UniProtKB - Q61125 (BKRB1_MOUSE)
Protein
B1 bradykinin receptor
Gene
Bdkrb1
Organism
Mus musculus (Mouse)
Status
Functioni
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
GO - Molecular functioni
- bradykinin receptor activity Source: MGI
- G protein-coupled receptor activity Source: GO_Central
- peptide binding Source: MGI
GO - Biological processi
- cell migration Source: MGI
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: MGI
- negative regulation of blood pressure Source: MGI
- negative regulation of cell growth Source: MGI
- negative regulation of protein phosphorylation Source: MGI
- positive regulation of leukocyte migration Source: MGI
- positive regulation of release of sequestered calcium ion into cytosol Source: MGI
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: MGI
- response to lipopolysaccharide Source: MGI
- response to mechanical stimulus Source: InterPro
- sensory perception of pain Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: B1 bradykinin receptorShort name: B1R Short name: BK-1 receptor |
Gene namesi | Name:Bdkrb1 Synonyms:Bdkrb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88144, Bdkrb1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
- neuron projection Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 62 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 80 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 81 – 101 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 102 – 118 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 119 – 139 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 161 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 162 – 182 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 183 – 214 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 215 – 235 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 236 – 258 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 259 – 279 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 280 – 302 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 303 – 323 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 324 – 334 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069184 | 1 – 334 | B1 bradykinin receptorAdd BLAST | 334 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 117 ↔ 196 | PROSITE-ProRule annotation | ||
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q61125 |
PRIDEi | Q61125 |
PTM databases
GlyGeni | Q61125, 3 sites |
PhosphoSitePlusi | Q61125 |
Expressioni
Tissue specificityi
Expressed in heart, liver and lung.
Inductioni
By lipopolysaccharide (LPS) in heart, liver and lung five hours after treatment.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000041347, Expressed in embryo and 54 other tissues |
ExpressionAtlasi | Q61125, baseline and differential |
Genevisiblei | Q61125, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045335 |
Chemistry databases
BindingDBi | Q61125 |
Miscellaneous databases
RNActi | Q61125, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222307 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | Q61125 |
OMAi | WTPYHFF |
OrthoDBi | 951204at2759 |
PhylomeDBi | Q61125 |
TreeFami | TF330024 |
Family and domain databases
InterProi | View protein in InterPro IPR001186, Brdyknn_1_rcpt IPR000496, Brdyknn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00425, BRADYKININR PR00993, BRADYKINNB1R PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q61125-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASQASLKLQ PSNQSQQAPP NITSCEGAPE AWDLLCRVLP GFVITVCFFG
60 70 80 90 100
LLGNLLVLSF FLLPWRRWWQ QRRQRLTIAE IYLANLAASD LVFVLGLPFW
110 120 130 140 150
AENVGNRFNW PFGSDLCRVV SGVIKANLFI SIFLVVAISQ DRYRLLVYPM
160 170 180 190 200
TSWGNRRRRQ AQVTCLLIWV AGGLLSTPTF LLRSVKVVPD LNISACILLF
210 220 230 240 250
PHEAWHFVRM VELNVLGFLL PLAAILYFNF HILASLRGQK EASRTRCGGP
260 270 280 290 300
KDSKTMGLIL TLVASFLVCW APYHFFAFLD FLVQVRVIQD CFWKELTDLG
310 320 330
LQLANFFAFV NSCLNPLIYV FAGRLFKTRV LGTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketS4R1G8 | S4R1G8_MOUSE | B1 bradykinin receptor | Bdkrb1 | 268 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | L → V in AAD00029 (Ref. 2) Curated | 1 | |
Sequence conflicti | 260 | L → P (Ref. 2) Curated | 1 | |
Sequence conflicti | 263 – 265 | VAS → SSL (Ref. 2) Curated | 3 | |
Sequence conflicti | 331 – 334 | LGTL → WELYKRCTSLKNAVLPSRKE LFQLSCWN in AAD00029 (Ref. 2) Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U47281 Genomic DNA Translation: AAA99778.1 U44436 Genomic DNA Translation: AAD00029.1 |
CCDSi | CCDS26155.1 |
PIRi | JC4681 |
RefSeqi | NP_031565.1, NM_007539.3 |
Genome annotation databases
Ensembli | ENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347 ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347 |
GeneIDi | 12061 |
KEGGi | mmu:12061 |
UCSCi | uc007oyn.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U47281 Genomic DNA Translation: AAA99778.1 U44436 Genomic DNA Translation: AAD00029.1 |
CCDSi | CCDS26155.1 |
PIRi | JC4681 |
RefSeqi | NP_031565.1, NM_007539.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045335 |
Chemistry databases
BindingDBi | Q61125 |
ChEMBLi | CHEMBL1250407 |
GuidetoPHARMACOLOGYi | 41 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q61125, 3 sites |
PhosphoSitePlusi | Q61125 |
Proteomic databases
PaxDbi | Q61125 |
PRIDEi | Q61125 |
Protocols and materials databases
Antibodypediai | 153, 310 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000041229; ENSMUSP00000045335; ENSMUSG00000041347 ENSMUST00000182899; ENSMUSP00000138118; ENSMUSG00000041347 |
GeneIDi | 12061 |
KEGGi | mmu:12061 |
UCSCi | uc007oyn.1, mouse |
Organism-specific databases
CTDi | 623 |
MGIi | MGI:88144, Bdkrb1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222307 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | Q61125 |
OMAi | WTPYHFF |
OrthoDBi | 951204at2759 |
PhylomeDBi | Q61125 |
TreeFami | TF330024 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 12061, 1 hit in 19 CRISPR screens |
PROi | PR:Q61125 |
RNActi | Q61125, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041347, Expressed in embryo and 54 other tissues |
ExpressionAtlasi | Q61125, baseline and differential |
Genevisiblei | Q61125, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001186, Brdyknn_1_rcpt IPR000496, Brdyknn_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00425, BRADYKININR PR00993, BRADYKINNB1R PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BKRB1_MOUSE | |
Accessioni | Q61125Primary (citable) accession number: Q61125 Secondary accession number(s): Q9Z1F4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries