Fadd

Functionⁱ

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).By similarity

GO - Molecular functionⁱ

caspase binding Source: MGI
death effector domain binding Source: MGI
death receptor binding Source: MGI
identical protein binding Source: MGI
protease binding Source: MGI
protein-containing complex binding Source: MGI
receptor serine/threonine kinase binding Source: MGI
tumor necrosis factor receptor binding Source: MGI
tumor necrosis factor receptor superfamily binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity Source: MGI
apoptotic process Source: UniProtKB
apoptotic signaling pathway Source: MGI
behavioral response to cocaine Source: Ensembl
cardiac muscle tissue development
Source: UniProtKB
Traceable author statementⁱ
- 18309324
cellular response to mechanical stimulus Source: Ensembl
defense response to virus Source: MGI
extrinsic apoptotic signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 10588860
extrinsic apoptotic signaling pathway in absence of ligand
Source: MGI
Inferred from mutant phenotypeⁱ
- 13679421
innate immune response
Source: UniProtKB
Traceable author statementⁱ
- 18309324
lymph node development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21876153
motor neuron apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 13679421
necroptotic signaling pathway Source: MGI
negative regulation of activation-induced cell death of T cells
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21876153
negative regulation of necroptotic process
Source: MGI
Inferred from genetic interactionⁱ
- 22089168
- 22675671
positive regulation of activated T cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21876153
positive regulation of adaptive immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21876153
positive regulation of apoptotic process Source: MGI
positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21876153
positive regulation of extrinsic apoptotic signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 22675671
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Source: MGI
Inferred from genetic interactionⁱ
- 16183742
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
positive regulation of interferon-gamma production
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21876153
positive regulation of interleukin-8 production Source: MGI
positive regulation of macrophage differentiation Source: MGI
positive regulation of proteolysis Source: MGI
positive regulation of T cell mediated cytotoxicity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21876153
positive regulation of transcription by RNA polymerase II Source: MGI
positive regulation of tumor necrosis factor production Source: MGI
positive regulation of type I interferon-mediated signaling pathway Source: MGI
regulation of necroptotic process Source: MGI
response to morphine Source: MGI
spleen development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21876153
T cell differentiation
Source: UniProtKB
Traceable author statementⁱ
- 18309324
T cell differentiation in thymus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21876153
T cell homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21876153
thymus development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21876153
TRAIL-activated apoptotic signaling pathway Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Immunity, Innate immunity

Biological process

Apoptosis, Immunity, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140534 via Death Receptors in the presence of ligand R-MMU-2562578 TRIF-mediated programmed cell death R-MMU-3371378 Regulation by c-FLIP R-MMU-5213460 RIPK1-mediated regulated necrosis R-MMU-5218900 CASP8 activity is inhibited R-MMU-5357786 TNFR1-induced proapoptotic signaling R-MMU-69416 Dimerization of procaspase-8 R-MMU-75157 FasL/ CD95L signaling R-MMU-75158 TRAIL signaling

Reactomeⁱ

R-MMU-140534 via Death Receptors in the presence of ligand
R-MMU-2562578 TRIF-mediated programmed cell death
R-MMU-3371378 Regulation by c-FLIP
R-MMU-5213460 RIPK1-mediated regulated necrosis
R-MMU-5218900 CASP8 activity is inhibited
R-MMU-5357786 TNFR1-induced proapoptotic signaling
R-MMU-69416 Dimerization of procaspase-8
R-MMU-75157 FasL/ CD95L signaling
R-MMU-75158 TRAIL signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: FAS-associated death domain protein Alternative name(s): FAS-associating death domain-containing protein Mediator of receptor induced toxicity Protein FADD
Gene namesⁱ	Name:Fadd Synonyms:Mort1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:109324 Fadd

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191280	1 – 205	FAS-associated death domain proteinAdd BLAST		205

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	191	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated.

