Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 170 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Zinc finger homeobox protein 3

Gene

Zfhx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (By similarity). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (PubMed:26232227). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri79 – 103C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri282 – 305C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri641 – 664C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri672 – 695C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri727 – 751C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri805 – 829C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri946 – 969C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri985 – 1009C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1041 – 1065C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1089 – 1113C2H2-type 10; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1233 – 1256C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1262 – 1285C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1370 – 1395C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1411 – 1433C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1439 – 1462C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1555 – 1579C2H2-type 16PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1606 – 1630C2H2-type 17PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1990 – 2013C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi2152 – 2211Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi2249 – 2308Homeobox 2PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2335 – 2358C2H2-type 19; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2539 – 2561C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
DNA bindingi2650 – 2709Homeobox 3PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri2720 – 2743C2H2-type 21PROSITE-ProRule annotationAdd BLAST24
DNA bindingi2952 – 3011Homeobox 4PROSITE-ProRule annotationAdd BLAST60
Zinc fingeri3032 – 3056C2H2-type 22PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3552 – 3576C2H2-type 23PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processMyogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8941855, RUNX3 regulates CDKN1A transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger homeobox protein 3
Alternative name(s):
AT motif-binding factor 1
AT-binding transcription factor 1
Alpha-fetoprotein enhancer-binding protein
Zinc finger homeodomain protein 3
Short name:
ZFH-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfhx3
Synonyms:Atbf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99948, Zfhx3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1963V → F in short circuit/sci mutant; shorter circadian period, homozygous lethality during embryonic development and diminished ability to activate the transcription of circadian-related neuropeptides. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000469311 – 3726Zinc finger homeobox protein 3Add BLAST3726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei426PhosphoserineBy similarity1
Modified residuei428PhosphothreonineBy similarity1
Modified residuei535PhosphoserineBy similarity1
Modified residuei573PhosphoserineBy similarity1
Modified residuei1207PhosphoserineBy similarity1
Modified residuei1600Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei2634Phosphoserine1 Publication1
Modified residuei2795Phosphoserine1 Publication1
Modified residuei2804Phosphoserine1 Publication1
Cross-linki2815Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki2815Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei2900Phosphoserine1 Publication1
Modified residuei2904PhosphoserineCombined sources1
Cross-linki3262Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei3434Phosphoserine1 Publication1
Modified residuei3443Phosphoserine1 Publication1
Modified residuei3457PhosphoserineBy similarity1
Modified residuei3616Phosphoserine1 Publication1
Modified residuei3700Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-2634 in embryonic and adult brain. Phosphorylated at Ser-1600, Ser-2795, Ser-2804, Ser-2900, Ser-3434, Ser-3443, Ser-3616 and Ser-3700 in the embryonic brain only. Hpyerphosphorylated in embryonic brain and phosphorylation decreases its sensitivity to calpain-mediated proteolysis.1 Publication
Adult brain-derived ZFHX3 is sensitive, but embryonic brain-derived ZFHX3 is resistant to calpain 1-mediated proteolysis.1 Publication
Ubiquitinated, leading to its proteasomal degradation.By similarity
Nuclear localization is essential for its sumoylation.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q61329

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61329

PeptideAtlas

More...
PeptideAtlasi
Q61329

PRoteomics IDEntifications database

More...
PRIDEi
Q61329

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61329

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61329

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in suprachiasmatic nucleus (SCN) of the brain (at protein level). Expressed in skeletal muscle. Levels of expression are high in myoblasts but low in differentiated muscle.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ALKBH4 and PIAS3 (By similarity).

Interacts with FNBP3.

Interacts with ESR1, RUNX3, TRIM25, SMAD2 and SMAD3 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q61329, 2 interactors

Molecular INTeraction database

More...
MINTi
Q61329

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000044612

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q61329, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q61329

