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UniProtKB - Q61361 (PGCB_MOUSE)

Protein

Brevican core protein

Gene

Bcan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cell adhesion Source: InterPro
  • central nervous system development Source: GO_Central
  • hippocampus development Source: MGI
  • synapse maturation Source: SynGO
View the complete GO annotation on QuickGO ...

Keywordsi

LigandHyaluronic acid, Lectin

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870 Chondroitin sulfate biosynthesis
R-MMU-2022923 Dermatan sulfate biosynthesis
R-MMU-2024101 CS/DS degradation
R-MMU-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Brevican core protein
Gene namesi
Name:Bcan
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1096385 Bcan

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001751223 – 883Brevican core proteinAdd BLAST861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 136By similarity
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 249By similarity
Disulfide bondi202 ↔ 223By similarity
Modified residuei224PhosphoserineCombined sources1
Disulfide bondi276 ↔ 351By similarity
Disulfide bondi300 ↔ 321By similarity
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei413PhosphoserineBy similarity1
Disulfide bondi626 ↔ 637By similarity
Disulfide bondi631 ↔ 646By similarity
Disulfide bondi648 ↔ 657By similarity
Disulfide bondi664 ↔ 675By similarity
Disulfide bondi692 ↔ 784By similarity
Disulfide bondi760 ↔ 776By similarity
Disulfide bondi791 ↔ 834By similarity
Disulfide bondi820 ↔ 847By similarity

Post-translational modificationi

Contains mostly chondroitin sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61361
PaxDbiQ61361
PeptideAtlasiQ61361
PRIDEiQ61361

PTM databases

iPTMnetiQ61361
PhosphoSitePlusiQ61361

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSMUSG00000004892 Expressed in 136 organ(s), highest expression level in cerebellum
CleanExiMM_BCAN
ExpressionAtlasiQ61361 baseline and differential
GenevisibleiQ61361 MM

Interactioni

Subunit structurei

Interacts with TNR.By similarity

Protein-protein interaction databases

IntActiQ61361, 2 interactors
MINTiQ61361
STRINGi10090.ENSMUSP00000088491

Structurei

3D structure databases

ProteinModelPortaliQ61361
SMRiQ61361
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 154Ig-like V-typeAdd BLAST120
Domaini156 – 251Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini256 – 353Link 2PROSITE-ProRule annotationAdd BLAST98
Domaini622 – 658EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini658 – 786C-type lectinPROSITE-ProRule annotationAdd BLAST129
Domaini789 – 849SushiPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the aggrecan/versican proteoglycan family.Curated

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IG1W Eukaryota
ENOG410XW3U LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000115520
HOVERGENiHBG008175
InParanoidiQ61361
KOiK06795
OMAiNNRYREY
OrthoDBiEOG091G0KN3
TreeFamiTF332134

