH66840.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17381.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001276391.1, NM_001289462.1 NP_001276392.1, NM_001289463.1 NP_032630.2, NM_008604.4 XP_006501158.1, XM_006501095.3 XP_006501161.1, XM_006501098.3
UniGeneⁱ	Mm.296022

Genome annotation databases

Ensemblⁱ	ENSMUST00000029400; ENSMUSP00000029400; ENSMUSG00000027820 ENSMUST00000194134; ENSMUSP00000142205; ENSMUSG00000027820 ENSMUST00000194150; ENSMUSP00000141544; ENSMUSG00000027820
GeneIDⁱ	17380
KEGGⁱ	mmu:17380
UCSC genome browser More...UCSCⁱ	uc008pjp.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61391	Uncharacterized protein (Fragment)		MOUSE		279	UniRef100_Q61391
Neprilysin (Fragment)		MOUSE		187
Neprilysin (Fragment)		MOUSE		133
Neprilysin (Fragment)		MOUSE		178

Protein	Similar proteins		Species	Score	Length	Source
Q61391	Neprilysin	)	HUMAN		750	UniRef90_P08473
Neprilysin		RAT		750
Neprilysin	)	RABIT		750
Neprilysin		PONAB		750
Neprilysin-like protein		CRIGR		769
+125

Protein	Similar proteins		Species	Score	Length	Source
Q61391	Neprilysin	)	HUMAN		750	UniRef50_P08473
Neprilysin		PONAB		750
Neprilysin	)	RABIT		750
Neprilysin		RAT		750
Neprilysin-like protein		CRIGR		769
+136

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81591 mRNA Translation: AAA37386.1 AK031446 mRNA Translation: BAC27410.1 AK033824 mRNA Translation: BAC28487.1 BC034092 mRNA Translation: AAH34092.1 BC066840 mRNA Translation: AAH66840.1
CCDSⁱ	CCDS17381.1
RefSeqⁱ	NP_001276391.1, NM_001289462.1 NP_001276392.1, NM_001289463.1 NP_032630.2, NM_008604.4 XP_006501158.1, XM_006501095.3 XP_006501161.1, XM_006501098.3
UniGeneⁱ	Mm.296022

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2YVC	X-ray	3.20	D/E/F	2-23	[»]
ProteinModelPortalⁱ	Q61391
SMRⁱ	Q61391
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201441, 2 interactors
IntActⁱ	Q61391, 3 interactors
MINTⁱ	Q61391
STRINGⁱ	10090.ENSMUSP00000029400

Chemistry databases

BindingDBⁱ	Q61391
ChEMBLⁱ	CHEMBL2642

Protein family/group databases

MEROPSⁱ	M13.001

MEROPSⁱ

M13.001

PTM databases

iPTMnetⁱ	Q61391
PhosphoSitePlusⁱ	Q61391

Proteomic databases

MaxQBⁱ	Q61391
PaxDbⁱ	Q61391
PeptideAtlasⁱ	Q61391
PRIDEⁱ	Q61391

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000029400; ENSMUSP00000029400; ENSMUSG00000027820 ENSMUST00000194134; ENSMUSP00000142205; ENSMUSG00000027820 ENSMUST00000194150; ENSMUSP00000141544; ENSMUSG00000027820
GeneIDⁱ	17380
KEGGⁱ	mmu:17380
UCSCⁱ	uc008pjp.2 mouse

Organism-specific databases

CTDⁱ	4311
MGIⁱ	MGI:97004 Mme

Phylogenomic databases

eggNOGⁱ	KOG3624 Eukaryota COG3590 LUCA
GeneTreeⁱ	ENSGT00760000119162
HOGENOMⁱ	HOG000245574
HOVERGENⁱ	HBG005554
InParanoidⁱ	Q61391
KOⁱ	K01389
OMAⁱ	APRNHDA
OrthoDBⁱ	EOG091G025Y
PhylomeDBⁱ	Q61391
TreeFamⁱ	TF315192

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-2022377 Metabolism of Angiotensinogen to Angiotensins
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceⁱ	Q61391
Protein Ontology More...PROⁱ	PR:Q61391
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027820 Expressed in 236 organ(s), highest expression level in epithelium of lens
CleanExⁱ	MM_MME
ExpressionAtlasⁱ	Q61391 baseline and differential
Genevisibleⁱ	Q61391 MM

Family and domain databases

CDDⁱ	cd08662 M13, 1 hit
Gene3Dⁱ	3.40.390.10, 1 hit
InterProⁱ	View protein in InterPro IPR024079 MetalloPept_cat_dom_sf IPR029727 MME/CD10/NEP IPR000718 Peptidase_M13 IPR018497 Peptidase_M13_C IPR008753 Peptidase_M13_N
PANTHERⁱ	PTHR11733 PTHR11733, 1 hit PTHR11733:SF114 PTHR11733:SF114, 1 hit
Pfamⁱ	View protein in Pfam PF01431 Peptidase_M13, 1 hit PF05649 Peptidase_M13_N, 1 hit
PRINTSⁱ	PR00786 NEPRILYSIN
PROSITEⁱ	View protein in PROSITE PS00142 ZINC_PROTEASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEP_MOUSE
Accessionⁱ	Q61391Primary (citable) accession number: Q61391 Secondary accession number(s): Q6NXX5, Q8K251
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Peptidase families
Classification of peptidase families and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q61391 (NEP_MOUSE)

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Neprilysin

Mme

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