UniProtKB - Q61288 (ACVL1_MOUSE)
Protein
Serine/threonine-protein kinase receptor R3
Gene
Acvrl1
Organism
Mus musculus (Mouse)
Status
Functioni
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.By similarity
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 228 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 329 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 207 – 215 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- activin binding Source: MGI
- activin receptor activity, type I Source: MGI
- ATP binding Source: MGI
- BMP receptor activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- protein kinase binding Source: MGI
- protein serine/threonine kinase activity Source: MGI
- SMAD binding Source: MGI
- transforming growth factor beta-activated receptor activity Source: MGI
- transforming growth factor beta binding Source: MGI
- transforming growth factor beta receptor activity, type I Source: MGI
GO - Biological processi
- angiogenesis Source: MGI
- artery development Source: BHF-UCL
- blood circulation Source: MGI
- blood vessel morphogenesis Source: MGI
- blood vessel remodeling Source: BHF-UCL
- BMP signaling pathway Source: MGI
- cellular response to BMP stimulus Source: MGI
- cellular response to growth factor stimulus Source: GO_Central
- cellular response to transforming growth factor beta stimulus Source: BHF-UCL
- dorsal/ventral pattern formation Source: GO_Central
- dorsal aorta morphogenesis Source: BHF-UCL
- endocardial cushion morphogenesis Source: BHF-UCL
- endothelial cell activation Source: DFLAT
- endothelial tube morphogenesis Source: MGI
- heart development Source: GO_Central
- in utero embryonic development Source: MGI
- lymphangiogenesis Source: BHF-UCL
- lymphatic endothelial cell differentiation Source: BHF-UCL
- negative regulation of blood vessel endothelial cell migration Source: MGI
- negative regulation of cell adhesion Source: MGI
- negative regulation of cell growth Source: MGI
- negative regulation of cell migration Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of DNA biosynthetic process Source: MGI
- negative regulation of endothelial cell differentiation Source: DFLAT
- negative regulation of endothelial cell migration Source: MGI
- negative regulation of endothelial cell proliferation Source: DFLAT
- negative regulation of focal adhesion assembly Source: MGI
- negative regulation of gene expression Source: BHF-UCL
- positive regulation of angiogenesis Source: MGI
- positive regulation of BMP signaling pathway Source: DFLAT
- positive regulation of endothelial cell differentiation Source: DFLAT
- positive regulation of endothelial cell proliferation Source: DFLAT
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
- positive regulation of transcription, DNA-templated Source: DFLAT
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- protein phosphorylation Source: MGI
- regulation of blood pressure Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- response to hypoxia Source: Ensembl
- retina vasculature development in camera-type eye Source: BHF-UCL
- signal transduction Source: MGI
- transforming growth factor beta receptor signaling pathway Source: MGI
- venous blood vessel development Source: BHF-UCL
- wound healing, spreading of epidermal cells Source: MGI
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Biological process | Angiogenesis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 3474 |
Reactomei | R-MMU-201451, Signaling by BMP |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase receptor R3 (EC:2.7.11.30)Short name: SKR3 Alternative name(s): Activin receptor-like kinase 1 Short name: ALK-1 TGF-B superfamily receptor type I Short name: TSR-I |
Gene namesi | Name:Acvrl1 Synonyms:Acvrlk1, Alk-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338946, Acvrl1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Plasma Membrane
- BMP receptor complex Source: GO_Central
- integral component of plasma membrane Source: MGI
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: MGI
- dendrite Source: MGI
- neuronal cell body Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 119 | ExtracellularSequence analysisAdd BLAST | 97 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 141 – 502 | CytoplasmicSequence analysisAdd BLAST | 362 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000024421 | 23 – 502 | Serine/threonine-protein kinase receptor R3Add BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 33 ↔ 50 | By similarity | ||
Disulfide bondi | 35 ↔ 40 | By similarity | ||
Disulfide bondi | 45 ↔ 68 | By similarity | ||
Disulfide bondi | 76 ↔ 88 | By similarity | ||
Disulfide bondi | 89 ↔ 94 | By similarity | ||
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 154 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | PhosphoserineCombined sources | 1 | |
Modified residuei | 160 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q61288 |
MaxQBi | Q61288 |
PaxDbi | Q61288 |
PeptideAtlasi | Q61288 |
PRIDEi | Q61288 |
PTM databases
GlyConnecti | 2704, 1 N-Linked glycan (1 site) |
GlyGeni | Q61288, 2 sites |
iPTMneti | Q61288 |
PhosphoSitePlusi | Q61288 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000530, Expressed in lung and 224 other tissues |
ExpressionAtlasi | Q61288, baseline and differential |
Genevisiblei | Q61288, MM |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: MGI
