UniProtKB - Q61169 (GATA6_MOUSE)
Transcription factor GATA-6
Gata6
Functioni
Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519).
May regulate genes that protect epithelial cells from bacterial infection (By similarity).
Involved in gene regulation specifically in the gastric epithelium (By similarity).
Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343).
Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343).
By similarity2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 384 – 408 | GATA-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 438 – 462 | GATA-type 2PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- chromatin binding Source: MGI
- cis-regulatory region sequence-specific DNA binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- double-stranded DNA binding Source: MGI
- NFAT protein binding Source: Ensembl
- protein kinase binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: MGI
- transcription coactivator binding Source: BHF-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- animal organ formation Source: MGI
- cardiac muscle cell differentiation Source: MGI
- cardiac muscle hypertrophy in response to stress Source: MGI
- cardiac muscle tissue development Source: MGI
- cardiac vascular smooth muscle cell differentiation Source: MGI
- cell fate commitment Source: GO_Central
- cellular response to BMP stimulus Source: MGI
- cellular response to gonadotropin stimulus Source: MGI
- cellular response to hypoxia Source: MGI
- club cell differentiation Source: MGI
- endodermal cell differentiation Source: MGI
- endodermal cell fate determination Source: MGI
- epithelial cell differentiation Source: MGI
- G1 to G0 transition involved in cell differentiation Source: Ensembl
- gene expression Source: MGI
- heart contraction Source: MGI
- intestinal epithelial cell differentiation Source: MGI
- in utero embryonic development Source: MGI
- liver development Source: MGI
- lung saccule development Source: MGI
- male gonad development Source: Ensembl
- negative regulation of apoptotic process Source: MGI
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
- negative regulation of sebum secreting cell proliferation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- negative regulation of transforming growth factor beta1 production Source: MGI
- negative regulation of transforming growth factor beta2 production Source: MGI
- odontogenesis of dentin-containing tooth Source: Ensembl
- outflow tract septum morphogenesis Source: MGI
- pancreas development Source: MGI
- pancreatic A cell differentiation Source: MGI
- phospholipid metabolic process Source: MGI
- positive regulation of angiogenesis Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of BMP signaling pathway Source: MGI
- positive regulation of cardiac muscle cell apoptotic process Source: MGI
- positive regulation of cardiac muscle cell proliferation Source: MGI
- positive regulation of cardiac muscle myoblast proliferation Source: MGI
- positive regulation of cardioblast differentiation Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transforming growth factor beta activation Source: MGI
- regulation of antimicrobial humoral response Source: MGI
- regulation of cell cycle Source: MGI
- regulation of gene expression Source: MGI
- response to cAMP Source: Ensembl
- response to estrogen Source: MGI
- response to growth factor Source: MGI
- response to retinoic acid Source: MGI
- response to toxic substance Source: Ensembl
- response to xenobiotic stimulus Source: MGI
- sebaceous gland cell differentiation Source: MGI
- sinoatrial node development Source: MGI
- skin epidermis development Source: MGI
- smooth muscle cell differentiation Source: MGI
- tube morphogenesis Source: MGI
- type B pancreatic cell differentiation Source: MGI
- type II pneumocyte differentiation Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-5683826, Surfactant metabolism R-MMU-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor GATA-6Alternative name(s): GATA-binding factor 6 |
Gene namesi | Name:Gata6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107516, Gata6 |
VEuPathDBi | HostDB:ENSMUSG00000005836 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nuclear membrane Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083424 | 1 – 589 | Transcription factor GATA-6Add BLAST | 589 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 266 | PhosphoserineBy similarity | 1 | |
Cross-linki | 423 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 467 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 478 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q61169 |
PaxDbi | Q61169 |
PeptideAtlasi | Q61169 |
PRIDEi | Q61169 |
ProteomicsDBi | 271191 [Q61169-1] 271192 [Q61169-2] |
PTM databases
iPTMneti | Q61169 |
PhosphoSitePlusi | Q61169 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000005836, Expressed in heart and 234 other tissues |
ExpressionAtlasi | Q61169, baseline and differential |
Genevisiblei | Q61169, MM |
Interactioni
Subunit structurei
Interacts with LMCD1.
