UniProtKB - Q61324 (ARNT2_MOUSE)

BLAST

>sp|Q61324|ARNT2_MOUSE Aryl hydrocarbon receptor nuclear translocator 2 OS=Mus musculus OX=10090 GN=Arnt2 PE=1 SV=2
MATPAAVNPPEMASDIPGSVALPVAPMAATGQVRMAGAMPARGGKRRSGMDFDDEDGEGP
SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTG
NKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFG
STLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICR
MRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEED
ADVGQGSKYCLVAIGRLQVTSSPVCMDMSGMSVPTEFLSRHNSDGIITFVDPRCISVIGY
QPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWLLIRTSSFTF
QNPYSDEIEYVICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSV
EKADAIFSQERDPRFAEMFAGISASEKKMMSSASASGSQQIYSQGSPFPAGHSGKAFSSS
VVHVPGVNDIQSSSSTGQNISQISRQLNQGQVAWTGSRPPFPGQPSKTQSSAFGIGSSHP
YPADPSSYSPLSSPAASSPSGNAYPSLANRTPGFAESGQSGGQFQGRPSEVWSQWQSQHH
GQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE

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History
Entry version 152 (07 Nov 2018)
Sequence version 2 (06 Feb 2007)
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Protein

Aryl hydrocarbon receptor nuclear translocator 2

Gene

Arnt2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).By similarity

GO - Molecular functionⁱ

aryl hydrocarbon receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 8657146
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 14701734
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8657146
DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27782878
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 8657146
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 8657146

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development Source: UniProtKB
central nervous system development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11318878
in utero embryonic development
Source: UniProtKB
Inferred from expression patternⁱ
- 12502753
negative regulation of apoptotic process Source: MGI
positive regulation of cell proliferation Source: MGI
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 8657146
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 8657146
regulation of transcription, DNA-templated
Source: MGI
Inferred from sequence orthologyⁱ
- 11782478
response to estradiol Source: Ensembl
response to hypoxia Source: MGI
response to toxic substance
Source: UniProtKB
Traceable author statementⁱ
- 12502753
response to xenobiotic stimulus
Source: UniProtKB
Traceable author statementⁱ
- 12502753
signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 12502753

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-211945 Phase I - Functionalization of compounds R-MMU-211976 Endogenous sterols R-MMU-211981 Xenobiotics R-MMU-8937144 Aryl hydrocarbon receptor signalling

Reactomeⁱ

R-MMU-211945 Phase I - Functionalization of compounds
R-MMU-211976 Endogenous sterols
R-MMU-211981 Xenobiotics
R-MMU-8937144 Aryl hydrocarbon receptor signalling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aryl hydrocarbon receptor nuclear translocator 2 Short name: ARNT protein 2
Gene namesⁱ	Name:Arnt2 Synonyms:Kiaa0307
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:107188 Arnt2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	86	L → E: Compromises SIM1:ARNT2 heterodimer stability. Compromises NPAS4:ARNT2 heterodimer stability. 1 Publication	1
Mutagenesisⁱ	106	L → E: Compromises SIM1:ARNT2 heterodimer stability. Compromises NPAS4:ARNT2 heterodimer stability. 1 Publication	1
Mutagenesisⁱ	141	L → E: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication	1
Mutagenesisⁱ	145	A → D: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication	1
Mutagenesisⁱ	238	I → D: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication	1
Mutagenesisⁱ	279	V → D: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication	1
Mutagenesisⁱ	340	R → A: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication	1
Mutagenesisⁱ	422	N → A: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127123	1 – 712	Aryl hydrocarbon receptor nuclear translocator 2Add BLAST		712

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	42	Omega-N-methylarginineCombined sources		1

Keywords - PTMⁱ

Methylation

Proteomic databases

PaxDbⁱ	Q61324
PeptideAtlas More...PeptideAtlasⁱ	Q61324
PRIDEⁱ	Q61324

PTM databases

iPTMnetⁱ	Q61324
PhosphoSitePlusⁱ	Q61324

Expressionⁱ

Tissue specificityⁱ

Restricted to adult brain and kidney.

