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Entry version 155 (13 Feb 2019)
Sequence version 4 (03 Oct 2012)
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Protein

Astrotactin-1

Gene

Astn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell-cell adhesion Source: MGI
  • cell migration Source: MGI
  • locomotory behavior Source: MGI
  • neuron cell-cell adhesion Source: MGI
  • neuron migration Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Astrotactin-1
Alternative name(s):
Neuronal migration protein GC14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Astn1
Synonyms:Astn, Kiaa0289
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1098567 Astn1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 153ExtracellularCuratedAdd BLAST132
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 388CytoplasmicCuratedAdd BLAST214
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Topological domaini410 – 1302ExtracellularCurated1 PublicationAdd BLAST893

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Slower than normal migration of granule cells in the developing cerebellum, leading to a decreased cerebellum size in adult mice and impaired skills in tasks that require coordinated movement and balance. Granule cells from mutant mice have a rounded shape and lack the elongated shape seen in wild-type. At 6 days after birth, increased granule cell apoptosis is observed, contrary to the situation in wild-type.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000748222 – 1302Astrotactin-1Add BLAST1281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei227PhosphoserineCombined sources1
Modified residuei337Omega-N-methylarginineCombined sources1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi463 ↔ 475By similarity
Disulfide bondi471 ↔ 490By similarity
Disulfide bondi492 ↔ 506By similarity
Disulfide bondi612 ↔ 625By similarity
Disulfide bondi619 ↔ 636By similarity
Disulfide bondi638 ↔ 651By similarity
Disulfide bondi660 ↔ 672By similarity
Disulfide bondi668 ↔ 692By similarity
Disulfide bondi694 ↔ 707By similarity
Glycosylationi729N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi742N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi785 ↔ 951By similarity
Glycosylationi804N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi876 ↔ 941By similarity
Disulfide bondi947 ↔ 954By similarity
Glycosylationi984N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1000 ↔ 1011By similarity
Disulfide bondi1013 ↔ 1026By similarity
Disulfide bondi1101 ↔ 1121By similarity
Disulfide bondi1153 ↔ 1240By similarity
Disulfide bondi1261 ↔ 1284By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q61137

PRoteomics IDEntifications database

More...
PRIDEi
Q61137

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q61137

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q61137

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain (at protein level) (PubMed:11861479). Expressed specifically in the brain. Expressed in the cerebellum, hippocampus, cerebrum and olfactory bulb (PubMed:8602532).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected in embryonic brain at 12 dpc. Expression increases thereafter, is highest in brain from pups 4 days after birth, and then decreases again. Expression is decreased 14 days after birth, and not detectable in adult brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026587 Expressed in 192 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q61137 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q61137 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ASTN2; the interaction is not calcium-dependent.1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q61137, 2 interactors

Molecular INTeraction database

More...
MINTi
Q61137

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q61137

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q61137

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini459 – 507EGF-like 1Add BLAST49
Domaini608 – 652EGF-like 2Add BLAST45
Domaini656 – 708EGF-like 3Add BLAST53
Domaini1030 – 1145Fibronectin type-IIIAdd BLAST116

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the astrotactin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHIU Eukaryota
ENOG4110VB2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003140

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034112

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050597

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q61137

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALYNILM

Database of Orthologous Groups

More...
OrthoDBi
39300at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332034

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026995 Astrotactin
IPR000742 EGF-like_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR020864 MACPF

