Transcription factor GATA-6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.8

    "LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding."
    Rath N., Wang Z., Lu M.M., Morrisey E.E.
    Mol. Cell. Biol. 25:8864-8873(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH LMCD1, DOMAIN GATA-TYPE ZINC-FINGER.
• cis-regulatory region sequence-specific DNA binding Source: MGI
• DNA binding Source: MGIInferred from direct assayⁱ
  • "GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression."
    Liu C., Glasser S.W., Wan H., Whitsett J.A.
    J. Biol. Chem. 277:4519-4525(2002) [PubMed] [Europe PMC] [Abstract]
  • "Plasticity and expanding complexity of the hepatic transcription factor network during liver development."
    Kyrmizi I., Hatzis P., Katrakili N., Tronche F., Gonzalez F.J., Talianidis I.
    Genes Dev. 20:2293-2305(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium."
    Weidenfeld J., Shu W., Zhang L., Millar S.E., Morrisey E.E.
    J. Biol. Chem. 277:21061-21070(2002) [PubMed] [Europe PMC] [Abstract]
  • "Wnt2 is a direct downstream target of GATA6 during early cardiogenesis."
    Alexandrovich A., Arno M., Patient R.K., Shah A.M., Pizzey J.A., Brewer A.C.
    Mech. Dev. 123:297-311(2006) [PubMed] [Europe PMC] [Abstract]
  • "GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo."
    Zhang Y., Rath N., Hannenhalli S., Wang Z., Cappola T., Kimura S., Atochina-Vasserman E., Lu M.M., Beers M.F., Morrisey E.E.
    Development 134:189-198(2007) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • Ref.1

    "GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm."
    Morrisey E.E., Ip H.S., Lu M.M., Parmacek M.S.
    Dev. Biol. 177:309-322(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
• double-stranded DNA binding Source: MGI
• protein kinase binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element."
    Rojas A., De Val S., Heidt A.B., Xu S.M., Bristow J., Black B.L.
    Development 132:3405-3417(2005) [PubMed] [Europe PMC] [Abstract]
  • Ref.8

    "LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding."
    Rath N., Wang Z., Lu M.M., Morrisey E.E.
    Mol. Cell. Biol. 25:8864-8873(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH LMCD1, DOMAIN GATA-TYPE ZINC-FINGER.
  • "Wnt2 is a direct downstream target of GATA6 during early cardiogenesis."
    Alexandrovich A., Arno M., Patient R.K., Shah A.M., Pizzey J.A., Brewer A.C.
    Mech. Dev. 123:297-311(2006) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of lung endoderm progenitor cell behavior by miR302/367."
    Tian Y., Zhang Y., Hurd L., Hannenhalli S., Liu F., Lu M.M., Morrisey E.E.
    Development 138:1235-1245(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II repressing transcription factor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6."
    Shirvani S., Xiang F., Koibuchi N., Chin M.T.
    Biochem. Biophys. Res. Commun. 339:151-156(2006) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium."
    Weidenfeld J., Shu W., Zhang L., Millar S.E., Morrisey E.E.
    J. Biol. Chem. 277:21061-21070(2002) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "Gata6 is an important regulator of mouse pancreas development."
    Decker K., Goldman D.C., Grasch C.L., Sussel L.
    Dev. Biol. 298:415-429(2006) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: MGI
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• animal organ formation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Gata6 is an important regulator of mouse pancreas development."
    Decker K., Goldman D.C., Grasch C.L., Sussel L.
    Dev. Biol. 298:415-429(2006) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice."
    Zhao R., Watt A.J., Battle M.A., Li J., Bondow B.J., Duncan S.A.
    Dev. Biol. 317:614-619(2008) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle hypertrophy in response to stress Source: MGIInferred from mutant phenotypeⁱ
  • "The transcription factor GATA-6 regulates pathological cardiac hypertrophy."
    van Berlo J.H., Elrod J.W., van den Hoogenhof M.M., York A.J., Aronow B.J., Duncan S.A., Molkentin J.D.