Gene expression databases

Bgeeⁱ	ENSMUSG00000015709 Expressed in 263 organ(s), highest expression level in cingulate cortex
CleanExⁱ	MM_ARNT2
ExpressionAtlasⁱ	Q61324 baseline and differential
Genevisibleⁱ	Q61324 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Heterodimer with NPAS4 or SIM1 (PubMed:27782878). Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein (By similarity). Interacts with TACC3 (PubMed:11025203).By similarity2 Publications

GO - Molecular functionⁱ

aryl hydrocarbon receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 8657146
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27782878

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198206, 1 interactor
IntActⁱ	Q61324, 2 interactors
STRINGⁱ	10090.ENSMUSP00000082154

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61324
SMRⁱ	Q61324
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	63 – 116	bHLHPROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	134 – 209	PAS 1PROSITE-ProRule annotationAdd BLAST	76
Domainⁱ	323 – 393	PAS 2PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	398 – 441	PACAdd BLAST	44

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	73 – 76	Poly-Arg	4
Compositional biasⁱ	440 – 445	Poly-Gln	6
Compositional biasⁱ	552 – 555	Poly-Ser	4

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410KD32 Eukaryota ENOG410XS5S LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000234380
HOVERGENⁱ	HBG000164
InParanoidⁱ	Q61324
KEGG Orthology (KO) More...KOⁱ	K15589
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03AI
PhylomeDBⁱ	Q61324
TreeFamⁱ	TF319983

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001067 Nuc_translocat IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit
PRINTSⁱ	PR00785 NCTRNSLOCATR
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q61324-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPAAVNPP EMASDIPGSV ALPVAPMAAT GQVRMAGAMP ARGGKRRSGM 
        60         70         80         90        100
DFDDEDGEGP SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP 
       110        120        130        140        150
DKLTILRMAV SHMKSMRGTG NKSTDGAYKP SFLTEQELKH LILEAADGFL 
       160        170        180        190        200
FVVAAETGRV IYVSDSVTPV LNQPQSEWFG STLYEQVHPD DVEKLREQLC 
       210        220        230        240        250
TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR MRCGNAPLDH 
       260        270        280        290        300
LPLNRITTMR KRFRNGLGPV KEGEAQYAVV HCTGYIKAWP PAGMTIPEED 
       310        320        330        340        350
ADVGQGSKYC LVAIGRLQVT SSPVCMDMSG MSVPTEFLSR HNSDGIITFV 
       360        370        380        390        400
DPRCISVIGY QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM 
       410        420        430        440        450
YRFRTKNREW LLIRTSSFTF QNPYSDEIEY VICTNTNVKQ LQQQQAELEV 
       460        470        480        490        500
HQRDGLSSYD LSQVPVPNLP AGVHEAGKSV EKADAIFSQE RDPRFAEMFA 
       510        520        530        540        550
GISASEKKMM SSASASGSQQ IYSQGSPFPA GHSGKAFSSS VVHVPGVNDI 
       560        570        580        590        600
QSSSSTGQNI SQISRQLNQG QVAWTGSRPP FPGQPSKTQS SAFGIGSSHP 
       610        620        630        640        650
YPADPSSYSP LSSPAASSPS GNAYPSLANR TPGFAESGQS GGQFQGRPSE 
       660        670        680        690        700
VWSQWQSQHH GQQSGEQHSH QQPGQTEVFQ DMLPMPGDPT QGTGNYNIED 
       710 
FADLGMFPPF SE

Length:712

Mass (Da):77,902

Last modified:February 6, 2007 - v2

Checksum:ⁱFACD27033F7F18DE

Isoform 2 (identifier: Q61324-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-11: Missing.

