Gata6

Functionⁱ

Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519). May regulate genes that protect epithelial cells from bacterial infection (By similarity). Involved in gene regulation specifically in the gastric epithelium (By similarity). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343).By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	384 – 408	GATA-type 1PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	438 – 462	GATA-type 2PROSITE-ProRule annotationAdd BLAST		25

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 16199866
DNA binding
Source: MGI
Inferred from direct assayⁱ
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
double-stranded DNA binding Source: MGI
enhancer sequence-specific DNA binding Source: MGI
protein kinase binding Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 21350014
RNA polymerase II repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16293227
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 11914369
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: MGI
Inferred from direct assayⁱ
- 8660897
transcription factor binding
Source: MGI
Inferred from physical interactionⁱ
- 16887115
transcription regulatory region DNA binding Source: MGI
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure formation involved in morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
animal organ formation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16887115
animal organ morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cardiac muscle cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 18400219
cardiac muscle hypertrophy in response to stress
Source: MGI
Inferred from mutant phenotypeⁱ
- 20705924
cardiac muscle tissue development
Source: MGI
Inferred from genetic interactionⁱ
- 20705924
cardiac vascular smooth muscle cell differentiation Source: MGI
cell development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to BMP stimulus
Source: MGI
Inferred from direct assayⁱ
- 20501701
cellular response to gonadotropin stimulus
Source: MGI
Inferred from direct assayⁱ
- 9231805
cellular response to hypoxia Source: MGI
Clara cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 17164424
endodermal cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 9832509
endodermal cell fate determination
Source: MGI
Inferred from direct assayⁱ
- 20308546
epithelial cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16887115
heart development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intestinal epithelial cell differentiation
Source: MGI
Inferred from sequence orthologyⁱ
- 9566909
in utero embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 20123909
- 9832509
liver development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15767668
lung saccule development
Source: MGI
Inferred from genetic interactionⁱ
- 17164424
male gonad development Source: Ensembl
negative regulation of apoptotic process Source: MGI
negative regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
negative regulation of transcription, DNA-templated Source: MGI
negative regulation of transcription by RNA polymerase II Source: MGI
negative regulation of transforming growth factor beta1 production Source: MGI
negative regulation of transforming growth factor beta2 production Source: MGI
outflow tract septum morphogenesis Source: MGI
pancreas development
Source: MGI
Inferred from mutant phenotypeⁱ
- 16887115
pancreatic A cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16887115
phospholipid metabolic process
Source: MGI
Inferred from genetic interactionⁱ
- 17164424
positive regulation of angiogenesis Source: MGI
positive regulation of apoptotic process Source: MGI
positive regulation of BMP signaling pathway Source: MGI
positive regulation of cardiac muscle cell apoptotic process Source: MGI
positive regulation of cardiac muscle cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 19084512
positive regulation of cardiac muscle myoblast proliferation Source: MGI
positive regulation of cardioblast differentiation
Source: BHF-UCL
Inferred from expression patternⁱ
- 16137232
positive regulation of cell cycle arrest Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
regulation of gene expression
Source: MGI
Inferred from genetic interactionⁱ
- 18400219
response to drug Source: MGI
response to estrogen
Source: MGI
Inferred from direct assayⁱ
- 9231805
response to growth factor Source: MGI
smooth muscle cell differentiation Source: MGI
tissue development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription by RNA polymerase II Source: MGI
tube morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 18400219
type B pancreatic cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 16887115
type II pneumocyte differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 17164424

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5683826 Surfactant metabolism R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-MMU-5683826 Surfactant metabolism
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor GATA-6 Alternative name(s): GATA-binding factor 6
Gene namesⁱ	Name:Gata6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:107516 Gata6

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083424	1 – 589	Transcription factor GATA-6Add BLAST		589

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	266	PhosphoserineBy similarity	1
Cross-linkⁱ	423	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	467	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	478	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q61169
PeptideAtlas More...PeptideAtlasⁱ	Q61169
PRIDEⁱ	Q61169

PTM databases

iPTMnetⁱ	Q61169
PhosphoSitePlusⁱ	Q61169

Expressionⁱ

Tissue specificityⁱ

Expressed in myocardium, vascular smooth muscle, gut epithelium, and osteoclasts.

