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Protein

T-complex protein 1 subunit zeta-2

Gene

Cct6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: InterPro
  • toxin transport Source: MGI

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta-2
Short name:
TCP-1-zeta-2
Alternative name(s):
CCT-zeta-2
Short name:
Cctz-2
Gene namesi
Name:Cct6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1329013 Cct6b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283641 – 531T-complex protein 1 subunit zeta-2Add BLAST531

Proteomic databases

EPDiQ61390
MaxQBiQ61390
PaxDbiQ61390
PRIDEiQ61390

PTM databases

iPTMnetiQ61390
PhosphoSitePlusiQ61390

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSMUSG00000020698 Expressed in 43 organ(s), highest expression level in testis
CleanExiMM_CCT6B
ExpressionAtlasiQ61390 baseline and differential
GenevisibleiQ61390 MM

Interactioni

Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ61390
IntActiQ61390, 1 interactor
STRINGi10090.ENSMUSP00000021040

Structurei

3D structure databases

ProteinModelPortaliQ61390
SMRiQ61390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359 Eukaryota
ENOG410XQ3Q LUCA
GeneTreeiENSGT00550000074743
HOGENOMiHOG000226733
HOVERGENiHBG103725
InParanoidiQ61390
KOiK09498
OMAiKSETDTX
OrthoDBiEOG091G07CE
PhylomeDBiQ61390
TreeFamiTF106333

Family and domain databases

CDDicd03342 TCP1_zeta, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02347 chap_CCT_zeta, 1 hit
PROSITEiView protein in PROSITE
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61390-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAIKIANPG AEVTRSQAAL AVNICAARGL QDVLRPTLGP KGALKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLHEMQIQ HPTASIIAKV AAAQDHVTGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIT EGFDVAKTKA LEVLDEIKVQ KEMKREILLD
160 170 180 190 200
VARTSLQTKV HAELADILTE AVVDSVLAIR RPGVPIDLFM VEIVEMRHKS
210 220 230 240 250
ETDTQLIRGL VLDHGARHPR MRKQVRDAYI LTCNVSLEYE KTEVSSGFFY
260 270 280 290 300
KTVEEKEKLV KAERKFIEDR VQKIIDLKQK VCAESNKGFV VINQKGIDPV
310 320 330 340 350
SLEMLAKHNI VALRRAKRRN LERLTLACGG LAVNSFEGLS EECLGHAGLV
360 370 380 390 400
FEYALGEEKF TFIEDCVNPL SVTLLVKGPN KHTLIQIKDA LRDGLRAVKN
410 420 430 440 450
AIEDGCVVPG AGAVEVAIAE ALVNYKHRVQ GRVRLGIQAF ADALLIIPKV
460 470 480 490 500
LAQNSGYDLQ ETLIKIQTKH AESKELLGID LNTGEPMAAA EAGIWDNYCV
510 520 530
KKHLLHSCTV IATNILLVDE IMRAGMSSLR D
Length:531
Mass (Da):58,185
Last modified:January 23, 2007 - v4
Checksum:i5B8C600231A1F6B5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AT05B1AT05_MOUSE
T-complex protein 1 subunit zeta-2
Cct6b
492Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112E → K in CAA90574 (PubMed:9013858).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50192 mRNA Translation: CAA90574.1
AB022086 Genomic DNA Translation: BAA81891.1
CCDSiCCDS25145.1
RefSeqiNP_033969.2, NM_009839.3
UniGeneiMm.4126

Genome annotation databases

EnsembliENSMUST00000021040; ENSMUSP00000021040; ENSMUSG00000020698
GeneIDi12467
KEGGimmu:12467
UCSCiuc007kmx.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50192 mRNA Translation: CAA90574.1
AB022086 Genomic DNA Translation: BAA81891.1
CCDSiCCDS25145.1
RefSeqiNP_033969.2, NM_009839.3
UniGeneiMm.4126

3D structure databases

ProteinModelPortaliQ61390
SMRiQ61390
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ61390
IntActiQ61390, 1 interactor
STRINGi10090.ENSMUSP00000021040

PTM databases

iPTMnetiQ61390
PhosphoSitePlusiQ61390

Proteomic databases

EPDiQ61390
MaxQBiQ61390
PaxDbiQ61390
PRIDEiQ61390

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021040; ENSMUSP00000021040; ENSMUSG00000020698
GeneIDi12467
KEGGimmu:12467
UCSCiuc007kmx.3 mouse

Organism-specific databases

CTDi10693
MGIiMGI:1329013 Cct6b

Phylogenomic databases

eggNOGiKOG0359 Eukaryota
ENOG410XQ3Q LUCA
GeneTreeiENSGT00550000074743
HOGENOMiHOG000226733
HOVERGENiHBG103725
InParanoidiQ61390
KOiK09498
OMAiKSETDTX
OrthoDBiEOG091G07CE
PhylomeDBiQ61390
TreeFamiTF106333

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRSiCct6b mouse
PROiPR:Q61390
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020698 Expressed in 43 organ(s), highest expression level in testis
CleanExiMM_CCT6B
ExpressionAtlasiQ61390 baseline and differential
GenevisibleiQ61390 MM

Family and domain databases

CDDicd03342 TCP1_zeta, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02347 chap_CCT_zeta, 1 hit
PROSITEiView protein in PROSITE
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCPW_MOUSE
AccessioniPrimary (citable) accession number: Q61390
Secondary accession number(s): Q9R1U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 146 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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