Sodium-dependent dopamine transporter

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dopamine:sodium symporter activity Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Profound neuronal plasticity in response to inactivation of the dopamine transporter."
    Jones S.R., Gainetdinov R.R., Jaber M., Giros B., Wightman R.M., Caron M.G.
    Proc Natl Acad Sci U S A 95:4029-4034(1998) [PubMed] [Europe PMC] [Abstract]
• dopamine binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm."
    Bailey A., Metaxas A., Yoo J.H., McGee T., Kitchen I.
    Eur J Neurosci 28:759-770(2008) [PubMed] [Europe PMC] [Abstract]
• drug binding Source: MGI
• metal ion binding Source: UniProtKB-KW
• monoamine transmembrane transporter activity Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3."
    Duan H., Wang J.
    J Pharmacol Exp Ther 335:743-753(2010) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter transmembrane transporter activity Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3."
    Duan H., Wang J.
    J Pharmacol Exp Ther 335:743-753(2010) [PubMed] [Europe PMC] [Abstract]
• norepinephrine:sodium symporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: MGI
• protein-containing complex binding Source: MGI
• protein N-terminus binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.6

    "Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3."
    Egana L.A., Cuevas R.A., Baust T.B., Parra L.A., Leak R.K., Hochendoner S., Pena K., Quiroz M., Hong W.C., Dorostkar M.M., Janz R., Sitte H.H., Torres G.E.
    J. Neurosci. 29:4592-4604(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH SYNGR3 AND SLC18A2, TISSUE SPECIFICITY.
• protein phosphatase 2A binding Source: MGI
• signaling receptor binding Source: MGI

GO - Biological processⁱ

• adenohypophysis development Source: MGIInferred from mutant phenotypeⁱ
  • "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter."
    Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G.
    Neuron 19:127-138(1997) [PubMed] [Europe PMC] [Abstract]
• aging Source: Ensembl
• dopamine biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • "Profound neuronal plasticity in response to inactivation of the dopamine transporter."
    Jones S.R., Gainetdinov R.R., Jaber M., Giros B., Wightman R.M., Caron M.G.
    Proc Natl Acad Sci U S A 95:4029-4034(1998) [PubMed] [Europe PMC] [Abstract]
• dopamine catabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Profound neuronal plasticity in response to inactivation of the dopamine transporter."
    Jones S.R., Gainetdinov R.R., Jaber M., Giros B., Wightman R.M., Caron M.G.
    Proc Natl Acad Sci U S A 95:4029-4034(1998) [PubMed] [Europe PMC] [Abstract]
• dopamine transport Source: MGIInferred from mutant phenotypeⁱ
  • "Profound neuronal plasticity in response to inactivation of the dopamine transporter."
    Jones S.R., Gainetdinov R.R., Jaber M., Giros B., Wightman R.M., Caron M.G.
    Proc Natl Acad Sci U S A 95:4029-4034(1998) [PubMed] [Europe PMC] [Abstract]
• dopamine uptake Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3."
    Duan H., Wang J.
    J Pharmacol Exp Ther 335:743-753(2010) [PubMed] [Europe PMC] [Abstract]
• dopamine uptake involved in synaptic transmission Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• hyaloid vascular plexus regression Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye."
    Nguyen M.T., Vemaraju S., Nayak G., Odaka Y., Buhr E.D., Alonzo N., Tran U., Batie M., Upton B.A., Darvas M., Kozmik Z., Rao S., Hegde R.S., Iuvone P.M., Van Gelder R.N., Lang R.A.
    Nat. Cell Biol. 21:420-429(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• lactation Source: MGIInferred from mutant phenotypeⁱ
  • "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter."
    Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G.
    Neuron 19:127-138(1997) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • "Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists."
    Ralph R.J., Paulus M.P., Fumagalli F., Caron M.G., Geyer M.A.
    J Neurosci 21:305-313(2001) [PubMed] [Europe PMC] [Abstract]
• monoamine transport Source: MGIInferred from sequence orthologyⁱ
  • "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity."
    Jiang W., Prokopenko O., Wong L., Inouye M., Mirochnitchenko O.
    Mol. Cell. Biol. 25:6496-6508(2005) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter transport Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3."
    Duan H., Wang J.
    J Pharmacol Exp Ther 335:743-753(2010) [PubMed] [Europe PMC] [Abstract]
• norepinephrine transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of multicellular organism growth Source: MGIInferred from mutant phenotypeⁱ
  • "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter."
    Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G.
    Neuron 19:127-138(1997) [PubMed] [Europe PMC] [Abstract]
• prepulse inhibition Source: MGIInferred from mutant phenotypeⁱ
  • "Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists."
    Ralph R.J., Paulus M.P., Fumagalli F., Caron M.G., Geyer M.A.
    J Neurosci 21:305-313(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of dopamine metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter."
    Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G.
    Neuron 19:127-138(1997) [PubMed] [Europe PMC] [Abstract]
  • "Profound neuronal plasticity in response to inactivation of the dopamine transporter."
    Jones S.R., Gainetdinov R.R., Jaber M., Giros B., Wightman R.M., Caron M.G.
    Proc Natl Acad Sci U S A 95:4029-4034(1998) [PubMed] [Europe PMC] [Abstract]
• response to cAMP Source: MGI
• response to cocaine Source: MGIInferred from direct assayⁱ
  • "Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm."
    Bailey A., Metaxas A., Yoo J.H., McGee T., Kitchen I.
    Eur J Neurosci 28:759-770(2008) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: Ensembl
• response to ethanol Source: MGI
• response to iron ion Source: Ensembl
• response to nicotine Source: Ensembl
• sensory perception of smell Source: MGIInferred from mutant phenotypeⁱ
  • "Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor."
    Tillerson J.L., Caudle W.M., Parent J.M., Gong C., Schallert T., Miller G.W.
    Behav Brain Res 172:97-105(2006) [PubMed] [Europe PMC] [Abstract]
• sodium ion transmembrane transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protease binding Source: MGI
• protein N-terminus binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.6