- SMAD binding Source: MGI
- transforming growth factor beta binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 197957, 1 interactor |
DIPi | DIP-47635N |
IntActi | Q61288, 5 interactors |
MINTi | Q61288 |
STRINGi | 10090.ENSMUSP00000000542 |
Chemistry databases
BindingDBi | Q61288 |
Miscellaneous databases
RNActi | Q61288, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 171 – 200 | GSPROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 201 – 502 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 302 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 72 – 75 | Mediates specificity for BMP ligandBy similarity | 4 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000161446 |
HOGENOMi | CLU_000288_8_5_1 |
InParanoidi | Q61288 |
OMAi | DPTYGEI |
OrthoDBi | 776697at2759 |
TreeFami | TF314724 |
Family and domain databases
InterProi | View protein in InterPro IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q61288-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLGSFRRGL LMLSVAFGLT RGDLAKPSKL VNCTCESPHC KRPFCQGSWC
60 70 80 90 100
TVVLVREQGR HPQVYRGCGS LNQELCLGRP TEFLNHHCCY RSFCNHNVSL
110 120 130 140 150
MLEATQTPSE EPEVDAHLPL ILGPVLALPV LVALGALGLW RVRRRQEKQR
160 170 180 190 200
DLHSDLGESS LILKASEQAD SMLGDFLDSD CTTGSGSGLP FLVQRTVARQ
210 220 230 240 250
VALVECVGKG RYGEVWRGSW HGESVAVKIF SSRDEQSWFR ETEIYNTVLL
260 270 280 290 300
RHDNILGFIA SDMTSRNSST QLWLITHYHE HGSLYDFLQR QTLEPQLALR
310 320 330 340 350
LAVSAACGLA HLHVEIFGTQ GKPAIAHRDL KSRNVLVKSN LQCCIADLGL
360 370 380 390 400
AVMHSQSSDY LDIGNNPRVG TKRYMAPEVL DEHIRTDCFE SYKWTDIWAF
410 420 430 440 450
GLVLWEIARR TIINGIVEDY RPPFYDMVPN DPSFEDMKKV VCVDQQTPTI
460 470 480 490 500
PNRLAADPVL SGLAQMMREC WYPNPSARLT ALRIKKTLQK LSHNPEKPKV
IH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YUY5 | D3YUY5_MOUSE | Serine/threonine-protein kinase rec... | Acvrl1 | 76 | Annotation score: | ||
D3Z7H9 | D3Z7H9_MOUSE | Serine/threonine-protein kinase rec... | Acvrl1 | 26 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | F → L in CAA83484 (PubMed:7750489).Curated | 1 | |
Sequence conflicti | 21 | R → Q (PubMed:7750489).Curated | 1 | |
Sequence conflicti | 23 | D → R (PubMed:7750489).Curated | 1 | |
Sequence conflicti | 25 – 26 | AK → RR in AAB03642 (PubMed:7488127).Curated | 2 | |
Sequence conflicti | 305 | A → P in CAA83484 (PubMed:7750489).Curated | 1 | |
Sequence conflicti | 358 – 359 | SD → NE in CAA83484 (PubMed:7750489).Curated | 2 | |
Sequence conflicti | 366 | N → T in CAA83484 (PubMed:7750489).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L48015 mRNA Translation: AAB03642.1 Z31664 mRNA Translation: CAA83484.1 AK160915 mRNA Translation: BAE36089.1 AK170870 mRNA Translation: BAE42083.1 CH466550 Genomic DNA Translation: EDL04061.1 CH466550 Genomic DNA Translation: EDL04063.1 BC015083 mRNA Translation: AAH15083.1 |
CCDSi | CCDS37215.1 |
PIRi | I48241 JC4337 |
RefSeqi | NP_001264186.1, NM_001277257.1 NP_001264187.1, NM_001277258.1 NP_001264188.1, NM_001277259.1 NP_033742.2, NM_009612.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L48015 mRNA Translation: AAB03642.1 Z31664 mRNA Translation: CAA83484.1 AK160915 mRNA Translation: BAE36089.1 AK170870 mRNA Translation: BAE42083.1 CH466550 Genomic DNA Translation: EDL04061.1 CH466550 Genomic DNA Translation: EDL04063.1 BC015083 mRNA Translation: AAH15083.1 |
CCDSi | CCDS37215.1 |
PIRi | I48241 JC4337 |
RefSeqi | NP_001264186.1, NM_001277257.1 NP_001264187.1, NM_001277258.1 NP_001264188.1, NM_001277259.1 NP_033742.2, NM_009612.3 |
3D structure databases
SMRi | Q61288 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 197957, 1 interactor |
DIPi | DIP-47635N |
IntActi | Q61288, 5 interactors |
MINTi | Q61288 |
STRINGi | 10090.ENSMUSP00000000542 |
Chemistry databases
BindingDBi | Q61288 |
ChEMBLi | CHEMBL4105896 |
PTM databases
GlyConnecti | 2704, 1 N-Linked glycan (1 site) |
GlyGeni | Q61288, 2 sites |
iPTMneti | Q61288 |
PhosphoSitePlusi | Q61288 |
Proteomic databases
jPOSTi | Q61288 |
MaxQBi | Q61288 |
PaxDbi | Q61288 |
PeptideAtlasi | Q61288 |
PRIDEi | Q61288 |
Protocols and materials databases
Antibodypediai | 2055, 588 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 94 |
MGIi | MGI:1338946, Acvrl1 |
Phylogenomic databases
eggNOGi | KOG2052, Eukaryota |
GeneTreei | ENSGT00940000161446 |
HOGENOMi | CLU_000288_8_5_1 |
InParanoidi | Q61288 |
OMAi | DPTYGEI |
OrthoDBi | 776697at2759 |
TreeFami | TF314724 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 3474 |
Reactomei | R-MMU-201451, Signaling by BMP |
Miscellaneous databases
BioGRID-ORCSi | 11482, 0 hits in 17 CRISPR screens |
ChiTaRSi | Acvrl1, mouse |
PROi | PR:Q61288 |
RNActi | Q61288, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000530, Expressed in lung and 224 other tissues |
ExpressionAtlasi | Q61288, baseline and differential |
Genevisiblei | Q61288, MM |
Family and domain databases
InterProi | View protein in InterPro IPR003605, GS_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF08515, TGF_beta_GS, 1 hit |
SMARTi | View protein in SMART SM00467, GS, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51256, GS, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACVL1_MOUSE | |
Accessioni | Q61288Primary (citable) accession number: Q61288 Secondary accession number(s): Q61289, Q91YR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index