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Protein

Neurexophilin-1

Gene

Nxph1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins.

GO - Molecular functioni

  • signaling receptor binding Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Neurexophilin-1
Gene namesi
Name:Nxph1
Synonyms:Nph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107492 Nxph1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002006022 – 271Neurexophilin-1Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ61200
PaxDbiQ61200
PRIDEiQ61200

PTM databases

PhosphoSitePlusiQ61200

Expressioni

Tissue specificityi

Brain, only in a scattered subpopulation of neurons that probably represent inhibitory interneurons.

Gene expression databases

BgeeiENSMUSG00000046178 Expressed in 163 organ(s), highest expression level in lateral septal nucleus
CleanExiMM_NXPH1
GenevisibleiQ61200 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060926

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 97IIAdd BLAST76
Regioni98 – 176IIIAdd BLAST79
Regioni177 – 185IV (linker domain)9
Regioni186 – 271V (Cys-rich)Add BLAST86

Sequence similaritiesi

Belongs to the neurexophilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJV8 Eukaryota
ENOG410YYWH LUCA
GeneTreeiENSGT00390000015950
HOGENOMiHOG000261694
HOVERGENiHBG052706
InParanoidiQ61200
KOiK16656
OMAiFQVTCAN
OrthoDBiEOG091G0GC5
PhylomeDBiQ61200
TreeFamiTF333047

Family and domain databases

InterProiView protein in InterPro
IPR010450 Nxph
IPR026845 NXPH/NXPE
PANTHERiPTHR17103 PTHR17103, 1 hit
PfamiView protein in Pfam
PF06312 Neurexophilin, 1 hit
PIRSFiPIRSF038019 Neurexophilin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61200-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAACWYVLL LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS
60 70 80 90 100
KDLSISRLLS QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP
110 120 130 140 150
RPRAKRRPIV KTGKFKKMFG WGDFHSNIKT VKLNLLITGK IVDHGNGTFS
160 170 180 190 200
VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ QTVIDAKDSK SFNCRIEYEK
210 220 230 240 250
VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI YISFYSTDYK
260 270
LVQKVCPDYN YHSDTPYFPS G
Length:271
Mass (Da):31,048
Last modified:February 1, 2005 - v2
Checksum:i1409A31DE111E647
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148T → N in BAC31708 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043942 mRNA Translation: BAC31708.1
AK047847 mRNA Translation: BAC33174.1
AK083014 mRNA Translation: BAC38730.1
BC145953 mRNA Translation: AAI45954.1
BC145955 mRNA Translation: AAI45956.1
U56651 Genomic DNA Translation: AAB18764.1
CCDSiCCDS39426.1
RefSeqiNP_032777.3, NM_008751.5
XP_006505073.1, XM_006505010.3
UniGeneiMm.46954

Genome annotation databases

EnsembliENSMUST00000060369; ENSMUSP00000060926; ENSMUSG00000046178
ENSMUST00000160300; ENSMUSP00000125274; ENSMUSG00000046178
GeneIDi18231
KEGGimmu:18231
UCSCiuc009ayb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043942 mRNA Translation: BAC31708.1
AK047847 mRNA Translation: BAC33174.1
AK083014 mRNA Translation: BAC38730.1
BC145953 mRNA Translation: AAI45954.1
BC145955 mRNA Translation: AAI45956.1
U56651 Genomic DNA Translation: AAB18764.1
CCDSiCCDS39426.1
RefSeqiNP_032777.3, NM_008751.5
XP_006505073.1, XM_006505010.3
UniGeneiMm.46954

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060926

PTM databases

PhosphoSitePlusiQ61200

Proteomic databases

MaxQBiQ61200
PaxDbiQ61200
PRIDEiQ61200

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060369; ENSMUSP00000060926; ENSMUSG00000046178
ENSMUST00000160300; ENSMUSP00000125274; ENSMUSG00000046178
GeneIDi18231
KEGGimmu:18231
UCSCiuc009ayb.1 mouse

Organism-specific databases

CTDi30010
MGIiMGI:107492 Nxph1

Phylogenomic databases

eggNOGiENOG410IJV8 Eukaryota
ENOG410YYWH LUCA
GeneTreeiENSGT00390000015950
HOGENOMiHOG000261694
HOVERGENiHBG052706
InParanoidiQ61200
KOiK16656
OMAiFQVTCAN
OrthoDBiEOG091G0GC5
PhylomeDBiQ61200
TreeFamiTF333047

Miscellaneous databases

PROiPR:Q61200
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046178 Expressed in 163 organ(s), highest expression level in lateral septal nucleus
CleanExiMM_NXPH1
GenevisibleiQ61200 MM

Family and domain databases

InterProiView protein in InterPro
IPR010450 Nxph
IPR026845 NXPH/NXPE
PANTHERiPTHR17103 PTHR17103, 1 hit
PfamiView protein in Pfam
PF06312 Neurexophilin, 1 hit
PIRSFiPIRSF038019 Neurexophilin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNXPH1_MOUSE
AccessioniPrimary (citable) accession number: Q61200
Secondary accession number(s): A6H6P7, Q8BHJ2, Q8BLP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 2005
Last modified: September 12, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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