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Protein

SHC-transforming protein 3

Gene

Shc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).By similarity

GO - Molecular functioni

  • phosphotyrosine residue binding Source: MGI
  • receptor tyrosine kinase binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-167044 Signalling to RAS
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
SHC-transforming protein 3
Alternative name(s):
Neuronal Shc
Short name:
N-Shc
SHC-transforming protein C
Src homology 2 domain-containing-transforming protein C3
Short name:
SH2 domain protein C3
Gene namesi
Name:Shc3
Synonyms:Nshc, ShcC
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:106179 Shc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977351 – 474SHC-transforming protein 3Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282PhosphoserineCombined sources1

Post-translational modificationi

Tyrosine phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61120
PaxDbiQ61120
PeptideAtlasiQ61120
PRIDEiQ61120

PTM databases

iPTMnetiQ61120
PhosphoSitePlusiQ61120

Expressioni

Tissue specificityi

Predominantly expressed in the adult brain.

Gene expression databases

BgeeiENSMUSG00000021448 Expressed in 98 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ61120 baseline and differential
GenevisibleiQ61120 MM

Interactioni

Subunit structurei

Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AppP120232EBI-79107,EBI-78814

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203216, 3 interactors
IntActiQ61120, 1 interactor
MINTiQ61120
STRINGi10090.ENSMUSP00000021898

Structurei

3D structure databases

ProteinModelPortaliQ61120
SMRiQ61120
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 214PIDPROSITE-ProRule annotationAdd BLAST186
Domaini379 – 470SH2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni215 – 378CH1Add BLAST164

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3697 Eukaryota
ENOG410XTJN LUCA
GeneTreeiENSGT00390000018860
HOGENOMiHOG000231974
HOVERGENiHBG050121
InParanoidiQ61120
KOiK17448
OMAiLKAEPWY
OrthoDBiEOG091G04DC
TreeFamiTF315807

Family and domain databases

CDDicd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029593 Shc3/ShcC/N-Shc
IPR035676 SHC_SH2
PANTHERiPTHR10337:SF4 PTHR10337:SF4, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q61120-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR
60 70 80 90 100
SLDFSTRTQV TREAISRVCE AVPGAKGALK KRKPPSKMLS SILGKSNLQF
110 120 130 140 150
AGMSISLTIS TASLNLRTPD SKQIIANHHM RSISFASGGD PDTTDYVAYV
160 170 180 190 200
AKDPVNRRAC HILECCDGLA QDVIGSIGQA FELRFKQYLQ CPSKVPALQD
210 220 230 240 250
RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL KGRPHAPEAA
260 270 280 290 300
QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE
310 320 330 340 350
TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS
360 370 380 390 400
KAASVECISP VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL
410 420 430 440 450
VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE GTIRTKDRVF DSISHLINYH
460 470
LESSLPIVSA GSELCLQQPV ERKP
Length:474
Mass (Da):52,121
Last modified:July 27, 2011 - v2
Checksum:i18550FB1C5F0F270
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3ZAX3Q3ZAX3_MOUSE
SHC-transforming protein 3
Shc3
341Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71A → R in AAC52508 (PubMed:8610109).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46854 mRNA Translation: AAC52508.1
BC103612 mRNA Translation: AAI03613.1
BC105644 mRNA Translation: AAI05645.1
BC105645 mRNA Translation: AAI05646.1
CCDSiCCDS49265.1
RefSeqiNP_033193.2, NM_009167.3
UniGeneiMm.131870

Genome annotation databases

EnsembliENSMUST00000021898; ENSMUSP00000021898; ENSMUSG00000021448
GeneIDi20418
KEGGimmu:20418
UCSCiuc007qmg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46854 mRNA Translation: AAC52508.1
BC103612 mRNA Translation: AAI03613.1
BC105644 mRNA Translation: AAI05645.1
BC105645 mRNA Translation: AAI05646.1
CCDSiCCDS49265.1
RefSeqiNP_033193.2, NM_009167.3
UniGeneiMm.131870

3D structure databases

ProteinModelPortaliQ61120
SMRiQ61120
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203216, 3 interactors
IntActiQ61120, 1 interactor
MINTiQ61120
STRINGi10090.ENSMUSP00000021898

PTM databases

iPTMnetiQ61120
PhosphoSitePlusiQ61120

Proteomic databases

MaxQBiQ61120
PaxDbiQ61120
PeptideAtlasiQ61120
PRIDEiQ61120

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021898; ENSMUSP00000021898; ENSMUSG00000021448
GeneIDi20418
KEGGimmu:20418
UCSCiuc007qmg.1 mouse

Organism-specific databases

CTDi53358
MGIiMGI:106179 Shc3

Phylogenomic databases

eggNOGiKOG3697 Eukaryota
ENOG410XTJN LUCA
GeneTreeiENSGT00390000018860
HOGENOMiHOG000231974
HOVERGENiHBG050121
InParanoidiQ61120
KOiK17448
OMAiLKAEPWY
OrthoDBiEOG091G04DC
TreeFamiTF315807

Enzyme and pathway databases

ReactomeiR-MMU-167044 Signalling to RAS
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-8853659 RET signaling

Miscellaneous databases

ChiTaRSiShc3 mouse
PROiPR:Q61120
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021448 Expressed in 98 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ61120 baseline and differential
GenevisibleiQ61120 MM

Family and domain databases

CDDicd01209 PTB_Shc, 1 hit
cd09925 SH2_SHC, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR006019 PID_Shc-like
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR029593 Shc3/ShcC/N-Shc
IPR035676 SHC_SH2
PANTHERiPTHR10337:SF4 PTHR10337:SF4, 1 hit
PfamiView protein in Pfam
PF00640 PID, 1 hit
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00629 SHCPIDOMAIN
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 1 hit
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHC3_MOUSE
AccessioniPrimary (citable) accession number: Q61120
Secondary accession number(s): Q3ZAX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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