Hypoxia-inducible factor 1-alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes."
    Biju M.P., Neumann A.K., Bensinger S.J., Johnson R.S., Turka L.A., Haase V.H.
    Mol Cell Biol 24:9038-9047(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity Source: MGI
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation."
    An H.J., Shin H., Jo S.G., Kim Y.J., Lee J.O., Paik S.G., Lee H.
    Biochim Biophys Acta 1813:2088-2098(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes."
    Biju M.P., Neumann A.K., Bensinger S.J., Johnson R.S., Turka L.A., Haase V.H.
    Mol Cell Biol 24:9038-9047(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Advanced glycated end-products affect HIF-transcriptional activity in renal cells."
    Bondeva T., Heinzig J., Ruhe C., Wolf G.
    Mol Endocrinol 27:1918-1933(2013) [PubMed] [Europe PMC] [Abstract]
• E-box binding Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The hypoxia-inducible microRNA cluster miR-199a~214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation."
    el Azzouzi H., Leptidis S., Dirkx E., Hoeks J., van Bree B., Brand K., McClellan E.A., Poels E., Sluimer J.C., van den Hoogenhof M.M., Armand A.S., Yin X., Langley S., Bourajjaj M., Olieslagers S., Krishnan J., Vooijs M., Kurihara H.

    , Stubbs A., Pinto Y.M., Krek W., Mayr M., da Costa Martins P.A., Schrauwen P., De Windt L.J.
    Cell Metab 18:341-354(2013) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: MGI
• histone deacetylase binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1."
    Seo H.W., Kim E.J., Na H., Lee M.O.
    FEBS Lett 583:55-60(2009) [PubMed] [Europe PMC] [Abstract]
• Hsp90 protein binding Source: MGI
• nuclear receptor binding Source: MGI
• p53 binding Source: MGI
• protein-containing complex binding Source: MGI
• protein domain specific binding Source: MGI
• protein heterodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "Structural integration in hypoxia-inducible factors."
    Wu D., Potluri N., Lu J., Kim Y., Rastinejad F.
    Nature 524:303-308(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (3.90 ANGSTROMS) OF 13-357 IN COMPLEXES WITH ARNT AND DNA, MUTAGENESIS OF ARG-170 AND VAL-191, REGION, INTERACTION WITH ARNT, FUNCTION.
• protein kinase binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development."
    Ema M., Taya S., Yokotani N., Sogawa K., Matsuda Y., Fujii-Kuriyama Y.
    Proc. Natl. Acad. Sci. U.S.A. 94:4273-4278(1997) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
• sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "Structural integration in hypoxia-inducible factors."
    Wu D., Potluri N., Lu J., Kim Y., Rastinejad F.
    Nature 524:303-308(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (3.90 ANGSTROMS) OF 13-357 IN COMPLEXES WITH ARNT AND DNA, MUTAGENESIS OF ARG-170 AND VAL-191, REGION, INTERACTION WITH ARNT, FUNCTION.
• transcription coactivator binding Source: UniProtKB
• ubiquitin protein ligase binding Source: MGI

GO - Biological processⁱ

• angiogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha."
    Compernolle V., Brusselmans K., Franco D., Moorman A., Dewerchin M., Collen D., Carmeliet P.
    Cardiovasc Res 60:569-579(2003) [PubMed] [Europe PMC] [Abstract]
  • "VEGFA is necessary for chondrocyte survival during bone development."
    Zelzer E., Mamluk R., Ferrara N., Johnson R.S., Schipani E., Olsen B.R.
    Development 131:2161-2171(2004) [PubMed] [Europe PMC] [Abstract]
• axonal transport of mitochondrion Source: UniProtKB
• B-1 B cell homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice."
    Kojima H., Gu H., Nomura S., Caldwell C.C., Kobata T., Carmeliet P., Semenza G.L., Sitkovsky M.V.
    Proc Natl Acad Sci U S A 99:2170-2174(2002) [PubMed] [Europe PMC] [Abstract]
• blood vessel development Source: MGIInferred from mutant phenotypeⁱ
  • "Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha."
    Iyer N.V., Kotch L.E., Agani F., Leung S.W., Laughner E., Wenger R.H., Gassmann M., Gearhart J.D., Lawler A.M., Yu A.Y., Semenza G.L.
