Bcl2-associated agonist of cell death

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• 14-3-3 protein binding Source: MGI
• cysteine-type endopeptidase activator activity involved in apoptotic process Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells."
    Quoyer J., Longuet C., Broca C., Linck N., Costes S., Varin E., Bockaert J., Bertrand G., Dalle S.
    J Biol Chem 285:1989-2002(2010) [PubMed] [Europe PMC] [Abstract]
• lipid binding Source: UniProtKB
• phospholipid binding Source: UniProtKB
• protein kinase B binding Source: MGI
• protein kinase binding Source: MGI
• protein phosphatase 2B binding Source: MGI
• protein phosphatase binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis."
    Chiang C.W., Kanies C., Kim K.W., Fang W.B., Parkhurst C., Xie M., Henry T., Yang E.
    Mol Cell Biol 23:6350-6362(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity Source: MGI
• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells."
    Quoyer J., Longuet C., Broca C., Linck N., Costes S., Varin E., Bockaert J., Bertrand G., Dalle S.
    J Biol Chem 285:1989-2002(2010) [PubMed] [Europe PMC] [Abstract]
• ADP metabolic process Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• apoptotic process Source: MGI
• apoptotic signaling pathway Source: MGIInferred from direct assayⁱ
  • Ref.10

    "Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity."
    Dramsi S., Scheid M.P., Maiti A., Hojabrpour P., Chen X., Schubert K., Goodlett D.R., Aebersold R., Duronio V.
    J. Biol. Chem. 277:6399-6405(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: PHOSPHORYLATION AT SER-155 AND SER-170, MUTAGENESIS OF SER-112; SER-155 AND SER-170, IDENTIFICATION BY MASS SPECTROMETRY.
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J Biol Chem 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• ATP metabolic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• cell population proliferation Source: MGIInferred from direct assayⁱ
  • "Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene."
    Tzung S.P., Fausto N., Hockenbery D.M.
    Am J Pathol 150:1985-1995(1997) [PubMed] [Europe PMC] [Abstract]
• cellular response to chromate Source: Ensembl
• cellular response to hypoxia Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipid Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to mechanical stimulus Source: Ensembl
• cellular response to nicotine Source: UniProtKB
• cellular response to organic substance Source: MGIInferred from sequence orthologyⁱ
  • "Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos."
    Hsieh Y.C., Chang M.S., Chen J.Y., Yen J.J., Lu I.C., Chou C.M., Huang C.J.
    Biochem Biophys Res Commun 304:667-675(2003) [PubMed] [Europe PMC] [Abstract]
• cerebral cortex development Source: Ensembl
• cytokine-mediated signaling pathway Source: MGIInferred from direct assayⁱ
  • "JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD."
    Yu C., Minemoto Y., Zhang J., Liu J., Tang F., Bui T.N., Xiang J., Lin A.
    Mol Cell 13:329-340(2004) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway Source: MGI
• extrinsic apoptotic signaling pathway in absence of ligand Source: MGIInferred from direct assayⁱ
  • "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad."
    Ayllon V., Cayla X., Garcia A., Fleischer A., Rebollo A.
    Eur J Immunol 32:1847-1855(2002) [PubMed] [Europe PMC] [Abstract]
  • "Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis."
    Chiang C.W., Kanies C., Kim K.W., Fang W.B., Parkhurst C., Xie M., Henry T., Yang E.
    Mol Cell Biol 23:6350-6362(2003) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway via death domain receptors Source: MGIInferred from mutant phenotypeⁱ
  • "Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis."
    Datta S.R., Ranger A.M., Lin M.Z., Sturgill J.F., Ma Y.C., Cowan C.W., Dikkes P., Korsmeyer S.J., Greenberg M.E.
    Dev Cell 3:631-643(2002) [PubMed] [Europe PMC] [Abstract]
• glucose catabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis."
    Danial N.N., Gramm C.F., Scorrano L., Zhang C.Y., Krauss S., Ranger A.M., Datta S.R., Greenberg M.E., Licklider L.J., Lowell B.B., Gygi S.P., Korsmeyer S.J.
    Nature 424:952-956(2003) [PubMed] [Europe PMC] [Abstract]
• glucose homeostasis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• intrinsic apoptotic signaling pathway Source: UniProtKB
• intrinsic apoptotic signaling pathway in response to DNA damage Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J Biol Chem 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• pore complex assembly Source: UniProtKB
• positive regulation of apoptotic process Source: UniProtKBInferred from direct assayⁱ
  • "Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells."
    Deng H., Zhang J., Yoon T., Song D., Li D., Lin A.
