FAS-associated death domain protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• caspase binding Source: UniProtKB
• death effector domain binding Source: MGI
• death receptor binding Source: MGI
• identical protein binding Source: MGI
• protease binding Source: MGI
• protein-containing complex binding Source: MGI
• receptor serine/threonine kinase binding Source: MGI
• tumor necrosis factor receptor binding Source: MGI
• tumor necrosis factor receptor superfamily binding Source: MGI

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity Source: MGI
• apoptotic process Source: UniProtKB
• apoptotic signaling pathway Source: MGI
• behavioral response to cocaine Source: Ensembl
• cardiac muscle tissue development Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "No death without life: vital functions of apoptotic effectors."
    Galluzzi L., Joza N., Tasdemir E., Maiuri M.C., Hengartner M., Abrams J.M., Tavernarakis N., Penninger J., Madeo F., Kroemer G.
    Cell Death Differ 15:1113-1123(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to mechanical stimulus Source: Ensembl
• death-inducing signaling complex assembly Source: MGI
• defense response to virus Source: MGI
• extrinsic apoptotic signaling pathway Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis."
    Estelles A., Charlton C.A., Blau H.M.
    Dev. Biol. 216:16-28(1999) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway in absence of ligand Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo."
    Ugolini G., Raoul C., Ferri A., Haenggeli C., Yamamoto Y., Salaun D., Henderson C.E., Kato A.C., Pettmann B., Hueber A.O.
    J Neurosci 23:8526-8531(2003) [PubMed] [Europe PMC] [Abstract]
• extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
• innate immune response Source: UniProtKBTraceable author statementⁱ
  • "No death without life: vital functions of apoptotic effectors."
    Galluzzi L., Joza N., Tasdemir E., Maiuri M.C., Hengartner M., Abrams J.M., Tavernarakis N., Penninger J., Madeo F., Kroemer G.
    Cell Death Differ 15:1113-1123(2008) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: Ensembl
• lymph node development Source: UniProtKB <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• motor neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo."
    Ugolini G., Raoul C., Ferri A., Haenggeli C., Yamamoto Y., Salaun D., Henderson C.E., Kato A.C., Pettmann B., Hueber A.O.
    J Neurosci 23:8526-8531(2003) [PubMed] [Europe PMC] [Abstract]
• necroptotic signaling pathway Source: MGI
• negative regulation of activation-induced cell death of T cells Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of necroptotic process Source: MGIInferred from genetic interactionⁱ
  • "TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members."
    Vanlangenakker N., Bertrand M.J., Bogaert P., Vandenabeele P., Vanden Berghe T.
    Cell Death Dis 2:e230-e230(2011) [PubMed] [Europe PMC] [Abstract]
  • "Survival function of the FADD-CASPASE-8-cFLIP(L) complex."
    Dillon C.P., Oberst A., Weinlich R., Janke L.J., Kang T.B., Ben-Moshe T., Mak T.W., Wallach D., Green D.R.
    Cell Rep 1:401-407(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of activated T cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of adaptive immune response Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: MGI
• positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of extrinsic apoptotic signaling pathway Source: MGIInferred from genetic interactionⁱ
  • "Survival function of the FADD-CASPASE-8-cFLIP(L) complex."
    Dillon C.P., Oberst A., Weinlich R., Janke L.J., Kang T.B., Ben-Moshe T., Mak T.W., Wallach D., Green D.R.
    Cell Rep 1:401-407(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
• positive regulation of interferon-gamma production Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-8 production Source: MGI
• positive regulation of macrophage differentiation Source: MGI
• positive regulation of proteolysis Source: MGI
• positive regulation of T cell mediated cytotoxicity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGI
• positive regulation of tumor necrosis factor production Source: MGI
• positive regulation of type I interferon-mediated signaling pathway Source: MGI
• regulation of necroptotic process Source: MGI
• response to morphine Source: MGI
• spleen development Source: UniProtKBInferred from genetic interactionⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• T cell differentiation Source: UniProtKBTraceable author statementⁱ
  • "No death without life: vital functions of apoptotic effectors."
    Galluzzi L., Joza N., Tasdemir E., Maiuri M.C., Hengartner M., Abrams J.M., Tavernarakis N., Penninger J., Madeo F., Kroemer G.
    Cell Death Differ 15:1113-1123(2008) [PubMed] [Europe PMC] [Abstract]
• T cell differentiation in thymus Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• T cell homeostasis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• thymus development Source: UniProtKBInferred from genetic interactionⁱ
  • "Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity."
    Lu J.V., Weist B.M., van Raam B.J., Marro B.S., Nguyen L.V., Srinivas P., Bell B.D., Luhrs K.A., Lane T.E., Salvesen G.S., Walsh C.M.
    Proc Natl Acad Sci U S A 108:15312-15317(2011) [PubMed] [Europe PMC] [Abstract]
• TRAIL-activated apoptotic signaling pathway Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• caspase binding Source: UniProtKB
• death effector domain binding Source: MGI
• death receptor binding Source: MGI
• identical protein binding Source: MGI
• protease binding Source: MGI
• receptor serine/threonine kinase binding Source: MGI
• tumor necrosis factor receptor binding Source: MGI
• tumor necrosis factor receptor superfamily binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDPFLVLLHS LSGSLSGNDL MELKFLCRER VSKRKLERVQ SGLDLFTVLL 
        60         70         80         90        100
EQNDLERGHT GLLRELLASL RRHDLLQRLD DFEAGTATAA PPGEADLQVA 
       110        120        130        140        150
FDIVCDNVGR DWKRLARELK VSEAKMDGIE EKYPRSLSER VRESLKVWKN 
       160        170        180        190        200
AEKKNASVAG LVKALRTCRL NLVADLVEEA QESVSKSENM SPVLRDSTVS 

SSETP                                                  

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references