Cct6b

Functionⁱ

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.By similarity

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein folding Source: InterPro
toxin transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 23716698

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Reactomeⁱ

R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-complex protein 1 subunit zeta-2 Short name: TCP-1-zeta-2 Alternative name(s): CCT-zeta-2 Short name: Cctz-2
Gene namesⁱ	Name:Cct6b
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1329013 Cct6b

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000128364	1 – 531	T-complex protein 1 subunit zeta-2Add BLAST		531

Proteomic databases

EPDⁱ	Q61390
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61390
PaxDbⁱ	Q61390
PRIDEⁱ	Q61390

PTM databases

iPTMnetⁱ	Q61390
PhosphoSitePlusⁱ	Q61390

Expressionⁱ

Tissue specificityⁱ

Testis specific.

Gene expression databases

Bgeeⁱ	ENSMUSG00000020698 Expressed in 43 organ(s), highest expression level in testis
CleanExⁱ	MM_CCT6B
ExpressionAtlasⁱ	Q61390 baseline and differential
Genevisibleⁱ	Q61390 MM

Interactionⁱ

Subunit structureⁱ

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

GO - Molecular functionⁱ

unfolded protein binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	Q61390
IntActⁱ	Q61390, 1 interactor
STRINGⁱ	10090.ENSMUSP00000021040

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61390
SMRⁱ	Q61390
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0359 Eukaryota ENOG410XQ3Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074743
HOGENOMⁱ	HOG000226733
HOVERGENⁱ	HBG103725
InParanoidⁱ	Q61390
KEGG Orthology (KO) More...KOⁱ	K09498
OMAⁱ	KSETDTX
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07CE
PhylomeDBⁱ	Q61390
TreeFamⁱ	TF106333

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03342 TCP1_zeta, 1 hit
Gene3Dⁱ	1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012722 Chap_CCT_zeta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 1 hit SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 1 hit
TIGRFAMsⁱ	TIGR02347 chap_CCT_zeta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q61390-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAIKIANPG AEVTRSQAAL AVNICAARGL QDVLRPTLGP KGALKMLVSG 
        60         70         80         90        100
AGDIKLTKDG NVLLHEMQIQ HPTASIIAKV AAAQDHVTGD GTTSNVLIIG 
       110        120        130        140        150
ELLKQADLYI SEGLHPRIIT EGFDVAKTKA LEVLDEIKVQ KEMKREILLD 
       160        170        180        190        200
VARTSLQTKV HAELADILTE AVVDSVLAIR RPGVPIDLFM VEIVEMRHKS 
       210        220        230        240        250
ETDTQLIRGL VLDHGARHPR MRKQVRDAYI LTCNVSLEYE KTEVSSGFFY 
       260        270        280        290        300
KTVEEKEKLV KAERKFIEDR VQKIIDLKQK VCAESNKGFV VINQKGIDPV 
       310        320        330        340        350
SLEMLAKHNI VALRRAKRRN LERLTLACGG LAVNSFEGLS EECLGHAGLV 
       360        370        380        390        400
FEYALGEEKF TFIEDCVNPL SVTLLVKGPN KHTLIQIKDA LRDGLRAVKN 
       410        420        430        440        450
AIEDGCVVPG AGAVEVAIAE ALVNYKHRVQ GRVRLGIQAF ADALLIIPKV 
       460        470        480        490        500
LAQNSGYDLQ ETLIKIQTKH AESKELLGID LNTGEPMAAA EAGIWDNYCV 
       510        520        530 
KKHLLHSCTV IATNILLVDE IMRAGMSSLR D

Length:531

Mass (Da):58,185

Last modified:January 23, 2007 - v4

Checksum:ⁱ5B8C600231A1F6B5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B1AT05	B1AT05_MOUSE		T-complex protein 1 subunit zeta-2 T-complex protein 1 subunit zeta-2	Cct6b	492	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	112	E → K in CAA90574 (PubMed:9013858).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z50192 mRNA Translation: CAA90574.1 AB022086 Genomic DNA Translation: BAA81891.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25145.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033969.2, NM_009839.3
UniGeneⁱ	Mm.4126

