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Protein

Heat shock 70 kDa protein 4

Gene

Hspa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 4
Alternative name(s):
Heat shock 70-related protein APG-2
Gene namesi
Name:Hspa4
Synonyms:Apg2, Hsp110
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1342292 Hspa4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782631 – 841Heat shock 70 kDa protein 4Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei89PhosphotyrosineBy similarity1
Modified residuei336PhosphotyrosineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei415PhosphoserineCombined sources1
Modified residuei430N6-acetyllysineBy similarity1
Modified residuei540PhosphothreonineCombined sources1
Modified residuei548PhosphoserineBy similarity1
Modified residuei661PhosphotyrosineCombined sources1
Modified residuei680N6-acetyllysineBy similarity1
Modified residuei757PhosphoserineBy similarity1
Modified residuei774N6-methyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ61316
MaxQBiQ61316
PaxDbiQ61316
PeptideAtlasiQ61316
PRIDEiQ61316

2D gel databases

REPRODUCTION-2DPAGEiQ61316

PTM databases

iPTMnetiQ61316
PhosphoSitePlusiQ61316
SwissPalmiQ61316

Expressioni

Gene expression databases

CleanExiMM_HSPA4

Interactioni

Subunit structurei

Interacts with TJP1/ZO-1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-46965N
IntActiQ61316, 8 interactors
MINTiQ61316
STRINGi10090.ENSMUSP00000020630

Structurei

3D structure databases

ProteinModelPortaliQ61316
SMRiQ61316
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0103 Eukaryota
COG0443 LUCA
HOVERGENiHBG047955
InParanoidiQ61316

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 2 hits
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61316-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSIGA
60 70 80 90 100
AAKSQVISNA KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG
110 120 130 140 150
IKVTYMEEER NFTTEQVTAM LLSKLKETAE SVLKKPVVDC VVSVPSFYTD
160 170 180 190 200
AERRSVMDAT QIAGLNCLRL MNETTAVALA YGIYKQDLPA LEEKPRNVVF
210 220 230 240 250
VDMGHSAYQV SVCAFNKGKL KVLATAFDTT LGGRKFDEVL VNHFCEEFGK
260 270 280 290 300
KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT
310 320 330 340 350
MNRGKFLEMC DDLLARVEPP LRSVLEQSKL KKEDIYAVEI VGGATRIPAV
360 370 380 390 400
KEKISKFFGK ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY
410 420 430 440 450
PISLRWNSPA EEGLSDCEVF PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ
460 470 480 490 500
DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV KVRVNVHGIF SVSSAALVEV
510 520 530 540 550
HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQQQPQT PAENKAESEE
560 570 580 590 600
METSQAGSKD KKTDQPPQAK KAKVKTSTVD LPIEHTLWQL DREMLALYTE
610 620 630 640 650
NEGKMIMQDK LEKERNDAKN AVEEYVYEMR DKLSGEYEKF VSEDDRNTFT
660 670 680 690 700
LKLEDTENWL YEDGEDQPKQ VYVDKLAELK SLGQPIKTRF QESEERPKLF
710 720 730 740 750
EELGKQIQQY MKVISSFKNK EDQYEHLDAA DVTKVEKSTN EAMEWMNSKL
760 770 780 790 800
NLQNKQSLTV DPVVKTKEIE AKIKELTSIC SPIISKPKPK VEPPKEEPKH
810 820 830 840
AEQNGPVDGQ GDNPGSQAAE HGADTAVPSD GDKKLPEMDI D
Length:841
Mass (Da):94,133
Last modified:November 1, 1996 - v1
Checksum:iE7FF19F555C115ED
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U2G2Q3U2G2_MOUSE
Heat shock 70 kDa protein 4
Hspa4 mCG_113604
842Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85904 mRNA Translation: BAA12914.1
UniGeneiMm.239865

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85904 mRNA Translation: BAA12914.1
UniGeneiMm.239865

3D structure databases

ProteinModelPortaliQ61316
SMRiQ61316
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46965N
IntActiQ61316, 8 interactors
MINTiQ61316
STRINGi10090.ENSMUSP00000020630

PTM databases

iPTMnetiQ61316
PhosphoSitePlusiQ61316
SwissPalmiQ61316

2D gel databases

REPRODUCTION-2DPAGEiQ61316

Proteomic databases

EPDiQ61316
MaxQBiQ61316
PaxDbiQ61316
PeptideAtlasiQ61316
PRIDEiQ61316

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1342292 Hspa4

Phylogenomic databases

eggNOGiKOG0103 Eukaryota
COG0443 LUCA
HOVERGENiHBG047955
InParanoidiQ61316

Miscellaneous databases

ChiTaRSiHspa4 mouse
PROiPR:Q61316
SOURCEiSearch...

Gene expression databases

CleanExiMM_HSPA4

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 2 hits
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP74_MOUSE
AccessioniPrimary (citable) accession number: Q61316
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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