    Genes Dev 12:149-162(1998) [PubMed] [Europe PMC] [Abstract]
• blood vessel morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "HIF-1 alpha is required for solid tumor formation and embryonic vascularization."
    Ryan H.E., Lo J., Johnson R.S.
    EMBO J 17:3005-3015(1998) [PubMed] [Europe PMC] [Abstract]
• camera-type eye morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development."
    Lange C.A., Luhmann U.F., Mowat F.M., Georgiadis A., West E.L., Abrahams S., Sayed H., Powner M.B., Fruttiger M., Smith A.J., Sowden J.C., Maxwell P.H., Ali R.R., Bainbridge J.W.
    Development 139:2340-2350(2012) [PubMed] [Europe PMC] [Abstract]
• cardiac ventricle morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha."
    Iyer N.V., Kotch L.E., Agani F., Leung S.W., Laughner E., Wenger R.H., Gassmann M., Gearhart J.D., Lawler A.M., Yu A.Y., Semenza G.L.
    Genes Dev 12:149-162(1998) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival."
    Schipani E., Ryan H.E., Didrickson S., Kobayashi T., Knight M., Johnson R.S.
    Genes Dev 15:2865-2876(2001) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "VEGFA is necessary for chondrocyte survival during bone development."
    Zelzer E., Mamluk R., Ferrara N., Johnson R.S., Schipani E., Olsen B.R.
    Development 131:2161-2171(2004) [PubMed] [Europe PMC] [Abstract]
• cellular glucose homeostasis Source: UniProtKB
• cellular iron ion homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development."
    Yoon D., Pastore Y.D., Divoky V., Liu E., Mlodnicka A.E., Rainey K., Ponka P., Semenza G.L., Schumacher A., Prchal J.T.
    J Biol Chem 281:25703-25711(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: MGIInferred from genetic interactionⁱ
  • "The hypoxia-inducible microRNA cluster miR-199a~214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation."
    el Azzouzi H., Leptidis S., Dirkx E., Hoeks J., van Bree B., Brand K., McClellan E.A., Poels E., Sluimer J.C., van den Hoogenhof M.M., Armand A.S., Yin X., Langley S., Bourajjaj M., Olieslagers S., Krishnan J., Vooijs M., Kurihara H.

    , Stubbs A., Pinto Y.M., Krek W., Mayr M., da Costa Martins P.A., Schrauwen P., De Windt L.J.
    Cell Metab 18:341-354(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: Ensembl
• cellular response to virus Source: MGI
• cerebral cortex development Source: MGIInferred from mutant phenotypeⁱ
  • "Defective brain development in mice lacking the Hif-1alpha gene in neural cells."
    Tomita S., Ueno M., Sakamoto M., Kitahama Y., Ueki M., Maekawa N., Sakamoto H., Gassmann M., Kageyama R., Ueda N., Gonzalez F.J., Takahama Y.
    Mol Cell Biol 23:6739-6749(2003) [PubMed] [Europe PMC] [Abstract]
• collagen metabolic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition."
    Higgins D.F., Kimura K., Bernhardt W.M., Shrimanker N., Akai Y., Hohenstein B., Saito Y., Johnson R.S., Kretzler M., Cohen C.D., Eckardt K.U., Iwano M., Haase V.H.
    J Clin Invest 117:3810-3820(2007) [PubMed] [Europe PMC] [Abstract]
• connective tissue replacement involved in inflammatory response wound healing Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition."
    Higgins D.F., Kimura K., Bernhardt W.M., Shrimanker N., Akai Y., Hohenstein B., Saito Y., Johnson R.S., Kretzler M., Cohen C.D., Eckardt K.U., Iwano M., Haase V.H.
    J Clin Invest 117:3810-3820(2007) [PubMed] [Europe PMC] [Abstract]
• digestive tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation."
    Lussier C.R., Brial F., Roy S.A., Langlois M.J., Verdu E.F., Rivard N., Perreault N., Boudreau F.
    PLoS One 5:e12378-e12378(2010) [PubMed] [Europe PMC] [Abstract]
• dopaminergic neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling."
    Milosevic J., Maisel M., Wegner F., Leuchtenberger J., Wenger R.H., Gerlach M., Storch A., Schwarz J.
    J Neurosci 27:412-421(2007) [PubMed] [Europe PMC] [Abstract]
• elastin metabolic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition."
