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Entry version 168 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Voltage-dependent R-type calcium channel subunit alpha-1E

Gene

Cacna1e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei310Calcium ion selectivity and permeabilityBy similarity1
Sitei658Calcium ion selectivity and permeabilityBy similarity1
Sitei1375Calcium ion selectivity and permeabilityBy similarity1
Sitei1666Calcium ion selectivity and permeabilityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi427 – 438PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi1755 – 1766PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-112308, Presynaptic depolarization and calcium channel opening
R-MMU-422356, Regulation of insulin secretion

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.11.3, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent R-type calcium channel subunit alpha-1E
Alternative name(s):
Brain calcium channel II
Short name:
BII
Calcium channel, L type, alpha-1 polypeptide, isoform 6
Voltage-gated calcium channel subunit alpha Cav2.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1e
Synonyms:Cach6, Cacnl1a6, Cchra1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106217, Cacna1e

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 90CytoplasmicSequence analysisAdd BLAST90
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei91 – 109Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini110 – 128ExtracellularSequence analysisAdd BLAST19
Transmembranei129 – 147Helical; Name=S2 of repeat ISequence analysisAdd BLAST19
Topological domaini148 – 159CytoplasmicSequence analysisAdd BLAST12
Transmembranei160 – 174Helical; Name=S3 of repeat ISequence analysisAdd BLAST15
Topological domaini175 – 186ExtracellularSequence analysisAdd BLAST12
Transmembranei187 – 206Helical; Name=S4 of repeat ISequence analysisAdd BLAST20
Topological domaini207 – 224CytoplasmicSequence analysisAdd BLAST18
Transmembranei225 – 245Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini246 – 327ExtracellularSequence analysisAdd BLAST82
Transmembranei328 – 351Helical; Name=S6 of repeat ISequence analysisAdd BLAST24
Topological domaini352 – 477CytoplasmicSequence analysisAdd BLAST126
Transmembranei478 – 497Helical; Name=S1 of repeat IISequence analysisAdd BLAST20
Topological domaini498 – 510ExtracellularSequence analysisAdd BLAST13
Transmembranei511 – 530Helical; Name=S2 of repeat IISequence analysisAdd BLAST20
Topological domaini531 – 539CytoplasmicSequence analysis9
Transmembranei540 – 558Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini559 – 568ExtracellularSequence analysis10
Transmembranei569 – 587Helical; Name=S4 of repeat IISequence analysisAdd BLAST19
Topological domaini588 – 606CytoplasmicSequence analysisAdd BLAST19
Transmembranei607 – 626Helical; Name=S5 of repeat IISequence analysisAdd BLAST20
Topological domaini627 – 679ExtracellularSequence analysisAdd BLAST53
Transmembranei680 – 704Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini705 – 1150CytoplasmicSequence analysisAdd BLAST446
Transmembranei1151 – 1167Helical; Name=S1 of repeat IIISequence analysisAdd BLAST17
Topological domaini1168 – 1191ExtracellularSequence analysisAdd BLAST24
Transmembranei1192 – 1211Helical; Name=S2 of repeat IIISequence analysisAdd BLAST20
Topological domaini1212 – 1219CytoplasmicSequence analysis8
Transmembranei1220 – 1242Helical; Name=S3 of repeat IIISequence analysisAdd BLAST23
Topological domaini1243 – 1256ExtracellularSequence analysisAdd BLAST14
Transmembranei1257 – 1274Helical; Name=S4 of repeat IIISequence analysisAdd BLAST18
Topological domaini1275 – 1293CytoplasmicSequence analysisAdd BLAST19
Transmembranei1294 – 1313Helical; Name=S5 of repeat IIISequence analysisAdd BLAST20
Topological domaini1314 – 1400ExtracellularSequence analysisAdd BLAST87
Transmembranei1401 – 1424Helical; Name=S6 of repeat IIISequence analysisAdd BLAST24
Topological domaini1425 – 1481CytoplasmicSequence analysisAdd BLAST57
Transmembranei1482 – 1500Helical; Name=S1 of repeat IVSequence analysisAdd BLAST19
Topological domaini1501 – 1515ExtracellularSequence analysisAdd BLAST15
Transmembranei1516 – 1535Helical; Name=S2 of repeat IVSequence analysisAdd BLAST20
Topological domaini1536 – 1543CytoplasmicSequence analysis8
Transmembranei1544 – 1562Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1563 – 1573ExtracellularSequence analysisAdd BLAST11
Transmembranei1574 – 1592Helical; Name=S4 of repeat IVSequence analysisAdd BLAST19
Topological domaini1593 – 1611CytoplasmicSequence analysisAdd BLAST19
Transmembranei1612 – 1631Helical; Name=S5 of repeat IVSequence analysisAdd BLAST20
Topological domaini1632 – 1700ExtracellularSequence analysisAdd BLAST69
Transmembranei1701 – 1726Helical; Name=S6 of repeat IVSequence analysisAdd BLAST26
Topological domaini1727 – 2272CytoplasmicSequence analysisAdd BLAST546