    "Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3."
    Egana L.A., Cuevas R.A., Baust T.B., Parra L.A., Leak R.K., Hochendoner S., Pena K., Quiroz M., Hong W.C., Dorostkar M.M., Janz R., Sitte H.H., Torres G.E.
    J. Neurosci. 29:4592-4604(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH SYNGR3 AND SLC18A2, TISSUE SPECIFICITY.
• protein phosphatase 2A binding Source: MGI
• signaling receptor binding Source: MGI

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSKSKCSVGP MSSVVAPAKE PNAVGPREVE LILVKEQNGV QLTNSTLINP 
        60         70         80         90        100
PQTPVEVQER ETWSKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV 
       110        120        130        140        150
PYLLFMVIAG MPLFYMELAL GQFNREGAAG VWKICPVLKG VGFTVILISF 
       160        170        180        190        200
YVGFFYNVII AWALHYFFSS FTMDLPWIHC NNTWNSPNCS DAHSSNSSDG 
       210        220        230        240        250
LGLNDTFGTT PAAEYFERGV LHLHQSRGID DLGPPRWQLT ACLVLVIVLL 
       260        270        280        290        300
YFSLWKGVKT SGKVVWITAT MPYVVLTALL LRGVTLPGAM DGIRAYLSVD 
       310        320        330        340        350
FYRLCEASVW IDAATQVCFS LGVGFGVLIA FSSYNKFTNN CYRDAIITTS 
       360        370        380        390        400
INSLTSFSSG FVVFSFLGYM AQKHNVPIRD VATDGPGLIF IIYPEAIATL 
       410        420        430        440        450
PLSSAWAAVF FLMLLTLGID SAMGGMESVI TGLVDEFQLL HRHRELFTLG 
       460        470        480        490        500
IVLATFLLSL FCVTNGGIYV FTLLDHFAAG TSILFGVLIE AIGVAWFYGV 
       510        520        530        540        550
QQFSDDIKQM TGQRPNLYWR LCWKLVSPCF LLYVVVVSIV TFRPPHYGAY 
       560        570        580        590        600
IFPDWANALG WIIATSSMAM VPIYATYKFC SLPGSFREKL AYAITPEKDR 
       610 
QLVDRGEVRQ FTLRHWLLV                                   

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families