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2624 – 2626Nuclear localization signalBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi461 – 491Poly-GluAdd BLAST31
Compositional biasi771 – 785Poly-AlaAdd BLAST15
Compositional biasi1314 – 1317Poly-Ala4
Compositional biasi1734 – 1748Poly-GlnAdd BLAST15
Compositional biasi1794 – 1799Poly-Gln6
Compositional biasi1856 – 1863Poly-Gln8
Compositional biasi2044 – 2059Poly-ProAdd BLAST16
Compositional biasi2405 – 2408Poly-Ala4
Compositional biasi3216 – 3220Poly-Pro5
Compositional biasi3380 – 3409Poly-GlnAdd BLAST30
Compositional biasi3412 – 3420Poly-Gln9
Compositional biasi3534 – 3550Poly-GlyAdd BLAST17
Compositional biasi3620 – 3623Poly-Pro4
Compositional biasi3659 – 3662Poly-Ser4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri79 – 103C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri282 – 305C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri641 – 664C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri672 – 695C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri727 – 751C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri805 – 829C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri946 – 969C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri985 – 1009C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1041 – 1065C2H2-type 9; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1089 – 1113C2H2-type 10; atypicalPROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1233 – 1256C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1262 – 1285C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1370 – 1395C2H2-type 13PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri1411 – 1433C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1439 – 1462C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1555 – 1579C2H2-type 16PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1606 – 1630C2H2-type 17PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri1990 – 2013C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2335 – 2358C2H2-type 19; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2539 – 2561C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2720 – 2743C2H2-type 21PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri3032 – 3056C2H2-type 22PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri3552 – 3576C2H2-type 23PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1146, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q61329

