UniProtKB - Q61390 (TCPW_MOUSE)
Protein
T-complex protein 1 subunit zeta-2
Gene
Cct6b
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.By similarity
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- protein folding chaperone Source: MGI
- unfolded protein binding Source: GO_Central
GO - Biological processi
- protein folding Source: MGI
- toxin transport Source: MGI
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-390471, Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Names & Taxonomyi
Protein namesi | Recommended name: T-complex protein 1 subunit zeta-2Short name: TCP-1-zeta-2 Alternative name(s): CCT-zeta-2 Short name: Cctz-2 |
Gene namesi | Name:Cct6b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1329013, Cct6b |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytosol
- chaperonin-containing T-complex Source: MGI
- cytosol Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000128364 | 1 – 531 | T-complex protein 1 subunit zeta-2Add BLAST | 531 |
Proteomic databases
EPDi | Q61390 |
jPOSTi | Q61390 |
MaxQBi | Q61390 |
PaxDbi | Q61390 |
PRIDEi | Q61390 |
ProteomicsDBi | 263266 |
PTM databases
iPTMneti | Q61390 |
PhosphoSitePlusi | Q61390 |
Expressioni
Tissue specificityi
Testis specific.
Gene expression databases
Bgeei | ENSMUSG00000020698, Expressed in spermatid and 81 other tissues |
ExpressionAtlasi | Q61390, baseline and differential |
Genevisiblei | Q61390, MM |
Interactioni
Subunit structurei
Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
By similarityGO - Molecular functioni
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 198570, 6 interactors |
CORUMi | Q61390 |
IntActi | Q61390, 1 interactor |
STRINGi | 10090.ENSMUSP00000021040 |
Miscellaneous databases
RNActi | Q61390, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCP-1 chaperonin family.Curated
Phylogenomic databases
eggNOGi | KOG0359, Eukaryota |
GeneTreei | ENSGT00940000156339 |
HOGENOMi | CLU_008891_3_1_1 |
InParanoidi | Q61390 |
OMAi | EDCINPR |
OrthoDBi | 482152at2759 |
PhylomeDBi | Q61390 |
TreeFami | TF106333 |
Family and domain databases
CDDi | cd03342, TCP1_zeta, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012722, Chap_CCT_zeta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02347, chap_CCT_zeta, 1 hit |
PROSITEi | View protein in PROSITE PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q61390-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAIKIANPG AEVTRSQAAL AVNICAARGL QDVLRPTLGP KGALKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLHEMQIQ HPTASIIAKV AAAQDHVTGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIT EGFDVAKTKA LEVLDEIKVQ KEMKREILLD
160 170 180 190 200
VARTSLQTKV HAELADILTE AVVDSVLAIR RPGVPIDLFM VEIVEMRHKS
210 220 230 240 250
ETDTQLIRGL VLDHGARHPR MRKQVRDAYI LTCNVSLEYE KTEVSSGFFY
260 270 280 290 300
KTVEEKEKLV KAERKFIEDR VQKIIDLKQK VCAESNKGFV VINQKGIDPV
310 320 330 340 350
SLEMLAKHNI VALRRAKRRN LERLTLACGG LAVNSFEGLS EECLGHAGLV
360 370 380 390 400
FEYALGEEKF TFIEDCVNPL SVTLLVKGPN KHTLIQIKDA LRDGLRAVKN
410 420 430 440 450
AIEDGCVVPG AGAVEVAIAE ALVNYKHRVQ GRVRLGIQAF ADALLIIPKV
460 470 480 490 500
LAQNSGYDLQ ETLIKIQTKH AESKELLGID LNTGEPMAAA EAGIWDNYCV
510 520 530
KKHLLHSCTV IATNILLVDE IMRAGMSSLR D
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AT05 | B1AT05_MOUSE | T-complex protein 1 subunit zeta-2 | Cct6b | 492 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 112 | E → K in CAA90574 (PubMed:9013858).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z50192 mRNA Translation: CAA90574.1 AB022086 Genomic DNA Translation: BAA81891.1 |
CCDSi | CCDS25145.1 |
RefSeqi | NP_033969.2, NM_009839.3 |
Genome annotation databases
Ensembli | ENSMUST00000021040; ENSMUSP00000021040; ENSMUSG00000020698 |
GeneIDi | 12467 |
KEGGi | mmu:12467 |
UCSCi | uc007kmx.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z50192 mRNA Translation: CAA90574.1 AB022086 Genomic DNA Translation: BAA81891.1 |
CCDSi | CCDS25145.1 |
RefSeqi | NP_033969.2, NM_009839.3 |
3D structure databases
SMRi | Q61390 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198570, 6 interactors |
CORUMi | Q61390 |
IntActi | Q61390, 1 interactor |
STRINGi | 10090.ENSMUSP00000021040 |
PTM databases
iPTMneti | Q61390 |
PhosphoSitePlusi | Q61390 |
Proteomic databases
EPDi | Q61390 |
jPOSTi | Q61390 |
MaxQBi | Q61390 |
PaxDbi | Q61390 |
PRIDEi | Q61390 |
ProteomicsDBi | 263266 |
Protocols and materials databases
Antibodypediai | 27366, 122 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021040; ENSMUSP00000021040; ENSMUSG00000020698 |
GeneIDi | 12467 |
KEGGi | mmu:12467 |
UCSCi | uc007kmx.3, mouse |
Organism-specific databases
CTDi | 10693 |
MGIi | MGI:1329013, Cct6b |
Phylogenomic databases
eggNOGi | KOG0359, Eukaryota |
GeneTreei | ENSGT00940000156339 |
HOGENOMi | CLU_008891_3_1_1 |
InParanoidi | Q61390 |
OMAi | EDCINPR |
OrthoDBi | 482152at2759 |
PhylomeDBi | Q61390 |
TreeFami | TF106333 |
Enzyme and pathway databases
Reactomei | R-MMU-390471, Association of TriC/CCT with target proteins during biosynthesis R-MMU-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Miscellaneous databases
BioGRID-ORCSi | 12467, 0 hits in 52 CRISPR screens |
ChiTaRSi | Cct6b, mouse |
PROi | PR:Q61390 |
RNActi | Q61390, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020698, Expressed in spermatid and 81 other tissues |
ExpressionAtlasi | Q61390, baseline and differential |
Genevisiblei | Q61390, MM |
Family and domain databases
CDDi | cd03342, TCP1_zeta, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012722, Chap_CCT_zeta IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02347, chap_CCT_zeta, 1 hit |
PROSITEi | View protein in PROSITE PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCPW_MOUSE | |
Accessioni | Q61390Primary (citable) accession number: Q61390 Secondary accession number(s): Q9R1U2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 159 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families