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q61160
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q61160
PaxDbⁱ	Q61160
PeptideAtlas More...PeptideAtlasⁱ	Q61160
PRIDEⁱ	Q61160

PTM databases

iPTMnetⁱ	Q61160
PhosphoSitePlusⁱ	Q61160

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000031077 Expressed in 217 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_FADD
Genevisibleⁱ	Q61160 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with PIDD1 (By similarity). Interacts with FAS (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Casp8	O89110	6	EBI-524415,EBI-851690
Fas	P25446	3	EBI-524415,EBI-296206
Ripk1	Q60855	8	EBI-524415,EBI-529119
Ripk3	Q9QZL0	6	EBI-524415,EBI-2367423

GO - Molecular functionⁱ

caspase binding Source: MGI
death effector domain binding Source: MGI
death receptor binding Source: MGI
identical protein binding Source: MGI
protease binding Source: MGI
receptor serine/threonine kinase binding Source: MGI
tumor necrosis factor receptor binding Source: MGI
tumor necrosis factor receptor superfamily binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199586, 13 interactors
ComplexPortalⁱ	CPX-1914 Ripoptosome
Database of interacting proteins More...DIPⁱ	DIP-34771N
IntActⁱ	Q61160, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q61160
STRINGⁱ	10090.ENSMUSP00000033394

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	94 – 118	Combined sources	25
Helixⁱ	123 – 132	Combined sources	10
Helixⁱ	137 – 152	Combined sources	16
Helixⁱ	153 – 156	Combined sources	4
Helixⁱ	158 – 168	Combined sources	11
Helixⁱ	171 – 181	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q61160
SMRⁱ	Q61160
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q61160

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 81	DEDPROSITE-ProRule annotationAdd BLAST		79
Domainⁱ	97 – 181	DeathPROSITE-ProRule annotationAdd BLAST		85

Domainⁱ

Contains a death domain involved in the binding of the corresponding domain within Fas receptor.

Phylogenomic databases

eggNOGⁱ	ENOG410J0KM Eukaryota ENOG41122TX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002105
HOGENOMⁱ	HOG000112490
HOVERGENⁱ	HBG000853
InParanoidⁱ	Q61160
KEGG Orthology (KO) More...KOⁱ	K02373
OMAⁱ	CQMNLVA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0SHT
PhylomeDBⁱ	Q61160
TreeFamⁱ	TF102046

Family and domain databases

InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR001875 DED_dom IPR016729 FADD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF01335 DED, 1 hit
PIRSFⁱ	PIRSF018586 FADD, 1 hit
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00031 DED, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS50168 DED, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q61160-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDPFLVLLHS LSGSLSGNDL MELKFLCRER VSKRKLERVQ SGLDLFTVLL 
        60         70         80         90        100
EQNDLERGHT GLLRELLASL RRHDLLQRLD DFEAGTATAA PPGEADLQVA 
       110        120        130        140        150
FDIVCDNVGR DWKRLARELK VSEAKMDGIE EKYPRSLSER VRESLKVWKN 
       160        170        180        190        200
AEKKNASVAG LVKALRTCRL NLVADLVEEA QESVSKSENM SPVLRDSTVS 

SSETP

Length:205

Mass (Da):22,960

Last modified:November 1, 1997 - v1

Checksum:ⁱ4BC8D86B33A58783

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	168	C → F in AAA97876 (PubMed:8565075).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U50406 mRNA Translation: AAB07789.1 U43184 mRNA Translation: AAA97876.1 AK084808 mRNA Translation: BAC39283.1 AK169798 mRNA Translation: BAE41374.1 AK170927 mRNA Translation: BAE42120.1 BC004584 mRNA Translation: AAH04584.1 BC021400 mRNA Translation: AAH21400.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22050.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034305.1, NM_010175.5
UniGeneⁱ	Mm.5126

Genome annotation databases

Ensemblⁱ	ENSMUST00000033394; ENSMUSP00000033394; ENSMUSG00000031077
GeneIDⁱ	14082
KEGGⁱ	mmu:14082
UCSC genome browser More...UCSCⁱ	uc009kql.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q61160	FAS-associated death domain protein		MUSSP		205	UniRef90_Q61160
FAS-associated death domain protein		MOUSE		205
UPI000A30769C		MUSPA		205
UPI000A3155F7		MUSCR		205