« Hide

        10         20         30         40         50
MASDIPGSVA LPVAPMAATG QVRMAGAMPA RGGKRRSGMD FDDEDGEGPS 
        60         70         80         90        100
KFSRENHSEI ERRRRNKMTQ YITELSDMVP TCSALARKPD KLTILRMAVS 
       110        120        130        140        150
HMKSMRGTGN KSTDGAYKPS FLTEQELKHL ILEAADGFLF VVAAETGRVI 
       160        170        180        190        200
YVSDSVTPVL NQPQSEWFGS TLYEQVHPDD VEKLREQLCT SENSMTGRIL 
       210        220        230        240        250
DLKTGTVKKE GQQSSMRMCM GSRRSFICRM RCGNAPLDHL PLNRITTMRK 
       260        270        280        290        300
RFRNGLGPVK EGEAQYAVVH CTGYIKAWPP AGMTIPEEDA DVGQGSKYCL 
       310        320        330        340        350
VAIGRLQVTS SPVCMDMSGM SVPTEFLSRH NSDGIITFVD PRCISVIGYQ 
       360        370        380        390        400
PQDLLGKDIL EFCHPEDQSH LRESFQQVVK LKGQVLSVMY RFRTKNREWL 
       410        420        430        440        450
LIRTSSFTFQ NPYSDEIEYV ICTNTNVKQL QQQQAELEVH QRDGLSSYDL 
       460        470        480        490        500
SQVPVPNLPA GVHEAGKSVE KADAIFSQER DPRFAEMFAG ISASEKKMMS 
       510        520        530        540        550
SASASGSQQI YSQGSPFPAG HSGKAFSSSV VHVPGVNDIQ SSSSTGQNIS 
       560        570        580        590        600
QISRQLNQGQ VAWTGSRPPF PGQPSKTQSS AFGIGSSHPY PADPSSYSPL 
       610        620        630        640        650
SSPAASSPSG NAYPSLANRT PGFAESGQSG GQFQGRPSEV WSQWQSQHHG 
       660        670        680        690        700
QQSGEQHSHQ QPGQTEVFQD MLPMPGDPTQ GTGNYNIEDF ADLGMFPPFS 

E

Show »

Length:701

Mass (Da):76,823

Checksum:ⁱ67C24CE8E77A7E59

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A140LHY4	A0A140LHY4_MOUSE	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator 2	Arnt2	206	Annotation score:
A0A140LIL3	A0A140LIL3_MOUSE	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator 2	Arnt2	93	Annotation score:
A0A140LHH4	A0A140LHH4_MOUSE	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator 2	Arnt2	167	Annotation score:
A0A140LID4	A0A140LID4_MOUSE	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator 2	Arnt2	91	Annotation score:
A0A140LHZ6	A0A140LHZ6_MOUSE	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator 2	Arnt2	160	Annotation score:
A0A140LID9	A0A140LID9_MOUSE	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator 2	Arnt2	52	Annotation score:
A0A140LIW9	A0A140LIW9_MOUSE	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator 2	Arnt2	123	Annotation score:

Sequence cautionⁱ

The sequence BAC41409 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	206	M → I in BAA09799 (PubMed:8657146).Curated		1
Sequence conflictⁱ	432	I → T in AAH54546 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_022689	1 – 11	Missing in isoform 2. 1 PublicationAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D63644 mRNA Translation: BAA09799.1 AB093225 mRNA Translation: BAC41409.1 Different initiation. BC054546 mRNA Translation: AAH54546.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS59733.1 [Q61324-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_031514.3, NM_007488.3 [Q61324-1] XP_006507303.1, XM_006507240.2 [Q61324-2] XP_006507305.1, XM_006507242.2 [Q61324-2] XP_011239957.1, XM_011241655.2 [Q61324-2]
UniGeneⁱ	Mm.38594

Genome annotation databases

Ensemblⁱ	ENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709 [Q61324-1] ENSMUST00000208232; ENSMUSP00000146413; ENSMUSG00000015709 [Q61324-2] ENSMUST00000209133; ENSMUSP00000147129; ENSMUSG00000015709 [Q61324-2]
GeneIDⁱ	11864
KEGGⁱ	mmu:11864
UCSC genome browser More...UCSCⁱ	uc009ief.2 mouse [Q61324-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61324	Isoform 2 of Aryl hydrocarbon receptor nuclear translocator 2		MOUSE		701	UniRef100_Q61324
Aryl hydrocarbon receptor nuclear translocator 2 (Fragment)		MOUSE		206
Aryl hydrocarbon receptor nuclear translocator 2 (Fragment)		MOUSE		93