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539391 – 2272Voltage-dependent R-type calcium channel subunit alpha-1EAdd BLAST2272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei428PhosphoserineCombined sources1
Modified residuei441PhosphothreonineCombined sources1
Modified residuei737PhosphoserineBy similarity1
Modified residuei746PhosphoserineCombined sources1
Modified residuei794PhosphoserineBy similarity1
Modified residuei816PhosphoserineCombined sources1
Modified residuei856PhosphoserineCombined sources1
Modified residuei948PhosphoserineBy similarity1
Modified residuei1099PhosphoserineBy similarity1
Glycosylationi1569N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1692N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2054PhosphoserineCombined sources1
Modified residuei2073PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q61290

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q61290

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61290

PRoteomics IDEntifications database

More...
PRIDEi
Q61290

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
273884

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q61290, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61290

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61290

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neuronal tissues, retina, spleen, and pancreatic islet cells.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EFHC1. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q61290, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000140937

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q61290, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati77 – 355IAdd BLAST279
Repeati463 – 707IIAdd BLAST245
Repeati1143 – 1429IIIAdd BLAST287
Repeati1466 – 1729IVAdd BLAST264
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1742 – 1777EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40DisorderedSequence analysisAdd BLAST40
Regioni375 – 392Binding to the beta subunitBy similarityAdd BLAST18
Regioni730 – 777DisorderedSequence analysisAdd BLAST48
Regioni854 – 994DisorderedSequence analysisAdd BLAST141
Regioni1091 – 1127DisorderedSequence analysisAdd BLAST37
Regioni2021 – 2186DisorderedSequence analysisAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi746 – 766Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi951 – 984Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi1098 – 1127Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi2025 – 2082Basic and acidic residuesSequence analysisAdd BLAST58
Compositional biasi2083 – 2116Polar residuesSequence analysisAdd BLAST34
Compositional biasi2155 – 2185Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q61290