The PANTHER Classification System

More...
PANTHERi
PTHR16592 PTHR16592, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00457 MACPF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q61137-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALAGLCALF ACCWGPAAVL ATAAGDVDPS KELECKLKSI TVSALPFLRE
60 70 80 90 100
NDLSIMHSPS ASEPKLLFSV RNDFPGEMVV VDDLENTELP YFVLEISGNT
110 120 130 140 150
EDIPLVRWRQ QWLENGTLLF HIHHQDGAPS LPGQDPTEEP QHESAEEELR
160 170 180 190 200
ILHISVMGGM IALLLSILCL VMILYTRRRW CKRRRVPQPQ KSASAEAANE
210 220 230 240 250
IHYIPSVLIG GHGRESLRNA RVQGHNSSGT LSIRETPILD GYEYDITDLR
260 270 280 290 300
HHLQRECMNG GEDFASQVTR TLDSLQGCNE KSGMDLTPGS DNAKLSLMNK
310 320 330 340 350
YKDNIIATSP VDSNHQQATL LSHTSSSQRK RINNKARAGS AFLNPEGDSS
360 370 380 390 400
TEAENDPQLT FYTDPSRSRR RSRVGSPRSP VNKTTLTLIS VTSCVIGLVC
410 420 430 440 450
SSHVSCPLVV KITLHVPEHL IADGSRFILL EGSQLDASDW LNPAQVVLFS
460 470 480 490 500
QQNSSGPWAM DLCARRLLDP CEHQCDPETG RREHRAAGEC LCYEGYMKDP
510 520 530 540 550
VHKHLCIRNE WGTNQGPWPY TIFQRGFDLV LGEQPSDKIF RFTYTLGEGM
560 570 580 590 600
WLPLSKSFVI PPAELAINPS AKCKTDMTVM EDAVEVREEL MTSSSFDSLE
610 620 630 640 650
VLLDSFGPVR DCSKDNGGCS KNFRCISDRK LDSTGCVCPS GLSPMKDSSG
660 670 680 690 700
CYDRHIGVDC SDGFNGGCEQ LCLQQMAPFP EDPTLYNILM FCGCIEDYKL
710 720 730 740 750
GVDGRSCQLV TETCPEGGDC GESREVPMNQ TLFGEMFFGY NNQSKEVATG
760 770 780 790 800
QVLKGTFRQN NFARGLDQQL PDGLVVASVP LENQCLEEIS EPTPDPDFLT
810 820 830 840 850
GMVNFSEVSG YPVLQHWKVR SVMYHIKLNQ AAISQAFSNA LHSLDGATSR
860 870 880 890 900
ADFVALLDQF GNHYIQEAVY GFEESCSIWY PNKQVQRRLW LEYEDISKGN
910 920 930 940 950
SPSDESEERE RDPKVLTFPE YIASLSDSGT KRMAAGVRME CQSKGRCPSS
960 970 980 990 1000
CPLCHVTSSP ETPAEPVLLE VTRASPIYEL VTNNQTQRLL QEATMSSLWC
1010 1020 1030 1040 1050
SGTGDVIEDW CRCDSTAFGA DGLPTCAPLP QPVLRLSTVH EPSSNLVVLE
1060 1070 1080 1090 1100
WEHSEPPIGV QIVDYLIRQE KVTDRMDHSK VETETVLSFV DDIISGAKAP
1110 1120 1130 1140 1150
CAMPSQVPDK QLTTISLIIR CLEPDTIYMF TLWGVDNTGR RSRPSDVIVK
1160 1170 1180 1190 1200
TPCPVVDDVK AQEIADKIYN LFNGYTSGKE QQTAYNTLLD LGSPTLHRVL
1210 1220 1230 1240 1250
YHYNQHYESF GEFTWRCEDE LGPRKAGLIL SQLGDLSSWC NGLLQEPKIS
1260 1270 1280 1290 1300
LRRGSLKYLG CRYSEIKPYG LDWSELSRDL RKTCEEQTLS VPYNDYGDSK

DI
Length:1,302
Mass (Da):144,884
Last modified:October 3, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC917C4281401C97
GO
Isoform 2 (identifier: Q61137-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     480-487: Missing.

