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Protein

Lysosomal-associated transmembrane protein 5

Gene

Laptm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a special functional role during embryogenesis and in adult hematopoietic cells.1 Publication

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: MGI

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.74.1.2 the 4 tms multidrug endosomal transporter (met) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 5
Alternative name(s):
Lysosomal-associated multitransmembrane protein 5
Retinoic acid-inducible E3 protein
Gene namesi
Name:Laptm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:108046 Laptm5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843581 – 261Lysosomal-associated transmembrane protein 5Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61168
MaxQBiQ61168
PaxDbiQ61168
PRIDEiQ61168

PTM databases

iPTMnetiQ61168
PhosphoSitePlusiQ61168
SwissPalmiQ61168

Expressioni

Tissue specificityi

Preferentially expressed in adult hematopoietic tissues. High levels in lymphoid and myeloid tissues.1 Publication

Developmental stagei

During embryonic development it is expressed in both hematopoietic and nonhematopoietic tissues.

Inductioni

By retinoic acid. Likely target of the activated retinoic acid receptor alpha.

Gene expression databases

BgeeiENSMUSG00000028581 Expressed in 274 organ(s), highest expression level in thymus
CleanExiMM_LAPTM5
ExpressionAtlasiQ61168 baseline and differential
GenevisibleiQ61168 MM

Interactioni

Subunit structurei

Binds to ubiquitin.

Protein-protein interaction databases

BioGridi201109, 2 interactors
DIPiDIP-37698N
IntActiQ61168, 3 interactors
MINTiQ61168
STRINGi10090.ENSMUSP00000118415

Structurei

3D structure databases

ProteinModelPortaliQ61168
SMRiQ61168
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi245 – 257Pro-richAdd BLAST13

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFZA Eukaryota
ENOG410YPPU LUCA
GeneTreeiENSGT00390000012862
HOVERGENiHBG052307
InParanoidiQ61168
KOiK12387
OMAiSQFIKMM
TreeFamiTF330843

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
IPR018397 Lysosomal-assoc_TM_prot5
PANTHERiPTHR12479:SF2 PTHR12479:SF2, 3 hits
PfamiView protein in Pfam
PF03821 Mtp, 1 hit
TIGRFAMsiTIGR00799 mtp, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q61168-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRAAPVRQ TCCCFNIRVA TIALAIYHIV MSVLLFIEHV VEVARGKVSC
60 70 80 90 100
RFFKMPYLRM ADLLSSFLLI GVLFIISISL LFGVVKNREK YLIPFLSLQI
110 120 130 140 150
MDFLLCLLTL LGSYIELPAY LKLARPRPGP SKVPLMTLQL LDFCLSILTL
160 170 180 190 200
CSSYMEVPTY LNFKSMNHMN YLPSQEGVPH SQFINMMLIF SVAFITVLIL
210 220 230 240 250
KVYMFKCVYT CYKFLKHMNS AMEDSSSKMF LKVALPSYEE ALSLPPKTPE
260
GDPAPPPYSE V
Length:261
Mass (Da):29,602
Last modified:November 1, 1996 - v1
Checksum:i70B3FA0AFE6743D1
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WH95F8WH95_MOUSE
Lysosomal-associated transmembrane ...
Laptm5
264Annotation score:
F6WX18F6WX18_MOUSE
Lysosomal-associated transmembrane ...
Laptm5
241Annotation score:
B1ASF7B1ASF7_MOUSE
Lysosomal-associated transmembrane ...
Laptm5
107Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56P → A in AAB48192 (PubMed:8839844).Curated1
Sequence conflicti116E → D in AAB48192 (PubMed:8839844).Curated1
Sequence conflicti126P → S in AAB48192 (PubMed:8839844).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51239 mRNA Translation: AAB08976.1
U29539 mRNA Translation: AAB48192.1
BC020993 mRNA Translation: AAH20993.1
BC055057 mRNA Translation: AAH55057.1
CCDSiCCDS18712.1
RefSeqiNP_034816.1, NM_010686.3
XP_017175490.1, XM_017320001.1
UniGeneiMm.271868

Genome annotation databases

EnsembliENSMUST00000151698; ENSMUSP00000118415; ENSMUSG00000028581
GeneIDi16792
KEGGimmu:16792
UCSCiuc008uzv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51239 mRNA Translation: AAB08976.1
U29539 mRNA Translation: AAB48192.1
BC020993 mRNA Translation: AAH20993.1
BC055057 mRNA Translation: AAH55057.1
CCDSiCCDS18712.1
RefSeqiNP_034816.1, NM_010686.3
XP_017175490.1, XM_017320001.1
UniGeneiMm.271868

3D structure databases

ProteinModelPortaliQ61168
SMRiQ61168
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201109, 2 interactors
DIPiDIP-37698N
IntActiQ61168, 3 interactors
MINTiQ61168
STRINGi10090.ENSMUSP00000118415

Protein family/group databases

TCDBi2.A.74.1.2 the 4 tms multidrug endosomal transporter (met) family

PTM databases

iPTMnetiQ61168
PhosphoSitePlusiQ61168
SwissPalmiQ61168

Proteomic databases

EPDiQ61168
MaxQBiQ61168
PaxDbiQ61168
PRIDEiQ61168

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000151698; ENSMUSP00000118415; ENSMUSG00000028581
GeneIDi16792
KEGGimmu:16792
UCSCiuc008uzv.1 mouse

Organism-specific databases

CTDi7805
MGIiMGI:108046 Laptm5

Phylogenomic databases

eggNOGiENOG410IFZA Eukaryota
ENOG410YPPU LUCA
GeneTreeiENSGT00390000012862
HOVERGENiHBG052307
InParanoidiQ61168
KOiK12387
OMAiSQFIKMM
TreeFamiTF330843

Miscellaneous databases

ChiTaRSiLaptm5 mouse
PROiPR:Q61168
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028581 Expressed in 274 organ(s), highest expression level in thymus
CleanExiMM_LAPTM5
ExpressionAtlasiQ61168 baseline and differential
GenevisibleiQ61168 MM

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
IPR018397 Lysosomal-assoc_TM_prot5
PANTHERiPTHR12479:SF2 PTHR12479:SF2, 3 hits
PfamiView protein in Pfam
PF03821 Mtp, 1 hit
TIGRFAMsiTIGR00799 mtp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAPM5_MOUSE
AccessioniPrimary (citable) accession number: Q61168
Secondary accession number(s): Q60923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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