Hspa4

Functionⁱ

GO - Molecular functionⁱ

activating transcription factor binding Source: MGI
ATP binding Source: UniProtKB-KW
protein-containing complex binding Source: MGI
RNA polymerase II transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chaperone-mediated protein complex assembly Source: MGI
negative regulation of apoptotic process Source: MGI
negative regulation of cell death Source: MGI
negative regulation of DNA binding Source: MGI
negative regulation of gene expression Source: MGI
negative regulation of protein phosphorylation Source: MGI
positive regulation of gene expression Source: MGI
positive regulation of protein binding Source: MGI
protein import into mitochondrial outer membrane Source: MGI
response to heat Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Stress response
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heat shock 70 kDa protein 4 Alternative name(s): Heat shock 70-related protein APG-2
Gene namesⁱ	Name:Hspa4 Synonyms:Apg2, Hsp110
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1342292 Hspa4

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000078263	1 – 841	Heat shock 70 kDa protein 4Add BLAST		841

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	53	N6-acetyllysineCombined sources	1
Modified residueⁱ	76	PhosphoserineCombined sources	1
Modified residueⁱ	89	PhosphotyrosineBy similarity	1
Modified residueⁱ	336	PhosphotyrosineCombined sources	1
Modified residueⁱ	393	PhosphoserineBy similarity	1
Modified residueⁱ	415	PhosphoserineCombined sources	1
Modified residueⁱ	430	N6-acetyllysineBy similarity	1
Modified residueⁱ	540	PhosphothreonineCombined sources	1
Modified residueⁱ	548	PhosphoserineBy similarity	1
Modified residueⁱ	661	PhosphotyrosineCombined sources	1
Modified residueⁱ	680	N6-acetyllysineBy similarity	1
Modified residueⁱ	757	PhosphoserineBy similarity	1
Modified residueⁱ	774	N6-methyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q61316
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61316
PaxDbⁱ	Q61316
PeptideAtlas More...PeptideAtlasⁱ	Q61316
PRIDEⁱ	Q61316

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q61316

REPRODUCTION-2DPAGEⁱ

Q61316

PTM databases

iPTMnetⁱ	Q61316
PhosphoSitePlusⁱ	Q61316
SwissPalmⁱ	Q61316

Expressionⁱ

Gene expression databases

CleanExⁱ	MM_HSPA4

CleanExⁱ

MM_HSPA4

Interactionⁱ

Subunit structureⁱ

Interacts with TJP1/ZO-1.By similarity

GO - Molecular functionⁱ

activating transcription factor binding Source: MGI
RNA polymerase II transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-46965N
IntActⁱ	Q61316, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q61316
STRINGⁱ	10090.ENSMUSP00000020630

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61316
SMRⁱ	Q61316
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0103 Eukaryota COG0443 LUCA
HOVERGENⁱ	HBG047955
InParanoidⁱ	Q61316

Family and domain databases

Gene3Dⁱ	1.20.1270.10, 1 hit 2.60.34.10, 1 hit
InterProⁱ	View protein in InterPro IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam
PANTHERⁱ	PTHR19375 PTHR19375, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00012 HSP70, 2 hits
PRINTSⁱ	PR00301 HEATSHOCK70
SUPFAMⁱ	SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 2 hits
PROSITEⁱ	View protein in PROSITE PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q61316-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSIGA 
        60         70         80         90        100
AAKSQVISNA KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG 
       110        120        130        140        150
IKVTYMEEER NFTTEQVTAM LLSKLKETAE SVLKKPVVDC VVSVPSFYTD 
       160        170        180        190        200
AERRSVMDAT QIAGLNCLRL MNETTAVALA YGIYKQDLPA LEEKPRNVVF 
       210        220        230        240        250
VDMGHSAYQV SVCAFNKGKL KVLATAFDTT LGGRKFDEVL VNHFCEEFGK 
       260        270        280        290        300
KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT 
       310        320        330        340        350
MNRGKFLEMC DDLLARVEPP LRSVLEQSKL KKEDIYAVEI VGGATRIPAV 
       360        370        380        390        400
KEKISKFFGK ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY 
       410        420        430        440        450
PISLRWNSPA EEGLSDCEVF PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ 
       460        470        480        490        500
DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV KVRVNVHGIF SVSSAALVEV 
       510        520        530        540        550
HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQQQPQT PAENKAESEE 
       560        570        580        590        600
METSQAGSKD KKTDQPPQAK KAKVKTSTVD LPIEHTLWQL DREMLALYTE 
       610        620        630        640        650
NEGKMIMQDK LEKERNDAKN AVEEYVYEMR DKLSGEYEKF VSEDDRNTFT 
       660        670        680        690        700
LKLEDTENWL YEDGEDQPKQ VYVDKLAELK SLGQPIKTRF QESEERPKLF 
       710        720        730        740        750
EELGKQIQQY MKVISSFKNK EDQYEHLDAA DVTKVEKSTN EAMEWMNSKL 
       760        770        780        790        800
NLQNKQSLTV DPVVKTKEIE AKIKELTSIC SPIISKPKPK VEPPKEEPKH 
       810        820        830        840 
AEQNGPVDGQ GDNPGSQAAE HGADTAVPSD GDKKLPEMDI D

