UniProtKB - Q61316 (HSP74_MOUSE)
Protein
Heat shock 70 kDa protein 4
Gene
Hspa4
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- activating transcription factor binding Source: MGI
- ATP binding Source: UniProtKB-KW
- protein-containing complex binding Source: MGI
- RNA polymerase II transcription factor binding Source: MGI
GO - Biological processi
- chaperone-mediated protein complex assembly Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cell death Source: MGI
- negative regulation of DNA binding Source: MGI
- negative regulation of gene expression Source: MGI
- negative regulation of protein phosphorylation Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of protein binding Source: MGI
- protein insertion into mitochondrial outer membrane Source: MGI
- response to heat Source: MGI
Keywordsi
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-3371453, Regulation of HSF1-mediated heat shock response |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock 70 kDa protein 4Alternative name(s): Heat shock 70-related protein APG-2 |
Gene namesi | Name:Hspa4 Synonyms:Apg2, Hsp110 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1342292, Hspa4 |
Subcellular locationi
Other locations
- Cytoplasm Curated
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular exosome Source: MGI
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- lipid droplet Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078263 | 1 – 841 | Heat shock 70 kDa protein 4Add BLAST | 841 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 76 | PhosphoserineCombined sources | 1 | |
Modified residuei | 89 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 336 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 393 | PhosphoserineBy similarity | 1 | |
Modified residuei | 415 | PhosphoserineCombined sources | 1 | |
Modified residuei | 430 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 540 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 548 | PhosphoserineBy similarity | 1 | |
Modified residuei | 661 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 680 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 757 | PhosphoserineBy similarity | 1 | |
Modified residuei | 774 | N6-methyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3824 |
EPDi | Q61316 |
jPOSTi | Q61316 |
MaxQBi | Q61316 |
PaxDbi | Q61316 |
PeptideAtlasi | Q61316 |
PRIDEi | Q61316 |
2D gel databases
REPRODUCTION-2DPAGEi | Q61316 |
PTM databases
iPTMneti | Q61316 |
PhosphoSitePlusi | Q61316 |
SwissPalmi | Q61316 |
Interactioni
Subunit structurei
Interacts with TJP1/ZO-1.
By similarityGO - Molecular functioni
- activating transcription factor binding Source: MGI
- RNA polymerase II transcription factor binding Source: MGI
Protein-protein interaction databases
DIPi | DIP-46965N |
IntActi | Q61316, 8 interactors |
MINTi | Q61316 |
STRINGi | 10090.ENSMUSP00000020630 |
Miscellaneous databases
RNActi | Q61316, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Phylogenomic databases
eggNOGi | KOG0103, Eukaryota |
InParanoidi | Q61316 |
Family and domain databases
CDDi | cd11737, HSPA4_NBD, 1 hit |
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam IPR042052, HSPA4_NBD |
Pfami | View protein in Pfam PF00012, HSP70, 2 hits |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 2 hits SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q61316-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSIGA
60 70 80 90 100
AAKSQVISNA KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG
110 120 130 140 150
IKVTYMEEER NFTTEQVTAM LLSKLKETAE SVLKKPVVDC VVSVPSFYTD
160 170 180 190 200
AERRSVMDAT QIAGLNCLRL MNETTAVALA YGIYKQDLPA LEEKPRNVVF
210 220 230 240 250
VDMGHSAYQV SVCAFNKGKL KVLATAFDTT LGGRKFDEVL VNHFCEEFGK
260 270 280 290 300
KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT
310 320 330 340 350
MNRGKFLEMC DDLLARVEPP LRSVLEQSKL KKEDIYAVEI VGGATRIPAV
360 370 380 390 400
KEKISKFFGK ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY
410 420 430 440 450
PISLRWNSPA EEGLSDCEVF PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ
460 470 480 490 500
DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV KVRVNVHGIF SVSSAALVEV
510 520 530 540 550
HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQQQPQT PAENKAESEE
560 570 580 590 600
METSQAGSKD KKTDQPPQAK KAKVKTSTVD LPIEHTLWQL DREMLALYTE
610 620 630 640 650
NEGKMIMQDK LEKERNDAKN AVEEYVYEMR DKLSGEYEKF VSEDDRNTFT
660 670 680 690 700
LKLEDTENWL YEDGEDQPKQ VYVDKLAELK SLGQPIKTRF QESEERPKLF
710 720 730 740 750
EELGKQIQQY MKVISSFKNK EDQYEHLDAA DVTKVEKSTN EAMEWMNSKL
760 770 780 790 800
NLQNKQSLTV DPVVKTKEIE AKIKELTSIC SPIISKPKPK VEPPKEEPKH
810 820 830 840
AEQNGPVDGQ GDNPGSQAAE HGADTAVPSD GDKKLPEMDI D
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3U2G2 | Q3U2G2_MOUSE | Heat shock 70 kDa protein 4 | Hspa4 | 842 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D85904 mRNA Translation: BAA12914.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D85904 mRNA Translation: BAA12914.1 |
3D structure databases
SMRi | Q61316 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-46965N |
IntActi | Q61316, 8 interactors |
MINTi | Q61316 |
STRINGi | 10090.ENSMUSP00000020630 |
PTM databases
iPTMneti | Q61316 |
PhosphoSitePlusi | Q61316 |
SwissPalmi | Q61316 |
2D gel databases
REPRODUCTION-2DPAGEi | Q61316 |
Proteomic databases
CPTACi | non-CPTAC-3824 |
EPDi | Q61316 |
jPOSTi | Q61316 |
MaxQBi | Q61316 |
PaxDbi | Q61316 |
PeptideAtlasi | Q61316 |
PRIDEi | Q61316 |
Organism-specific databases
MGIi | MGI:1342292, Hspa4 |
Phylogenomic databases
eggNOGi | KOG0103, Eukaryota |
InParanoidi | Q61316 |
Enzyme and pathway databases
Reactomei | R-MMU-3371453, Regulation of HSF1-mediated heat shock response |
Miscellaneous databases
ChiTaRSi | Hspa4, mouse |
PROi | PR:Q61316 |
RNActi | Q61316, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd11737, HSPA4_NBD, 1 hit |
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam IPR042052, HSPA4_NBD |
Pfami | View protein in Pfam PF00012, HSP70, 2 hits |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF100934, SSF100934, 2 hits SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSP74_MOUSE | |
Accessioni | Q61316Primary (citable) accession number: Q61316 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | August 12, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families