UniProtKB - Q61121 (GPR19_MOUSE)
Protein
Probable G-protein coupled receptor 19
Gene
Gpr19
Organism
Mus musculus (Mouse)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 19 |
Gene namesi | Name:Gpr19 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:892973, Gpr19 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cilium Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 69 | ExtracellularSequence analysisAdd BLAST | 69 | |
Transmembranei | 70 – 90 | Helical; Name=1Add BLAST | 21 | |
Topological domaini | 91 – 102 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 103 – 123 | Helical; Name=2Add BLAST | 21 | |
Topological domaini | 124 – 152 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 153 – 173 | Helical; Name=3Add BLAST | 21 | |
Topological domaini | 174 – 182 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 183 – 203 | Helical; Name=4Add BLAST | 21 | |
Topological domaini | 204 – 221 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 222 – 242 | Helical; Name=5Add BLAST | 21 | |
Topological domaini | 243 – 277 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 278 – 298 | Helical; Name=6Add BLAST | 21 | |
Topological domaini | 299 – 309 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 310 – 332 | Helical; Name=7Add BLAST | 23 | |
Topological domaini | 333 – 415 | CytoplasmicSequence analysisAdd BLAST | 83 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069539 | 1 – 415 | Probable G-protein coupled receptor 19Add BLAST | 415 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 138 ↔ 210 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q61121 |
PRIDEi | Q61121 |
PTM databases
GlyGeni | Q61121, 2 sites |
PhosphoSitePlusi | Q61121 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032641, Expressed in femur and 272 other tissues |
ExpressionAtlasi | Q61121, baseline and differential |
Genevisiblei | Q61121, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000047630 |
Miscellaneous databases
RNActi | Q61121, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160365 |
HOGENOMi | CLU_009579_20_0_1 |
InParanoidi | Q61121 |
PhylomeDBi | Q61121 |
TreeFami | TF331630 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q61121-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVFAHRMDND QPPVVTATLL VPLQNSSCAE AAEALLPHGL MGLHEEHSWM
60 70 80 90 100
SNRTELQYEL NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT
110 120 130 140 150
NYFVVSMACA DLLISVASTP FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG
160 170 180 190 200
VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KKMIAASWIL DAAFVTPVFF
210 220 230 240 250
FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSILII LFYQKVIKYI
260 270 280 290 300
WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP
310 320 330 340 350
HEQDYKKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM
360 370 380 390 400
KCYRSNAYTI TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK
410
KLAWPINSNP PNTFV
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SSP1 | A0A1L1SSP1_MOUSE | Probable G-protein-coupled receptor... | Gpr19 | 464 | Annotation score: | ||
A0A1N9MDH9 | A0A1N9MDH9_MOUSE | Probable G-protein-coupled receptor... | Gpr19 | 501 | Annotation score: | ||
A0A0N4SVJ1 | A0A0N4SVJ1_MOUSE | Probable G-protein-coupled receptor... | Gpr19 | 135 | Annotation score: | ||
A0A0N4SV21 | A0A0N4SV21_MOUSE | Probable G-protein-coupled receptor... | Gpr19 | 78 | Annotation score: | ||
A0A0N4SWA6 | A0A0N4SWA6_MOUSE | Probable G-protein-coupled receptor... | Gpr19 | 96 | Annotation score: | ||
A0A1L1SUR2 | A0A1L1SUR2_MOUSE | Probable G-protein-coupled receptor... | Gpr19 | 54 | Annotation score: | ||
A0A1L1SRU3 | A0A1L1SRU3_MOUSE | Probable G-protein-coupled receptor... | Gpr19 | 32 | Annotation score: | ||