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q61329

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61329-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGCDSPVVS GKDNGCGIPQ HRQWTELNSA HLPDKPSSME QPTGESHGPL
60 70 80 90 100
DSLRAPFNER LADSSTSAGP PAEPASKEVS CNECSASFSS LQTYMEHHCP
110 120 130 140 150
GTHPPPALRE ESASDTSEEG EEESDVENLA GEIVYQPDGS AYIVESLSQL
160 170 180 190 200
AQSGAACGSS SGSGAVPSLF LNSLPGVGGK QGDPSCAAPV YPQIINTSHI
210 220 230 240 250
ASSFGKWFEG SDPAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS
260 270 280 290 300
AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH
310 320 330 340 350
AVHDHRMTLS EEERKLLSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP
360 370 380 390 400
LVSTGNLIGP GHSFYGKFSG IRMEGEEALP AVAAAGPEQP QAGLLTPSTL
410 420 430 440 450
LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GDKQESGGHQ
460 470 480 490 500
DCFSEKVEPA EEEEAEEEEE EEEEAEEEEE EEEEEEEEEE EASKGLFPND
510 520 530 540 550
LEEELEDSPS EESGPPAGGT TKKDLALSNP SISNSPLMPN VLQTLSRGPA
560 570 580 590 600
STTSNSASNF VVFDGANRRS RLSFNSEGVR ANVAEGRRLD FADESANKDS
610 620 630 640 650
ATAPEPNEST EGDDGGFVPH HQHAGSLCEL GVGESPSGSG VECPKCDTVL
660 670 680 690 700
GSSRSLGGHM TMMHSRNSCK TLKCPKCNWH YKYQQTLEAH MKEKHPEPGG
710 720 730 740 750
SCVYCKSGQP HPRLARGESY TCGYKPFRCE VCNYSTTTKG NLSIHMQSDK
760 770 780 790 800
HLNNMQNLQN GGGEQVFSHS AGAAAAAAAA AAAAANIGSS WGAPSPTKPK
810 820 830 840 850
TKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM TQIQHNRHLG
860 870 880 890 900
LGSLPSPAEA ELYQYYLAQN MNLPNLKMDS TASDAQFMMS GFQLDPTGPM
910 920 930 940 950
AAMTPALVGG EIPLDMRLGG GQLVSEELMN LGESFIQTND PSLKLFQCAV
960 970 980 990 1000
CNKFTTDNLD MLGLHMNVER SLSEDEWKAV MGDSYQCKLC RYNTQLKANF
1010 1020 1030 1040 1050
QLHCKTDKHV QKYQLVAHIK EGGKANEWRL KCVAIGNPVH LKCNACDYYT
1060 1070 1080 1090 1100
NSLEKLRLHT VNSRHEASLK LYKHLQQHES GVEGESCYYH CVLCNYSTKA
1110 1120 1130 1140 1150
KLNLIQHVRS MKHQRSESLR KLQRLQKGLP EEDEDLGQIF TIRRCPSTDP
1160 1170 1180 1190 1200
EEPVEDAEGP SEASADPEEL AKDQGSGSEE GQSKRAASSS QAEKELTDSP
1210 1220 1230 1240 1250
ATTKRTSFPG SSETPLSSKR PKASEEIKPE QMYQCPYCKY SNADVNRLRV
1260 1270 1280 1290 1300
HAMTQHSVQP LLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT
1310 1320 1330 1340 1350
APEMVMPSSM FLPAAAADRD GNSTLEEVGK QPEASEDPGK NILPPASMEH
1360 1370 1380 1390 1400
GGDLKPTSAD PSCGREDSGF LCWKKGCNQV FKTSATLQTH FNEVHAKRPQ
1410 1420 1430 1440 1450
LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT
1460 1470 1480 1490 1500
FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE
1510 1520 1530 1540 1550
EDKEEESDLE DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD
1560 1570 1580 1590 1600
PSRPYKCTVC KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS
1610 1620 1630 1640 1650
PDNKPFKCNT CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGNSNGTG
1660 1670 1680 1690 1700
NSGGVSLSSS TPSPVGSSGA NNTFTATNPS SAAMAPSVNA LSQVPPESVV
1710 1720 1730 1740 1750
MPPLGNPISA NIASPSEPKE ANRKKLADMI ASRQQQQQQQ QQQQQQAQTL
1760 1770 1780 1790 1800
AQAQAQVQAH LQQELQQQAA LIQSQLFNPT LLPHFPMTTE TLLQLQQQQH
1810 1820 1830 1840 1850
LLFPFYIPSA EFQLNPEVSL PVTSGALTLT GSGPGLLEDL KVQVQIPQQS
1860 1870 1880 1890 1900
HQQILQQQQQ QSQLSLSQSH SALLQPSQHP EKKNKVVIKE KDKESQRERE
1910 1920 1930 1940 1950
GPEGAEGNTG PQESLPDASK AKEKKDLAPG GGSEGTMLPP RIASDARGNA
1960 1970 1980 1990 2000
TKALLENFGF ELVIQYNENK QKAQKKNGKA EQGGESLEKL ECDSCGKLFS
2010 2020 2030 2040 2050
NILILKSHQE HVHQNYFPFK QLERFAKQYR EHYDKLYPLR PQTPEPPPPP
2060 2070 2080 2090 2100
PPPPPPPLPT APPQPASAPA IPASAPPITS PTIAPAQPSV PLTQLSMPME
2110 2120 2130 2140 2150
LPIFSPLMMQ TMPLQTLPAQ LPPQLGPVEP LPADLAQLYQ HQLNPTLLQQ
2160 2170 2180 2190 2200
QNKRPRTRIT DDQLRVLRQY FDINNSPSEE QIKEMADKSG LPQKVIKHWF
2210 2220 2230 2240 2250
RNTLFKERQR NKDSPYNFSN PPITSLEELK IDSRPPSPEP QKQEYWGSKR
2260 2270 2280 2290 2300
SSRTRFTDYQ LRVLQDFFDA NAYPKDDEFE QLSNLLNLPT RVIVVWFQNA
2310 2320 2330 2340 2350
RQKARKNYEN QGEGKDGERR ELTNDRYIRT SNLNYQCKKC SLVFQRIFDL
