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Protein

FAS-associated death domain protein

Gene

Fadd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-140534 via Death Receptors in the presence of ligand
R-MMU-2562578 TRIF-mediated programmed cell death
R-MMU-3371378 Regulation by c-FLIP
R-MMU-5213460 RIPK1-mediated regulated necrosis
R-MMU-5218900 CASP8 activity is inhibited
R-MMU-5357786 TNFR1-induced proapoptotic signaling
R-MMU-69416 Dimerization of procaspase-8
R-MMU-75157 FasL/ CD95L signaling
R-MMU-75158 TRAIL signaling

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated death domain protein
Alternative name(s):
FAS-associating death domain-containing protein
Mediator of receptor induced toxicity
Protein FADD
Gene namesi
Name:Fadd
Synonyms:Mort1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109324 Fadd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912801 – 205FAS-associated death domain proteinAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61160
MaxQBiQ61160
PaxDbiQ61160
PeptideAtlasiQ61160
PRIDEiQ61160

PTM databases

iPTMnetiQ61160
PhosphoSitePlusiQ61160

Expressioni

Gene expression databases

BgeeiENSMUSG00000031077 Expressed in 217 organ(s), highest expression level in primary oocyte
CleanExiMM_FADD
GenevisibleiQ61160 MM

Interactioni

Subunit structurei

Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with PIDD1 (By similarity). Interacts with FAS (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199586, 13 interactors
ComplexPortaliCPX-1914 Ripoptosome
DIPiDIP-34771N
IntActiQ61160, 15 interactors
MINTiQ61160
STRINGi10090.ENSMUSP00000033394

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ61160
SMRiQ61160
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ61160

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81DEDPROSITE-ProRule annotationAdd BLAST79
Domaini97 – 181DeathPROSITE-ProRule annotationAdd BLAST85

Domaini

Contains a death domain involved in the binding of the corresponding domain within Fas receptor.

Phylogenomic databases

eggNOGiENOG410J0KM Eukaryota
ENOG41122TX LUCA
GeneTreeiENSGT00390000002105
HOGENOMiHOG000112490
HOVERGENiHBG000853
InParanoidiQ61160
KOiK02373
OMAiCQMNLVA
OrthoDBiEOG091G0SHT
PhylomeDBiQ61160
TreeFamiTF102046

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001875 DED_dom
IPR016729 FADD
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF01335 DED, 1 hit
PIRSFiPIRSF018586 FADD, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50168 DED, 1 hit

Sequencei

Sequence statusi: Complete.

Q61160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPFLVLLHS LSGSLSGNDL MELKFLCRER VSKRKLERVQ SGLDLFTVLL
60 70 80 90 100
EQNDLERGHT GLLRELLASL RRHDLLQRLD DFEAGTATAA PPGEADLQVA
110 120 130 140 150
FDIVCDNVGR DWKRLARELK VSEAKMDGIE EKYPRSLSER VRESLKVWKN
160 170 180 190 200
AEKKNASVAG LVKALRTCRL NLVADLVEEA QESVSKSENM SPVLRDSTVS

SSETP
Length:205
Mass (Da):22,960
Last modified:November 1, 1997 - v1
Checksum:i4BC8D86B33A58783
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168C → F in AAA97876 (PubMed:8565075).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50406 mRNA Translation: AAB07789.1
U43184 mRNA Translation: AAA97876.1
AK084808 mRNA Translation: BAC39283.1
AK169798 mRNA Translation: BAE41374.1
AK170927 mRNA Translation: BAE42120.1
BC004584 mRNA Translation: AAH04584.1
BC021400 mRNA Translation: AAH21400.1
CCDSiCCDS22050.1
RefSeqiNP_034305.1, NM_010175.5
UniGeneiMm.5126

Genome annotation databases

EnsembliENSMUST00000033394; ENSMUSP00000033394; ENSMUSG00000031077
GeneIDi14082
KEGGimmu:14082
UCSCiuc009kql.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50406 mRNA Translation: AAB07789.1
U43184 mRNA Translation: AAA97876.1
AK084808 mRNA Translation: BAC39283.1
AK169798 mRNA Translation: BAE41374.1
AK170927 mRNA Translation: BAE42120.1
BC004584 mRNA Translation: AAH04584.1
BC021400 mRNA Translation: AAH21400.1
CCDSiCCDS22050.1
RefSeqiNP_034305.1, NM_010175.5
UniGeneiMm.5126

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FADNMR-A89-183[»]
ProteinModelPortaliQ61160
SMRiQ61160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199586, 13 interactors
ComplexPortaliCPX-1914 Ripoptosome
DIPiDIP-34771N
IntActiQ61160, 15 interactors
MINTiQ61160
STRINGi10090.ENSMUSP00000033394

PTM databases

iPTMnetiQ61160
PhosphoSitePlusiQ61160

Proteomic databases

EPDiQ61160
MaxQBiQ61160
PaxDbiQ61160
PeptideAtlasiQ61160
PRIDEiQ61160

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033394; ENSMUSP00000033394; ENSMUSG00000031077
GeneIDi14082
KEGGimmu:14082
UCSCiuc009kql.1 mouse

Organism-specific databases

CTDi8772
MGIiMGI:109324 Fadd

Phylogenomic databases

eggNOGiENOG410J0KM Eukaryota
ENOG41122TX LUCA
GeneTreeiENSGT00390000002105
HOGENOMiHOG000112490
HOVERGENiHBG000853
InParanoidiQ61160
KOiK02373
OMAiCQMNLVA
OrthoDBiEOG091G0SHT
PhylomeDBiQ61160
TreeFamiTF102046

Enzyme and pathway databases

ReactomeiR-MMU-140534 via Death Receptors in the presence of ligand
R-MMU-2562578 TRIF-mediated programmed cell death
R-MMU-3371378 Regulation by c-FLIP
R-MMU-5213460 RIPK1-mediated regulated necrosis
R-MMU-5218900 CASP8 activity is inhibited
R-MMU-5357786 TNFR1-induced proapoptotic signaling
R-MMU-69416 Dimerization of procaspase-8
R-MMU-75157 FasL/ CD95L signaling
R-MMU-75158 TRAIL signaling

Miscellaneous databases

EvolutionaryTraceiQ61160
PROiPR:Q61160
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031077 Expressed in 217 organ(s), highest expression level in primary oocyte
CleanExiMM_FADD
GenevisibleiQ61160 MM

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001875 DED_dom
IPR016729 FADD
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF01335 DED, 1 hit
PIRSFiPIRSF018586 FADD, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50168 DED, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFADD_MOUSE
AccessioniPrimary (citable) accession number: Q61160
Secondary accession number(s): Q3TC37, Q61082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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