    Higgins D.F., Kimura K., Bernhardt W.M., Shrimanker N., Akai Y., Hohenstein B., Saito Y., Johnson R.S., Kretzler M., Cohen C.D., Eckardt K.U., Iwano M., Haase V.H.
    J Clin Invest 117:3810-3820(2007) [PubMed] [Europe PMC] [Abstract]
• embryonic hemopoiesis Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development."
    Yoon D., Pastore Y.D., Divoky V., Liu E., Mlodnicka A.E., Rainey K., Ponka P., Semenza G.L., Schumacher A., Prchal J.T.
    J Biol Chem 281:25703-25711(2006) [PubMed] [Europe PMC] [Abstract]
• embryonic placenta development Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation."
    Cowden Dahl K.D., Fryer B.H., Mack F.A., Compernolle V., Maltepe E., Adelman D.M., Carmeliet P., Simon M.C.
    Mol Cell Biol 25:10479-10491(2005) [PubMed] [Europe PMC] [Abstract]
• epithelial cell differentiation involved in mammary gland alveolus development Source: MGIInferred from mutant phenotypeⁱ
  • "HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland."
    Seagroves T.N., Hadsell D., McManaman J., Palmer C., Liao D., McNulty W., Welm B., Wagner K.U., Neville M., Johnson R.S.
    Development 130:1713-1724(2003) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition."
    Higgins D.F., Kimura K., Bernhardt W.M., Shrimanker N., Akai Y., Hohenstein B., Saito Y., Johnson R.S., Kretzler M., Cohen C.D., Eckardt K.U., Iwano M., Haase V.H.
    J Clin Invest 117:3810-3820(2007) [PubMed] [Europe PMC] [Abstract]
• glucose homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of skeletal muscle HIF-1alpha results in altered exercise endurance."
    Mason S.D., Howlett R.A., Kim M.J., Olfert I.M., Hogan M.C., McNulty W., Hickey R.P., Wagner P.D., Kahn C.R., Giordano F.J., Johnson R.S.
    PLoS Biol 2:e288-e288(2004) [PubMed] [Europe PMC] [Abstract]
  • "The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis."
    Lum J.J., Bui T., Gruber M., Gordan J.D., DeBerardinis R.J., Covello K.L., Simon M.C., Thompson C.B.
    Genes Dev 21:1037-1049(2007) [PubMed] [Europe PMC] [Abstract]
• heart looping Source: MGIInferred from mutant phenotypeⁱ
  • "Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha."
    Compernolle V., Brusselmans K., Franco D., Moorman A., Dewerchin M., Collen D., Carmeliet P.
    Cardiovasc Res 60:569-579(2003) [PubMed] [Europe PMC] [Abstract]
• hemoglobin biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development."
    Yoon D., Pastore Y.D., Divoky V., Liu E., Mlodnicka A.E., Rainey K., Ponka P., Semenza G.L., Schumacher A., Prchal J.T.
    J Biol Chem 281:25703-25711(2006) [PubMed] [Europe PMC] [Abstract]
• hypoxia-inducible factor-1alpha signaling pathway Source: MGIInferred from direct assayⁱ
  • "Expression of neural cell adhesion molecule (NCAM) during the first molar development in the mouse."
    Obara N., Takeda M.
    Anat Embryol (Berl) 187:209-219(1993) [PubMed] [Europe PMC] [Abstract]
• intestinal epithelial cell maturation Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation."
    Lussier C.R., Brial F., Roy S.A., Langlois M.J., Verdu E.F., Rivard N., Perreault N., Boudreau F.
    PLoS One 5:e12378-e12378(2010) [PubMed] [Europe PMC] [Abstract]
• iris morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development."
    Lange C.A., Luhmann U.F., Mowat F.M., Georgiadis A., West E.L., Abrahams S., Sayed H., Powner M.B., Fruttiger M., Smith A.J., Sowden J.C., Maxwell P.H., Ali R.R., Bainbridge J.W.
    Development 139:2340-2350(2012) [PubMed] [Europe PMC] [Abstract]
• lactate metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of skeletal muscle HIF-1alpha results in altered exercise endurance."
    Mason S.D., Howlett R.A., Kim M.J., Olfert I.M., Hogan M.C., McNulty W., Hickey R.P., Wagner P.D., Kahn C.R., Giordano F.J., Johnson R.S.