2360 2370 2380 2390 2400
IKHQKKLCYK DEDEEGQDDS QNEDSMDAME ILTPTSSSCS TPMPSQAYST
2410 2420 2430 2440 2450
PAPSAAAANT APSAFLQLTA ETDELATFNS KAEASDEKPK QADPPSAQPN
2460 2470 2480 2490 2500
QTQEKQGQPK PEMQQQLEQL EQKTNAPQPK LPQPAAPSLP QPPPQAPPPQ
2510 2520 2530 2540 2550
CPLPQSSPSP SQLSHLPLKP LHTSTPQQLA NLPPQLIPYQ CDQCKLAFPS
2560 2570 2580 2590 2600
FEHWQEHQQL HFLSAQNQFI HPQFLDRSLD MPFMLFDPSN PLLASQLLSG
2610 2620 2630 2640 2650
AIPQIPASSA TSPSTPTSTM NTLKRKLEEK ASASPGENDS GTGGEEPQRD
2660 2670 2680 2690 2700
KRLRTTITPE QLEILYQKYL LDSNPTRKML DHIAHEVGLK KRVVQVWFQN
2710 2720 2730 2740 2750
TRARERKGQF RAVGPAQAHR RCPFCRALFK AKTALEAHIR SRHWHEAKRA
2760 2770 2780 2790 2800
GYNLTLSAML LDCDGGLQMK GDIFDGTSFS HLPPSSSDGQ GVPLSPVSKT
2810 2820 2830 2840 2850
MELSPRTLLS PSSIKVEGIE DFESPSMSSV NLNFDQTKLD NDDCSSVNTA
2860 2870 2880 2890 2900
ITDTTTGDEG NADNDSATGI ATETKSSAPN EGLTKAAMMA MSEYEDRLSS
2910 2920 2930 2940 2950
GLVSPAPSFY SKEYDNEGTV DYSETSSLAD PCSPSPGASG SAGKSGDGGD
2960 2970 2980 2990 3000
RPGQKRFRTQ MTNLQLKVLK SCFNDYRTPT MLECEVLGND IGLPKRVVQV
3010 3020 3030 3040 3050
WFQNARAKEK KSKLSMAKHF GINQTSYEGP KTECTLCGIK YSARLSVRDH
3060 3070 3080 3090 3100
IFSQQHISKV KDTIGSQLDK EKEYFDPATV RQLMAQQELD RIKKANEVLG
3110 3120 3130 3140 3150
LAAQQQGMFD NAPLQALNLP TTYPALQGIP PVLLPGLNRP SLPGFTPANT
3160 3170 3180 3190 3200
ALTSPKPNLM GLPSTTVPSP GLPTSGLPNK PSSASLSSPT PAQATMAMAP
3210 3220 3230 3240 3250
QPPPQPQQPQ PPVQQPPPPP AAQQIPAPQL TPQQQRKDKD GEKGKEKEKA
3260 3270 3280 3290 3300
HKGKGEPLPV PKKEKGEAPP AGTGTISAPL PAMEYAVDPA QLQALQAALT
3310 3320 3330 3340 3350
SDPTALLTSQ FLPYFVPGFS PYYAPQIPGA LQSGYLQPMY GMEGLFPYSP
3360 3370 3380 3390 3400
ALSRPLMGLS PGSLLQQYQQ YQQSLQEAIQ QQQQQQQQQQ QQQQQQQRQL
3410 3420 3430 3440 3450
QQQQQQQQQK VQQQQQQQQQ PKASQTPVPQ GAASPDKDPA KESPKPEEQK
3460 3470 3480 3490 3500
NVPRELSPLL PKPPEEPEAE SKSASADSLC DPFIVPKVQY KLVCRKCQAG
3510 3520 3530 3540 3550
FGDEEAARSH LKSLCCFGQS VVNLQEMVLH VPTGSGGGGG GGGGSGGGGG
3560 3570 3580 3590 3600
SYHCLACESA LCGEEALSQH LESALHKHRT ITRAARNAKE HPSLLPHSAC
3610 3620 3630 3640 3650
FPDPSTASTS QSAAHSNDSP PPPSAAPSSS ASPHASRKSW PPVGSRASAA
3660 3670 3680 3690 3700
KPPSFPPLSS SSTVTSSSCS TSGVQPSMPT DDYSEESDTD LSQKSDGPAS
3710 3720
PVEGPKDPSC PKDSGLTSVG TDTFRL
Length:3,726
Mass (Da):406,570
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i915ACBE588A72C98
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QMD3E9QMD3_MOUSE
Zinc finger homeobox protein 3
Zfhx3
3,723Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WQ36A0A087WQ36_MOUSE
Zinc finger homeobox protein 3
Zfhx3
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D26046 mRNA Translation: BAA05046.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26046 mRNA Translation: BAA05046.1

3D structure databases

SMRiQ61329
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ61329, 2 interactors
MINTiQ61329
STRINGi10090.ENSMUSP00000044612

PTM databases

iPTMnetiQ61329
PhosphoSitePlusiQ61329

Proteomic databases

MaxQBiQ61329
PaxDbiQ61329
PeptideAtlasiQ61329
PRIDEiQ61329

Organism-specific databases

MGIiMGI:99948, Zfhx3

Phylogenomic databases

eggNOGiKOG1146, Eukaryota
InParanoidiQ61329
PhylomeDBiQ61329

Enzyme and pathway databases

ReactomeiR-MMU-8941855, RUNX3 regulates CDKN1A transcription

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zfhx3, mouse

Protein Ontology

More...
PROi
PR:Q61329
RNActiQ61329, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00086, homeodomain, 4 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00046, Homeodomain, 4 hits
PF00096, zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00389, HOX, 4 hits
SM00355, ZnF_C2H2, 23 hits
SM00451, ZnF_U1, 7 hits
SUPFAMiSSF46689, SSF46689, 4 hits
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00027, HOMEOBOX_1, 2 hits
PS50071, HOMEOBOX_2, 4 hits
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFHX3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61329
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again