Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q61221 (HIF1A_MOUSE)

Protein

Hypoxia-inducible factor 1-alpha

Gene

Hif1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity).By similarity4 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-MMU-1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8857538 PTK6 promotes HIF1A stabilization
R-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxia-inducible factor 1-alpha
Short name:
HIF-1-alpha
Short name:
HIF1-alpha
Alternative name(s):
ARNT-interacting protein
Gene namesi
Name:Hif1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:106918 Hif1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi170R → A: Decreases heterodimer formation with ARNT. Impairs heterodimer formation with ARNT; when associated with D-191. 1 Publication1
Mutagenesisi191V → D: Decreases heterodimer formation with ARNT. Impairs heterodimer formation with ARNT; when associated with A-170. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL6046

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272211 – 836Hypoxia-inducible factor 1-alphaAdd BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei247Phosphoserine; by CK1By similarity1
Cross-linki391Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei4024-hydroxyprolineBy similarity1
Cross-linki476Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei545N6-acetyllysine; alternateBy similarity1
Cross-linki545Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarityCurated
Cross-linki551Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarityCurated
Cross-linki560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarityCurated
Modified residuei564Phosphoserine; by GSK3-betaBy similarity1
Modified residuei568Phosphothreonine; by GSK3-betaBy similarity1
Modified residuei5774-hydroxyprolineBy similarity1
Modified residuei589Phosphoserine; by PLK3By similarity1
Modified residuei602Phosphoserine; by GSK3-betaBy similarity1
Modified residuei668Phosphoserine; by PLK3By similarity1
Modified residuei719N6-acetyllysineBy similarity1
Modified residuei810S-nitrosocysteineBy similarity1
Modified residuei813(3S)-3-hydroxyasparagineBy similarity1

Post-translational modificationi

S-nitrosylation of Cys-810 may be responsible for increased recruitment of p300 coactivator necessary for transcriptional activity of HIF-1 complex.By similarity
Requires phosphorylation for DNA-binding. Phosphorylation at Ser-247 by CSNK1D/CK1 represses kinase activity and impairs ARNT binding (By similarity). Phosphorylation by GSK3-beta and PLK3 promote degradation by the proteasome.By similarity1 Publication
Sumoylated; with SUMO1 under hypoxia. Sumoylation is enhanced through interaction with RWDD3. Both sumoylation and desumoylation seem to be involved in the regulation of its stability during hypoxia. Sumoylation can promote either its stabilization or its VHL-dependent degradation by promoting hydroxyproline-independent HIF1A-VHL complex binding, thus leading to HIF1A ubiquitination and proteasomal degradation. Desumoylation by SENP1 increases its stability amd transcriptional activity. There is a disaccord between various publications on the effect of sumoylation and desumoylation on its stability and transcriptional activity.2 Publications
Acetylation of Lys-545 by ARD1 increases interaction with VHL and stimulates subsequent proteasomal degradation. Deacetylation of Lys-719 by SIRT2 increases its interaction with and hydroxylation by EGLN1 thereby inactivating HIF1A activity by inducing its proteasomal degradation (By similarity).By similarity
Ubiquitinated; in normoxia, following hydroxylation and interaction with VHL. Lys-545 appears to be the principal site of ubiquitination. Clioquinol, the Cu/Zn-chelator, inhibits ubiquitination through preventing hydroxylation at Asn-813 (By similarity).By similarity
The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains.By similarity
In normoxia, is hydroxylated on Pro-402 and Pro-577 in the oxygen-dependent degradation domain (ODD) by EGLN1/PHD2 and EGLN2/PHD1. EGLN3/PHD3 has also been shown to hydroxylate Pro-577. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Deubiquitinated by USP20. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization (By similarity). In normoxia, is hydroxylated on Asn-813 by HIF1AN, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation. Repressed by iron ion, via Fe2+ prolyl hydroxylase (PHD) enzymes-mediated hydroxylation and subsequent proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Hydroxylation, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