    Int. J. Biochem. Cell Biol. 43:409-415(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process by virus Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J Biol Chem 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of B cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis."
    Datta S.R., Ranger A.M., Lin M.Z., Sturgill J.F., Ma Y.C., Cowan C.W., Dikkes P., Korsmeyer S.J., Greenberg M.E.
    Dev Cell 3:631-643(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
• positive regulation of epithelial cell proliferation Source: UniProtKB
• positive regulation of glucokinase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of granulosa cell apoptotic process Source: MGI
• positive regulation of insulin secretion Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: CAFAInferred from direct assayⁱ
  • "Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells."
    Kuper C., Bartels H., Beck F.X., Neuhofer W.
    Kidney Int 80:938-945(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitochondrial membrane potential Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron death Source: MGI
• positive regulation of proteolysis Source: MGI
• positive regulation of release of cytochrome c from mitochondria Source: MGI
• positive regulation of T cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis."
    Datta S.R., Ranger A.M., Lin M.Z., Sturgill J.F., Ma Y.C., Cowan C.W., Dikkes P., Korsmeyer S.J., Greenberg M.E.
    Dev Cell 3:631-643(2002) [PubMed] [Europe PMC] [Abstract]
• positive regulation of type B pancreatic cell development Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of apoptotic process Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death."
    Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., Korsmeyer S.J.
    Cell 80:285-291(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD."
    Yu C., Minemoto Y., Zhang J., Liu J., Tang F., Bui T.N., Xiang J., Lin A.
    Mol Cell 13:329-340(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of mitochondrial membrane permeability Source: UniProtKB
• release of cytochrome c from mitochondria Source: MGIInferred from mutant phenotypeⁱ
  • "Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis."
    Datta S.R., Ranger A.M., Lin M.Z., Sturgill J.F., Ma Y.C., Cowan C.W., Dikkes P., Korsmeyer S.J., Greenberg M.E.
    Dev Cell 3:631-643(2002) [PubMed] [Europe PMC] [Abstract]
• response to amino acid Source: Ensembl
• response to benzene Source: Ensembl
• response to calcium ion Source: Ensembl
• response to drug Source: Ensembl
• response to estradiol Source: Ensembl
• response to ethanol Source: Ensembl
• response to glucocorticoid Source: Ensembl
• response to glucose Source: Ensembl
• response to hydrogen peroxide Source: Ensembl
• response to oleic acid Source: Ensembl
• response to progesterone Source: Ensembl
• response to testosterone Source: Ensembl
• spermatogenesis Source: Ensembl
• suppression by virus of host apoptotic process Source: MGIInferred from direct assayⁱ
  • "BAD is a pro-survival factor prior to activation of its pro-apoptotic function."
    Seo S.Y., Chen Y.B., Ivanovska I., Ranger A.M., Hong S.J., Dawson V.L., Korsmeyer S.J., Bellows D.S., Fannjiang Y., Hardwick J.M.
    J Biol Chem 279:42240-42249(2004) [PubMed] [Europe PMC] [Abstract]
• type B pancreatic cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Dual role of proapoptotic BAD in insulin secretion and beta cell survival."
    Danial N.N., Walensky L.D., Zhang C.Y., Choi C.S., Fisher J.K., Molina A.J., Datta S.R., Pitter K.L., Bird G.H., Wikstrom J.D., Deeney J.T., Robertson K., Morash J., Kulkarni A., Neschen S., Kim S., Greenberg M.E., Corkey B.E.

    , Shirihai O.S., Shulman G.I., Lowell B.B., Korsmeyer S.J.
    Nat Med 14:144-153(2008) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• 14-3-3 protein binding Source: MGI
• protein kinase B binding Source: MGI
• protein kinase binding Source: MGI
• protein phosphatase 2B binding Source: MGI
• protein phosphatase binding Source: MGIInferred from physical interactionⁱ
  • "Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis."
    Chiang C.W., Kanies C., Kim K.W., Fang W.B., Parkhurst C., Xie M., Henry T., Yang E.
    Mol Cell Biol 23:6350-6362(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MGTPKQPSLA PAHALGLRKS DPGIRSLGSD AGGRRWRPAA QSMFQIPEFE 
        60         70         80         90        100
PSEQEDASAT DRGLGPSLTE DQPGPYLAPG LLGSNIHQQG RAATNSHHGG 
       110        120        130        140        150
AGAMETRSRH SSYPAGTEED EGMEEELSPF RGRSRSAPPN LWAAQRYGRE 
       160        170        180        190        200
LRRMSDEFEG SFKGLPRPKS AGTATQMRQS AGWTRIIQSW WDRNLGKGGS 

TPSQ                                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families