Serine/threonine-protein kinase receptor R3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• [receptor-protein]-L-threonine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  + ATP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  = [receptor-protein]-O-phospho-L-threonine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  + ADP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.
  EC:2.7.11.30
  • Search proteins in UniProtKB for this EC number.
  • See the description of this EC number in ENZYME.
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

  . Show »« Hide
  [receptor-protein]-L-threonine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  

  L-threonine residue

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  ATP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  =

  [receptor-protein]-O-phospho-L-threonine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  

  O-phospho-L-threonine residue

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  ADP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  
• [receptor-protein]-L-serine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  + ATP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  = [receptor-protein]-O-phospho-L-serine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  + ADP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.
  EC:2.7.11.30
  • Search proteins in UniProtKB for this EC number.
  • See the description of this EC number in ENZYME.
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

  . Show »« Hide
  [receptor-protein]-L-serine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  

  L-serine residue

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  ATP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  =

  [receptor-protein]-O-phospho-L-serine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  

  O-phospho-L-serine residue

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  ADP

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activin binding Source: MGI
• activin receptor activity, type I Source: MGI
• ATP binding Source: MGI
• BMP receptor activity Source: UniProtKB
• metal ion binding Source: UniProtKB-KW
• protein kinase binding Source: MGI
• protein serine/threonine kinase activity Source: MGI
• SMAD binding Source: MGI
• transforming growth factor beta-activated receptor activity Source: MGI
• transforming growth factor beta binding Source: MGI
• transforming growth factor beta receptor activity, type I Source: MGI

GO - Biological processⁱ

• angiogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis."
    Oh S.P., Seki T., Goss K.A., Imamura T., Yi Y., Donahoe P.K., Li L., Miyazono K., ten Dijke P., Kim S., Li E.
    Proc. Natl. Acad. Sci. U.S.A. 97:2626-2631(2000) [PubMed] [Europe PMC] [Abstract]
  • "Arteriovenous malformations in mice lacking activin receptor-like kinase-1."
    Urness L.D., Sorensen L.K., Li D.Y.
    Nat. Genet. 26:328-331(2000) [PubMed] [Europe PMC] [Abstract]
• artery development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "ALK1 signaling regulates early postnatal lymphatic vessel development."
    Niessen K., Zhang G., Ridgway J.B., Chen H., Yan M.
    Blood 115:1654-1661(2010) [PubMed] [Europe PMC] [Abstract]
• blood circulation Source: MGI
• blood vessel morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Activin receptor-like kinase 1 is essential for placental vascular development in mice."
    Hong K.H., Seki T., Oh S.P.
    Lab. Invest. 87:670-679(2007) [PubMed] [Europe PMC] [Abstract]
  • "ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2."
    Park S.O., Lee Y.J., Seki T., Hong K.H., Fliess N., Jiang Z., Park A., Wu X., Kaartinen V., Roman B.L., Oh S.P.
    Blood 111:633-642(2008) [PubMed] [Europe PMC] [Abstract]
• blood vessel remodeling Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "ALK1 signaling regulates early postnatal lymphatic vessel development."
    Niessen K., Zhang G., Ridgway J.B., Chen H., Yan M.
    Blood 115:1654-1661(2010) [PubMed] [Europe PMC] [Abstract]
• BMP signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis."
    Somekawa S., Imagawa K., Hayashi H., Sakabe M., Ioka T., Sato G.E., Inada K., Iwamoto T., Mori T., Uemura S., Nakagawa O., Saito Y.
    Proc. Natl. Acad. Sci. U.S.A. 109:12064-12069(2012) [PubMed] [Europe PMC] [Abstract]
• cellular response to BMP stimulus Source: MGI
• cellular response to growth factor stimulus Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to transforming growth factor beta stimulus Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice."
    Blaney Davidson E.N., Remst D.F., Vitters E.L., van Beuningen H.M., Blom A.B., Goumans M.J., van den Berg W.B., van der Kraan P.M.
    J. Immunol. 182:7937-7945(2009) [PubMed] [Europe PMC] [Abstract]
• dorsal aorta morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor."
    Sorensen L.K., Brooke B.S., Li D.Y., Urness L.D.
    Dev. Biol. 261:235-250(2003) [PubMed] [Europe PMC] [Abstract]
• endocardial cushion morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor."
    Sorensen L.K., Brooke B.S., Li D.Y., Urness L.D.
    Dev. Biol. 261:235-250(2003) [PubMed] [Europe PMC] [Abstract]
• endothelial cell activation Source: DFLAT <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo."
    Suzuki Y., Ohga N., Morishita Y., Hida K., Miyazono K., Watabe T.
    J. Cell. Sci. 123:1684-1692(2010) [PubMed] [Europe PMC] [Abstract]
• endothelial tube morphogenesis Source: MGI
• heart development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2."
    Park S.O., Lee Y.J., Seki T., Hong K.H., Fliess N., Jiang Z., Park A., Wu X., Kaartinen V., Roman B.L., Oh S.P.
    Blood 111:633-642(2008) [PubMed] [Europe PMC] [Abstract]
• lymphangiogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "ALK1 signaling regulates early postnatal lymphatic vessel development."
    Niessen K., Zhang G., Ridgway J.B., Chen H., Yan M.
    Blood 115:1654-1661(2010) [PubMed] [Europe PMC] [Abstract]
• lymphatic endothelial cell differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "ALK1 signaling regulates early postnatal lymphatic vessel development."
    Niessen K., Zhang G., Ridgway J.B., Chen H., Yan M.
    Blood 115:1654-1661(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of blood vessel endothelial cell migration Source: MGI
• negative regulation of cell adhesion Source: MGI
• negative regulation of cell growth Source: MGI
• negative regulation of cell migration Source: MGI
• negative regulation of cell population proliferation Source: MGI
• negative regulation of DNA biosynthetic process Source: MGI
• negative regulation of endothelial cell differentiation Source: DFLATInferred from direct assayⁱ
  • "BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo."
    Suzuki Y., Ohga N., Morishita Y., Hida K., Miyazono K., Watabe T.
    J. Cell. Sci. 123:1684-1692(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of endothelial cell migration Source: MGI
• negative regulation of endothelial cell proliferation Source: DFLATInferred from direct assayⁱ
  • "BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo."
    Suzuki Y., Ohga N., Morishita Y., Hida K., Miyazono K., Watabe T.
    J. Cell. Sci. 123:1684-1692(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of focal adhesion assembly Source: MGI
• negative regulation of gene expression Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor."
    Sorensen L.K., Brooke B.S., Li D.Y., Urness L.D.
    Dev. Biol. 261:235-250(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "LRG1 promotes angiogenesis by modulating endothelial TGF-beta signalling."
    Wang X., Abraham S., McKenzie J.A.G., Jeffs N., Swire M., Tripathi V.B., Luhmann U.F.O., Lange C.A.K., Zhai Z., Arthur H.M., Bainbridge J., Moss S.E., Greenwood J.
    Nature 499:306-311(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of BMP signaling pathway Source: DFLATInferred from direct assayⁱ
  • "BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo."
    Suzuki Y., Ohga N., Morishita Y., Hida K., Miyazono K., Watabe T.
    J. Cell. Sci. 123:1684-1692(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell differentiation Source: DFLATInferred from direct assayⁱ
  • "BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo."
    Suzuki Y., Ohga N., Morishita Y., Hida K., Miyazono K., Watabe T.
    J. Cell. Sci. 123:1684-1692(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell proliferation Source: DFLATInferred from direct assayⁱ
  • "BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo."
    Suzuki Y., Ohga N., Morishita Y., Hida K., Miyazono K., Watabe T.
    J. Cell. Sci. 123:1684-1692(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
• positive regulation of transcription, DNA-templated Source: DFLATInferred from mutant phenotypeⁱ
  • "BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo."
    Suzuki Y., Ohga N., Morishita Y., Hida K., Miyazono K., Watabe T.
    J. Cell. Sci. 123:1684-1692(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor."
    Sorensen L.K., Brooke B.S., Li D.Y., Urness L.D.
    Dev. Biol. 261:235-250(2003) [PubMed] [Europe PMC] [Abstract]
• protein phosphorylation Source: MGI
• regulation of blood pressure Source: MGI
• regulation of transcription, DNA-templated Source: MGI
• response to hypoxia Source: Ensembl
• retina vasculature development in camera-type eye Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "ALK1 signaling regulates early postnatal lymphatic vessel development."
    Niessen K., Zhang G., Ridgway J.B., Chen H., Yan M.
    Blood 115:1654-1661(2010) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: MGI
• transforming growth factor beta receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • "Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling."
    Goumans M.J., Valdimarsdottir G., Itoh S., Lebrin F., Larsson J., Mummery C., Karlsson S., ten Dijke P.
    Mol. Cell 12:817-828(2003) [PubMed] [Europe PMC] [Abstract]
• venous blood vessel development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "ALK1 signaling regulates early postnatal lymphatic vessel development."
    Niessen K., Zhang G., Ridgway J.B., Chen H., Yan M.
    Blood 115:1654-1661(2010) [PubMed] [Europe PMC] [Abstract]
• wound healing, spreading of epidermal cells Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: MGI
• SMAD binding Source: MGI
• transforming growth factor beta binding Source: MGI

