UniProtKB - Q61286 (HTF4_MOUSE)

BLAST

>sp|Q61286|HTF4_MOUSE Transcription factor 12 OS=Mus musculus OX=10090 GN=Tcf12 PE=1 SV=2
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGMDERGGTTSW
GTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPFMNSNLIGKTSERGSFSLY
SRDSGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDSVALDPLQA
KKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSSDLWSS
SNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRG
STSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNP
STPVGSPSPLTGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCE
QSRMEDRLDRLDDAIHVLRNHAVGPSTSLPTSHSDIHSLLGPSHNASIGNLNSNYGGSSL
VTNSRSASMVGTHREDSVSLNGNHSVLSSTVAASNTELNHKTPENFRGGVQNQSGSVVPT
EIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREK
ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRE
RNLNPKAACLKRREEEKVSAASAEPPNTLPGAHPGLSESTNPMGHL

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History
Entry version 159 (07 Nov 2018)
Sequence version 2 (27 Jul 2011)
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Protein

Transcription factor 12

Gene

Tcf12

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').1 Publication

GO - Molecular functionⁱ

bHLH transcription factor binding Source: MGI
cAMP response element binding Source: MGI
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 1321336
- 1922066
DNA-binding transcription factor activity Source: MGI
E-box binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18214987
HMG box domain binding Source: MGI
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18214987
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
SMAD binding Source: MGI
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 18958875
positive regulation of neuron differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 18214987
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 1321336
positive regulation of transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375170 CDO in myogenesis R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Reactomeⁱ

R-MMU-375170 CDO in myogenesis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor 12 Short name: TCF-12 Alternative name(s): Class A helix-loop-helix transcription factor ME1 DNA-binding protein HTF4 E-box-binding protein Transcription factor HTF-4
Gene namesⁱ	Name:Tcf12 Synonyms:Alf1, Meb
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:101877 Tcf12

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are smaller than their wild-type littermates and fail to thrive 14 days after birth.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127230	1 – 706	Transcription factor 12Add BLAST		706

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	47	PhosphoserineBy similarity	1
Modified residueⁱ	67	PhosphoserineBy similarity	1
Modified residueⁱ	79	PhosphoserineBy similarity	1
Modified residueⁱ	98	PhosphoserineCombined sources	1
Cross-linkⁱ	110	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	116	PhosphoserineBy similarity	1
Modified residueⁱ	124	PhosphoserineCombined sources	1
Cross-linkⁱ	181	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	313	PhosphothreonineBy similarity	1
Modified residueⁱ	333	PhosphoserineBy similarity	1
Cross-linkⁱ	543	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	564	PhosphoserineBy similarity	1
Cross-linkⁱ	574	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	581	PhosphothreonineBy similarity	1
Modified residueⁱ	582	PhosphoserineBy similarity	1
Modified residueⁱ	583	PhosphoserineBy similarity	1
Cross-linkⁱ	633	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	677	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Isoform ALF1A (identifier: Q61286-2)
Modified residueⁱ	392	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q61286
PeptideAtlas More...PeptideAtlasⁱ	Q61286
PRIDEⁱ	Q61286

PTM databases

iPTMnetⁱ	Q61286
PhosphoSitePlusⁱ	Q61286

Expressionⁱ

Tissue specificityⁱ

Widely expressed.

Developmental stageⁱ

Abundantly expressed during development of the central nervous system, in particular in proliferating neuroblasts and in cells at the initial stages of differentiation. Also expressed at high levels in morphogenetically active regions such as limb buds, somites and mesonephric tubules. Expression decreases once cellular differentiation is over.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000032228 Expressed in 345 organ(s), highest expression level in ureter smooth muscle
CleanExⁱ	MM_TCF12
ExpressionAtlasⁱ	Q61286 baseline and differential
Genevisibleⁱ	Q61286 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins and RUNX1T1 (By similarity). Interacts with PTF1A. Interacts with NEUROD2. Interacts with BHLHA9.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Tal1	P22091	2	EBI-8006499,EBI-8006437

With

Entry

#Exp.