1 PublicationGO - Molecular functioni
- NFAT protein binding Source: Ensembl
- protein kinase binding Source: MGI
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- transcription coactivator binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 199843, 12 interactors |
IntActi | Q61169, 3 interactors |
MINTi | Q61169 |
STRINGi | 10090.ENSMUSP00000041774 |
Miscellaneous databases
RNActi | Q61169, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 62 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 209 – 274 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 479 – 534 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 34 – 49 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 494 – 534 | Polar residuesSequence analysisAdd BLAST | 41 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 384 – 408 | GATA-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 438 – 462 | GATA-type 2PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1601, Eukaryota |
GeneTreei | ENSGT00940000160814 |
HOGENOMi | CLU_027524_0_0_1 |
InParanoidi | Q61169 |
OMAi | ENSMLHC |
OrthoDBi | 807790at2759 |
PhylomeDBi | Q61169 |
TreeFami | TF315391 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR008013, GATA_N IPR028437, TF_GATA_6 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit PTHR10071:SF23, PTHR10071:SF23, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits PF05349, GATA-N, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG
60 70 80 90 100
DRGPCGASNC RTPQLDAEAV AGPPGRSLLL SPYASHPFAA AHGAAAPGVA
110 120 130 140 150
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT
160 170 180 190 200
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLSG
210 220 230 240 250
LPYLQGAGSG PSNHAGGAGA HPGWSQASAD SPPYGGGGAA GGGAAGPGGA
260 270 280 290 300
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGTGAGS VSGGGGSLAA
310 320 330 340 350
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMAAPLT PAWPAGPFET
360 370 380 390 400
PVLHSLQGRA GAPLPVPRGP STDLLEDLSE SRECVNCGSI QTPLWRRDGT
410 420 430 440 450
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR
460 470 480 490 500
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG
510 520 530 540 550
NSSGSVPMTP TSSSSNSDDC TKNTSPSTQA TTSGVGASVM SAVGENANPE
560 570 580
NSDLKYSGQD GLYIGVSLSS PAEVTSSVRQ DSWCALALA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q4L2W4 | A0A3Q4L2W4_MOUSE | Transcription factor GATA-6 | Gata6 | 161 | Annotation score: | ||
A0A3Q4EHT4 | A0A3Q4EHT4_MOUSE | Transcription factor GATA-6 | Gata6 | 63 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 297 | S → T in AAB37426 (PubMed:8660897).Curated | 1 | |
Sequence conflicti | 416 | G → A in AAC52841 (PubMed:8812463).Curated | 1 | |
Sequence conflicti | 536 | G → R in AAC52841 (PubMed:8812463).Curated | 1 | |
Sequence conflicti | 538 | Missing in AAC52841 (PubMed:8812463).Curated | 1 | |
Sequence conflicti | 546 | N → K in AAC52841 (PubMed:8812463).Curated | 1 | |
Sequence conflicti | 589 | A → V in AAB37426 (PubMed:8660897).Curated | 1 | |
Sequence conflicti | 589 | A → V in AAD55267 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035779 | 1 – 146 | Missing in isoform 2. 2 PublicationsAdd BLAST | 146 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S82462 mRNA Translation: AAB37426.1 Frameshift. AF179425 mRNA Translation: AAD55267.1 AK142381 mRNA Translation: BAE25049.1 CH466592 Genomic DNA Translation: EDL22985.1 U51335 mRNA Translation: AAC52841.1 Frameshift. |
CCDSi | CCDS29059.1 [Q61169-1] |
RefSeqi | NP_034388.2, NM_010258.3 [Q61169-1] |
Genome annotation databases
Ensembli | ENSMUST00000047762; ENSMUSP00000041774; ENSMUSG00000005836 [Q61169-1] |
GeneIDi | 14465 |
KEGGi | mmu:14465 |
UCSCi | uc008ebj.1, mouse [Q61169-1] |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S82462 mRNA Translation: AAB37426.1 Frameshift. AF179425 mRNA Translation: AAD55267.1 AK142381 mRNA Translation: BAE25049.1 CH466592 Genomic DNA Translation: EDL22985.1 U51335 mRNA Translation: AAC52841.1 Frameshift. |
CCDSi | CCDS29059.1 [Q61169-1] |
RefSeqi | NP_034388.2, NM_010258.3 [Q61169-1] |
3D structure databases
SMRi | Q61169 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199843, 12 interactors |
IntActi | Q61169, 3 interactors |
MINTi | Q61169 |
STRINGi | 10090.ENSMUSP00000041774 |
PTM databases
iPTMneti | Q61169 |
PhosphoSitePlusi | Q61169 |
Proteomic databases
MaxQBi | Q61169 |
PaxDbi | Q61169 |
PeptideAtlasi | Q61169 |
PRIDEi | Q61169 |
ProteomicsDBi | 271191 [Q61169-1] 271192 [Q61169-2] |
Protocols and materials databases
Antibodypediai | 22009, 516 antibodies from 36 providers |
DNASUi | 14465 |
Genome annotation databases
Ensembli | ENSMUST00000047762; ENSMUSP00000041774; ENSMUSG00000005836 [Q61169-1] |
GeneIDi | 14465 |
KEGGi | mmu:14465 |
UCSCi | uc008ebj.1, mouse [Q61169-1] |
Organism-specific databases
CTDi | 2627 |
MGIi | MGI:107516, Gata6 |
VEuPathDBi | HostDB:ENSMUSG00000005836 |
Phylogenomic databases
eggNOGi | KOG1601, Eukaryota |
GeneTreei | ENSGT00940000160814 |
HOGENOMi | CLU_027524_0_0_1 |
InParanoidi | Q61169 |
OMAi | ENSMLHC |
OrthoDBi | 807790at2759 |
PhylomeDBi | Q61169 |
TreeFami | TF315391 |
Enzyme and pathway databases
Reactomei | R-MMU-5683826, Surfactant metabolism R-MMU-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
BioGRID-ORCSi | 14465, 3 hits in 67 CRISPR screens |
PROi | PR:Q61169 |
RNActi | Q61169, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000005836, Expressed in heart and 234 other tissues |
ExpressionAtlasi | Q61169, baseline and differential |
Genevisiblei | Q61169, MM |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR008013, GATA_N IPR028437, TF_GATA_6 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit PTHR10071:SF23, PTHR10071:SF23, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits PF05349, GATA-N, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GATA6_MOUSE | |
Accessioni | Q61169Primary (citable) accession number: Q61169 Secondary accession number(s): P97729, Q3UQJ2, Q9QZK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot