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Entry version 160 (03 Jul 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Laminin subunit beta-2

Gene

Lamb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.1 Publication
Laminin-3 (S-laminin) regulates the formation of motor nerve terminals.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3000157 Laminin interactions
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit beta-2
Alternative name(s):
Laminin-11 subunit beta
Laminin-14 subunit beta
Laminin-15 subunit beta
Laminin-3 subunit beta
Laminin-4 subunit beta
Laminin-7 subunit beta
Laminin-9 subunit beta
S-laminin subunit beta
Short name:
S-LAM beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lamb2
Synonyms:Lams
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99916 Lamb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001706936 – 1799Laminin subunit beta-2Add BLAST1764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi286 ↔ 295PROSITE-ProRule annotation
Disulfide bondi288 ↔ 313PROSITE-ProRule annotation
Disulfide bondi315 ↔ 324PROSITE-ProRule annotation
Disulfide bondi327 ↔ 347PROSITE-ProRule annotation
Disulfide bondi350 ↔ 359PROSITE-ProRule annotation
Disulfide bondi352 ↔ 377PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi392 ↔ 410PROSITE-ProRule annotation
Disulfide bondi413 ↔ 426PROSITE-ProRule annotation
Disulfide bondi415 ↔ 441PROSITE-ProRule annotation
Disulfide bondi443 ↔ 452PROSITE-ProRule annotation
Disulfide bondi455 ↔ 470PROSITE-ProRule annotation
Disulfide bondi473 ↔ 487PROSITE-ProRule annotation
Disulfide bondi475 ↔ 494PROSITE-ProRule annotation
Disulfide bondi496 ↔ 505PROSITE-ProRule annotation
Disulfide bondi508 ↔ 522PROSITE-ProRule annotation
Disulfide bondi525 ↔ 537PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
Disulfide bondi784 ↔ 796PROSITE-ProRule annotation
Disulfide bondi786 ↔ 803PROSITE-ProRule annotation
Disulfide bondi805 ↔ 814PROSITE-ProRule annotation
Disulfide bondi817 ↔ 829PROSITE-ProRule annotation
Disulfide bondi832 ↔ 844PROSITE-ProRule annotation
Disulfide bondi834 ↔ 851PROSITE-ProRule annotation
Disulfide bondi853 ↔ 862PROSITE-ProRule annotation
Disulfide bondi865 ↔ 875PROSITE-ProRule annotation
Disulfide bondi878 ↔ 887PROSITE-ProRule annotation
Disulfide bondi880 ↔ 894PROSITE-ProRule annotation
Disulfide bondi897 ↔ 906PROSITE-ProRule annotation
Disulfide bondi909 ↔ 925PROSITE-ProRule annotation
Disulfide bondi928 ↔ 944PROSITE-ProRule annotation
Disulfide bondi930 ↔ 955PROSITE-ProRule annotation
Disulfide bondi957 ↔ 966PROSITE-ProRule annotation
Disulfide bondi969 ↔ 984PROSITE-ProRule annotation
Disulfide bondi987 ↔ 1001PROSITE-ProRule annotation
Disulfide bondi989 ↔ 1008PROSITE-ProRule annotation
Disulfide bondi1011 ↔ 1020PROSITE-ProRule annotation
Disulfide bondi1023 ↔ 1036PROSITE-ProRule annotation
Disulfide bondi1039 ↔ 1059PROSITE-ProRule annotation
Disulfide bondi1041 ↔ 1066PROSITE-ProRule annotation
Disulfide bondi1068 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1080 ↔ 1093PROSITE-ProRule annotation
Glycosylationi1086N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1096 ↔ 1108PROSITE-ProRule annotation
Disulfide bondi1098 ↔ 1115PROSITE-ProRule annotation
Disulfide bondi1117 ↔ 1126PROSITE-ProRule annotation
Disulfide bondi1129 ↔ 1141PROSITE-ProRule annotation
Disulfide bondi1144 ↔ 1156PROSITE-ProRule annotation
Disulfide bondi1146 ↔ 1163PROSITE-ProRule annotation
Disulfide bondi1165 ↔ 1174PROSITE-ProRule annotation
Disulfide bondi1177 ↔ 1188PROSITE-ProRule annotation
Disulfide bondi1191InterchainCurated
Disulfide bondi1194InterchainCurated
Glycosylationi1250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1500N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1533PhosphoserineBy similarity1
Disulfide bondi1798InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q61292