PaxDbiQ61221
PRIDEiQ61221

PTM databases

iPTMnetiQ61221
PhosphoSitePlusiQ61221

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000021109 Expressed in 332 organ(s), highest expression level in retina
CleanExiMM_HIF1A
ExpressionAtlasiQ61221 baseline and differential
GenevisibleiQ61221 MM

Interactioni

Subunit structurei

Interacts with HIF3A isoform 2 (PubMed:21546903). Interacts with the ARNT; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Interacts with Interacts with NCOA1, NCOA2, APEX and HSP90. Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to polyubiquitination and subsequent HIF1A proteasomal degradation. During hypoxia, sumoylated HIF1A also binds VHL; the interaction promotes the ubiquitination of HIF1A. Interacts with SENP1; the interaction desumoylates HIF1A resulting in stabilization and activation of transcription. Interacts (Via the ODD domain) with ARD1A; the interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia. Interacts with RWDD3; the interaction enhances HIF1A sumoylation. Interacts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and hypoxia-mimicking conditions. Interacts with USP20. Interacts with RACK1; promotes HIF1A ubiquitination and proteasome-mediated degradation. Interacts with EP300 (via TAZ-type 1 domain); the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts with CREBBP (via TAZ-type 1 domain). Interacts with SIRT2. Interacts (deacetylated form) with EGLN1 (By similarity). Interacts with TSGA10. Interacts (via N-terminus) with USP19. Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability. Interacts with CBFA2T3. Interacts with HSP90AA1 and HSP90AB1 (By similarity).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi200304, 20 interactors
DIPiDIP-31083N
IntActiQ61221, 15 interactors
MINTiQ61221
STRINGi10090.ENSMUSP00000021530

Chemistry databases

BindingDBiQ61221

Structurei

3D structure databases

ProteinModelPortaliQ61221
SMRiQ61221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 70bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini80 – 155PAS 1PROSITE-ProRule annotationAdd BLAST76
Domaini228 – 298PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini302 – 345PACAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 401Interaction with TSGA101 PublicationAdd BLAST401
Regioni21 – 30DNA-binding1 Publication10
Regioni170 – 191Required for heterodimer formation with ARNT1 PublicationAdd BLAST22
Regioni380 – 417N-terminal VHL recognition siteBy similarityAdd BLAST38
Regioni401 – 613ODDAdd BLAST213
Regioni544 – 588NTADAdd BLAST45
Regioni569 – 585C-terminal VHL recognition siteBy similarityAdd BLAST17
Regioni589 – 795IDAdd BLAST207
Regioni796 – 836CTADAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi728 – 731Nuclear localization signalSequence analysis4

Domaini

Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID) (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3558 Eukaryota
ENOG410YK57 LUCA
GeneTreeiENSGT00760000118788
HOVERGENiHBG060456
InParanoidiQ61221
KOiK08268
OrthoDBiEOG091G0486
PhylomeDBiQ61221
TreeFamiTF317772

