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Protein

Ceruloplasmin

Gene

Cp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 6 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi120Copper 1; type 2By similarity1
Metal bindingi122Copper 2; type 3By similarity1
Metal bindingi179Copper 2; type 3By similarity1
Metal bindingi181Copper 3; type 3By similarity1
Metal bindingi294Copper 4; type 1By similarity1
Metal bindingi337Copper 4; type 1By similarity1
Metal bindingi342Copper 4; type 1By similarity1
Metal bindingi651Copper 5; type 1By similarity1
Metal bindingi694Copper 5; type 1By similarity1
Metal bindingi699Copper 5; type 1By similarity1
Metal bindingi704Copper 5; type 1By similarity1
Metal bindingi989Copper 6; type 1By similarity1
Metal bindingi992Copper 1; type 2By similarity1
Metal bindingi994Copper 3; type 3By similarity1
Metal bindingi1034Copper 3; type 3By similarity1
Metal bindingi1035Copper 6; type 1By similarity1
Metal bindingi1036Copper 2; type 3By similarity1
Metal bindingi1040Copper 6; type 1By similarity1
Metal bindingi1045Copper 6; type 1By similarity1

GO - Molecular functioni

  • chaperone binding Source: MGI
  • copper ion binding Source: MGI
  • ferroxidase activity Source: MGI
  • oxidoreductase activity, oxidizing metal ions Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCopper transport, Ion transport, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

BRENDAi1.16.3.1 3474
ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-425410 Metal ion SLC transporters
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ceruloplasmin (EC:1.16.3.1)
Alternative name(s):
Ferroxidase
Gene namesi
Name:Cp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88476 Cp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000000291320 – 1061CeruloplasminAdd BLAST1042

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi173 ↔ 199By similarity
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi275 ↔ 356By similarity
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi529 ↔ 555By similarity
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi632 ↔ 713By similarity
Glycosylationi757N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi869 ↔ 895By similarity
Glycosylationi921N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61147
PaxDbiQ61147
PeptideAtlasiQ61147
PRIDEiQ61147

PTM databases

GlyConnecti689
iPTMnetiQ61147
PhosphoSitePlusiQ61147
SwissPalmiQ61147

Expressioni

Tissue specificityi

Expressed in many tissues, including liver, eye and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000003617 Expressed in 221 organ(s), highest expression level in liver
CleanExiMM_CP
ExpressionAtlasiQ61147 baseline and differential
GenevisibleiQ61147 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198851, 1 interactor
IntActiQ61147, 6 interactors
MINTiQ61147
STRINGi10090.ENSMUSP00000103965

Structurei

3D structure databases

ProteinModelPortaliQ61147
SMRiQ61147
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 356F5/8 type A 1Add BLAST337
Domaini20 – 199Plastocyanin-like 1Add BLAST180
Domaini208 – 356Plastocyanin-like 2Add BLAST149
Domaini369 – 713F5/8 type A 2Add BLAST345
Domaini369 – 555Plastocyanin-like 3Add BLAST187
Domaini565 – 713Plastocyanin-like 4Add BLAST149
Domaini725 – 1056F5/8 type A 3Add BLAST332
Domaini725 – 895Plastocyanin-like 5Add BLAST171
Domaini903 – 1056Plastocyanin-like 6Add BLAST154

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
GeneTreeiENSGT00910000143988
HOGENOMiHOG000231499
HOVERGENiHBG003674
InParanoidiQ61147
KOiK13624
OMAiMGMGNEV
PhylomeDBiQ61147
TreeFamiTF329807

