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Protein

45 kDa calcium-binding protein

Gene

Sdf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi110 – 1211PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi149 – 1602PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi208 – 2193PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi245 – 2564PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi290 – 3015PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi326 – 3376PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: BHF-UCL
  • identical protein binding Source: MGI

GO - Biological processi

  • calcium ion regulated exocytosis Source: MGI
  • cerebellum development Source: BHF-UCL
  • fat cell differentiation Source: BHF-UCL
  • response to ethanol Source: BHF-UCL
  • UV protection Source: BHF-UCL
  • zymogen granule exocytosis Source: MGI

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
45 kDa calcium-binding protein
Short name:
Cab45
Alternative name(s):
Stromal cell-derived factor 4
Short name:
SDF-4
Gene namesi
Name:Sdf4
Synonyms:Cab45
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:108079 Sdf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000000415736 – 36145 kDa calcium-binding proteinAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei98PhosphoserineBy similarity1
Modified residuei192PhosphothreonineBy similarity1
Modified residuei216PhosphothreonineBy similarity1
Modified residuei264PhosphothreonineBy similarity1
Modified residuei298PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ61112
PaxDbiQ61112
PeptideAtlasiQ61112
PRIDEiQ61112

PTM databases

iPTMnetiQ61112
PhosphoSitePlusiQ61112

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000029076
CleanExiMM_SDF4
GenevisibleiQ61112 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203141, 1 interactor
STRINGi10090.ENSMUSP00000053175

Structurei

3D structure databases

ProteinModelPortaliQ61112
SMRiQ61112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 132EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini136 – 171EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini196 – 231EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini232 – 267EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini277 – 312EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini313 – 348EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 361Necessary for intracellular retention in Golgi apparatus lumenAdd BLAST54

Domaini

Binds calcium, probably via its EF-hands.

Sequence similaritiesi

Belongs to the CREC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4251 Eukaryota
ENOG410XSH7 LUCA
GeneTreeiENSGT00550000074546
HOGENOMiHOG000007329
HOVERGENiHBG097344
InParanoidiQ61112
KOiK19934
OMAiAKQMIAI
OrthoDBiEOG091G0GSA
PhylomeDBiQ61112
TreeFamiTF314849

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 5 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 5 hits
PS50222 EF_HAND_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61112-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVWLVAMTPR QSSLCGLAAH GLWFLGLVLL MDATARPANH SSTRERAANR
60 70 80 90 100
EENEIMPPDH LNGVKLEMDG HLNKDFHQEV FLGKDMDGFD EDSEPRRSRR
110 120 130 140 150
KLMVIFSKVD VNTDRRISAK EMQHWIMEKT AEHFQEAVKE NKLHFRAVDP
160 170 180 190 200
DGDGHVSWDE YKVKFLASKG HNEREIAEAI KNHEELKVDE ETQEVLGNLR
210 220 230 240 250
DRWYQADNPP ADLLLTEDEF LSFLHPEHSR GMLKFMVKEI FRDLDQDGDK
260 270 280 290 300
QLSLPEFISL PVGTVENQQG QDIDDNWVKD RKKEFEELID SNHDGIVTME
310 320 330 340 350
ELENYMDPMN EYNALNEAKQ MIAIADENQN HHLEPEEILK YSEFFTGSKL
360
MDYARNVHEE F
Length:361
Mass (Da):42,064
Last modified:November 1, 1997 - v1
Checksum:i2599E99F5F81A913
GO
Isoform 2 (identifier: Q61112-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-218: TQEVLGNLRDRWYQADNPPADLLLTED → IALHFLLLTGGPLSCSSGETSICLSRL
     219-361: Missing.

Show »
Length:218
Mass (Da):24,843
Checksum:i4E2CEDDA099881ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti281R → K in CAB45A. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037450192 – 218TQEVL…LLTED → IALHFLLLTGGPLSCSSGET SICLSRL in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_037451219 – 361Missing in isoform 2. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45977 mRNA Translation: AAB01812.1
U45978 mRNA Translation: AAB01813.1
D50461 mRNA Translation: BAA09052.1
AK157860 mRNA Translation: BAE34238.1
AK163400 mRNA Translation: BAE37334.1
AK167113 mRNA Translation: BAE39261.1
AL627204 Genomic DNA Translation: CAM13857.1
AL627204 Genomic DNA Translation: CAO78017.1
CH466594 Genomic DNA Translation: EDL15066.1
BC068152 mRNA Translation: AAH68152.1
CCDSiCCDS19054.1 [Q61112-1]
CCDS80198.1 [Q61112-2]
RefSeqiNP_001289396.1, NM_001302467.1 [Q61112-1]
NP_001289397.1, NM_001302468.1 [Q61112-1]
NP_001289398.1, NM_001302469.1 [Q61112-2]
NP_035471.1, NM_011341.5 [Q61112-1]
UniGeneiMm.293517

Genome annotation databases

EnsembliENSMUST00000050078; ENSMUSP00000053175; ENSMUSG00000029076 [Q61112-1]
ENSMUST00000097734; ENSMUSP00000095340; ENSMUSG00000029076 [Q61112-2]
ENSMUST00000105578; ENSMUSP00000101203; ENSMUSG00000029076 [Q61112-1]
ENSMUST00000105579; ENSMUSP00000101204; ENSMUSG00000029076 [Q61112-1]
GeneIDi20318
KEGGimmu:20318
UCSCiuc008wfr.2 mouse [Q61112-1]
uc056zys.1 mouse [Q61112-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAB45_MOUSE
AccessioniPrimary (citable) accession number: Q61112
Secondary accession number(s): Q3TK84, Q3TQP8, Q61113
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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