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Protein

ATP-binding cassette sub-family D member 2

Gene

Abcd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi512 – 519ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • fatty acid beta-oxidation Source: UniProtKB
  • positive regulation of fatty acid beta-oxidation Source: MGI
  • response to bacterium Source: MGI
  • very long-chain fatty acid catabolic process Source: MGI
  • very long-chain fatty acid metabolic process Source: MGI

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 2
Alternative name(s):
Adrenoleukodystrophy-related protein
Gene namesi
Name:Abcd2
Synonyms:Aldr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1349467 Abcd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei144 – 164HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei251 – 271HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei351 – 371HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933071 – 741ATP-binding cassette sub-family D member 2Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61285
PaxDbiQ61285
PRIDEiQ61285

PTM databases

iPTMnetiQ61285
PhosphoSitePlusiQ61285

Interactioni

Subunit structurei

Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205032, 1 interactor
IntActiQ61285, 4 interactors
STRINGi10090.ENSMUSP00000068940

Structurei

3D structure databases

ProteinModelPortaliQ61285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 399ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST293
Domaini479 – 705ABC transporterPROSITE-ProRule annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 218Interaction with PEX19By similarityAdd BLAST218

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0064 Eukaryota
COG4178 LUCA
HOGENOMiHOG000206081
HOVERGENiHBG050438
InParanoidiQ61285
KOiK05676
PhylomeDBiQ61285
TreeFamiTF105205

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR031239 ABCD2
IPR027417 P-loop_NTPase
PANTHERiPTHR11384:SF24 PTHR11384:SF24, 1 hit
PfamiView protein in Pfam
PF06472 ABC_membrane_2, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHMLNAAAY RVKWTRSGAA KRAACLVAAA YALKTLYPII GKRLKQPGHR
60 70 80 90 100
KAKAEAYSPA ENREILHCTE IICKKPAPGL NAAFFKQLLE LRKILFPKLV
110 120 130 140 150
TTETGWLCLH SVALISRTFL SIYVAGLDGK IVKSIVEKKP RTFIIKLIKW
160 170 180 190 200
LMIAIPATFV NSAIRYLECK LALAFRTRLV DHAYETYFAN QTYYKVINMD
210 220 230 240 250
GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVILTSY TLIRTATSRG
260 270 280 290 300
ASPIGPTLLA GLVVYATAKV LKACSPKFGS LVAEEAHRKG YLRYVHSRII
310 320 330 340 350
ANVEEIAFYR GHKVEMKQLQ KCYKALAYQM NLILSKRLWY IMIEQFLMKY
360 370 380 390 400
VWSSCGLIMV AIPIITATGF ADGDLEDGPK QAMVSDRTEA FTTARNLLAS
410 420 430 440 450
GADAIERIMS SYKEITELAG YTARVYNMFW VFDEVKRGIY KRTVTQEPEN
460 470 480 490 500
HSKRGGNLEL PLSDTLAIKG TVIDVDHGII CENVPIITPA GEVVASRLNF
510 520 530 540 550
KVEEGMHLLI TGPNGCGKSS LFRILSGLWP VYEGVLYKPP PQHMFYIPQR
560 570 580 590 600
PYMSLGSLRD QVIYPDSADD MREKGYTDQD LERILHSVHL YHIVQREGGW
610 620 630 640 650
DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ
660 670 680 690 700
AAIGAGISLL SITHRPSLWK YHTHLLQFDG EGGWRFEQLD TAIRLTLSEE
710 720 730 740
KQKLESQLAG IPKMQQRLNE LCKILGEDSV LKTIQTPEKT S
Length:741
Mass (Da):83,483
Last modified:November 1, 1996 - v1
Checksum:i24B9952F7B1B49D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296H → R in BAC38542 (PubMed:16141072).Curated1
Sequence conflicti737P → A in BAC34641 (PubMed:16141072).Curated1
Sequence conflicti737P → A in BAC38542 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48670 mRNA Translation: CAA88589.1
AK051445 mRNA Translation: BAC34641.1
AK082588 mRNA Translation: BAC38542.1
BC019187 mRNA Translation: AAH19187.1
CCDSiCCDS27760.1
RefSeqiNP_036124.2, NM_011994.2
UniGeneiMm.295456

Genome annotation databases

GeneIDi26874
KEGGimmu:26874
UCSCiuc007xhx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiABCD2_MOUSE
AccessioniPrimary (citable) accession number: Q61285
Secondary accession number(s): Q8BQ63, Q8C4B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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