Peroxiredoxin-2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• [thioredoxin]-dithiol

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  + a hydroperoxide

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  = [thioredoxin]-disulfide

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  + an alcohol

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  + H₂O

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  By similarity

  Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:P32119 (PRDX2_HUMAN)
  EC:1.11.1.24
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  • See the description of this EC number in ENZYME.
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  By similarity

  Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:P32119 (PRDX2_HUMAN)
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

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  [thioredoxin]-dithiol

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  L-cysteine residue

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  Position: n

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  L-cysteine residue

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  Position: n+3

  zoom

  +

  a hydroperoxide

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  zoom

  =

  [thioredoxin]-disulfide

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  L-cystine residue

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  +

  an alcohol

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  zoom

  +

  H₂O

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  • See the description of this molecule in ChEBI.

  

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• antioxidant activity Source: MGI
• peroxidase activity Source: MGI <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury."
    Ichimiya S., Davis J.G., O'Rourke D.M., Katsumata M., Greene M.I.
    DNA Cell Biol. 16:311-321(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• selenium binding Source: MGITraceable author statementⁱ
  • "Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells."
    Gladyshev V.N., Factor V.M., Housseau F., Hatfield D.L.
    Biochem Biophys Res Commun 251:488-493(1998) [PubMed] [Europe PMC] [Abstract]
• thioredoxin peroxidase activity Source: MGI <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • Ref.1

    "Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury."
    Ichimiya S., Davis J.G., O'Rourke D.M., Katsumata M., Greene M.I.
    DNA Cell Biol. 16:311-321(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

GO - Biological processⁱ

• activation of MAPK activity Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock."
    Yang C.S., Lee D.S., Song C.H., An S.J., Li S., Kim J.M., Kim C.S., Yoo D.G., Jeon B.H., Yang H.Y., Lee T.H., Lee Z.W., El-Benna J., Yu D.Y., Jo E.K.
    J Exp Med 204:583-594(2007) [PubMed] [Europe PMC] [Abstract]
• cell redox homeostasis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to oxidative stress Source: MGI
• defense response to tumor cell Source: Ensembl
• homeostasis of number of cells Source: MGIInferred from mutant phenotypeⁱ
  • "Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus."
    Moon E.Y., Han Y.H., Lee D.S., Han Y.M., Yu D.Y.
    Eur J Immunol 34:2119-2128(2004) [PubMed] [Europe PMC] [Abstract]
• hydrogen peroxide catabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II."
    Choi M.H., Lee I.K., Kim G.W., Kim B.U., Han Y.H., Yu D.Y., Park H.S., Kim K.Y., Lee J.S., Choi C., Bae Y.S., Lee B.I., Rhee S.G., Kang S.W.
    Nature 435:347-353(2005) [PubMed] [Europe PMC] [Abstract]
• hydrogen peroxide metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus."
    Moon E.Y., Han Y.H., Lee D.S., Han Y.M., Yu D.Y.
    Eur J Immunol 34:2119-2128(2004) [PubMed] [Europe PMC] [Abstract]
  • "Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock."
    Yang C.S., Lee D.S., Song C.H., An S.J., Li S., Kim J.M., Kim C.S., Yoo D.G., Jeon B.H., Yang H.Y., Lee T.H., Lee Z.W., El-Benna J., Yu D.Y., Jo E.K.
    J Exp Med 204:583-594(2007) [PubMed] [Europe PMC] [Abstract]
• leukocyte activation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extrinsic apoptotic signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus."
    Moon E.Y., Han Y.H., Lee D.S., Han Y.M., Yu D.Y.
    Eur J Immunol 34:2119-2128(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury."
    Ichimiya S., Davis J.G., O'Rourke D.M., Katsumata M., Greene M.I.
    DNA Cell Biol. 16:311-321(1997) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• negative regulation of lipopolysaccharide-mediated signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock."
    Yang C.S., Lee D.S., Song C.H., An S.J., Li S., Kim J.M., Kim C.S., Yoo D.G., Jeon B.H., Yang H.Y., Lee T.H., Lee Z.W., El-Benna J., Yu D.Y., Jo E.K.
    J Exp Med 204:583-594(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron apoptotic process Source: MGI
• negative regulation of NF-kappaB transcription factor activity Source: MGIInferred from mutant phenotypeⁱ
  • "Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock."
    Yang C.S., Lee D.S., Song C.H., An S.J., Li S., Kim J.M., Kim C.S., Yoo D.G., Jeon B.H., Yang H.Y., Lee T.H., Lee Z.W., El-Benna J., Yu D.Y., Jo E.K.
    J Exp Med 204:583-594(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of T cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene."
    Moon E.Y., Noh Y.W., Han Y.H., Kim S.U., Kim J.M., Yu D.Y., Lim J.S.
    Immunol Lett 102:184-190(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood coagulation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs."
    Li W., Febbraio M., Reddy S.P., Yu D.Y., Yamamoto M., Silverstein R.L.
    J Clin Invest 120:3996-4006(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of apoptotic process Source: MGI
• regulation of hydrogen peroxide metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock."
    Yang C.S., Lee D.S., Song C.H., An S.J., Li S., Kim J.M., Kim C.S., Yoo D.G., Jeon B.H., Yang H.Y., Lee T.H., Lee Z.W., El-Benna J., Yu D.Y., Jo E.K.
    J Exp Med 204:583-594(2007) [PubMed] [Europe PMC] [Abstract]
• removal of superoxide radicals Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs."
    Li W., Febbraio M., Reddy S.P., Yu D.Y., Yamamoto M., Silverstein R.L.
    J Clin Invest 120:3996-4006(2010) [PubMed] [Europe PMC] [Abstract]
• respiratory burst involved in inflammatory response Source: MGIInferred from mutant phenotypeⁱ
  • "Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock."
    Yang C.S., Lee D.S., Song C.H., An S.J., Li S., Kim J.M., Kim C.S., Yoo D.G., Jeon B.H., Yang H.Y., Lee T.H., Lee Z.W., El-Benna J., Yu D.Y., Jo E.K.
    J Exp Med 204:583-594(2007) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: MGIInferred from mutant phenotypeⁱ
  • "Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock."
    Yang C.S., Lee D.S., Song C.H., An S.J., Li S., Kim J.M., Kim C.S., Yoo D.G., Jeon B.H., Yang H.Y., Lee T.H., Lee Z.W., El-Benna J., Yu D.Y., Jo E.K.
    J Exp Med 204:583-594(2007) [PubMed] [Europe PMC] [Abstract]
• response to oxidative stress Source: MGI
• T cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus."
    Moon E.Y., Han Y.H., Lee D.S., Han Y.M., Yu D.Y.
    Eur J Immunol 34:2119-2128(2004) [PubMed] [Europe PMC] [Abstract]
• thymus development Source: MGIInferred from mutant phenotypeⁱ
  • "Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus."
    Moon E.Y., Han Y.H., Lee D.S., Han Y.M., Yu D.Y.
    Eur J Immunol 34:2119-2128(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MASGNAQIGK SAPDFTATAV VDGAFKEIKL SDYRGKYVVL FFYPLDFTFV 
        60         70         80         90        100
CPTEIIAFSD HAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN 
       110        120        130        140        150
IPLLADVTKS LSQNYGVLKN DEGIAYRGLF IIDAKGVLRQ ITVNDLPVGR 
       160        170        180        190 
SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families