Gene expression databases

Bgeeⁱ	ENSMUSG00000005836 Expressed in 205 organ(s), highest expression level in cardiac atrium
CleanExⁱ	MM_GATA6
Genevisibleⁱ	Q61169 MM

Interactionⁱ

Subunit structureⁱ

Interacts with LMCD1.1 Publication

GO - Molecular functionⁱ

protein kinase binding Source: MGI
RNA polymerase II repressing transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16293227
transcription factor binding
Source: MGI
Inferred from physical interactionⁱ
- 16887115

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199843, 11 interactors
IntActⁱ	Q61169, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q61169
STRINGⁱ	10090.ENSMUSP00000041774

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q61169
SMRⁱ	Q61169
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	173 – 183	Poly-AlaAdd BLAST	11
Compositional biasⁱ	322 – 328	Poly-His	7
Compositional biasⁱ	443 – 447	Poly-Thr	5

Domainⁱ

The GATA-type zinc fingers mediate interaction with LMCD1.1 Publication

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	384 – 408	GATA-type 1PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	438 – 462	GATA-type 2PROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1601 Eukaryota COG5641 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119221
HOGENOMⁱ	HOG000047700
HOVERGENⁱ	HBG051703
InParanoidⁱ	Q61169
KEGG Orthology (KO) More...KOⁱ	K17897
OMAⁱ	GAHPGWP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AUR
PhylomeDBⁱ	Q61169
TreeFamⁱ	TF315391

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 2 hits
Gene3Dⁱ	3.30.50.10, 2 hits
InterProⁱ	View protein in InterPro IPR008013 GATA_N IPR016375 TF_GATA_4/5/6 IPR039355 Transcription_factor_GATA IPR000679 Znf_GATA IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR10071 PTHR10071, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00320 GATA, 2 hits PF05349 GATA-N, 1 hit
PIRSFⁱ	PIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSⁱ	PR00619 GATAZNFINGER
SMARTⁱ	View protein in SMART SM00401 ZnF_GATA, 2 hits
PROSITEⁱ	View protein in PROSITE PS00344 GATA_ZN_FINGER_1, 2 hits PS50114 GATA_ZN_FINGER_2, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket

Isoform 1 (identifier: Q61169-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG 
        60         70         80         90        100
DRGPCGASNC RTPQLDAEAV AGPPGRSLLL SPYASHPFAA AHGAAAPGVA 
       110        120        130        140        150
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT 
       160        170        180        190        200
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLSG 
       210        220        230        240        250
LPYLQGAGSG PSNHAGGAGA HPGWSQASAD SPPYGGGGAA GGGAAGPGGA 
       260        270        280        290        300
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGTGAGS VSGGGGSLAA 
       310        320        330        340        350
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMAAPLT PAWPAGPFET 
       360        370        380        390        400
PVLHSLQGRA GAPLPVPRGP STDLLEDLSE SRECVNCGSI QTPLWRRDGT 
       410        420        430        440        450
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR 
       460        470        480        490        500
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG 
       510        520        530        540        550
NSSGSVPMTP TSSSSNSDDC TKNTSPSTQA TTSGVGASVM SAVGENANPE 
       560        570        580 
NSDLKYSGQD GLYIGVSLSS PAEVTSSVRQ DSWCALALA

Length:589

Mass (Da):59,307

Last modified:November 25, 2008 - v3

Checksum:ⁱ1A55474DA65EC6ED

GO

Isoform 2 (identifier: Q61169-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-146: Missing.

« Hide

        10         20         30         40         50
MYQTLAALSS QGPAAYDGAP GGFVHSAAAA AAAAAAASSP VYVPTTRVGS 
        60         70         80         90        100
MLSGLPYLQG AGSGPSNHAG GAGAHPGWSQ ASADSPPYGG GGAAGGGAAG 
       110        120        130        140        150
PGGAGSATAH ASARFPYSPS PPMANGAARD PGGYVAAGGT GAGSVSGGGG 
       160        170        180        190        200
SLAAMGGREH QYSSLSAARP LNGTYHHHHH HHPTYSPYMA APLTPAWPAG 
       210        220        230        240        250
PFETPVLHSL QGRAGAPLPV PRGPSTDLLE DLSESRECVN CGSIQTPLWR 
       260        270        280        290        300
RDGTGHYLCN ACGLYSKMNG LSRPLIKPQK RVPSSRRLGL SCANCHTTTT 
       310        320        330        340        350
TLWRRNAEGE PVCNACGLYM KLHGVPRPLA MKKEGIQTRK RKPKNINKSK 
       360        370        380        390        400
ACSGNSSGSV PMTPTSSSSN SDDCTKNTSP STQATTSGVG ASVMSAVGEN 
       410        420        430        440 
ANPENSDLKY SGQDGLYIGV SLSSPAEVTS SVRQDSWCAL ALA

Note: Produced by alternative initiation at Met-147 of isoform 1.