    PLoS Biol 2:e288-e288(2004) [PubMed] [Europe PMC] [Abstract]
• lactation Source: MGIInferred from mutant phenotypeⁱ
  • "HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland."
    Seagroves T.N., Hadsell D., McManaman J., Palmer C., Liao D., McNulty W., Welm B., Wagner K.U., Neville M., Johnson R.S.
    Development 130:1713-1724(2003) [PubMed] [Europe PMC] [Abstract]
• muscle cell cellular homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of skeletal muscle HIF-1alpha results in altered exercise endurance."
    Mason S.D., Howlett R.A., Kim M.J., Olfert I.M., Hogan M.C., McNulty W., Hickey R.P., Wagner P.D., Kahn C.R., Giordano F.J., Johnson R.S.
    PLoS Biol 2:e288-e288(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia."
    Zhang H., Bosch-Marce M., Shimoda L.A., Tan Y.S., Baek J.H., Wesley J.B., Gonzalez F.J., Semenza G.L.
    J Biol Chem 283:10892-10903(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of bone mineralization Source: MGIInferred from mutant phenotypeⁱ
  • "Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency."
    Komatsu D.E., Bosch-Marce M., Semenza G.L., Hadjiargyrou M.
    J Bone Miner Res 22:366-374(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: MGI
• negative regulation of growth Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival."
    Schipani E., Ryan H.E., Didrickson S., Kobayashi T., Knight M., Johnson R.S.
    Genes Dev 15:2865-2876(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of mesenchymal cell apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death."
    Kotch L.E., Iyer N.V., Laughner E., Semenza G.L.
    Dev Biol 209:254-267(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Defective brain development in mice lacking the Hif-1alpha gene in neural cells."
    Tomita S., Ueno M., Sakamoto M., Kitahama Y., Ueki M., Maekawa N., Sakamoto H., Gassmann M., Kageyama R., Ueda N., Gonzalez F.J., Takahama Y.
    Mol Cell Biol 23:6739-6749(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ossification Source: CACAOInferred from mutant phenotypeⁱ
  • "Hypoxia-inducible factor-1alpha protein negatively regulates load-induced bone formation."
    Riddle R.C., Leslie J.M., Gross T.S., Clemens T.L.
    J Biol Chem 286:44449-44456(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Source: MGI
• negative regulation of reactive oxygen species metabolic process Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia."
    Zhang H., Bosch-Marce M., Shimoda L.A., Tan Y.S., Baek J.H., Wesley J.B., Gonzalez F.J., Semenza G.L.
    J Biol Chem 283:10892-10903(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of thymocyte apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes."
    Biju M.P., Neumann A.K., Bensinger S.J., Johnson R.S., Turka L.A., Haase V.H.
    Mol Cell Biol 24:9038-9047(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of TOR signaling Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation."
    Lussier C.R., Brial F., Roy S.A., Langlois M.J., Verdu E.F., Rivard N., Perreault N., Boudreau F.
    PLoS One 5:e12378-e12378(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGI
• negative regulation of vasoconstriction Source: MGI
• neural crest cell migration Source: MGIInferred from mutant phenotypeⁱ
  • "Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha."
    Compernolle V., Brusselmans K., Franco D., Moorman A., Dewerchin M., Collen D., Carmeliet P.
    Cardiovasc Res 60:569-579(2003) [PubMed] [Europe PMC] [Abstract]
• neural fold elevation formation Source: MGIInferred from mutant phenotypeⁱ
  • "Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death."
    Kotch L.E., Iyer N.V., Laughner E., Semenza G.L.
    Dev Biol 209:254-267(1999) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha."
    Iyer N.V., Kotch L.E., Agani F., Leung S.W., Laughner E., Wenger R.H., Gassmann M., Gearhart J.D., Lawler A.M., Yu A.Y., Semenza G.L.
    Genes Dev 12:149-162(1998) [PubMed] [Europe PMC] [Abstract]
• oxygen homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha."
    Iyer N.V., Kotch L.E., Agani F., Leung S.W., Laughner E., Wenger R.H., Gassmann M., Gearhart J.D., Lawler A.M., Yu A.Y., Semenza G.L.
    Genes Dev 12:149-162(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: MGI
• positive regulation of apoptotic process Source: MGI
• positive regulation of autophagy Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia."
