Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase theta-2

Gene

Gstt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-2 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-2
Gene namesi
Name:Gstt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:106188 Gstt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859411 – 244Glutathione S-transferase theta-2Add BLAST244

Proteomic databases

EPDiQ61133
PaxDbiQ61133
PeptideAtlasiQ61133
PRIDEiQ61133

PTM databases

iPTMnetiQ61133
PhosphoSitePlusiQ61133

Expressioni

Tissue specificityi

In liver, highest expression found in central vein limiting plate hepatocytes. Also expressed in interlobular bile duct epithelial cells. In lung, expressed in Clara cells and ciliated cells of the bronchiolar epithelium and in type II alveolar cells of the lung parenchyma.

Gene expression databases

BgeeiENSMUSG00000033318
CleanExiMM_GSTT2
ExpressionAtlasiQ61133 baseline and differential
GenevisibleiQ61133 MM

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiQ61133, 2 interactors
MINTiQ61133
STRINGi10090.ENSMUSP00000046324

Structurei

3D structure databases

ProteinModelPortaliQ61133
SMRiQ61133
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82GST N-terminalAdd BLAST81
Domaini88 – 230GST C-terminalAdd BLAST143

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00540000069741
HOGENOMiHOG000125747
HOVERGENiHBG051854
InParanoidiQ61133
KOiK00799
OMAiVEEYLSW
OrthoDBiEOG091G0PCG
TreeFamiTF325759

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q61133-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELYLDLL SQPSRAVYIF AKKNGIPFQT RTVDILKGQH MSEQFSQVNC
60 70 80 90 100
LNKVPVLKDG SFVLTESTAI LIYLSSKYQV ADHWYPADLQ ARAQVHEYLG
110 120 130 140 150
WHADNIRGTF GVLLWTKVLG PLIGVQVPQE KVERNRDRMV LVLQQLEDKF
160 170 180 190 200
LRDRAFLVGQ QVTLADLMSL EELMQPVALG YNLFEGRPQL TAWRERVEAF
210 220 230 240
LGAELCQEAH STILSILGQA AKKMLPVPPP EVHASMQLRI ARIP
Length:244
Mass (Da):27,634
Last modified:October 3, 2012 - v4
Checksum:i3F45D6E12DA3DF29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38Missing in AAB03533 (PubMed:8617493).Curated1
Sequence conflicti67S → R in AAB03533 (PubMed:8617493).Curated1
Sequence conflicti178A → G in AAB03534 (PubMed:8617493).Curated1
Sequence conflicti206C → Y in AAB03534 (PubMed:8617493).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48419 Genomic DNA Translation: AAB03533.1
U48420 mRNA Translation: AAB03534.1
X98056 mRNA Translation: CAA66666.1
AK002392 mRNA Translation: BAB22065.1
AK158939 mRNA Translation: BAE34734.1
AC142499 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL31881.1
BC012707 mRNA Translation: AAH12707.1
CCDSiCCDS48601.1
PIRiS71879
RefSeqiNP_034491.2, NM_010361.2
XP_006513303.1, XM_006513240.1
UniGeneiMm.24118

Genome annotation databases

EnsembliENSMUST00000038257; ENSMUSP00000046324; ENSMUSG00000033318
ENSMUST00000220440; ENSMUSP00000151239; ENSMUSG00000033318
GeneIDi14872
KEGGimmu:14872
UCSCiuc011xgs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGSTT2_MOUSE
AccessioniPrimary (citable) accession number: Q61133
Secondary accession number(s): Q61134, Q64472, Q91VB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health