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPLLLSLLA ALVLTQAPAA LADDLKEDSS EDRAFRVRIG ATQLRGVLGG 
        60         70         80         90        100
ALAIPCHVHH LRPPHSRRAA PGFPRVKWTF LSGDREVEVL VARGLRVKVN 
       110        120        130        140        150
EAYRFRVALP AYPASLTDVS LVLSELRPND SGVYRCEVQH GIDDSSDAVE 
       160        170        180        190        200
VKVKGVVFLY REGSARYAFS FAGAQEACAR IGARIATPEQ LYAAYLGGYE 
       210        220        230        240        250
QCDAGWLSDQ TVRYPIQNPR EACSGDMDGY PGVRNYGVVG PDDLYDVYCY 
       260        270        280        290        300
AEDLNGELFL GAPPSKLTWE EARDYCLERG AQIASTGQLY AAWNGGLDRC 
       310        320        330        340        350
SPGWLADGSV RYPIITPSQR CGGGLPGVKT LFLFPNQTGF PSKQNRFNVY 
       360        370        380        390        400
CFRDSAHPSA SSEASSPASD GLEAIVTVTE KLEELQLPQE AMESESRGAI 
       410        420        430        440        450
YSIPISEDGG GGSSTPEDPA EAPRTPLESE TQSIAPPTES SEEEGVALEE 
       460        470        480        490        500
EERFKDLEAL EEEKEQEDLW VWPRELSSPL PTGSETEHSL SQVSPPAQAV 
       510        520        530        540        550
LQLGASPSPG PPRVRGPPAE TLLPPREGSP TSTPGGAREV GGETGSPELS 
       560        570        580        590        600
GVPRESEEAG SSSLEDGPSL LPATWAPVGP RELETPSEEK SGRTVLAGTS 
       610        620        630        640        650
VQAQPVLPTD SASHGGVAVA PSSGDCIPSP CHNGGTCLEE KEGFRCLCLP 
       660        670        680        690        700
GYGGDLCDVG LHFCSPGWEA FQGACYKHFS TRRSWEEAES QCRALGAHLT 
       710        720        730        740        750
SICTPEEQDF VNDRYREYQW IGLNDRTIEG DFLWSDGAPL LYENWNPGQP 
       760        770        780        790        800
DSYFLSGENC VVMVWHDQGQ WSDVPCNYHL SYTCKMGLVS CGPPPQLPLA 
       810        820        830        840        850
QIFGRPRLRY AVDTVLRYRC RDGLAQRNLP LIRCQENGLW EAPQISCVPR 
       860        870        880 
RPGRALRSMD APEGPRGQLS RHRKAPLTPP SSL
Length:883
Mass (Da):95,815
Last modified:July 27, 2011 - v2
Checksum:i64DDE4D951D2042A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YW95A0A0A6YW95_MOUSE
Brevican core protein
Bcan
105Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42T → A in CAA60575 (PubMed:9286696).Curated1
Sequence conflicti65H → R in CAA60575 (PubMed:9286696).Curated1
Sequence conflicti504G → D in CAA60575 (PubMed:9286696).Curated1
Sequence conflicti514V → F in CAA60575 (PubMed:9286696).Curated1
Sequence conflicti528 – 530GSP → WSA in CAA60575 (PubMed:9286696).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87096 mRNA Translation: CAA60575.1
CH466547 Genomic DNA Translation: EDL15323.1
BC052032 mRNA Translation: AAH52032.1
CCDSiCCDS17462.1
PIRiS57653
RefSeqiNP_001103228.1, NM_001109758.1
NP_031555.2, NM_007529.2
XP_006500999.1, XM_006500936.3
XP_006501000.1, XM_006500937.3
UniGeneiMm.4598

Genome annotation databases

EnsembliENSMUST00000090971; ENSMUSP00000088491; ENSMUSG00000004892
GeneIDi12032
KEGGimmu:12032
UCSCiuc008pto.2 mouse

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Brevican

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87096 mRNA Translation: CAA60575.1
CH466547 Genomic DNA Translation: EDL15323.1
BC052032 mRNA Translation: AAH52032.1
CCDSiCCDS17462.1
PIRiS57653
RefSeqiNP_001103228.1, NM_001109758.1
NP_031555.2, NM_007529.2
XP_006500999.1, XM_006500936.3
XP_006501000.1, XM_006500937.3
UniGeneiMm.4598

3D structure databases

ProteinModelPortaliQ61361
SMRiQ61361
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61361, 2 interactors
MINTiQ61361
STRINGi10090.ENSMUSP00000088491

PTM databases

iPTMnetiQ61361
PhosphoSitePlusiQ61361

Proteomic databases

MaxQBiQ61361
PaxDbiQ61361
PeptideAtlasiQ61361
PRIDEiQ61361

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090971; ENSMUSP00000088491; ENSMUSG00000004892
GeneIDi12032
KEGGimmu:12032
UCSCiuc008pto.2 mouse

Organism-specific databases

CTDi63827
MGIiMGI:1096385 Bcan

Phylogenomic databases

eggNOGiENOG410IG1W Eukaryota
ENOG410XW3U LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000115520
HOVERGENiHBG008175
InParanoidiQ61361
KOiK06795
OMAiNNRYREY
OrthoDBiEOG091G0KN3
TreeFamiTF332134

Enzyme and pathway databases

ReactomeiR-MMU-1474228 Degradation of the extracellular matrix
R-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022870 Chondroitin sulfate biosynthesis
R-MMU-2022923 Dermatan sulfate biosynthesis
R-MMU-2024101 CS/DS degradation
R-MMU-3000178 ECM proteoglycans

Miscellaneous databases

ChiTaRSiBcan mouse
PROiPR:Q61361
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004892 Expressed in 136 organ(s), highest expression level in cerebellum
CleanExiMM_BCAN
ExpressionAtlasiQ61361 baseline and differential
GenevisibleiQ61361 MM

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGCB_MOUSE
AccessioniPrimary (citable) accession number: Q61361
Secondary accession number(s): Q80WT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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