    Zhang H., Bosch-Marce M., Shimoda L.A., Tan Y.S., Baek J.H., Wesley J.B., Gonzalez F.J., Semenza G.L.
    J Biol Chem 283:10892-10903(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia."
    Zhang H., Bosch-Marce M., Shimoda L.A., Tan Y.S., Baek J.H., Wesley J.B., Gonzalez F.J., Semenza G.L.
    J Biol Chem 283:10892-10903(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood vessel endothelial cell migration Source: MGI
• positive regulation of cell population proliferation Source: MGI
• positive regulation of chemokine-mediated signaling pathway Source: MGI
• positive regulation of cytokine production involved in inflammatory response Source: UniProtKB
• positive regulation of epithelial cell migration Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition."
    Higgins D.F., Kimura K., Bernhardt W.M., Shrimanker N., Akai Y., Hohenstein B., Saito Y., Johnson R.S., Kretzler M., Cohen C.D., Eckardt K.U., Iwano M., Haase V.H.
    J Clin Invest 117:3810-3820(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of erythrocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development."
    Yoon D., Pastore Y.D., Divoky V., Liu E., Mlodnicka A.E., Rainey K., Ponka P., Semenza G.L., Schumacher A., Prchal J.T.
    J Biol Chem 281:25703-25711(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: MGI
• positive regulation of gluconeogenesis Source: MGI
• positive regulation of hormone biosynthetic process Source: MGI
• positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets."
    Cheng K., Ho K., Stokes R., Scott C., Lau S.M., Hawthorne W.J., O'Connell P.J., Loudovaris T., Kay T.W., Kulkarni R.N., Okada T., Wang X.L., Yim S.H., Shah Y., Grey S.T., Biankin A.V., Kench J.G., Laybutt D.R.

    , Gonzalez F.J., Kahn C.R., Gunton J.E.
    J Clin Invest 120:2171-2183(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of macroautophagy Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains."
    Bellot G., Garcia-Medina R., Gounon P., Chiche J., Roux D., Pouyssegur J., Mazure N.M.
    Mol Cell Biol 29:2570-2581(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuroblast proliferation Source: MGIInferred from genetic interactionⁱ
  • "Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling."
    Milosevic J., Maisel M., Wegner F., Leuchtenberger J., Wenger R.H., Gerlach M., Storch A., Schwarz J.
    J Neurosci 27:412-421(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
• positive regulation of signaling receptor activity Source: MGI
• positive regulation of smooth muscle cell proliferation Source: MGI
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "The hypoxia-inducible microRNA cluster miR-199a~214 targets myocardial PPARdelta and impairs mitochondrial fatty acid oxidation."
    el Azzouzi H., Leptidis S., Dirkx E., Hoeks J., van Bree B., Brand K., McClellan E.A., Poels E., Sluimer J.C., van den Hoogenhof M.M., Armand A.S., Yin X., Langley S., Bourajjaj M., Olieslagers S., Krishnan J., Vooijs M., Kurihara H.

    , Stubbs A., Pinto Y.M., Krek W., Mayr M., da Costa Martins P.A., Schrauwen P., De Windt L.J.
    Cell Metab 18:341-354(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
• positive regulation of vascular endothelial growth factor production Source: UniProtKB
• positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival."
    Schipani E., Ryan H.E., Didrickson S., Kobayashi T., Knight M., Johnson R.S.
    Genes Dev 15:2865-2876(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of aerobic respiration Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia."
    Zhang H., Bosch-Marce M., Shimoda L.A., Tan Y.S., Baek J.H., Wesley J.B., Gonzalez F.J., Semenza G.L.
    J Biol Chem 283:10892-10903(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of catalytic activity Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of skeletal muscle HIF-1alpha results in altered exercise endurance."
    Mason S.D., Howlett R.A., Kim M.J., Olfert I.M., Hogan M.C., McNulty W., Hickey R.P., Wagner P.D., Kahn C.R., Giordano F.J., Johnson R.S.
    PLoS Biol 2:e288-e288(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis."
    Lum J.J., Bui T., Gruber M., Gordan J.D., DeBerardinis R.J., Covello K.L., Simon M.C., Thompson C.B.