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q61292

PeptideAtlas

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PeptideAtlasi
Q61292

PRoteomics IDEntifications database

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PRIDEi
Q61292

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2460

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61292

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q61292

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Neuromuscular synapse and kidney glomerulus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052911 Expressed in 282 organ(s), highest expression level in decidua

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q61292 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q61292 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-7 (laminin-321 or KS-laminin), laminin-9 (laminin-421), laminin-11 (laminin-521), laminin-14 (laminin-423) and laminin-15 (laminin-523).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201102, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3010 Laminin-121 complex
CPX-3011 Laminin-221 complex
CPX-3014 Laminin-321 complex
CPX-3017 Laminin-521 complex
CPX-3019 Laminin-423 complex
CPX-3020 Laminin-522 complex
CPX-3021 Laminin-523 complex
CPX-3031 Laminin-421 complex

Protein interaction database and analysis system

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IntActi
Q61292, 2 interactors

Molecular INTeraction database

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MINTi
Q61292

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000069087

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q61292

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 285Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini286 – 349Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST64
Domaini350 – 412Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini413 – 472Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST60
Domaini473 – 524Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST52
Domaini525 – 555Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd BLAST31
Domaini564 – 778Laminin IV type BPROSITE-ProRule annotationAdd BLAST215
Domaini784 – 831Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini832 – 877Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST46
Domaini878 – 927Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST50
Domaini928 – 986Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST59
Domaini987 – 1038Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST52
Domaini1039 – 1095Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST57
Domaini1096 – 1143Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST48
Domaini1144 – 1190Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1191 – 1410Domain IIAdd BLAST220
Regioni1411 – 1443Domain alphaAdd BLAST33
Regioni1444 – 1799Domain IAdd BLAST356

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1257 – 1304Sequence analysisAdd BLAST48
Coiled coili1473 – 1527Sequence analysisAdd BLAST55
Coiled coili1577 – 1791Sequence analysisAdd BLAST215

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994 Eukaryota
ENOG410XPEG LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007552

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q61292

KEGG Orthology (KO)

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KOi
K06243

Identification of Orthologs from Complete Genome Data

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OMAi
QIQIYNT

Database of Orthologous Groups

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OrthoDBi
65841at2759

TreeFam database of animal gene trees

More...
TreeFami
TF312903

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 12 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q61292-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWASGEPGR GRQGQPLPWE LRLGLLLSVL AATLAQAPSL DVPGCSRGSC
60 70 80 90 100
YPATGDLLVG RADRLTASST CGLHSPQPYC IVSHLQDEKK CFLCDSRRPF
110 120 130 140 150
SARDNPNSHR IQNVVTSFAP QRRTAWWQSE NGVPMVTIQL DLEAEFHFTH
160 170 180 190 200
LIMTFKTFRP AAMLVERSAD FGRTWHVYRY FSYDCGADFP GIPLAPPRRW
210 220 230 240 250
DDVVCESRYS EIEPSTEGEV IYRVLDPAIP IPDPYSSRIQ NLLKITNLRV
260 270 280 290 300
NLTRLHTLGD NLLDPRREIR EKYYYALYEL VIRGNCFCYG HASQCAPAPG
310 320 330 340 350
APAHAEGMVH GACICKHNTR GLNCEQCQDF YQDLPWHPAE DGHTHACRKC
360 370 380 390 400
ECNGHTHSCH FDMAVYLASG NVSGGVCDGC QHNTAGRHCE FCRPFFYRDP
410 420 430 440 450
TKDMRDPAVC RPCDCDPMGS QDGGRCDSHD DPVLGLVSGQ CRCKEHVVGT
460 470 480 490 500
RCQQCRDGFF GLSASDPRGC QRCQCNSRGT VPGSSPCDSS SGTCFCKRLV
510 520 530 540 550
TGHGCDRCLP GHWGLSHDLL GCRPCDCDVG GALDPQCDEA TGQCRCRQHM
560 570 580 590 600
IGRRCEQVQP GYFRPFLDHL TWEAEAAQGQ GLEVVERLVT NRETPSWTGP
610 620 630 640 650
GFVRLREGQE VEFLVTSLPR AMDYDLLLRW EPQVPEQWAE LELMVQRPGP
660 670 680 690 700
VSAHSPCGHV LPKDDRIQGM LHPNTRFLVF PRPVCLEPGI SYKLKLKLIG
710 720 730 740 750
TGGRAQPETS YSGLLIDSLV LQPHVLVLEM FSGGDAAALE RRTTFERYRC
760 770 780 790 800
HEEGLMPSKA PLSETCAPLL ISVSALIYNG ALPCQCDPQG SLSSECSPHG
810 820 830 840 850
GQCRCKPGVV GRRCDVCATG YYGFGPAGCQ ACQCSPDGAL SALCEGTSGQ
860 870 880 890 900
CPCRPGAFGL RCDHCQRGQW GFPNCRPCVC NGRADECDTH TGACLGCRDY
910 920 930 940 950
TGGEHCERCI AGFHGDPRLP YGGQCRPCPC PEGPGSQRHF ATSCHRDGYS
960 970 980 990 1000
QQIVCQCREG YTGLRCEACA PGHFGDPSKP GGRCQLCECS GNIDPMDPDA
1010 1020 1030 1040 1050
CDPHTGQCLR CLHNTEGPHC GYCKPGFHGQ AARQSCHRCT CNLLGTDPRR
1060 1070 1080 1090 1100
CPSTDLCHCD PSTGQCPCLP HVQGLNCDHC APNFWNFTSG RGCQPCACHP
1110 1120 1130 1140 1150
SRARGPTCNE FTGQCHCHAG FGGRTCSECQ ELYWGDPGLQ CRACDCDPRG
1160 1170 1180 1190 1200
IDKPQCHRST GHCSCRPGVS GVRCDQCARG FSGVFPACHP CHACFGDWDR
1210 1220 1230 1240 1250
VVQDLAARTR RLEQWAQELQ QTGVLGAFES SFLNMQGKLG MVQAIMSARN
1260 1270 1280 1290 1300
ASAASTAKLV EATEGLRHEI GKTTERLTQL EAELTAVQDE NFNANHALSG
1310 1320 1330 1340 1350
LERDGLALNL TLRQLDQHLE ILKHSNFLGA YDSIRHAHSQ STEAERRANA
1360 1370 1380 1390 1400
STFAVPSPVS NSADTRRRTE VLMGAQKENF NRQHLANQQA LGRLSAHAHT
1410 1420 1430 1440 1450
LSLTGINELV CGAPGDAPCA TSPCGGAGCR DEDGQPRCGG LGCSGAAATA
1460 1470 1480 1490 1500
DLALGRARHT QAELQRALVE GGGILSRVSE TRRQAEEAQQ RAQAALDKAN
1510 1520 1530 1540 1550
ASRGQVEQAN QELRELIQNV KDFLSQEGAD PDSIEMVATR VLDISIPASP
1560 1570 1580 1590 1600
EQIQRLASEI AERVRSLADV DTILAHTMGD VRRAEQLLQD AHRARSRAEG
1610 1620 1630 1640 1650
ERQKAETVQA ALEEAQRAQG AAQGAIWGAV VDTQNTEQTL QRVQERMAGA
1660 1670 1680 1690 1700
EKSLNSAGER ARQLDALLEA LKLKRAGNSL AASTAEETAG SAQSRAREAE
1710 1720 1730 1740 1750
KQLREQVGDQ YQTVRALAER KAEGVLAAQA RAEQLRDEAR DLLQAAQDKL
1760 1770 1780 1790
QRLQELEGTY EENERALEGK AAQLDGLEAR MRSVLQAINL QVQIYNTCQ
Length:1,799
Mass (Da):196,579
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37CA24B9CDA0791F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWY6A0A0A6YWY6_MOUSE
Laminin subunit beta-2
Lamb2
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YY71A0A0A6YY71_MOUSE
Laminin subunit beta-2
Lamb2
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWI2A0A0A6YWI2_MOUSE
Laminin subunit beta-2
Lamb2
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti545R → P in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti581G → V in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti677F → V in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti956Q → H in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti959E → A in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti973H → P in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1306L → F in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1449T → P in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1460T → S in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1487E → A in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1627W → R in AAC53535 (PubMed:8662701).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U43541, U42624 Genomic DNA Translation: AAC53535.1
CH466560 Genomic DNA Translation: EDL21291.1
CH466560 Genomic DNA Translation: EDL21292.1
BC026051 mRNA Translation: AAH26051.1
X75928 mRNA Translation: CAA53532.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS23528.1

