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Protein

Transcription factor AP-2 gamma

Gene

Tfap2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3232118 SUMOylation of transcription factors
R-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-MMU-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2 gamma
Short name:
AP2-gamma
Alternative name(s):
AP-2.2
Activating enhancer-binding protein 2 gamma
Gene namesi
Name:Tfap2c
Synonyms:Tcfap2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:106032 Tfap2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001848041 – 449Transcription factor AP-2 gammaAdd BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei251Phosphoserine; by PKABy similarity1
Modified residuei433PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated on Lys-10; which inhibits transcriptional activity.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61312
PaxDbiQ61312
PRIDEiQ61312

PTM databases

iPTMnetiQ61312
PhosphoSitePlusiQ61312

Expressioni

Tissue specificityi

Expressed in lung, ovary and testis. Expressed in most squamous epithelia. Also, detected in several exocrine glands including the prostate, the preputial and salivary glands, serous glands of the tongue and ocular harderian glands.

Inductioni

During retinoic acid-mediated differentiation.

Gene expression databases

BgeeiENSMUSG00000028640 Expressed in 294 organ(s), highest expression level in placenta
CleanExiMM_TCFAP2C
ExpressionAtlasiQ61312 baseline and differential
GenevisibleiQ61312 MM

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with UBE2I (By similarity). Interacts with CITED4. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204013, 2 interactors
IntActiQ61312, 1 interactor
MINTiQ61312
STRINGi10090.ENSMUSP00000129922

Structurei

3D structure databases

ProteinModelPortaliQ61312
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni292 – 423H-S-H (helix-span-helix), dimerizationAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 64PPxY motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 109Gln/Pro-rich (transactivation domain)Add BLAST80

Domaini

The PPxY motif mediates interaction with WWOX.By similarity

Sequence similaritiesi

Belongs to the AP-2 family.Curated

Phylogenomic databases

eggNOGiKOG3811 Eukaryota
ENOG410XR9E LUCA
GeneTreeiENSGT00550000074577
HOGENOMiHOG000231737
HOVERGENiHBG002455
InParanoidiQ61312
KOiK09177
TreeFamiTF313718

Family and domain databases

InterProiView protein in InterPro
IPR004979 TF_AP2
IPR013854 TF_AP2_C
IPR008123 TF_AP2_gamma
PANTHERiPTHR10812 PTHR10812, 1 hit
PfamiView protein in Pfam
PF03299 TF_AP-2, 1 hit
PRINTSiPR01751 AP2CTNSCPFCT
PR01748 AP2TNSCPFCT

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q61312-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLWKITDNVK YEEDCEDRHD SSSNGNPRIP HLSSPGQHLY SPAPPLSHTG
60 70 80 90 100
VAEYQPPPYF PPPYQQLAYS QSADHYSHLG EAYAAAMNPL HQPAATGSQQ
110 120 130 140 150
QAWPGRQSQE GSSLASHHSR SASLIPHISG LEGGSVSARR EVYRRSDLLL
160 170 180 190 200
PHAHALEAGL AENLGLHEMA HPIEEVQNVD DAHLLLHDQT VIRKGPISMT
210 220 230 240 250
KNPLGLPCQK DLVGVVMNPS EVFCSVPGRL SLLSSTSKYK VTVAEVQRRL
260 270 280 290 300
SPPECLNASL LGGVLRRAKS KNGGRSLREK LDKIGLNLPA GRRKAAHVTL
310 320 330 340 350
LTSLVEGEAV HLARDFAYVC EAEFPSKAVA DYLTRPHLGG RNEMATRKSM
360 370 380 390 400
LLAAQQVCKE FTDLLHQDRT PNGNNRPAQV LEPNIQNCLS HFSLITHGFG
410 420 430 440
SQAICAAVSA VQNYIKEALI AIDKSYMNPG DQSPADSSKT MEKMEKHRK
Length:449
Mass (Da):49,137
Last modified:July 27, 2011 - v2
Checksum:i92490E234697B6A3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3ULB3Q3ULB3_MOUSE
Transcription factor AP-2 gamma
Tfap2c Tcfap2c
488Annotation score:
A2APA8A2APA8_MOUSE
Transcription factor AP-2 gamma
Tfap2c
513Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67 – 68LA → VV in CAA64357 (PubMed:8660922).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94694 mRNA Translation: CAA64357.1
AK145166 mRNA Translation: BAE26271.1
AL833787 Genomic DNA Translation: CAM18031.1
CH466551 Genomic DNA Translation: EDL06609.1
BC003778 mRNA Translation: AAH03778.1
CCDSiCCDS17135.1
RefSeqiNP_001153168.1, NM_001159696.1
NP_033361.2, NM_009335.2
UniGeneiMm.3629

Genome annotation databases

EnsembliENSMUST00000030391; ENSMUSP00000030391; ENSMUSG00000028640
GeneIDi21420
KEGGimmu:21420
UCSCiuc008ocz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94694 mRNA Translation: CAA64357.1
AK145166 mRNA Translation: BAE26271.1
AL833787 Genomic DNA Translation: CAM18031.1
CH466551 Genomic DNA Translation: EDL06609.1
BC003778 mRNA Translation: AAH03778.1
CCDSiCCDS17135.1
RefSeqiNP_001153168.1, NM_001159696.1
NP_033361.2, NM_009335.2
UniGeneiMm.3629

3D structure databases

ProteinModelPortaliQ61312
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204013, 2 interactors
IntActiQ61312, 1 interactor
MINTiQ61312
STRINGi10090.ENSMUSP00000129922

PTM databases

iPTMnetiQ61312
PhosphoSitePlusiQ61312

Proteomic databases

MaxQBiQ61312
PaxDbiQ61312
PRIDEiQ61312

Protocols and materials databases

DNASUi21420
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030391; ENSMUSP00000030391; ENSMUSG00000028640
GeneIDi21420
KEGGimmu:21420
UCSCiuc008ocz.2 mouse

Organism-specific databases

CTDi7022
MGIiMGI:106032 Tfap2c

Phylogenomic databases

eggNOGiKOG3811 Eukaryota
ENOG410XR9E LUCA
GeneTreeiENSGT00550000074577
HOGENOMiHOG000231737
HOVERGENiHBG002455
InParanoidiQ61312
KOiK09177
TreeFamiTF313718

Enzyme and pathway databases

ReactomeiR-MMU-3232118 SUMOylation of transcription factors
R-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-MMU-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors

Miscellaneous databases

ChiTaRSiTfap2c mouse
PROiPR:Q61312
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028640 Expressed in 294 organ(s), highest expression level in placenta
CleanExiMM_TCFAP2C
ExpressionAtlasiQ61312 baseline and differential
GenevisibleiQ61312 MM

Family and domain databases

InterProiView protein in InterPro
IPR004979 TF_AP2
IPR013854 TF_AP2_C
IPR008123 TF_AP2_gamma
PANTHERiPTHR10812 PTHR10812, 1 hit
PfamiView protein in Pfam
PF03299 TF_AP-2, 1 hit
PRINTSiPR01751 AP2CTNSCPFCT
PR01748 AP2TNSCPFCT
ProtoNetiSearch...

Entry informationi

Entry nameiAP2C_MOUSE
AccessioniPrimary (citable) accession number: Q61312
Secondary accession number(s): Q99L72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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