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR001321 HIF-1_alpha
IPR014887 HIF-1_TAD_C
IPR021537 HIF_alpha_subunit
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
PfamiView protein in Pfam
PF11413 HIF-1, 1 hit
PF08778 HIF-1a_CTAD, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
PRINTSiPR01080 HYPOXIAIF1A
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61221-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGAGGENEK KKMSSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV 
        60         70         80         90        100
SSHLDKASVM RLTISYLRVR KLLDAGGLDS EDEMKAQMDC FYLKALDGFV 
       110        120        130        140        150
MVLTDDGDMV YISDNVNKYM GLTQFELTGH SVFDFTHPCD HEEMREMLTH 
       160        170        180        190        200
RNGPVRKGKE LNTQRSFFLR MKCTLTSRGR TMNIKSATWK VLHCTGHIHV 
       210        220        230        240        250
YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK TFLSRHSLDM 
       260        270        280        290        300
KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV 
       310        320        330        340        350
TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL 
       360        370        380        390        400
IFSLQQTESV LKPVESSDMK MTQLFTKVES EDTSCLFDKL KKEPDALTLL 
       410        420        430        440        450
APAAGDTIIS LDFGSDDTET EDQQLEDVPL YNDVMFPSSN EKLNINLAMS 
       460        470        480        490        500
PLPSSETPKP LRSSADPALN QEVALKLESS PESLGLSFTM PQIQDQPASP 
       510        520        530        540        550
SDGSTRQSSP ERLLQENVNT PNFSQPNSPS EYCFDVDSDM VNVFKLELVE 
       560        570        580        590        600
KLFAEDTEAK NPFSTQDTDL DLEMLAPYIP MDDDFQLRSF DQLSPLESNS 
       610        620        630        640        650
PSPPSMSTVT GFQQTQLQKP TITATATTTA TTDESKTETK DNKEDIKILI 
       660        670        680        690        700
ASPSSTQVPQ ETTTAKASAY SGTHSRTASP DRAGKRVIEQ TDKAHPRSLN 
       710        720        730        740        750
LSATLNQRNT VPEEELNPKT IASQNAQRKR KMEHDGSLFQ AAGIGTLLQQ 
       760        770        780        790        800
PGDCAPTMSL SWKRVKGFIS SEQNGTEQKT IILIPSDLAC RLLGQSMDES 
       810        820        830 
GLPQLTSYDC EVNAPIQGSR NLLQGEELLR ALDQVN
Length:836
Mass (Da):93,516
Last modified:July 3, 2003 - v3
Checksum:i84D64ECAC2CC753B
GO
Isoform 2 (identifier: Q61221-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     512-525: Missing.

Show »
Length:822
Mass (Da):91,874
Checksum:i8DC6E7C1772AF1BF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1E9A0A0R4J1E9_MOUSE
Hypoxia-inducible factor 1-alpha
Hif1a
810Annotation score:
A0A0R4J1F0A0A0R4J1F0_MOUSE
Hypoxia-inducible factor 1-alpha
Hif1a
258Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12K → NR in BAC28578 (PubMed:16141072).Curated1
Sequence conflicti31S → T in AAC52730 (PubMed:8702901).Curated1
Sequence conflicti128T → A in AAC52730 (PubMed:8702901).Curated1
Sequence conflicti128T → A in CAA64833 (PubMed:8660378).Curated1
Sequence conflicti351I → L in AAC52730 (PubMed:8702901).Curated1
Sequence conflicti369M → K in AAH26139 (PubMed:15489334).Curated1
Sequence conflicti382D → A in AAH26139 (PubMed:15489334).Curated1
Sequence conflicti397L → H in BAC28578 (PubMed:16141072).Curated1
Sequence conflicti569D → G in BAC28578 (PubMed:16141072).Curated1
Sequence conflicti660Q → K in BAC28305 (PubMed:16141072).Curated1
Sequence conflicti700N → K in AAC52730 (PubMed:8702901).Curated1
Sequence conflicti700N → K in AAC53455 (PubMed:9368100).Curated1
Sequence conflicti700N → K in AAC53461 (PubMed:9368100).Curated1
Sequence conflicti799E → V in CAA64833 (PubMed:8660378).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007739512 – 525Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59496 Genomic DNA Translation: AAC52730.1
AF003695 mRNA Translation: AAC53455.1
AF004155
, AF004141, AF004142, AF004143, AF004144, AF004145, AF004146, AF004147, AF004148, AF004149, AF004150, AF004151, AF004152, AF004153, AF004154 Genomic DNA Translation: AAC53461.1
Y09085 Genomic DNA Translation: CAA70305.1
Y09085, Y13656 Genomic DNA Translation: CAA70306.1
AK034087 mRNA Translation: BAC28578.1
AK076395 mRNA Translation: BAC36320.1
AK033471 mRNA Translation: BAC28305.1
AK017853 mRNA Translation: BAB30975.1
BC026139 mRNA Translation: AAH26139.1
X95580 mRNA Translation: CAA64833.1
X95002 mRNA Translation: CAA64458.1
CCDSiCCDS25977.1 [Q61221-1]
PIRiJC4837
RefSeqiNP_001300848.1, NM_001313919.1
NP_001300849.1, NM_001313920.1
NP_034561.2, NM_010431.2 [Q61221-1]
XP_017170450.1, XM_017314961.1 [Q61221-2]
UniGeneiMm.3879
Mm.446610