    Circ. Res. 107:1032-1040(2010) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle tissue development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "The transcription factor GATA-6 regulates pathological cardiac hypertrophy."
    van Berlo J.H., Elrod J.W., van den Hoogenhof M.M., York A.J., Aronow B.J., Duncan S.A., Molkentin J.D.
    Circ. Res. 107:1032-1040(2010) [PubMed] [Europe PMC] [Abstract]
• cardiac vascular smooth muscle cell differentiation Source: MGI
• cell fate commitment Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to BMP stimulus Source: MGIInferred from direct assayⁱ
  • "Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals."
    Karamboulas K., Dranse H.J., Underhill T.M.
    J. Cell. Sci. 123:2068-2076(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to gonadotropin stimulus Source: MGIInferred from direct assayⁱ
  • "Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary."
    Heikinheimo M., Ermolaeva M., Bielinska M., Rahman N.A., Narita N., Huhtaniemi I.T., Tapanainen J.S., Wilson D.B.
    Endocrinology 138:3505-3514(1997) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: MGI
• club cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo."
    Zhang Y., Rath N., Hannenhalli S., Wang Z., Cappola T., Kimura S., Atochina-Vasserman E., Lu M.M., Beers M.F., Morrisey E.E.
    Development 134:189-198(2007) [PubMed] [Europe PMC] [Abstract]
• endodermal cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo."
    Morrisey E.E., Tang Z., Sigrist K., Lu M.M., Jiang F., Ip H.S., Parmacek M.S.
    Genes Dev. 12:3579-3590(1998) [PubMed] [Europe PMC] [Abstract]
• endodermal cell fate determination Source: MGIInferred from direct assayⁱ
  • "Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo."
    Morris S.A., Teo R.T., Li H., Robson P., Glover D.M., Zernicka-Goetz M.
    Proc. Natl. Acad. Sci. U.S.A. 107:6364-6369(2010) [PubMed] [Europe PMC] [Abstract]
• epithelial cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Gata6 is an important regulator of mouse pancreas development."
    Decker K., Goldman D.C., Grasch C.L., Sussel L.
    Dev. Biol. 298:415-429(2006) [PubMed] [Europe PMC] [Abstract]
• intestinal epithelial cell differentiation Source: MGIInferred from sequence orthologyⁱ
  • "Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation."
    Gao X., Sedgwick T., Shi Y.B., Evans T.
    Mol. Cell. Biol. 18:2901-2911(1998) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal."
    Niakan K.K., Ji H., Maehr R., Vokes S.A., Rodolfa K.T., Sherwood R.I., Yamaki M., Dimos J.T., Chen A.E., Melton D.A., McMahon A.P., Eggan K.
    Genes Dev. 24:312-326(2010) [PubMed] [Europe PMC] [Abstract]
  • "GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo."
    Morrisey E.E., Tang Z., Sigrist K., Lu M.M., Jiang F., Ip H.S., Parmacek M.S.
    Genes Dev. 12:3579-3590(1998) [PubMed] [Europe PMC] [Abstract]
• liver development Source: MGIInferred from mutant phenotypeⁱ
  • "GATA6 is essential for embryonic development of the liver but dispensable for early heart formation."
    Zhao R., Watt A.J., Li J., Luebke-Wheeler J., Morrisey E.E., Duncan S.A.
    Mol. Cell. Biol. 25:2622-2631(2005) [PubMed] [Europe PMC] [Abstract]
• lung saccule development Source: MGIInferred from genetic interactionⁱ
  • "GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo."
    Zhang Y., Rath N., Hannenhalli S., Wang Z., Cappola T., Kimura S., Atochina-Vasserman E., Lu M.M., Beers M.F., Morrisey E.E.
    Development 134:189-198(2007) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: Ensembl
• negative regulation of apoptotic process Source: MGI
• negative regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGI
• negative regulation of transforming growth factor beta1 production Source: MGI
• negative regulation of transforming growth factor beta2 production Source: MGI
• outflow tract septum morphogenesis Source: MGI
• pancreas development Source: MGIInferred from mutant phenotypeⁱ
  • "Gata6 is an important regulator of mouse pancreas development."