Note: No experimental confirmation available.
Show »
Length:1,294
Mass (Da):143,950
Checksum:i35EA0CADED41FFB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWE6A0A0A6YWE6_MOUSE
Astrotactin-1
Astn1
1,172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TPU9Q3TPU9_MOUSE
Astrotactin-1
Astn1
840Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXJ4A0A0A6YXJ4_MOUSE
Astrotactin-1
Astn1
893Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YVT7A0A0A6YVT7_MOUSE
Astrotactin-1
Astn1
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWD1A0A0A6YWD1_MOUSE
Astrotactin-1
Astn1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWJ9A0A0A6YWJ9_MOUSE
Astrotactin-1
Astn1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC52516 differs from that shown. Reason: Frameshift at positions 84, 92, 185, 274, 370, 439, 469, 488, 592 and 595.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti216S → T in AAC52516 (PubMed:8602532).Curated1
Sequence conflicti369R → L in AAC52516 (PubMed:8602532).Curated1
Sequence conflicti396I → L in BAC41406 (PubMed:12465718).Curated1
Sequence conflicti421I → M in AAH94666 (PubMed:15489334).Curated1
Sequence conflicti437A → R in AAC52516 (PubMed:8602532).Curated1
Sequence conflicti681E → D in BAC41406 (PubMed:12465718).Curated1
Sequence conflicti1045N → T in BAC41406 (PubMed:12465718).Curated1
Sequence conflicti1067I → Y in AAC52516 (PubMed:8602532).Curated1
Sequence conflicti1214Missing in AAC52516 (PubMed:8602532).Curated1
Sequence conflicti1260 – 1261GC → AG in AAC52516 (PubMed:8602532).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014917480 – 487Missing in isoform 2. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC091266 Genomic DNA No translation available.
AC118728 Genomic DNA No translation available.
AC119867 Genomic DNA No translation available.
AC158910 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39354.1
BC054545 mRNA Translation: AAH54545.1
BC094666 mRNA Translation: AAH94666.1
U48797 mRNA Translation: AAC52516.1 Frameshift.
AB093222 mRNA Translation: BAC41406.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS56648.1 [Q61137-1]
CCDS78721.1 [Q61137-2]

NCBI Reference Sequences

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RefSeqi
NP_001192133.1, NM_001205204.1 [Q61137-1]
NP_031521.2, NM_007495.4 [Q61137-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.329586

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000046110; ENSMUSP00000039711; ENSMUSG00000026587 [Q61137-2]
ENSMUST00000193042; ENSMUSP00000142322; ENSMUSG00000026587 [Q61137-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11899

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:11899

UCSC genome browser

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UCSCi
uc007ddu.3 mouse [Q61137-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091266 Genomic DNA No translation available.
AC118728 Genomic DNA No translation available.
AC119867 Genomic DNA No translation available.
AC158910 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39354.1
BC054545 mRNA Translation: AAH54545.1
BC094666 mRNA Translation: AAH94666.1
U48797 mRNA Translation: AAC52516.1 Frameshift.
AB093222 mRNA Translation: BAC41406.2
CCDSiCCDS56648.1 [Q61137-1]
CCDS78721.1 [Q61137-2]
RefSeqiNP_001192133.1, NM_001205204.1 [Q61137-1]
NP_031521.2, NM_007495.4 [Q61137-2]
UniGeneiMm.329586

3D structure databases

ProteinModelPortaliQ61137
SMRiQ61137
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61137, 2 interactors
MINTiQ61137

PTM databases

iPTMnetiQ61137
PhosphoSitePlusiQ61137

Proteomic databases

PaxDbiQ61137
PRIDEiQ61137

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046110; ENSMUSP00000039711; ENSMUSG00000026587 [Q61137-2]
ENSMUST00000193042; ENSMUSP00000142322; ENSMUSG00000026587 [Q61137-1]
GeneIDi11899
KEGGimmu:11899
UCSCiuc007ddu.3 mouse [Q61137-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
460
MGIiMGI:1098567 Astn1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IHIU Eukaryota
ENOG4110VB2 LUCA
GeneTreeiENSGT00390000003140
HOGENOMiHOG000034112
HOVERGENiHBG050597
InParanoidiQ61137
OMAiALYNILM
OrthoDBi39300at2759
TreeFamiTF332034

Miscellaneous databases

Protein Ontology

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PROi
PR:Q61137

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026587 Expressed in 192 organ(s), highest expression level in forebrain
ExpressionAtlasiQ61137 baseline and differential
GenevisibleiQ61137 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
InterProiView protein in InterPro
IPR026995 Astrotactin
IPR000742 EGF-like_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR020864 MACPF
PANTHERiPTHR16592 PTHR16592, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00457 MACPF, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASTN1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q61137
Secondary accession number(s): G5E8A1
, Q505A0, Q7TQG3, Q8CHH2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2012
Last modified: February 13, 2019
This is version 155 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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