A0A1L1SRV5 | A0A1L1SRV5_MOUSE | Probable G-protein-coupled receptor... | Gpr19 | 67 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | S → G in AAA93354 (Ref. 1) Curated | 1 | |
Sequence conflicti | 304 | D → G in AAH50187 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 323 | S → P in AAH50187 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016527 | 1 – 6 | Missing in isoform 2. 3 Publications | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46923 mRNA Translation: AAA93354.1 AK132917 mRNA Translation: BAE21421.1 AK140770 mRNA Translation: BAE24474.1 BC021648 mRNA Translation: AAH21648.1 BC050187 mRNA Translation: AAH50187.1 |
CCDSi | CCDS20641.1 [Q61121-2] CCDS51937.1 [Q61121-1] |
RefSeqi | NP_001161166.1, NM_001167694.2 [Q61121-1] NP_001161167.1, NM_001167695.2 [Q61121-2] NP_001161168.1, NM_001167696.2 [Q61121-2] NP_001161169.1, NM_001167697.2 [Q61121-1] NP_001161171.1, NM_001167699.2 [Q61121-1] NP_001161172.1, NM_001167700.2 [Q61121-2] NP_032183.2, NM_008157.3 [Q61121-2] XP_006505617.1, XM_006505554.1 XP_017176882.1, XM_017321393.1 |
Genome annotation databases
Ensembli | ENSMUST00000046255; ENSMUSP00000047630; ENSMUSG00000032641 [Q61121-1] ENSMUST00000111932; ENSMUSP00000107563; ENSMUSG00000032641 [Q61121-2] ENSMUST00000116515; ENSMUSP00000112214; ENSMUSG00000032641 [Q61121-2] ENSMUST00000165392; ENSMUSP00000127876; ENSMUSG00000032641 [Q61121-2] |
GeneIDi | 14760 |
KEGGi | mmu:14760 |
UCSCi | uc009ekv.3, mouse [Q61121-1] uc009eky.3, mouse [Q61121-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46923 mRNA Translation: AAA93354.1 AK132917 mRNA Translation: BAE21421.1 AK140770 mRNA Translation: BAE24474.1 BC021648 mRNA Translation: AAH21648.1 BC050187 mRNA Translation: AAH50187.1 |
CCDSi | CCDS20641.1 [Q61121-2] CCDS51937.1 [Q61121-1] |
RefSeqi | NP_001161166.1, NM_001167694.2 [Q61121-1] NP_001161167.1, NM_001167695.2 [Q61121-2] NP_001161168.1, NM_001167696.2 [Q61121-2] NP_001161169.1, NM_001167697.2 [Q61121-1] NP_001161171.1, NM_001167699.2 [Q61121-1] NP_001161172.1, NM_001167700.2 [Q61121-2] NP_032183.2, NM_008157.3 [Q61121-2] XP_006505617.1, XM_006505554.1 XP_017176882.1, XM_017321393.1 |
3D structure databases
SMRi | Q61121 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000047630 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q61121, 2 sites |
PhosphoSitePlusi | Q61121 |
Proteomic databases
PaxDbi | Q61121 |
PRIDEi | Q61121 |
Protocols and materials databases
Antibodypediai | 2961, 150 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000046255; ENSMUSP00000047630; ENSMUSG00000032641 [Q61121-1] ENSMUST00000111932; ENSMUSP00000107563; ENSMUSG00000032641 [Q61121-2] ENSMUST00000116515; ENSMUSP00000112214; ENSMUSG00000032641 [Q61121-2] ENSMUST00000165392; ENSMUSP00000127876; ENSMUSG00000032641 [Q61121-2] |
GeneIDi | 14760 |
KEGGi | mmu:14760 |
UCSCi | uc009ekv.3, mouse [Q61121-1] uc009eky.3, mouse [Q61121-2] |
Organism-specific databases
CTDi | 2842 |
MGIi | MGI:892973, Gpr19 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160365 |
HOGENOMi | CLU_009579_20_0_1 |
InParanoidi | Q61121 |
PhylomeDBi | Q61121 |
TreeFami | TF331630 |
Miscellaneous databases
BioGRID-ORCSi | 14760, 0 hits in 18 CRISPR screens |
ChiTaRSi | Gpr19, mouse |
PROi | PR:Q61121 |
RNActi | Q61121, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032641, Expressed in femur and 272 other tissues |
ExpressionAtlasi | Q61121, baseline and differential |
Genevisiblei | Q61121, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR19_MOUSE | |
Accessioni | Q61121Primary (citable) accession number: Q61121 Secondary accession number(s): Q810I4, Q8VDJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | December 6, 2005 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families