Family and domain databases

Gene3Di2.60.40.420, 6 hits
InterProiView protein in InterPro
IPR027150 CP
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR024715 Factor_5/8_like
PANTHERiPTHR44048:SF5 PTHR44048:SF5, 1 hit
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 3 hits
PIRSFiPIRSF000354 Factors_V_VIII, 1 hit
SUPFAMiSSF49503 SSF49503, 6 hits
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 3 hits
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q61147-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLLLSTFI FLYSSLALAR DKHYFIGITE AVWDYASGTE EKKLISVDTE
60 70 80 90 100
QSNFYLQNGP DRIGRKYKKA LYFEYTDGTF SKTIDKPAWL GFLGPVIKAE
110 120 130 140 150
VEDKVYVHLK NLASRIYTFH AHGVTYTKEY EGAVYPDNTT DFQRADDKVL
160 170 180 190 200
PGQQYVYVLH ANEPSPGEGD SNCVTRIYHS HVDAPKDIAS GLIGPLILCK
210 220 230 240 250
KGSLYKEKEK NIDQEFVLMF SVVDENLSWY LEDNIKTFCS EPEKVDKDNE
260 270 280 290 300
DFQESNRMYS INGYTFGSLP GLSMCAADRV KWYLFGMGNE VDVHSAFFHG
310 320 330 340 350
QALTSRNYQT DIINLFPATL IDAYMVAQNP GVWMLSCQNL NHLKAGLQAF
360 370 380 390 400
FQVRDCNKPS PEDNIQDRHV RHYYIAAEEV IWNYAPSGTD IFTGENLTAL
410 420 430 440 450
ESDSRVFFEQ GATRIGGSYK KMAYREYTDG SFTNRKQRGP DEEHLGILGP
460 470 480 490 500
VIWAEVGDTI KVTFHNKGQH PLSIQPMGVS FTAENEGTYY GPPGRSSQQA
510 520 530 540 550
ASHVAPKETF TYEWTVPKEM GPTYADPVCL SKMYYSGVDP TKDIFTGLIG
560 570 580 590 600
PMKICKKGSL LADGRQKDVD KEFYLFPTVF DENESLLLDD NIRMFTTAPD
610 620 630 640 650
QVDKEDEDFQ ESNKMHSMNG FMYGNQPGLN MCLGESIVWY LFSAGNEADV
660 670 680 690 700
HGIYFSGNTY LSKGERRDTA NLFPHKSLTL LMNPDTKGTF DVECLTTDHY
710 720 730 740 750
TGGMKQKYTV NQCQRQFEDF TVYLGERTYY VAAVEVEWDY SPSRAWEKEL
760 770 780 790 800
HHLQEQNVSN VFLDKEEFFI GSKYKKVVYR QFTDSSFREQ VKRRAEDEHL
810 820 830 840 850
GILGPPIHAN VGDKVKVVFK NMATRPYSIH AHGVKTESST VVPTLPGEVR
860 870 880 890 900
TYTWQIPERS GAGREDSACI PWAYYSTVDR VKDLYSGLIG PLIVCRKSYV
910 920 930 940 950
KVFSPKKKME FFLLFLVFDE NESWYLDDNI KTYSEHPEKV NKDNEEFLES
960 970 980 990 1000
NKMHAINGKM FGNLQGLTMH VKDEVNWYVM GMGNEIDLHT VHFHGHSFQY
1010 1020 1030 1040 1050
KHRGVYSSDV FDLFPGTYQT LEMFPQTPGT WLLHCHVTDH VHAGMATTYT
1060
VLPVEQETKS G
Length:1,061
Mass (Da):121,151
Last modified:December 4, 2007 - v2
Checksum:i16A2DAEA4F483886
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X8Q5G3X8Q5_MOUSE
Ceruloplasmin
Cp mCG_19773
1,085Annotation score:
E9PZD8E9PZD8_MOUSE
Ceruloplasmin
Cp
1,086Annotation score:
G3X9T8G3X9T8_MOUSE
Ceruloplasmin
Cp mCG_19773
1,060Annotation score:
G3UWP5G3UWP5_MOUSE
Ceruloplasmin
Cp
197Annotation score:
G3UXG1G3UXG1_MOUSE
Ceruloplasmin
Cp
120Annotation score:
G3UZ53G3UZ53_MOUSE
Ceruloplasmin
Cp
58Annotation score:
G3UXD2G3UXD2_MOUSE
Ceruloplasmin
Cp
52Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354R → Q in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti361 – 362PE → SK in AAB07996 (PubMed:8690795).Curated2
Sequence conflicti366 – 368QDR → RGK in AAB07996 (PubMed:8690795).Curated3
Sequence conflicti389T → I in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti394 – 396GEN → EEK in AAB07996 (PubMed:8690795).Curated3
Sequence conflicti400 – 401LE → SG in AAB07996 (PubMed:8690795).Curated2
Sequence conflicti405R → G in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti437Q → E in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti471P → H in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti495R → A in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti537G → A in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti597T → H in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti627 – 630PGLN → SWPH in AAB07996 (PubMed:8690795).Curated4
Sequence conflicti662S → C in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti666R → E in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti732A → D in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti796E → EE in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti850R → A in AAB07996 (PubMed:8690795).Curated1
Sequence conflicti979V → L in AAB07996 (PubMed:8690795).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49430 mRNA Translation: AAB07996.1
BC062957 mRNA Translation: AAH62957.1
CCDSiCCDS38401.1
RefSeqiNP_001263177.1, NM_001276248.1
NP_031778.2, NM_007752.3
UniGeneiMm.13787