Genome annotation databases

EnsembliENSMUST00000021530; ENSMUSP00000021530; ENSMUSG00000021109 [Q61221-1]
GeneIDi15251
KEGGimmu:15251
UCSCiuc007nwo.2 mouse [Q61221-2]
uc007nwq.2 mouse [Q61221-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59496 Genomic DNA Translation: AAC52730.1
AF003695 mRNA Translation: AAC53455.1
AF004155
, AF004141, AF004142, AF004143, AF004144, AF004145, AF004146, AF004147, AF004148, AF004149, AF004150, AF004151, AF004152, AF004153, AF004154 Genomic DNA Translation: AAC53461.1
Y09085 Genomic DNA Translation: CAA70305.1
Y09085, Y13656 Genomic DNA Translation: CAA70306.1
AK034087 mRNA Translation: BAC28578.1
AK076395 mRNA Translation: BAC36320.1
AK033471 mRNA Translation: BAC28305.1
AK017853 mRNA Translation: BAB30975.1
BC026139 mRNA Translation: AAH26139.1
X95580 mRNA Translation: CAA64833.1
X95002 mRNA Translation: CAA64458.1
CCDSiCCDS25977.1 [Q61221-1]
PIRiJC4837
RefSeqiNP_001300848.1, NM_001313919.1
NP_001300849.1, NM_001313920.1
NP_034561.2, NM_010431.2 [Q61221-1]
XP_017170450.1, XM_017314961.1 [Q61221-2]
UniGeneiMm.3879
Mm.446610

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZPRX-ray3.90B13-357[»]
ProteinModelPortaliQ61221
SMRiQ61221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200304, 20 interactors
DIPiDIP-31083N
IntActiQ61221, 15 interactors
MINTiQ61221
STRINGi10090.ENSMUSP00000021530

Chemistry databases

BindingDBiQ61221
ChEMBLiCHEMBL6046

PTM databases

iPTMnetiQ61221
PhosphoSitePlusiQ61221

Proteomic databases

PaxDbiQ61221
PRIDEiQ61221

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021530; ENSMUSP00000021530; ENSMUSG00000021109 [Q61221-1]
GeneIDi15251
KEGGimmu:15251
UCSCiuc007nwo.2 mouse [Q61221-2]
uc007nwq.2 mouse [Q61221-1]

Organism-specific databases

CTDi3091
MGIiMGI:106918 Hif1a

Phylogenomic databases

eggNOGiKOG3558 Eukaryota
ENOG410YK57 LUCA
GeneTreeiENSGT00760000118788
HOVERGENiHBG060456
InParanoidiQ61221
KOiK08268
OrthoDBiEOG091G0486
PhylomeDBiQ61221
TreeFamiTF317772

Enzyme and pathway databases

ReactomeiR-MMU-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-MMU-1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8857538 PTK6 promotes HIF1A stabilization
R-MMU-8951664 Neddylation

Miscellaneous databases

ChiTaRSiHif1a mouse
PROiPR:Q61221
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021109 Expressed in 332 organ(s), highest expression level in retina
CleanExiMM_HIF1A
ExpressionAtlasiQ61221 baseline and differential
GenevisibleiQ61221 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR001321 HIF-1_alpha
IPR014887 HIF-1_TAD_C
IPR021537 HIF_alpha_subunit
IPR036638 HLH_DNA-bd_sf
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR013655 PAS_fold_3
PfamiView protein in Pfam
PF11413 HIF-1, 1 hit
PF08778 HIF-1a_CTAD, 1 hit
PF00989 PAS, 1 hit
PF08447 PAS_3, 1 hit
PRINTSiPR01080 HYPOXIAIF1A
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 2 hits
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHIF1A_MOUSE
AccessioniPrimary (citable) accession number: Q61221
Secondary accession number(s): O08741
, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 3, 2003
Last modified: November 7, 2018
This is version 207 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again