    Decker K., Goldman D.C., Grasch C.L., Sussel L.
    Dev. Biol. 298:415-429(2006) [PubMed] [Europe PMC] [Abstract]
• pancreatic A cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Gata6 is an important regulator of mouse pancreas development."
    Decker K., Goldman D.C., Grasch C.L., Sussel L.
    Dev. Biol. 298:415-429(2006) [PubMed] [Europe PMC] [Abstract]
• phospholipid metabolic process Source: MGIInferred from genetic interactionⁱ
  • "GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo."
    Zhang Y., Rath N., Hannenhalli S., Wang Z., Cappola T., Kimura S., Atochina-Vasserman E., Lu M.M., Beers M.F., Morrisey E.E.
    Development 134:189-198(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: MGI
• positive regulation of apoptotic process Source: MGI
• positive regulation of BMP signaling pathway Source: MGI
• positive regulation of cardiac muscle cell apoptotic process Source: MGI
• positive regulation of cardiac muscle cell proliferation Source: MGIInferred from genetic interactionⁱ
  • "Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development."
    Maitra M., Schluterman M.K., Nichols H.A., Richardson J.A., Lo C.W., Srivastava D., Garg V.
    Dev. Biol. 326:368-377(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle myoblast proliferation Source: MGI
• positive regulation of cardioblast differentiation Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis."
    Brewer A.C., Alexandrovich A., Mjaatvedt C.H., Shah A.M., Patient R.K., Pizzey J.A.
    Stem Cells Dev. 14:425-439(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell cycle arrest Source: MGI
• positive regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression."
    Liu C., Glasser S.W., Wan H., Whitsett J.A.
    J. Biol. Chem. 277:4519-4525(2002) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm."
    Morrisey E.E., Ip H.S., Lu M.M., Parmacek M.S.
    Dev. Biol. 177:309-322(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  • "Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo."
    Di Lisi R., Millino C., Calabria E., Altruda F., Schiaffino S., Ausoni S.
    J. Biol. Chem. 273:25371-25380(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium."
    Weidenfeld J., Shu W., Zhang L., Millar S.E., Morrisey E.E.
    J. Biol. Chem. 277:21061-21070(2002) [PubMed] [Europe PMC] [Abstract]
  • "The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression."
    Ritz-Laser B., Mamin A., Brun T., Avril I., Schwitzgebel V.M., Philippe J.
    Mol. Endocrinol. 19:759-770(2005) [PubMed] [Europe PMC] [Abstract]
  • Ref.8

    "LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding."
    Rath N., Wang Z., Lu M.M., Morrisey E.E.
    Mol. Cell. Biol. 25:8864-8873(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH LMCD1, DOMAIN GATA-TYPE ZINC-FINGER.
  • "Wnt2 is a direct downstream target of GATA6 during early cardiogenesis."
    Alexandrovich A., Arno M., Patient R.K., Shah A.M., Pizzey J.A., Brewer A.C.
    Mech. Dev. 123:297-311(2006) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm."
    Morrisey E.E., Ip H.S., Lu M.M., Parmacek M.S.
    Dev. Biol. 177:309-322(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  • "GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo."
    Morrisey E.E., Tang Z., Sigrist K., Lu M.M., Jiang F., Ip H.S., Parmacek M.S.
    Genes Dev. 12:3579-3590(1998) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: MGIInferred from genetic interactionⁱ
  • "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice."
    Zhao R., Watt A.J., Battle M.A., Li J., Bondow B.J., Duncan S.A.
    Dev. Biol. 317:614-619(2008) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: MGI
• response to estrogen Source: MGIInferred from direct assayⁱ
  • "Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary."
    Heikinheimo M., Ermolaeva M., Bielinska M., Rahman N.A., Narita N., Huhtaniemi I.T., Tapanainen J.S., Wilson D.B.
