UniProtKB - Q61324 (ARNT2_MOUSE)
Protein
Aryl hydrocarbon receptor nuclear translocator 2
Gene
Arnt2
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).By similarity
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- protein-containing complex binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- brain development Source: UniProtKB
- central nervous system development Source: UniProtKB
- in utero embryonic development Source: UniProtKB
- negative regulation of apoptotic process Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: MGI
- response to estradiol Source: Ensembl
- response to hypoxia Source: MGI
- response to toxic substance Source: UniProtKB
- response to xenobiotic stimulus Source: UniProtKB
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-211945, Phase I - Functionalization of compounds R-MMU-211976, Endogenous sterols R-MMU-211981, Xenobiotics R-MMU-8937144, Aryl hydrocarbon receptor signalling |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptor nuclear translocator 2Short name: ARNT protein 2 |
Gene namesi | Name:Arnt2 Synonyms:Kiaa0307 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107188, Arnt2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationBy similarity
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: InterPro
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 86 | L → E: Compromises SIM1:ARNT2 heterodimer stability. Compromises NPAS4:ARNT2 heterodimer stability. 1 Publication | 1 | |
Mutagenesisi | 106 | L → E: Compromises SIM1:ARNT2 heterodimer stability. Compromises NPAS4:ARNT2 heterodimer stability. 1 Publication | 1 | |
Mutagenesisi | 141 | L → E: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication | 1 | |
Mutagenesisi | 145 | A → D: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication | 1 | |
Mutagenesisi | 238 | I → D: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication | 1 | |
Mutagenesisi | 279 | V → D: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication | 1 | |
Mutagenesisi | 340 | R → A: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication | 1 | |
Mutagenesisi | 422 | N → A: Compromises SIM1:ARNT2 heterodimer stability. Does not compromises NPAS4:ARNT2 heterodimer stability. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127123 | 1 – 712 | Aryl hydrocarbon receptor nuclear translocator 2Add BLAST | 712 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 42 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
MethylationProteomic databases
PaxDbi | Q61324 |
PeptideAtlasi | Q61324 |
PRIDEi | Q61324 |
PTM databases
iPTMneti | Q61324 |
PhosphoSitePlusi | Q61324 |
Expressioni
Tissue specificityi
Restricted to adult brain and kidney.
Gene expression databases
Bgeei | ENSMUSG00000015709, Expressed in cingulate cortex and 278 other tissues |
Genevisiblei | Q61324, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198206, 25 interactors |
IntActi | Q61324, 2 interactors |
STRINGi | 10090.ENSMUSP00000082154 |
Miscellaneous databases
RNActi | Q61324, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 63 – 116 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 134 – 209 | PAS 1PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 323 – 393 | PAS 2PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 398 – 441 | PACAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 73 – 76 | Poly-Arg | 4 | |
Compositional biasi | 440 – 445 | Poly-Gln | 6 | |
Compositional biasi | 552 – 555 | Poly-Ser | 4 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000158198 |
HOGENOMi | CLU_011864_1_1_1 |
InParanoidi | Q61324 |
OrthoDBi | 331262at2759 |
PhylomeDBi | Q61324 |
TreeFami | TF319983 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q61324-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATPAAVNPP EMASDIPGSV ALPVAPMAAT GQVRMAGAMP ARGGKRRSGM
60 70 80 90 100
DFDDEDGEGP SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP
110 120 130 140 150
DKLTILRMAV SHMKSMRGTG NKSTDGAYKP SFLTEQELKH LILEAADGFL
160 170 180 190 200
FVVAAETGRV IYVSDSVTPV LNQPQSEWFG STLYEQVHPD DVEKLREQLC
210 220 230 240 250
TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR MRCGNAPLDH
260 270 280 290 300
LPLNRITTMR KRFRNGLGPV KEGEAQYAVV HCTGYIKAWP PAGMTIPEED
310 320 330 340 350
ADVGQGSKYC LVAIGRLQVT SSPVCMDMSG MSVPTEFLSR HNSDGIITFV
360 370 380 390 400
DPRCISVIGY QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM
410 420 430 440 450
YRFRTKNREW LLIRTSSFTF QNPYSDEIEY VICTNTNVKQ LQQQQAELEV
460 470 480 490 500
HQRDGLSSYD LSQVPVPNLP AGVHEAGKSV EKADAIFSQE RDPRFAEMFA
510 520 530 540 550
GISASEKKMM SSASASGSQQ IYSQGSPFPA GHSGKAFSSS VVHVPGVNDI
560 570 580 590 600
QSSSSTGQNI SQISRQLNQG QVAWTGSRPP FPGQPSKTQS SAFGIGSSHP
610 620 630 640 650
YPADPSSYSP LSSPAASSPS GNAYPSLANR TPGFAESGQS GGQFQGRPSE
660 670 680 690 700
VWSQWQSQHH GQQSGEQHSH QQPGQTEVFQ DMLPMPGDPT QGTGNYNIED
710
FADLGMFPPF SE
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A140LHY4 | A0A140LHY4_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arnt2 | 206 | Annotation score: | ||
A0A140LHH4 | A0A140LHH4_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arnt2 | 167 | Annotation score: | ||
A0A140LIL3 | A0A140LIL3_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arnt2 | 93 | Annotation score: | ||
A0A140LID4 | A0A140LID4_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arnt2 | 91 | Annotation score: | ||
A0A140LHZ6 | A0A140LHZ6_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arnt2 | 160 | Annotation score: | ||
A0A140LID9 | A0A140LID9_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arnt2 | 52 | Annotation score: | ||
A0A140LIW9 | A0A140LIW9_MOUSE | Aryl hydrocarbon receptor nuclear t... | Arnt2 | 123 | Annotation score: |
Sequence cautioni
The sequence BAC41409 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 206 | M → I in BAA09799 (PubMed:8657146).Curated | 1 | |
Sequence conflicti | 432 | I → T in AAH54546 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022689 | 1 – 11 | Missing in isoform 2. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63644 mRNA Translation: BAA09799.1 AB093225 mRNA Translation: BAC41409.1 Different initiation. BC054546 mRNA Translation: AAH54546.1 |
CCDSi | CCDS59733.1 [Q61324-1] |
RefSeqi | NP_031514.3, NM_007488.3 [Q61324-1] XP_006507303.1, XM_006507240.2 [Q61324-2] XP_006507305.1, XM_006507242.2 [Q61324-2] XP_011239957.1, XM_011241655.2 [Q61324-2] |
Genome annotation databases
Ensembli | ENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709 [Q61324-1] ENSMUST00000208232; ENSMUSP00000146413; ENSMUSG00000015709 [Q61324-2] ENSMUST00000209133; ENSMUSP00000147129; ENSMUSG00000015709 [Q61324-2] |
GeneIDi | 11864 |
KEGGi | mmu:11864 |
UCSCi | uc009ief.2, mouse [Q61324-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63644 mRNA Translation: BAA09799.1 AB093225 mRNA Translation: BAC41409.1 Different initiation. BC054546 mRNA Translation: AAH54546.1 |
CCDSi | CCDS59733.1 [Q61324-1] |
RefSeqi | NP_031514.3, NM_007488.3 [Q61324-1] XP_006507303.1, XM_006507240.2 [Q61324-2] XP_006507305.1, XM_006507242.2 [Q61324-2] XP_011239957.1, XM_011241655.2 [Q61324-2] |
3D structure databases
SMRi | Q61324 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198206, 25 interactors |
IntActi | Q61324, 2 interactors |
STRINGi | 10090.ENSMUSP00000082154 |
PTM databases
iPTMneti | Q61324 |
PhosphoSitePlusi | Q61324 |
Proteomic databases
PaxDbi | Q61324 |
PeptideAtlasi | Q61324 |
PRIDEi | Q61324 |
Protocols and materials databases
Antibodypediai | 3911, 270 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709 [Q61324-1] ENSMUST00000208232; ENSMUSP00000146413; ENSMUSG00000015709 [Q61324-2] ENSMUST00000209133; ENSMUSP00000147129; ENSMUSG00000015709 [Q61324-2] |
GeneIDi | 11864 |
KEGGi | mmu:11864 |
UCSCi | uc009ief.2, mouse [Q61324-1] |
Organism-specific databases
CTDi | 9915 |
MGIi | MGI:107188, Arnt2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3561, Eukaryota |
GeneTreei | ENSGT00940000158198 |
HOGENOMi | CLU_011864_1_1_1 |
InParanoidi | Q61324 |
OrthoDBi | 331262at2759 |
PhylomeDBi | Q61324 |
TreeFami | TF319983 |
Enzyme and pathway databases
Reactomei | R-MMU-211945, Phase I - Functionalization of compounds R-MMU-211976, Endogenous sterols R-MMU-211981, Xenobiotics R-MMU-8937144, Aryl hydrocarbon receptor signalling |
Miscellaneous databases
BioGRID-ORCSi | 11864, 0 hits in 17 CRISPR screens |
ChiTaRSi | Arnt2, mouse |
PROi | PR:Q61324 |
RNActi | Q61324, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015709, Expressed in cingulate cortex and 278 other tissues |
Genevisiblei | Q61324, MM |
Family and domain databases
CDDi | cd00083, HLH, 1 hit cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001067, Nuc_translocat IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit |
PRINTSi | PR00785, NCTRNSLOCATR |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARNT2_MOUSE | |
Accessioni | Q61324Primary (citable) accession number: Q61324 Secondary accession number(s): Q7TQG2, Q8CHG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | February 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot