Acvr1b

Functionⁱ

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.2 Publications

Catalytic activityⁱ

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Activity regulationⁱ

Activin receptor type-2 (ACVR2A or ACVR2B) activates the type-1 receptor through phosphorylation of its regulatory GS domain.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	234	ATPPROSITE-ProRule annotation		1
Active siteⁱ	335	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	213 – 221	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

activin binding
Source: MGI
Inferred from physical interactionⁱ
- 7577669
activin receptor activity, type I Source: MGI
ATP binding Source: MGI
growth factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inhibin binding Source: MGI
metal ion binding Source: UniProtKB-KW
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18039968
SMAD binding Source: MGI
transforming growth factor beta-activated receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transforming growth factor beta receptor activity, type I
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transmembrane receptor protein serine/threonine kinase activity
Source: MGI
Traceable author statementⁱ
- 9512518

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activin receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 16115198
cell surface receptor signaling pathway
Source: MGI
Traceable author statementⁱ
- 9512518
central nervous system development Source: Ensembl
development of primary female sexual characteristics Source: Ensembl
extrinsic apoptotic signaling pathway Source: MGI
G1/S transition of mitotic cell cycle Source: MGI
hair follicle development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16127153
in utero embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15485907
- 16564040
mesoderm development
Source: MGI
Inferred from sequence orthologyⁱ
- 9012495
negative regulation of cell growth Source: MGI
negative regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 23152446
nodal signaling pathway Source: MGI
pattern specification process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptidyl-threonine phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 18039968
positive regulation of activin receptor signaling pathway Source: MGI
positive regulation of erythrocyte differentiation Source: MGI
positive regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 23152446
positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
positive regulation of transcription by RNA polymerase II Source: MGI
positive regulation of trophoblast cell migration Source: MGI
protein autophosphorylation Source: MGI
protein phosphorylation Source: MGI
regulation of signal transduction
Source: MGI
Inferred from direct assayⁱ
- 17936261
regulation of transcription, DNA-templated Source: MGI
signal transduction Source: MGI
transforming growth factor beta receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1502540 Signaling by Activin

Reactomeⁱ

R-MMU-1502540 Signaling by Activin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Activin receptor type-1B (EC:2.7.11.30) Alternative name(s): Activin receptor type IB Short name: ACTR-IB Activin receptor-like kinase 4 Short name: ALK-4 Serine/threonine-protein kinase receptor R2 Short name: SKR2
Gene namesⁱ	Name:Acvr1b Synonyms:Alk4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1338944 Acvr1b

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 126	ExtracellularSequence analysisAdd BLAST	103
Transmembraneⁱ	127 – 149	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	150 – 505	CytoplasmicSequence analysisAdd BLAST	356

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Leads to hair loss.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000024418	24 – 505	Activin receptor type-1BAdd BLAST		482

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	43	N-linked (GlcNAc...) asparagineSequence analysis		1
Modified residueⁱ	380	PhosphotyrosineBy similarity		1

Post-translational modificationⁱ

Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates association with SMAD7 (By similarity).By similarity

Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex (By similarity).By similarity

Ubiquitinated.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61271
PaxDbⁱ	Q61271
PRIDEⁱ	Q61271

PTM databases

iPTMnetⁱ	Q61271
PhosphoSitePlusⁱ	Q61271

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000000532 Expressed in 314 organ(s), highest expression level in neocortex
CleanExⁱ	MM_ACVR1B
ExpressionAtlasⁱ	Q61271 baseline and differential
Genevisibleⁱ	Q61271 MM

Interactionⁱ

Subunit structureⁱ

Forms an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Interacts with TDP2 (By similarity). Interacts with AIP1, FKBP1A, IGSF1, TDGF1, SMAD2, SMAD3 and SMAD7 (By similarity).By similarity

GO - Molecular functionⁱ

growth factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inhibin binding Source: MGI
SMAD binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	197954, 2 interactors
CORUMⁱ	Q61271
IntActⁱ	Q61271, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q61271
STRINGⁱ	10090.ENSMUSP00000000544

Chemistry databases

BindingDBⁱ	Q61271

BindingDBⁱ

Q61271

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61271
SMRⁱ	Q61271
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	177 – 206	GSPROSITE-ProRule annotationAdd BLAST		30
Domainⁱ	207 – 497	Protein kinasePROSITE-ProRule annotationAdd BLAST		291

Domainⁱ

The GS domain is a 30-amino-acid sequence adjacent to the N-terminal boundary of the kinase domain and highly conserved in all other known type-1 receptors but not in type-2 receptors. The GS domain is the site of activation through phosphorylation by the II receptors (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2052 Eukaryota ENOG410XQT0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000230587
HOVERGENⁱ	HBG054502
InParanoidⁱ	Q61271
KEGG Orthology (KO) More...KOⁱ	K13567
OMAⁱ	GPVFLLC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BIU
PhylomeDBⁱ	Q61271
TreeFamⁱ	TF314724

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR003605 GS_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF00069 Pkinase, 1 hit PF08515 TGF_beta_GS, 1 hit
SMARTⁱ	View protein in SMART SM00467 GS, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51256 GS, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q61271-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG 
        60         70         80         90        100
ACMVSIFNLD GVEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF 
       110        120        130        140        150
CNKIDLRVPS GHLKEPAHPS MWGPVELVGI IAGPVFLLFL IIIIVFLVIN 
       160        170        180        190        200
YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ DLVYDLSTSG SGSGLPLFVQ 
       210        220        230        240        250
RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE ERSWFREAEI 
       260        270        280        290        300
YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 
       310        320        330        340        350
IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA 
       360        370        380        390        400
IADLGLAVRH DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC 
       410        420        430        440        450
ADIYALGLVY WEIARRCNSG GVHEDYQLPY YDLVPSDPSI EEMRKVVCDQ 
       460        470        480        490        500
KLRPNVPNWW QSYEALRVMG KMMRECWYAN GAARLTALRI KKTLSQLSVQ 

EDVKI

Length:505

Mass (Da):56,700

Last modified:November 1, 1996 - v1

Checksum:ⁱ56E9EEF1607A2517

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z31663 mRNA Translation: CAA83483.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27846.1
NCBI Reference Sequences More...RefSeqⁱ	NP_031421.1, NM_007395.3
UniGeneⁱ	Mm.308467

Genome annotation databases

Ensemblⁱ	ENSMUST00000000544; ENSMUSP00000000544; ENSMUSG00000000532
GeneIDⁱ	11479
KEGGⁱ	mmu:11479
UCSC genome browser More...UCSCⁱ	uc007xsr.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q61271	Receptor protein serine/threonine kinase		MOUSE		505	UniRef100_Q61271

Protein	Similar proteins		Species	Score	Length	Source
Q61271	Activin receptor type-1B		HUMAN		505	UniRef90_P36896
Activin receptor type-1B		RAT		505
Receptor protein serine/threonine kinase		PANTR		505
Receptor protein serine/threonine kinase		AOTNA		524
Receptor protein serine/threonine kinase		MACNE		514
+98

Protein	Similar proteins		Species	Score	Length	Source
Q61271	Activin receptor type-1B		HUMAN		505	UniRef50_P36896
Activin receptor type-1B		RAT		505
Receptor protein serine/threonine kinase		PANTR		505
Receptor protein serine/threonine kinase		AOTNA		524
Receptor protein serine/threonine kinase		MACNE		514
+175

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z31663 mRNA Translation: CAA83483.1
CCDSⁱ	CCDS27846.1
RefSeqⁱ	NP_031421.1, NM_007395.3
UniGeneⁱ	Mm.308467

3D structure databases

ProteinModelPortalⁱ	Q61271
SMRⁱ	Q61271
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	197954, 2 interactors
CORUMⁱ	Q61271
IntActⁱ	Q61271, 1 interactor
MINTⁱ	Q61271
STRINGⁱ	10090.ENSMUSP00000000544

Chemistry databases

BindingDBⁱ	Q61271

BindingDBⁱ

Q61271

PTM databases

iPTMnetⁱ	Q61271
PhosphoSitePlusⁱ	Q61271

Proteomic databases

MaxQBⁱ	Q61271
PaxDbⁱ	Q61271
PRIDEⁱ	Q61271

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000000544; ENSMUSP00000000544; ENSMUSG00000000532
GeneIDⁱ	11479
KEGGⁱ	mmu:11479
UCSCⁱ	uc007xsr.1 mouse

Organism-specific databases

CTDⁱ	91
MGIⁱ	MGI:1338944 Acvr1b

Phylogenomic databases

eggNOGⁱ	KOG2052 Eukaryota ENOG410XQT0 LUCA
GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000230587
HOVERGENⁱ	HBG054502
InParanoidⁱ	Q61271
KOⁱ	K13567
OMAⁱ	GPVFLLC
OrthoDBⁱ	EOG091G0BIU
PhylomeDBⁱ	Q61271
TreeFamⁱ	TF314724

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1502540 Signaling by Activin

Reactomeⁱ

R-MMU-1502540 Signaling by Activin

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q61271
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000532 Expressed in 314 organ(s), highest expression level in neocortex
CleanExⁱ	MM_ACVR1B
ExpressionAtlasⁱ	Q61271 baseline and differential
Genevisibleⁱ	Q61271 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR003605 GS_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF00069 Pkinase, 1 hit PF08515 TGF_beta_GS, 1 hit
SMARTⁱ	View protein in SMART SM00467 GS, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS51256 GS, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACV1B_MOUSE
Accessionⁱ	Q61271Primary (citable) accession number: Q61271
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniParc

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Supporting data

UniProtKB - Q61271 (ACV1B_MOUSE)

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Activin receptor type-1B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytosol

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