IntAct

Notes

Tal1

P22091

EBI-8006499,EBI-8006437

GO - Molecular functionⁱ

bHLH transcription factor binding Source: MGI
HMG box domain binding Source: MGI
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18214987
protein homodimerization activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SMAD binding Source: MGI
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204000, 17 interactors
CORUMⁱ	Q61286
Database of interacting proteins More...DIPⁱ	DIP-42840N
IntActⁱ	Q61286, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q61286
STRINGⁱ	10090.ENSMUSP00000034755

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61286
SMRⁱ	Q61286
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	601 – 654	bHLHPROSITE-ProRule annotationAdd BLAST		54

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	119 – 140	Leucine-zipperAdd BLAST		22
Regionⁱ	656 – 679	Class A specific domainAdd BLAST		24

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	181 – 188	Nuclear localization signalSequence analysis		8

Phylogenomic databases

eggNOGⁱ	KOG3910 Eukaryota ENOG410XYUA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046438
HOGENOMⁱ	HOG000234180
HOVERGENⁱ	HBG003854
InParanoidⁱ	Q61286
KEGG Orthology (KO) More...KOⁱ	K15603
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07E2
TreeFamⁱ	TF321672

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show all Align All

Isoform ALF1B (identifier: Q61286-1) [UniParc]FASTA Add to basket

Also known as: ME1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG 
        60         70         80         90        100
MDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGTHEGLSPT 
       110        120        130        140        150
PFMNSNLIGK TSERGSFSLY SRDSGLSGCQ SSLLRQDLGL GSPAQLSSSG 
       160        170        180        190        200
KPGTPYYSFS ATSSRRRPLH DSVALDPLQA KKVRKVPPGL PSSVYAPSPN 
       210        220        230        240        250
SDDFNRESPS YPSPKPPTSM FASTFFMQDG THSSSDLWSS SNGMSQPGFG 
       260        270        280        290        300
GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 
       310        320        330        340        350
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD 
       360        370        380        390        400
HTSSSFPSNP STPVGSPSPL TGTSQWPRAG GQAPSSPSYE NSLHSLKNRV 
       410        420        430        440        450
EQQLHEHLQD AMSFLKDVCE QSRMEDRLDR LDDAIHVLRN HAVGPSTSLP 
       460        470        480        490        500
TSHSDIHSLL GPSHNASIGN LNSNYGGSSL VTNSRSASMV GTHREDSVSL 
       510        520        530        540        550
NGNHSVLSST VAASNTELNH KTPENFRGGV QNQSGSVVPT EIKTENKEKD 
       560        570        580        590        600
ENLHEPPSSD DMKSDDESSQ KDIKVSSRGR TSSTNEDEDL NPEQKIEREK 
       610        620        630        640        650
ERRMANNARE RLRVRDINEA FKELGRMCQL HLKSEKPQTK LLILHQAVAV 
       660        670        680        690        700
ILSLEQQVRE RNLNPKAACL KRREEEKVSA ASAEPPNTLP GAHPGLSEST 

NPMGHL

Length:706

Mass (Da):75,811

Last modified:July 27, 2011 - v2

Checksum:ⁱ4394FE95A297F68C

Isoform ALF1A (identifier: Q61286-2) [UniParc]FASTA Add to basket

Also known as: ME1B

The sequence of this isoform differs from the canonical sequence as follows:
397-420: Missing.

« Hide

        10         20         30         40         50
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG 
        60         70         80         90        100
MDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGTHEGLSPT 
       110        120        130        140        150
PFMNSNLIGK TSERGSFSLY SRDSGLSGCQ SSLLRQDLGL GSPAQLSSSG 
       160        170        180        190        200
KPGTPYYSFS ATSSRRRPLH DSVALDPLQA KKVRKVPPGL PSSVYAPSPN 
       210        220        230        240        250
SDDFNRESPS YPSPKPPTSM FASTFFMQDG THSSSDLWSS SNGMSQPGFG 
       260        270        280        290        300
GILGTSTSHM SQSSSYGSLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 
       310        320        330        340        350
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD 
       360        370        380        390        400
HTSSSFPSNP STPVGSPSPL TGTSQWPRAG GQAPSSPSYE NSLHSLQSRM 
       410        420        430        440        450
EDRLDRLDDA IHVLRNHAVG PSTSLPTSHS DIHSLLGPSH NASIGNLNSN 
       460        470        480        490        500
YGGSSLVTNS RSASMVGTHR EDSVSLNGNH SVLSSTVAAS NTELNHKTPE 
       510        520        530        540        550
NFRGGVQNQS GSVVPTEIKT ENKEKDENLH EPPSSDDMKS DDESSQKDIK 
       560        570        580        590        600
VSSRGRTSST NEDEDLNPEQ KIEREKERRM ANNARERLRV RDINEAFKEL 
       610        620        630        640        650
GRMCQLHLKS EKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE 
       660        670        680 
EEKVSAASAE PPNTLPGAHP GLSESTNPMG HL

Show »

Length:682

Mass (Da):72,931

Checksum:ⁱAE86072FA32586AA

Computationally mapped potential isoform sequencesⁱ

There are 13 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	V9GX46	V9GX46_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	536	Annotation score:
	V9GWU2	V9GWU2_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	666	Annotation score:
	Q3UXQ3	Q3UXQ3_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	477	Annotation score:
	V9GXC3	V9GXC3_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	523	Annotation score:
	V9GXR6	V9GXR6_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	279	Annotation score:
	V9GX18	V9GX18_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	127	Annotation score:
	V9GXP0	V9GXP0_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	79	Annotation score:
	V9GX29	V9GX29_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	58	Annotation score:
	V9GXG5	V9GXG5_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	57	Annotation score:
	V9GXM8	V9GXM8_MOUSE	Transcription factor 12 Transcription factor 12	Tcf12	57	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	416	K → E in M97635 (PubMed:8261111).Curated	1
Sequence conflictⁱ	537	V → F in M97635 (PubMed:8261111).Curated	1
Sequence conflictⁱ	537	V → F in M97636 (PubMed:8261111).Curated	1
Sequence conflictⁱ	687	N → S in CAA46052 (PubMed:1321336).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002105	397 – 420	Missing in isoform ALF1A. 1 PublicationAdd BLAST		24

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64840 mRNA Translation: CAA46052.1 M97635 mRNA No translation available. M97636 mRNA No translation available. AC093483 Genomic DNA No translation available. AC157575 Genomic DNA No translation available. AC159001 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23329.1 [Q61286-1] CCDS72272.1 [Q61286-2]
PIRⁱ	C45020 S19958
NCBI Reference Sequences More...RefSeqⁱ	NP_001240794.1, NM_001253865.1 NP_035674.2, NM_011544.3 [Q61286-1] XP_006511057.1, XM_006510994.3 [Q61286-1] XP_006511060.1, XM_006510997.2 [Q61286-2]
UniGeneⁱ	Mm.171615 Mm.480117

Genome annotation databases

Ensemblⁱ	ENSMUST00000034755; ENSMUSP00000034755; ENSMUSG00000032228 [Q61286-2] ENSMUST00000183404; ENSMUSP00000139365; ENSMUSG00000032228 [Q61286-1] ENSMUST00000184783; ENSMUSP00000139364; ENSMUSG00000032228 [Q61286-1] ENSMUST00000185117; ENSMUSP00000138925; ENSMUSG00000032228 [Q61286-2]
GeneIDⁱ	21406
KEGGⁱ	mmu:21406
UCSC genome browser More...UCSCⁱ	uc009qpf.2 mouse [Q61286-1] uc009qpg.2 mouse [Q61286-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61286	Transcription factor 12		RAT		707	UniRef90_Q61286
Transcription factor 12 (Fragment)		PAPHA		160
Uncharacterized protein		AOTNA		764
Transcription factor 12 (Fragment)		HUMAN		69
transcription factor 12 isoform X1		DELLE		721
+239
Q61286-2	Transcription factor 12 (Fragment)		MOUSE		523	UniRef90_Q61286-2
Uncharacterized protein		CHLSB		682
TCF12 isoform 27 (Fragment)		PONAB		47
TCF12 isoform 1 (Fragment)		PANTR		47
Transcription factor 12 (Fragment)		HUMAN		48
+28

Protein	Similar proteins		Species	Score	Length	Source
Q61286	Transcription factor 12		RAT		707	UniRef50_Q61286
Transcription factor 12 (Fragment)		PAPHA		160
Transcription factor 12 (Fragment)		CHICK		657
Uncharacterized protein		AOTNA		764
Transcription factor 12 (Fragment)		HUMAN		69
+752
Q61286-2	Transcription factor 4	)	HUMAN		667	UniRef50_P15884
Transcription factor 4		MOUSE		670
Transcription factor 4		CANLF		642
Transcription factor 4		RAT		589
Transcription factor 4 (Fragment)		CHICK		85
+1660

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64840 mRNA Translation: CAA46052.1 M97635 mRNA No translation available. M97636 mRNA No translation available. AC093483 Genomic DNA No translation available. AC157575 Genomic DNA No translation available. AC159001 Genomic DNA No translation available.
CCDSⁱ	CCDS23329.1 [Q61286-1] CCDS72272.1 [Q61286-2]
PIRⁱ	C45020 S19958
RefSeqⁱ	NP_001240794.1, NM_001253865.1 NP_035674.2, NM_011544.3 [Q61286-1] XP_006511057.1, XM_006510994.3 [Q61286-1] XP_006511060.1, XM_006510997.2 [Q61286-2]
UniGeneⁱ	Mm.171615 Mm.480117

3D structure databases

ProteinModelPortalⁱ	Q61286
SMRⁱ	Q61286
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204000, 17 interactors
CORUMⁱ	Q61286
DIPⁱ	DIP-42840N
IntActⁱ	Q61286, 4 interactors
MINTⁱ	Q61286
STRINGⁱ	10090.ENSMUSP00000034755

PTM databases

iPTMnetⁱ	Q61286
PhosphoSitePlusⁱ	Q61286

Proteomic databases

PaxDbⁱ	Q61286
PeptideAtlasⁱ	Q61286
PRIDEⁱ	Q61286

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034755; ENSMUSP00000034755; ENSMUSG00000032228 [Q61286-2] ENSMUST00000183404; ENSMUSP00000139365; ENSMUSG00000032228 [Q61286-1] ENSMUST00000184783; ENSMUSP00000139364; ENSMUSG00000032228 [Q61286-1] ENSMUST00000185117; ENSMUSP00000138925; ENSMUSG00000032228 [Q61286-2]
GeneIDⁱ	21406
KEGGⁱ	mmu:21406
UCSCⁱ	uc009qpf.2 mouse [Q61286-1] uc009qpg.2 mouse [Q61286-2]

Organism-specific databases

CTDⁱ	6938
MGIⁱ	MGI:101877 Tcf12

Phylogenomic databases

eggNOGⁱ	KOG3910 Eukaryota ENOG410XYUA LUCA
GeneTreeⁱ	ENSGT00510000046438
HOGENOMⁱ	HOG000234180
HOVERGENⁱ	HBG003854
InParanoidⁱ	Q61286
KOⁱ	K15603
OrthoDBⁱ	EOG091G07E2
TreeFamⁱ	TF321672

Enzyme and pathway databases

Reactomeⁱ	R-MMU-375170 CDO in myogenesis R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Reactomeⁱ

R-MMU-375170 CDO in myogenesis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

Miscellaneous databases

ChiTaRSⁱ	Tcf12 mouse
Protein Ontology More...PROⁱ	PR:Q61286
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032228 Expressed in 345 organ(s), highest expression level in ureter smooth muscle
CleanExⁱ	MM_TCF12
ExpressionAtlasⁱ	Q61286 baseline and differential
Genevisibleⁱ	Q61286 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HTF4_MOUSE
Accessionⁱ	Q61286Primary (citable) accession number: Q61286 Secondary accession number(s): E9QPN4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61286 (HTF4_MOUSE)

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Transcription factor 12

Tcf12

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