Protein	Similar proteins		Species	Score	Length	Source
Q61160	FAS-associated death domain protein	)	HUMAN		208	UniRef50_Q13158
FAS-associated death domain protein		BOVIN		209
FAS-associated death domain protein		PONAB		208
FAS-associated death domain protein		NOMLE		208
FAS-associated death domain protein		MACFA		208
+74

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U50406 mRNA Translation: AAB07789.1 U43184 mRNA Translation: AAA97876.1 AK084808 mRNA Translation: BAC39283.1 AK169798 mRNA Translation: BAE41374.1 AK170927 mRNA Translation: BAE42120.1 BC004584 mRNA Translation: AAH04584.1 BC021400 mRNA Translation: AAH21400.1
CCDSⁱ	CCDS22050.1
RefSeqⁱ	NP_034305.1, NM_010175.5
UniGeneⁱ	Mm.5126

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1FAD	NMR	-	A	89-183	[»]
ProteinModelPortalⁱ	Q61160
SMRⁱ	Q61160
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199586, 13 interactors
ComplexPortalⁱ	CPX-1914 Ripoptosome
DIPⁱ	DIP-34771N
IntActⁱ	Q61160, 15 interactors
MINTⁱ	Q61160
STRINGⁱ	10090.ENSMUSP00000033394

PTM databases

iPTMnetⁱ	Q61160
PhosphoSitePlusⁱ	Q61160

Proteomic databases

EPDⁱ	Q61160
MaxQBⁱ	Q61160
PaxDbⁱ	Q61160
PeptideAtlasⁱ	Q61160
PRIDEⁱ	Q61160

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033394; ENSMUSP00000033394; ENSMUSG00000031077
GeneIDⁱ	14082
KEGGⁱ	mmu:14082
UCSCⁱ	uc009kql.1 mouse

Organism-specific databases

CTDⁱ	8772
MGIⁱ	MGI:109324 Fadd

Phylogenomic databases

eggNOGⁱ	ENOG410J0KM Eukaryota ENOG41122TX LUCA
GeneTreeⁱ	ENSGT00390000002105
HOGENOMⁱ	HOG000112490
HOVERGENⁱ	HBG000853
InParanoidⁱ	Q61160
KOⁱ	K02373
OMAⁱ	CQMNLVA
OrthoDBⁱ	EOG091G0SHT
PhylomeDBⁱ	Q61160
TreeFamⁱ	TF102046

Enzyme and pathway databases

Reactomeⁱ	R-MMU-140534 via Death Receptors in the presence of ligand R-MMU-2562578 TRIF-mediated programmed cell death R-MMU-3371378 Regulation by c-FLIP R-MMU-5213460 RIPK1-mediated regulated necrosis R-MMU-5218900 CASP8 activity is inhibited R-MMU-5357786 TNFR1-induced proapoptotic signaling R-MMU-69416 Dimerization of procaspase-8 R-MMU-75157 FasL/ CD95L signaling R-MMU-75158 TRAIL signaling

Reactomeⁱ

R-MMU-140534 via Death Receptors in the presence of ligand
R-MMU-2562578 TRIF-mediated programmed cell death
R-MMU-3371378 Regulation by c-FLIP
R-MMU-5213460 RIPK1-mediated regulated necrosis
R-MMU-5218900 CASP8 activity is inhibited
R-MMU-5357786 TNFR1-induced proapoptotic signaling
R-MMU-69416 Dimerization of procaspase-8
R-MMU-75157 FasL/ CD95L signaling
R-MMU-75158 TRAIL signaling

Miscellaneous databases

EvolutionaryTraceⁱ	Q61160
Protein Ontology More...PROⁱ	PR:Q61160
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031077 Expressed in 217 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_FADD
Genevisibleⁱ	Q61160 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR001875 DED_dom IPR016729 FADD
Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF01335 DED, 1 hit
PIRSFⁱ	PIRSF018586 FADD, 1 hit
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM00031 DED, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit
PROSITEⁱ	View protein in PROSITE PS50017 DEATH_DOMAIN, 1 hit PS50168 DED, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FADD_MOUSE
Accessionⁱ	Q61160Primary (citable) accession number: Q61160 Secondary accession number(s): Q3TC37, Q61082
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q61160 (FADD_MOUSE)

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FAS-associated death domain protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