Protein sequence database of the Protein Information Resource

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PIRi
I48749

NCBI Reference Sequences

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RefSeqi
NP_032509.2, NM_008483.3
XP_006511711.1, XM_006511648.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000065014; ENSMUSP00000069087; ENSMUSG00000052911

Database of genes from NCBI RefSeq genomes

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GeneIDi
16779

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:16779

UCSC genome browser

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UCSCi
uc009rpr.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43541, U42624 Genomic DNA Translation: AAC53535.1
CH466560 Genomic DNA Translation: EDL21291.1
CH466560 Genomic DNA Translation: EDL21292.1
BC026051 mRNA Translation: AAH26051.1
X75928 mRNA Translation: CAA53532.1
CCDSiCCDS23528.1
PIRiI48749
RefSeqiNP_032509.2, NM_008483.3
XP_006511711.1, XM_006511648.2

3D structure databases

SMRiQ61292
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201102, 2 interactors
ComplexPortaliCPX-3010 Laminin-121 complex
CPX-3011 Laminin-221 complex
CPX-3014 Laminin-321 complex
CPX-3017 Laminin-521 complex
CPX-3019 Laminin-423 complex
CPX-3020 Laminin-522 complex
CPX-3021 Laminin-523 complex
CPX-3031 Laminin-421 complex
IntActiQ61292, 2 interactors
MINTiQ61292
STRINGi10090.ENSMUSP00000069087

PTM databases

GlyConnecti2460
iPTMnetiQ61292
PhosphoSitePlusiQ61292

Proteomic databases

MaxQBiQ61292
PaxDbiQ61292
PeptideAtlasiQ61292
PRIDEiQ61292

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065014; ENSMUSP00000069087; ENSMUSG00000052911
GeneIDi16779
KEGGimmu:16779
UCSCiuc009rpr.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3913
MGIiMGI:99916 Lamb2

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00940000156060
HOGENOMiHOG000007552
InParanoidiQ61292
KOiK06243
OMAiQIQIYNT
OrthoDBi65841at2759
TreeFamiTF312903

Enzyme and pathway databases

ReactomeiR-MMU-3000157 Laminin interactions
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Lamb2 mouse

Protein Ontology

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PROi
PR:Q61292

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000052911 Expressed in 282 organ(s), highest expression level in decidua
ExpressionAtlasiQ61292 baseline and differential
GenevisibleiQ61292 MM

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 12 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMB2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61292
Secondary accession number(s): Q62182, Q8R0Y0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 3, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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