    Genes Dev 21:1037-1049(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: ParkinsonsUK-UCLInferred from mutant phenotypeⁱ
  • "Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia."
    Zhang H., Bosch-Marce M., Shimoda L.A., Tan Y.S., Baek J.H., Wesley J.B., Gonzalez F.J., Semenza G.L.
    J Biol Chem 283:10892-10903(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of glycolytic process Source: MGIInferred from genetic interactionⁱ
  • "The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis."
    Lum J.J., Bui T., Gruber M., Gordan J.D., DeBerardinis R.J., Covello K.L., Simon M.C., Thompson C.B.
    Genes Dev 21:1037-1049(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of protein neddylation Source: UniProtKB
• regulation of thymocyte apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes."
    Biju M.P., Neumann A.K., Bensinger S.J., Johnson R.S., Turka L.A., Haase V.H.
    Mol Cell Biol 24:9038-9047(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes."
    Biju M.P., Neumann A.K., Bensinger S.J., Johnson R.S., Turka L.A., Haase V.H.
    Mol Cell Biol 24:9038-9047(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: MGIInferred from mutant phenotypeⁱ
  • "Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha."
    Park S.K., Dadak A.M., Haase V.H., Fontana L., Giaccia A.J., Johnson R.S.
    Mol Cell Biol 23:4959-4971(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of transforming growth factor beta2 production Source: MGI
• response to fungicide Source: MGI
• response to hypoxia Source: MGIInferred from direct assayⁱ
  • "Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn."
    Mochizuki Y., Nakamura T., Kanetake H., Kanda S.
    J Cell Sci 115:175-183(2002) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha."
    Li H., Ko H.P., Whitlock J.P. Jr.
    J. Biol. Chem. 271:21262-21267(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
• response to iron ion Source: Ensembl
• response to muscle activity Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of skeletal muscle HIF-1alpha results in altered exercise endurance."
    Mason S.D., Howlett R.A., Kim M.J., Olfert I.M., Hogan M.C., McNulty W., Hickey R.P., Wagner P.D., Kahn C.R., Giordano F.J., Johnson R.S.
    PLoS Biol 2:e288-e288(2004) [PubMed] [Europe PMC] [Abstract]
• response to reactive oxygen species Source: UniProtKB
• retina vasculature development in camera-type eye Source: MGIInferred from mutant phenotypeⁱ
  • "HIF1A is essential for the development of the intermediate plexus of the retinal vasculature."
    Caprara C., Thiersch M., Lange C., Joly S., Samardzija M., Grimm C.
    Invest Ophthalmol Vis Sci 52:2109-2117(2011) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: MGI
• vascular endothelial growth factor production Source: MGI
• vasculature development Source: MGIInferred from genetic interactionⁱ
  • "Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis."
    Chen Y., Doughman Y.Q., Gu S., Jarrell A., Aota S., Cvekl A., Watanabe M., Dunwoodie S.L., Johnson R.S., van Heyningen V., Kleinjan D.A., Beebe D.C., Yang Y.C.
    Development 135:2939-2948(2008) [PubMed] [Europe PMC] [Abstract]
• visual learning Source: MGIInferred from mutant phenotypeⁱ
  • "Defective brain development in mice lacking the Hif-1alpha gene in neural cells."
    Tomita S., Ueno M., Sakamoto M., Kitahama Y., Ueki M., Maekawa N., Sakamoto H., Gassmann M., Kageyama R., Ueda N., Gonzalez F.J., Takahama Y.
    Mol Cell Biol 23:6739-6749(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• enzyme binding Source: MGI
• histone deacetylase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1."
    Seo H.W., Kim E.J., Na H., Lee M.O.
    FEBS Lett 583:55-60(2009) [PubMed] [Europe PMC] [Abstract]
• Hsp90 protein binding Source: MGI
• nuclear receptor binding Source: MGI
• p53 binding Source: MGI
• protein domain specific binding Source: MGI
• protein heterodimerization activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.15

    "Structural integration in hypoxia-inducible factors."
    Wu D., Potluri N., Lu J., Kim Y., Rastinejad F.
    Nature 524:303-308(2015) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (3.90 ANGSTROMS) OF 13-357 IN COMPLEXES WITH ARNT AND DNA, MUTAGENESIS OF ARG-170 AND VAL-191, REGION, INTERACTION WITH ARNT, FUNCTION.