Genome annotation databases

Ensemblⁱ	ENSMUST00000021040; ENSMUSP00000021040; ENSMUSG00000020698
GeneIDⁱ	12467
KEGGⁱ	mmu:12467
UCSC genome browser More...UCSCⁱ	uc007kmx.3 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61390	Chaperonin containing Tcp1, subunit 6b (Zeta)		MOUSE		531	UniRef100_Q61390
UPI0003D6E81C		MOUSE		465

Protein	Similar proteins		Species	Score	Length	Source
Q61390	Chaperonin containing Tcp1, subunit 6b (Zeta)		MOUSE		531	UniRef90_Q61390
Chaperonin containing Tcp1, subunit 6B (Zeta 2)		RAT		531
UPI00038BC24F		MICOH		531
UPI000A309DE3		MUSPA		531
UPI000A3161CA		MUSCR		531
+4

Protein	Similar proteins		Species	Score	Length	Source
Q61390	T-complex protein 1 subunit zeta		HUMAN		531	UniRef50_P40227
T-complex protein 1 subunit zeta		MOUSE		531
T-complex protein 1 subunit zeta		RABIT		531
T-complex protein 1 subunit zeta	)	BOVIN		531
T-complex protein 1 subunit zeta		PONAB		531
+1059

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z50192 mRNA Translation: CAA90574.1 AB022086 Genomic DNA Translation: BAA81891.1
CCDSⁱ	CCDS25145.1
RefSeqⁱ	NP_033969.2, NM_009839.3
UniGeneⁱ	Mm.4126

3D structure databases

ProteinModelPortalⁱ	Q61390
SMRⁱ	Q61390
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	Q61390
IntActⁱ	Q61390, 1 interactor
STRINGⁱ	10090.ENSMUSP00000021040

PTM databases

iPTMnetⁱ	Q61390
PhosphoSitePlusⁱ	Q61390

Proteomic databases

EPDⁱ	Q61390
MaxQBⁱ	Q61390
PaxDbⁱ	Q61390
PRIDEⁱ	Q61390

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021040; ENSMUSP00000021040; ENSMUSG00000020698
GeneIDⁱ	12467
KEGGⁱ	mmu:12467
UCSCⁱ	uc007kmx.3 mouse

Organism-specific databases

CTDⁱ	10693
MGIⁱ	MGI:1329013 Cct6b

Phylogenomic databases

eggNOGⁱ	KOG0359 Eukaryota ENOG410XQ3Q LUCA
GeneTreeⁱ	ENSGT00550000074743
HOGENOMⁱ	HOG000226733
HOVERGENⁱ	HBG103725
InParanoidⁱ	Q61390
KOⁱ	K09498
OMAⁱ	KSETDTX
OrthoDBⁱ	EOG091G07CE
PhylomeDBⁱ	Q61390
TreeFamⁱ	TF106333

Enzyme and pathway databases

Reactomeⁱ	R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Reactomeⁱ

R-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRSⁱ	Cct6b mouse
Protein Ontology More...PROⁱ	PR:Q61390
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020698 Expressed in 43 organ(s), highest expression level in testis
CleanExⁱ	MM_CCT6B
ExpressionAtlasⁱ	Q61390 baseline and differential
Genevisibleⁱ	Q61390 MM

Family and domain databases

CDDⁱ	cd03342 TCP1_zeta, 1 hit
Gene3Dⁱ	1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit
InterProⁱ	View protein in InterPro IPR012722 Chap_CCT_zeta IPR017998 Chaperone_TCP-1 IPR002194 Chaperonin_TCP-1_CS IPR002423 Cpn60/TCP-1 IPR027409 GroEL-like_apical_dom_sf IPR027413 GROEL-like_equatorial_sf IPR027410 TCP-1-like_intermed_sf
Pfamⁱ	View protein in Pfam PF00118 Cpn60_TCP1, 1 hit
PRINTSⁱ	PR00304 TCOMPLEXTCP1
SUPFAMⁱ	SSF48592 SSF48592, 1 hit SSF52029 SSF52029, 1 hit SSF54849 SSF54849, 1 hit
TIGRFAMsⁱ	TIGR02347 chap_CCT_zeta, 1 hit
PROSITEⁱ	View protein in PROSITE PS00751 TCP1_2, 1 hit PS00995 TCP1_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TCPW_MOUSE
Accessionⁱ	Q61390Primary (citable) accession number: Q61390 Secondary accession number(s): Q9R1U2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61390 (TCPW_MOUSE)

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T-complex protein 1 subunit zeta-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