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MTLGSFRRGL LMLSVAFGLT RGDLAKPSKL VNCTCESPHC KRPFCQGSWC 
        60         70         80         90        100
TVVLVREQGR HPQVYRGCGS LNQELCLGRP TEFLNHHCCY RSFCNHNVSL 
       110        120        130        140        150
MLEATQTPSE EPEVDAHLPL ILGPVLALPV LVALGALGLW RVRRRQEKQR 
       160        170        180        190        200
DLHSDLGESS LILKASEQAD SMLGDFLDSD CTTGSGSGLP FLVQRTVARQ 
       210        220        230        240        250
VALVECVGKG RYGEVWRGSW HGESVAVKIF SSRDEQSWFR ETEIYNTVLL 
       260        270        280        290        300
RHDNILGFIA SDMTSRNSST QLWLITHYHE HGSLYDFLQR QTLEPQLALR 
       310        320        330        340        350
LAVSAACGLA HLHVEIFGTQ GKPAIAHRDL KSRNVLVKSN LQCCIADLGL 
       360        370        380        390        400
AVMHSQSSDY LDIGNNPRVG TKRYMAPEVL DEHIRTDCFE SYKWTDIWAF 
       410        420        430        440        450
GLVLWEIARR TIINGIVEDY RPPFYDMVPN DPSFEDMKKV VCVDQQTPTI 
       460        470        480        490        500
PNRLAADPVL SGLAQMMREC WYPNPSARLT ALRIKKTLQK LSHNPEKPKV 

IH                                                     

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. Human and mouse protein kinases
   Human and mouse protein kinases: classification and index