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Protein

BPI fold-containing family B member 1

Gene

Bpifb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. May be involved in formation of the left-right axis in the node of the developing embryo.2 Publications

Miscellaneous

Asymmetric expression in the embryonic node is dependent on Invs and Dnahc11.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 1
Alternative name(s):
Long palate, lung and nasal epithelium carcinoma-associated protein 1
Gene namesi
Name:Bpifb1
Synonyms:Lplunc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2137431 Bpifb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001718122 – 474BPI fold-containing family B member 1Add BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 200By similarity
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61114
PaxDbiQ61114
PeptideAtlasiQ61114
PRIDEiQ61114

PTM databases

iPTMnetiQ61114
PhosphoSitePlusiQ61114

Expressioni

Tissue specificityi

Expressed in tongue, lung, thymus, and stomach. Expressed in epithelia of palate, anterior pharynx, trachea and upper bronchi. Expressed in distal tip of papillae in the anterior third of the tongue and in serous cells of von Ebner glands in the posterior third of the tongue. Expressed in columnar epithelium of the duodenum in embryonic gut at 16.5 dpc.2 Publications

Developmental stagei

Detectable in crown cells of the embryonic node from E7.5. Initial uniform expression develops asymmetrically with a higher level on the left side of the node until expression disappears around E13.5. Expressed in antrum pyloricum of the stomach from E11.5 to E16.5 and in dorsal tongue epithelium from E14.5 to E16.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000027485 Expressed in 229 organ(s), highest expression level in cochlea
CleanExiMM_U46068
GenevisibleiQ61114 MM

Interactioni

Protein-protein interaction databases

IntActiQ61114, 1 interactor
MINTiQ61114
STRINGi10090.ENSMUSP00000028987

Structurei

3D structure databases

ProteinModelPortaliQ61114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPI/LBP/Plunc superfamily. Plunc family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00920000149112
HOGENOMiHOG000231564
HOVERGENiHBG052339
InParanoidiQ61114
OMAiLCPVIKA
OrthoDBiEOG091G0CAE
PhylomeDBiQ61114
TreeFamiTF338541

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR021193 Bpifb1
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF037186 PLUNC_long_form, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61114-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGPWIITLL CGLLGATLVQ ANVYPPAVLN LGPEVIQKHL TQALKDHDAT
60 70 80 90 100
AILQELPLLR AMQDKSGSIP ILDSFVHTVL RYIIWMKVTS ANILQLDVQP
110 120 130 140 150
STYDQELVVR IPLDMVAGLN TPLIKTIVEF QMSTEVQALI RVERSKSGPA
160 170 180 190 200
HLNLSDCSSN ESTLRLSLLH KLSFVVNSLA KNVMNLLVPA LPQIVKNHLC
210 220 230 240 250
PVIQQAFDDM YEDFLRLTTA PIALSPGALE FGLLSPAIQD SNILLNLKAK
260 270 280 290 300
LLDSQARVTN WFNNSATSLM ETTPDRAPFS LTVRQDLVNA IVTTLVPKEE
310 320 330 340 350
LVILLRFVIP DVARQLQMDI KEINAEAANK LGPTQMLKIF THSTPHIVLN
360 370 380 390 400
EGSARAAQSV VLEVFPTNTD VRPFFSLGIE ASYEAQFFTE DNRLMLNFNN
410 420 430 440 450
VSIERIKLMI SDIKLFDPEV LKDTLTKILE YTLLPNENGK LRTGVPMSMS
460 470
KALGYEKAMW SVSKGALKLT PASS
Length:474
Mass (Da):52,455
Last modified:May 2, 2006 - v4
Checksum:i4CDF2CB13BA4F57A
GO

Sequence cautioni

The sequence AAA87581 differs from that shown. Reason: Frameshift at position 69.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137Q → R in AAH60982 (PubMed:15489334).Curated1
Sequence conflicti361V → M in AAH60982 (PubMed:15489334).Curated1
Sequence conflicti395M → T in AAI00437 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46068 mRNA Translation: AAA87581.3 Frameshift.
AL732601 Genomic DNA No translation available.
BC060982 mRNA Translation: AAH60982.1
BC100436 mRNA Translation: AAI00437.1
CCDSiCCDS16927.1
RefSeqiNP_001012392.1, NM_001012392.1
NP_700467.2, NM_153418.2
UniGeneiMm.3783

Genome annotation databases

EnsembliENSMUST00000028987; ENSMUSP00000028987; ENSMUSG00000027485
ENSMUST00000081816; ENSMUSP00000080501; ENSMUSG00000027485
GeneIDi228801
KEGGimmu:228801
UCSCiuc008niw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46068 mRNA Translation: AAA87581.3 Frameshift.
AL732601 Genomic DNA No translation available.
BC060982 mRNA Translation: AAH60982.1
BC100436 mRNA Translation: AAI00437.1
CCDSiCCDS16927.1
RefSeqiNP_001012392.1, NM_001012392.1
NP_700467.2, NM_153418.2
UniGeneiMm.3783

3D structure databases

ProteinModelPortaliQ61114
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61114, 1 interactor
MINTiQ61114
STRINGi10090.ENSMUSP00000028987

PTM databases

iPTMnetiQ61114
PhosphoSitePlusiQ61114

Proteomic databases

MaxQBiQ61114
PaxDbiQ61114
PeptideAtlasiQ61114
PRIDEiQ61114

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028987; ENSMUSP00000028987; ENSMUSG00000027485
ENSMUST00000081816; ENSMUSP00000080501; ENSMUSG00000027485
GeneIDi228801
KEGGimmu:228801
UCSCiuc008niw.1 mouse

Organism-specific databases

CTDi92747
MGIiMGI:2137431 Bpifb1

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00920000149112
HOGENOMiHOG000231564
HOVERGENiHBG052339
InParanoidiQ61114
OMAiLCPVIKA
OrthoDBiEOG091G0CAE
PhylomeDBiQ61114
TreeFamiTF338541

Enzyme and pathway databases

ReactomeiR-MMU-6803157 Antimicrobial peptides

Miscellaneous databases

ChiTaRSiBpifb1 mouse
PROiPR:Q61114
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027485 Expressed in 229 organ(s), highest expression level in cochlea
CleanExiMM_U46068
GenevisibleiQ61114 MM

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR032942 BPI/LBP/Plunc
IPR021193 Bpifb1
IPR001124 Lipid-bd_serum_glycop_C
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF037186 PLUNC_long_form, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBPIB1_MOUSE
AccessioniPrimary (citable) accession number: Q61114
Secondary accession number(s): A2AJD5, Q497Q1, Q4VC32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 2, 2006
Last modified: November 7, 2018
This is version 122 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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