Protein	Similar proteins		Species	Score	Length	Source
Q61324	Aryl hydrocarbon receptor nuclear translocator 2		RAT		712	UniRef90_Q61324
Isoform 2 of Aryl hydrocarbon receptor nuclear translocator 2		MOUSE		701
Uncharacterized protein		CAVPO		715
aryl hydrocarbon receptor nuclear translocator 2 isoform X2		MESAU		712
Uncharacterized protein		PIG		701
+49

Protein	Similar proteins		Species	Score	Length	Source
Q61324	Aryl hydrocarbon receptor nuclear translocator 2		RAT		712	UniRef50_Q61324
Aryl hydrocarbon receptor nuclear translocator 2		DANRE		737
Aryl hydrocarbon receptor nuclear translocator 2		HUMAN		717
Isoform 2 of Aryl hydrocarbon receptor nuclear translocator 2		MOUSE		701
Uncharacterized protein		CAVPO		715
+623

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D63644 mRNA Translation: BAA09799.1 AB093225 mRNA Translation: BAC41409.1 Different initiation. BC054546 mRNA Translation: AAH54546.1
CCDSⁱ	CCDS59733.1 [Q61324-1]
RefSeqⁱ	NP_031514.3, NM_007488.3 [Q61324-1] XP_006507303.1, XM_006507240.2 [Q61324-2] XP_006507305.1, XM_006507242.2 [Q61324-2] XP_011239957.1, XM_011241655.2 [Q61324-2]
UniGeneⁱ	Mm.38594

3D structure databases

ProteinModelPortalⁱ	Q61324
SMRⁱ	Q61324
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198206, 1 interactor
IntActⁱ	Q61324, 2 interactors
STRINGⁱ	10090.ENSMUSP00000082154

PTM databases

iPTMnetⁱ	Q61324
PhosphoSitePlusⁱ	Q61324

Proteomic databases

PaxDbⁱ	Q61324
PeptideAtlasⁱ	Q61324
PRIDEⁱ	Q61324

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709 [Q61324-1] ENSMUST00000208232; ENSMUSP00000146413; ENSMUSG00000015709 [Q61324-2] ENSMUST00000209133; ENSMUSP00000147129; ENSMUSG00000015709 [Q61324-2]
GeneIDⁱ	11864
KEGGⁱ	mmu:11864
UCSCⁱ	uc009ief.2 mouse [Q61324-1]

Organism-specific databases

CTDⁱ	9915
MGIⁱ	MGI:107188 Arnt2
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410KD32 Eukaryota ENOG410XS5S LUCA
GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000234380
HOVERGENⁱ	HBG000164
InParanoidⁱ	Q61324
KOⁱ	K15589
OrthoDBⁱ	EOG091G03AI
PhylomeDBⁱ	Q61324
TreeFamⁱ	TF319983

Enzyme and pathway databases

Reactomeⁱ	R-MMU-211945 Phase I - Functionalization of compounds R-MMU-211976 Endogenous sterols R-MMU-211981 Xenobiotics R-MMU-8937144 Aryl hydrocarbon receptor signalling

Reactomeⁱ

R-MMU-211945 Phase I - Functionalization of compounds
R-MMU-211976 Endogenous sterols
R-MMU-211981 Xenobiotics
R-MMU-8937144 Aryl hydrocarbon receptor signalling

Miscellaneous databases

ChiTaRSⁱ	Arnt2 mouse
Protein Ontology More...PROⁱ	PR:Q61324
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000015709 Expressed in 263 organ(s), highest expression level in cingulate cortex
CleanExⁱ	MM_ARNT2
ExpressionAtlasⁱ	Q61324 baseline and differential
Genevisibleⁱ	Q61324 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001067 Nuc_translocat IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit
PRINTSⁱ	PR00785 NCTRNSLOCATR
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARNT2_MOUSE
Accessionⁱ	Q61324Primary (citable) accession number: Q61324 Secondary accession number(s): Q7TQG2, Q8CHG9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	February 6, 2007
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61324 (ARNT2_MOUSE)

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Aryl hydrocarbon receptor nuclear translocator 2

Arnt2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