Show »

Length:443

Mass (Da):44,702

Checksum:ⁱ27B98CD21D42D223

GO

Sequence cautionⁱ

The sequence AAB37426 differs from that shown. Reason: Frameshift at positions 360 and 368.Curated

The sequence AAC52841 differs from that shown. Reason: Frameshift at position 572.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	297	S → T in AAB37426 (PubMed:8660897).Curated	1
Sequence conflictⁱ	416	G → A in AAC52841 (PubMed:8812463).Curated	1
Sequence conflictⁱ	536	G → R in AAC52841 (PubMed:8812463).Curated	1
Sequence conflictⁱ	538	Missing in AAC52841 (PubMed:8812463).Curated	1
Sequence conflictⁱ	546	N → K in AAC52841 (PubMed:8812463).Curated	1
Sequence conflictⁱ	589	A → V in AAB37426 (PubMed:8660897).Curated	1
Sequence conflictⁱ	589	A → V in AAD55267 (Ref. 2) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035779	1 – 146	Missing in isoform 2. 2 PublicationsAdd BLAST		146

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S82462 mRNA Translation: AAB37426.1 Frameshift. AF179425 mRNA Translation: AAD55267.1 AK142381 mRNA Translation: BAE25049.1 CH466592 Genomic DNA Translation: EDL22985.1 U51335 mRNA Translation: AAC52841.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29059.1 [Q61169-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_034388.2, NM_010258.3 [Q61169-1]
UniGeneⁱ	Mm.329287

Genome annotation databases

Ensemblⁱ	ENSMUST00000047762; ENSMUSP00000041774; ENSMUSG00000005836 [Q61169-1]
GeneIDⁱ	14465
KEGGⁱ	mmu:14465
UCSC genome browser More...UCSCⁱ	uc008ebj.1 mouse [Q61169-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation

Protein	Similar proteins		Species	Score	Length	Source
Q61169	Isoform 2 of Transcription factor GATA-6		MOUSE		443	UniRef90_Q61169
UPI000A30DD5C		MUSPA		590
UPI000A314F9F		MUSCR		589
Transcription factor GATA-6 (Fragment)		MOUSE		470
UPI0003D72D62		MOUSE		590

Protein	Similar proteins		Species	Score	Length	Source
Q61169	Transcription factor GATA-6		HUMAN		595	UniRef50_Q92908
Transcription factor GATA-6		RAT		587
Transcription factor GATA-6 (Fragment)		PIG		451
Uncharacterized protein		FELCA		646
GATA binding protein 6		GORGO		596
+75

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S82462 mRNA Translation: AAB37426.1 Frameshift. AF179425 mRNA Translation: AAD55267.1 AK142381 mRNA Translation: BAE25049.1 CH466592 Genomic DNA Translation: EDL22985.1 U51335 mRNA Translation: AAC52841.1 Frameshift.
CCDSⁱ	CCDS29059.1 [Q61169-1]
RefSeqⁱ	NP_034388.2, NM_010258.3 [Q61169-1]
UniGeneⁱ	Mm.329287

3D structure databases

ProteinModelPortalⁱ	Q61169
SMRⁱ	Q61169
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199843, 11 interactors
IntActⁱ	Q61169, 2 interactors
MINTⁱ	Q61169
STRINGⁱ	10090.ENSMUSP00000041774

PTM databases

iPTMnetⁱ	Q61169
PhosphoSitePlusⁱ	Q61169

Proteomic databases

PaxDbⁱ	Q61169
PeptideAtlasⁱ	Q61169
PRIDEⁱ	Q61169

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	14465
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047762; ENSMUSP00000041774; ENSMUSG00000005836 [Q61169-1]
GeneIDⁱ	14465
KEGGⁱ	mmu:14465
UCSCⁱ	uc008ebj.1 mouse [Q61169-1]

Organism-specific databases

CTDⁱ	2627
MGIⁱ	MGI:107516 Gata6

Phylogenomic databases

eggNOGⁱ	KOG1601 Eukaryota COG5641 LUCA
GeneTreeⁱ	ENSGT00760000119221
HOGENOMⁱ	HOG000047700
HOVERGENⁱ	HBG051703
InParanoidⁱ	Q61169
KOⁱ	K17897
OMAⁱ	GAHPGWP
OrthoDBⁱ	EOG091G0AUR
PhylomeDBⁱ	Q61169
TreeFamⁱ	TF315391

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5683826 Surfactant metabolism R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-MMU-5683826 Surfactant metabolism
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q61169
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005836 Expressed in 205 organ(s), highest expression level in cardiac atrium
CleanExⁱ	MM_GATA6
Genevisibleⁱ	Q61169 MM

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 2 hits
Gene3Dⁱ	3.30.50.10, 2 hits
InterProⁱ	View protein in InterPro IPR008013 GATA_N IPR016375 TF_GATA_4/5/6 IPR039355 Transcription_factor_GATA IPR000679 Znf_GATA IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR10071 PTHR10071, 1 hit
Pfamⁱ	View protein in Pfam PF00320 GATA, 2 hits PF05349 GATA-N, 1 hit
PIRSFⁱ	PIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSⁱ	PR00619 GATAZNFINGER
SMARTⁱ	View protein in SMART SM00401 ZnF_GATA, 2 hits
PROSITEⁱ	View protein in PROSITE PS00344 GATA_ZN_FINGER_1, 2 hits PS50114 GATA_ZN_FINGER_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GATA6_MOUSE
Accessionⁱ	Q61169Primary (citable) accession number: Q61169 Secondary accession number(s): P97729, Q3UQJ2, Q9QZK3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61169 (GATA6_MOUSE)

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Transcription factor GATA-6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