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q61290

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005449, VDCC_R_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45628:SF5, PTHR45628:SF5, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01633, RVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q61290-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARFGEAVVV GRPGSGDGDS DQSRNRQGTP VPASGPAAAY KQSKAQRART
60 70 80 90 100
MALYNPIPVR QNCFTVNRSL FIFGEDNIVR KYAKKLIDWP PFEYMILATI
110 120 130 140 150
IANCIVLALE QHLPEDDKTP MSRRLEKTEP YFIGIFCFEA GIKIVALGFI
160 170 180 190 200
FHKGSYLRNG WNVMDFIVVL SGILATAGTH FNTHVDLRAL RAVRVLRPLK
210 220 230 240 250
LVSGIPSLQI VLKSIMKAMV PLLQIGLLLF FAILMFAIIG LEFYSGKLHR
260 270 280 290 300
ACFMNNSGIL EGFDPPHPCG VQGCPAGYEC KDWIGPNDGI TQFDNILFAV
310 320 330 340 350
LTVFQCITME GWTTVLYNTN DALGATWNWL YFIPLIIIGS FFVLNLVLGV
360 370 380 390 400
LSGEFAKERE RVENRRAFMK LRRQQQIERE LNGYRAWIDK AEEVMLAEEN
410 420 430 440 450
KNSGTSALEV LRRATIKRSR TEAMTRDSSD EHCVDISSVG TPLARASIKS
460 470 480 490 500
TKVDGASYFR HKERLLRISI RHMVKSQVFY WIVLSVVALN TACVAIVHHN
510 520 530 540 550
QPQWLTHLLY YAEFLFLGLF LLEMSLKMYG MGPRLYFHSS FNCFDFGVTV
560 570 580 590 600
GSIFEVVWAI FRPGTSFGIS VLRALRLLRI FKITKYWASL RNLVVSLMSS
610 620 630 640 650
MKSIISLLFL LFLFIVVFAL LGMQLFGGRF NFNDGTPSAN FDTFPAAIMT
660 670 680 690 700
VFQILTGEDW NEVMYNGIRS QGGVSSGMWS AIYFIVLTLF GNYTLLNVFL
710 720 730 740 750
AIAVDNLANA QELTKDEQEE EEAFNQKHAL QKAKEVSPMS APNMPSIERD
760 770 780 790 800
RRRRHHMSMW EPRSSHLRER RRRHHMSVWE QRTSQLRRHM QMSSQEALNK
810 820 830 840 850
EEAPPMNPLN PLNPLSPLNP LNAHPSLYRR PRPIEGLALG LGLEKCEEER
860 870 880 890 900
ISRGGSLKGD IGGLTSALDN QRSPLSLGKR EPPWLPRSCH GNCDPIQQEA
910 920 930 940 950
GGGETVVTFE DRARHRQSQR RSRHRRVRTE GKDSASASRS RSASQERSLD
960 970 980 990 1000
EGVSVEGEKE HEPHSSHRSK EPTIHEEERT QDLRRTNSLM VPRGSGLVGA
1010 1020 1030 1040 1050
LDEAETPLVQ PQPELEVGKD AALTEQEAEG SSEQALLGDV QLDVGRGISQ
1060 1070 1080 1090 1100
SEPDLSCMTA NMDKATTEST SVTVAIPDVD PLVDSTVVNI SNKTDGEASP
1110 1120 1130 1140 1150
LKEAETKEEE EEVEKKKKQK KEKRETGKAM VPHSSMFIFS TTNPIRRACH
1160 1170 1180 1190 1200
YIVNLRYFEM CILLVIAASS IALAAEDPVL TNSERNKVLR YFDYVFTGVF
1210 1220 1230 1240 1250
TFEMVIKMID QGLILQDGSY FRDLWNILDF VVVVGALVAF ALANALGTNK
1260 1270 1280 1290 1300
GRDIKTIKSL RVLRVLRPLK TIKRLPKLKA VFDCVVTSLK NVFNILIVYK
1310 1320 1330 1340 1350
LFMFIFAVIA VQLFKGKFFY CTDSSKDTEK ECIGNYVDHE KNKMEVKGRE
1360 1370 1380 1390 1400
WKRHEFHYDN IIWALLTLFT VSTGEGWPQV LQHSVDVTEE DRGPSRSNRM
1410 1420 1430 1440 1450
EMSIFYVVYF VVFPFFFVNI FVALIIITFQ EQGDKMMEEC SLEKNERACI
1460 1470 1480 1490 1500
DFAISAKPLT RYMPQNRHTF QYRVWHFVVS PSFEYTIMAM IALNTVVLMM
1510 1520 1530 1540 1550
KYYTAPCTYE LALKYLNIAF TMVFSLECVL KVIAFGFLNY FRDTWNIFDF
1560 1570 1580 1590 1600
ITVIGSITEI ILTDSKLVNT SGFNMSFLKL FRAARLIKLL RQGYTIRILL
1610 1620 1630 1640 1650
WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ VFGNIKLDEE SHINRHNNFR
1660 1670 1680 1690 1700
SFFGSLMLLF RSATGEAWQE IMLSCLGEKG CEPDTTAPSG QNESERCGTD
1710 1720 1730 1740 1750
LAYVYFVSFI FFCSFLMLNL FVAVIMDNFE YLTRDSSILG PHHLDEFVRV