    Endocrinology 138:3505-3514(1997) [PubMed] [Europe PMC] [Abstract]
• response to growth factor Source: MGI
• smooth muscle cell differentiation Source: MGI
• transcription by RNA polymerase II Source: MGI
• tube morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice."
    Zhao R., Watt A.J., Battle M.A., Li J., Bondow B.J., Duncan S.A.
    Dev. Biol. 317:614-619(2008) [PubMed] [Europe PMC] [Abstract]
• type B pancreatic cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Gata6 is an important regulator of mouse pancreas development."
    Decker K., Goldman D.C., Grasch C.L., Sussel L.
    Dev. Biol. 298:415-429(2006) [PubMed] [Europe PMC] [Abstract]
• type II pneumocyte differentiation Source: MGIInferred from genetic interactionⁱ
  • "GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo."
    Zhang Y., Rath N., Hannenhalli S., Wang Z., Cappola T., Kimura S., Atochina-Vasserman E., Lu M.M., Beers M.F., Morrisey E.E.
    Development 134:189-198(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: MGI
• RNA polymerase II repressing transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "CHF1/Hey2 suppresses SM-MHC promoter activity through an interaction with GATA-6."
    Shirvani S., Xiang F., Koibuchi N., Chin M.T.
    Biochem. Biophys. Res. Commun. 339:151-156(2006) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "Gata6 is an important regulator of mouse pancreas development."
    Decker K., Goldman D.C., Grasch C.L., Sussel L.
    Dev. Biol. 298:415-429(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG 
        60         70         80         90        100
DRGPCGASNC RTPQLDAEAV AGPPGRSLLL SPYASHPFAA AHGAAAPGVA 
       110        120        130        140        150
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT 
       160        170        180        190        200
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLSG 
       210        220        230        240        250
LPYLQGAGSG PSNHAGGAGA HPGWSQASAD SPPYGGGGAA GGGAAGPGGA 
       260        270        280        290        300
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGTGAGS VSGGGGSLAA 
       310        320        330        340        350
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMAAPLT PAWPAGPFET 
       360        370        380        390        400
PVLHSLQGRA GAPLPVPRGP STDLLEDLSE SRECVNCGSI QTPLWRRDGT 
       410        420        430        440        450
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR 
       460        470        480        490        500
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG 
       510        520        530        540        550
NSSGSVPMTP TSSSSNSDDC TKNTSPSTQA TTSGVGASVM SAVGENANPE 
       560        570        580 
NSDLKYSGQD GLYIGVSLSS PAEVTSSVRQ DSWCALALA             

        10         20         30         40         50
MYQTLAALSS QGPAAYDGAP GGFVHSAAAA AAAAAAASSP VYVPTTRVGS 
        60         70         80         90        100
MLSGLPYLQG AGSGPSNHAG GAGAHPGWSQ ASADSPPYGG GGAAGGGAAG 
       110        120        130        140        150
PGGAGSATAH ASARFPYSPS PPMANGAARD PGGYVAAGGT GAGSVSGGGG 
       160        170        180        190        200
SLAAMGGREH QYSSLSAARP LNGTYHHHHH HHPTYSPYMA APLTPAWPAG 
       210        220        230        240        250
PFETPVLHSL QGRAGAPLPV PRGPSTDLLE DLSESRECVN CGSIQTPLWR 
       260        270        280        290        300
RDGTGHYLCN ACGLYSKMNG LSRPLIKPQK RVPSSRRLGL SCANCHTTTT 
       310        320        330        340        350
TLWRRNAEGE PVCNACGLYM KLHGVPRPLA MKKEGIQTRK RKPKNINKSK 
       360        370        380        390        400
ACSGNSSGSV PMTPTSSSSN SDDCTKNTSP STQATTSGVG ASVMSAVGEN 
       410        420        430        440 
ANPENSDLKY SGQDGLYIGV SLSSPAEVTS SVRQDSWCAL ALA        

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot