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Protein

Alpha-1-syntrophin

Gene

Snta1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 acidic component 1
Syntrophin-1
Gene namesi
Name:Snta1
Synonyms:Snt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:101772 Snta1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840071 – 503Alpha-1-syntrophinAdd BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineCombined sources1
Modified residuei178PhosphoserineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61234
PaxDbiQ61234
PeptideAtlasiQ61234
PRIDEiQ61234

PTM databases

iPTMnetiQ61234
PhosphoSitePlusiQ61234

Expressioni

Tissue specificityi

High expression in skeletal muscle. Expressed at intermediate level in heart, kidney and brain, and at low level in intestine, liver, lung and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000027488 Expressed in 227 organ(s), highest expression level in gastrocnemius
CleanExiMM_SNTA1
ExpressionAtlasiQ61234 baseline and differential
GenevisibleiQ61234 MM

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with MAPK12, TGFA, GA and F-actin (By similarity). Interacts with the other members of the syntrophin family: SNTB1 and SNTB2; with dystrophin protein DMD and related proteins DTNA and UTRN; SGCG and SGCA of the dystrophin glycoprotein complex; NOS1; GRB2; calmodulin and the sodium channel proteins SCN4A and SCN5A. Interacts with MYOC; regulates muscle hypertrophy.By similarity7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ61234
DIPiDIP-32898N
IntActiQ61234, 10 interactors
MINTiQ61234
STRINGi10090.ENSMUSP00000105350

Structurei

Secondary structure

1503
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ61234
SMRiQ61234
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61234

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 263PH 1PROSITE-ProRule annotationAdd BLAST258
Domaini81 – 164PDZPROSITE-ProRule annotationAdd BLAST84
Domaini287 – 399PH 2PROSITE-ProRule annotationAdd BLAST113
Domaini447 – 503SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni481 – 503Calmodulin-bindingAdd BLAST23

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-bisphosphate.
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.
The SU domain binds calmodulin in a calcium-dependent manner.

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMRM Eukaryota
ENOG410XS4Y LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ61234
OMAiIGWLTEQ
OrthoDBiEOG091G0O31
PhylomeDBiQ61234
TreeFamiTF317932

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR028552 SNTA1
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PTHR10554:SF6 PTHR10554:SF6, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q61234-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGRRAPRT GLLELRCGAG SGAGGERWQR VLLSLAEDAL TVSPADGEPG
60 70 80 90 100
PEPEPAQLNG AAEPGAAPPQ LPEALLLQRR RVTVRKADAG GLGISIKGGR
110 120 130 140 150
ENKMPILISK IFKGLAADQT EALFVGDAIL SVNGEDLSSA THDEAVQALK
160 170 180 190 200
KTGKEVVLEV KYMKEVSPYF KNSAGGTSVG WDSPPASPLQ RQPSSPGPQP
210 220 230 240 250
RNLSEAKHVS LKMAYVSRRC TPTDPEPRYL EICAADGQDA VFLRAKDEAS
260 270 280 290 300
ARSWAGAIQA QIGTFIPWVK DELQALLTAT GTAGSQDIKQ IGWLTEQLPS
310 320 330 340 350
GGTAPTLALL TEKELLFYCS LPQSREALSR PTRTAPLIAT SSAHRLVHSG
360 370 380 390 400
PSKGSVPYDA ELSFALRTGT RHGVDTHLFS VESPQELAAW TRQLVDGCHR
410 420 430 440 450
AAEGIQEVST ACTWNGRPCS LSVHIDKGFT LWAAEPGAAR AMLLRQPFEK
460 470 480 490 500
LQMSSDDGTS LLFLDFGGAE GEIQLDLHSC PKTMVFIIHS FLSAKVTRLG

LLA
Length:503
Mass (Da):53,665
Last modified:November 1, 1996 - v1
Checksum:i161BA76CAF50AE96
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AKD7A2AKD7_MOUSE
Alpha-1-syntrophin
Snta1
499Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16R → C in AAH18546 (PubMed:15489334).Curated1
Sequence conflicti341 – 344Missing in AAH18546 (PubMed:15489334).Curated4
Sequence conflicti405I → V in AAH18546 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00677 mRNA Translation: AAC52119.1
BC018546 mRNA Translation: AAH18546.1
PIRiI84771
UniGeneiMm.1541

Genome annotation databases

EnsembliENSMUST00000028991; ENSMUSP00000028991; ENSMUSG00000027488

Similar proteinsi

Entry informationi

Entry nameiSNTA1_MOUSE
AccessioniPrimary (citable) accession number: Q61234
Secondary accession number(s): Q8VEF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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