1760 1770 1780 1790 1800
WAEYDRAACG RIHYTEMYEM LTLMSPPLGL GKRCPSKVAY KRLVLMNMPV
1810 1820 1830 1840 1850
AEDMTVHFTS TLMALIRTAL DIKIAKGGAD RQQLDSELQK ETLAIWPHLS
1860 1870 1880 1890 1900
QKMLDLLVPM PKASDLTVGK IYAAMMIMDY YKQSKVKKQR QQLEEQKNAP
1910 1920 1930 1940 1950
MFQRMEPSSL PQEIIANAKA LPYLQQDPVS GLSGRSGYPS MSPLSPQEIF
1960 1970 1980 1990 2000
QLACMDPADD GQFQEQQSLV VTDPSSMRRS FSTIRDKRSN SSWLEEFSME
2010 2020 2030 2040 2050
RSSENTYKSR RRSYHSSLRL SAHRLNSDSG HKSDTHRSGG RERGRSKERK
2060 2070 2080 2090 2100
HLLSPDVSRC NSEERGTQAD WESPERRQSR SPSEGRSQTP NRQGTGSLSE
2110 2120 2130 2140 2150
SSIPSISDTS TPRRSRRQLP PVPPKPRPLL SYSSLMRHTG GISPPPDGSE
2160 2170 2180 2190 2200
GGSPLASQAL ESNSACLTES SNSLHPQQGQ HPSPQHYISE PYLALHEDSH
2210 2220 2230 2240 2250
ASDCGEEETL TFEAAVATSL GRSNTIGSAP PLRHSWQMPN GHYRRRRWGA
2260 2270
WAGMMCGAVS DLLSDTEEDD KC
Length:2,272
Mass (Da):257,236
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70D9200B9E0C87A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WS83A0A087WS83_MOUSE
Voltage-dependent R-type calcium ch...
Cacna1e
2,273Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QK20E9QK20_MOUSE
Voltage-dependent R-type calcium ch...
Cacna1e
1,965Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLU3A0A1D5RLU3_MOUSE
Voltage-dependent R-type calcium ch...
Cacna1e
2,254Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BF18A0A571BF18_MOUSE
Voltage-dependent R-type calcium ch...
Cacna1e
585Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BPS0A0A2I3BPS0_MOUSE
Voltage-dependent R-type calcium ch...
Cacna1e
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L29346 mRNA Translation: AAA59206.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C54972

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29346 mRNA Translation: AAA59206.1
PIRiC54972

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ61290, 5 interactors
STRINGi10090.ENSMUSP00000140937

Protein family/group databases

TCDBi1.A.1.11.3, the voltage-gated ion channel (vic) superfamily

PTM databases

GlyGeniQ61290, 3 sites
iPTMnetiQ61290
PhosphoSitePlusiQ61290

Proteomic databases

EPDiQ61290
MaxQBiQ61290
PaxDbiQ61290
PRIDEiQ61290
ProteomicsDBi273884

Organism-specific databases

MGIiMGI:106217, Cacna1e

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
InParanoidiQ61290
PhylomeDBiQ61290

Enzyme and pathway databases

ReactomeiR-MMU-112308, Presynaptic depolarization and calcium channel opening
R-MMU-422356, Regulation of insulin secretion

Miscellaneous databases

Protein Ontology

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PROi
PR:Q61290
RNActiQ61290, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048, EF_hand_dom
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005449, VDCC_R_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR45628:SF5, PTHR45628:SF5, 2 hits
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01633, RVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1E_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61290
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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