Length:841

Mass (Da):94,133

Last modified:November 1, 1996 - v1

Checksum:ⁱE7FF19F555C115ED

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q3U2G2	Q3U2G2_MOUSE		Heat shock 70 kDa protein 4 Heat shock 70 kDa protein 4 (Heat shock protein 4, isoform CRA_a)	Hspa4 mCG_113604	842	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D85904 mRNA Translation: BAA12914.1
UniGeneⁱ	Mm.239865

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61316	Heat shock 70 kDa protein 4		RAT		840	UniRef90_O88600
Heat shock 70 kDa protein 4		PONAB		840
Heat shock 70 kDa protein 4		HUMAN		840
Heat shock 70 kDa protein 4		CANLF		840
heat shock 70 kDa protein 4 isoform X1		Enhydra lutris kenyoni		880
+158

Protein	Similar proteins		Species	Score	Length	Source
Q61316	Heat shock protein 105 kDa		MOUSE		858	UniRef50_Q61699
Heat shock protein 105 kDa		BOVIN		859
Heat shock protein 105 kDa		RAT		858
Heat shock protein 105 kDa		HUMAN		858
Heat shock protein 105 kDa		PONAB		858
+682

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D85904 mRNA Translation: BAA12914.1
UniGeneⁱ	Mm.239865

3D structure databases

ProteinModelPortalⁱ	Q61316
SMRⁱ	Q61316
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-46965N
IntActⁱ	Q61316, 8 interactors
MINTⁱ	Q61316
STRINGⁱ	10090.ENSMUSP00000020630

PTM databases

iPTMnetⁱ	Q61316
PhosphoSitePlusⁱ	Q61316
SwissPalmⁱ	Q61316

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q61316

REPRODUCTION-2DPAGEⁱ

Q61316

Proteomic databases

EPDⁱ	Q61316
MaxQBⁱ	Q61316
PaxDbⁱ	Q61316
PeptideAtlasⁱ	Q61316
PRIDEⁱ	Q61316

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

MGIⁱ	MGI:1342292 Hspa4

Phylogenomic databases

eggNOGⁱ	KOG0103 Eukaryota COG0443 LUCA
HOVERGENⁱ	HBG047955
InParanoidⁱ	Q61316

Miscellaneous databases

ChiTaRSⁱ	Hspa4 mouse
Protein Ontology More...PROⁱ	PR:Q61316
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_HSPA4

CleanExⁱ

MM_HSPA4

Family and domain databases

Gene3Dⁱ	1.20.1270.10, 1 hit 2.60.34.10, 1 hit
InterProⁱ	View protein in InterPro IPR018181 Heat_shock_70_CS IPR029048 HSP70_C_sf IPR029047 HSP70_peptide-bd_sf IPR013126 Hsp_70_fam
PANTHERⁱ	PTHR19375 PTHR19375, 1 hit
Pfamⁱ	View protein in Pfam PF00012 HSP70, 2 hits
PRINTSⁱ	PR00301 HEATSHOCK70
SUPFAMⁱ	SSF100920 SSF100920, 1 hit SSF100934 SSF100934, 2 hits
PROSITEⁱ	View protein in PROSITE PS00329 HSP70_2, 1 hit PS01036 HSP70_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HSP74_MOUSE
Accessionⁱ	Q61316Primary (citable) accession number: Q61316
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61316 (HSP74_MOUSE)

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Heat shock 70 kDa protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