Genome annotation databases

EnsembliENSMUST00000091309; ENSMUSP00000088857; ENSMUSG00000003617
GeneIDi12870
KEGGimmu:12870
UCSCiuc008orz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49430 mRNA Translation: AAB07996.1
BC062957 mRNA Translation: AAH62957.1
CCDSiCCDS38401.1
RefSeqiNP_001263177.1, NM_001276248.1
NP_031778.2, NM_007752.3
UniGeneiMm.13787

3D structure databases

ProteinModelPortaliQ61147
SMRiQ61147
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198851, 1 interactor
IntActiQ61147, 6 interactors
MINTiQ61147
STRINGi10090.ENSMUSP00000103965

PTM databases

GlyConnecti689
iPTMnetiQ61147
PhosphoSitePlusiQ61147
SwissPalmiQ61147

Proteomic databases

MaxQBiQ61147
PaxDbiQ61147
PeptideAtlasiQ61147
PRIDEiQ61147

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091309; ENSMUSP00000088857; ENSMUSG00000003617
GeneIDi12870
KEGGimmu:12870
UCSCiuc008orz.2 mouse

Organism-specific databases

CTDi1356
MGIiMGI:88476 Cp

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
GeneTreeiENSGT00910000143988
HOGENOMiHOG000231499
HOVERGENiHBG003674
InParanoidiQ61147
KOiK13624
OMAiMGMGNEV
PhylomeDBiQ61147
TreeFamiTF329807

Enzyme and pathway databases

BRENDAi1.16.3.1 3474
ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-425410 Metal ion SLC transporters
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-917937 Iron uptake and transport

Miscellaneous databases

ChiTaRSiCp mouse
PROiPR:Q61147
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003617 Expressed in 221 organ(s), highest expression level in liver
CleanExiMM_CP
ExpressionAtlasiQ61147 baseline and differential
GenevisibleiQ61147 MM

Family and domain databases

Gene3Di2.60.40.420, 6 hits
InterProiView protein in InterPro
IPR027150 CP
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR024715 Factor_5/8_like
PANTHERiPTHR44048:SF5 PTHR44048:SF5, 1 hit
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 3 hits
PIRSFiPIRSF000354 Factors_V_VIII, 1 hit
SUPFAMiSSF49503 SSF49503, 6 hits
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 3 hits
PS00080 MULTICOPPER_OXIDASE2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCERU_MOUSE
AccessioniPrimary (citable) accession number: Q61147
Secondary accession number(s): Q6P5C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 4, 2007
Last modified: November 7, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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