• protein kinase binding Source: MGI
• transcription coactivator binding Source: UniProtKB
• ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEGAGGENEK KKMSSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV 
        60         70         80         90        100
SSHLDKASVM RLTISYLRVR KLLDAGGLDS EDEMKAQMDC FYLKALDGFV 
       110        120        130        140        150
MVLTDDGDMV YISDNVNKYM GLTQFELTGH SVFDFTHPCD HEEMREMLTH 
       160        170        180        190        200
RNGPVRKGKE LNTQRSFFLR MKCTLTSRGR TMNIKSATWK VLHCTGHIHV 
       210        220        230        240        250
YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK TFLSRHSLDM 
       260        270        280        290        300
KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV 
       310        320        330        340        350
TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL 
       360        370        380        390        400
IFSLQQTESV LKPVESSDMK MTQLFTKVES EDTSCLFDKL KKEPDALTLL 
       410        420        430        440        450
APAAGDTIIS LDFGSDDTET EDQQLEDVPL YNDVMFPSSN EKLNINLAMS 
       460        470        480        490        500
PLPSSETPKP LRSSADPALN QEVALKLESS PESLGLSFTM PQIQDQPASP 
       510        520        530        540        550
SDGSTRQSSP ERLLQENVNT PNFSQPNSPS EYCFDVDSDM VNVFKLELVE 
       560        570        580        590        600
KLFAEDTEAK NPFSTQDTDL DLEMLAPYIP MDDDFQLRSF DQLSPLESNS 
       610        620        630        640        650
PSPPSMSTVT GFQQTQLQKP TITATATTTA TTDESKTETK DNKEDIKILI 
       660        670        680        690        700
ASPSSTQVPQ ETTTAKASAY SGTHSRTASP DRAGKRVIEQ TDKAHPRSLN 
       710        720        730        740        750
LSATLNQRNT VPEEELNPKT IASQNAQRKR KMEHDGSLFQ AAGIGTLLQQ 
       760        770        780        790        800
PGDCAPTMSL SWKRVKGFIS SEQNGTEQKT IILIPSDLAC RLLGQSMDES 
       810        820        830 
GLPQLTSYDC EVNAPIQGSR NLLQGEELLR ALDQVN                

        10         20         30         40         50
MEGAGGENEK KKMSSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV 
        60         70         80         90        100
SSHLDKASVM RLTISYLRVR KLLDAGGLDS EDEMKAQMDC FYLKALDGFV 
       110        120        130        140        150
MVLTDDGDMV YISDNVNKYM GLTQFELTGH SVFDFTHPCD HEEMREMLTH 
       160        170        180        190        200
RNGPVRKGKE LNTQRSFFLR MKCTLTSRGR TMNIKSATWK VLHCTGHIHV 
       210        220        230        240        250
YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK TFLSRHSLDM 
       260        270        280        290        300
KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV 
       310        320        330        340        350
TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL 
       360        370        380        390        400
IFSLQQTESV LKPVESSDMK MTQLFTKVES EDTSCLFDKL KKEPDALTLL 
       410        420        430        440        450
APAAGDTIIS LDFGSDDTET EDQQLEDVPL YNDVMFPSSN EKLNINLAMS 
       460        470        480        490        500
PLPSSETPKP LRSSADPALN QEVALKLESS PESLGLSFTM PQIQDQPASP 
       510        520        530        540        550
SDGSTRQSSP EPNSPSEYCF DVDSDMVNVF KLELVEKLFA EDTEAKNPFS 
       560        570        580        590        600
TQDTDLDLEM LAPYIPMDDD FQLRSFDQLS PLESNSPSPP SMSTVTGFQQ 
       610        620        630        640        650
TQLQKPTITA TATTTATTDE SKTETKDNKE DIKILIASPS STQVPQETTT 
       660        670        680        690        700
AKASAYSGTH SRTASPDRAG KRVIEQTDKA HPRSLNLSAT LNQRNTVPEE 
       710        720        730        740        750
ELNPKTIASQ NAQRKRKMEH DGSLFQAAGI GTLLQQPGDC APTMSLSWKR 
       760        770        780        790        800
VKGFISSEQN GTEQKTIILI PSDLACRLLG QSMDESGLPQ LTSYDCEVNA 
       810        820 
PIQGSRNLLQ GEELLRALDQ VN                               

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references