UniProtKB - Q61098 (IL18R_MOUSE)
Protein
Interleukin-18 receptor 1
Gene
Il18r1
Organism
Mus musculus (Mouse)
Status
Functioni
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (PubMed:26099046).By similarity1 Publication
Catalytic activityi
- EC:3.2.2.6PROSITE-ProRule annotationThis reaction proceeds in the forwardPROSITE-ProRule annotation direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 452 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- interleukin-18 binding Source: UniProtKB
- interleukin-18 receptor activity Source: MGI
- NAD(P)+ nucleosidase activity Source: UniProtKB-EC
- NAD+ nucleotidase, cyclic ADP-ribose generating Source: UniProtKB-EC
GO - Biological processi
- inflammatory response Source: UniProtKB-KW
- interleukin-18-mediated signaling pathway Source: MGI
- natural killer cell activation Source: MGI
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of interferon-gamma production Source: MGI
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: MGI
- positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
- T-helper 1 cell differentiation Source: MGI
Keywordsi
Molecular function | Hydrolase, Receptor |
Biological process | Inflammatory response |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-18 receptor 1 (EC:3.2.2.6PROSITE-ProRule annotation)Short name: IL-18R-1 Short name: IL-18R1 Alternative name(s): CD218 antigen-like family member A IL1 receptor-related protein Short name: IL-1Rrp Short name: IL1R-rp Interleukin-18 receptor alpha Short name: IL-18R-alpha Short name: IL-18Ralpha CD_antigen: CD218a |
Gene namesi | Name:Il18r1Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105383, Il18r1 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type I membrane protein Curated
Plasma Membrane
- interleukin-18 receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 326 | ExtracellularSequence analysisAdd BLAST | 307 | |
Transmembranei | 327 – 347 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 348 – 537 | CytoplasmicSequence analysisAdd BLAST | 190 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000015449 | 20 – 537 | Interleukin-18 receptor 1Add BLAST | 518 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 22 ↔ 41 | By similarity | ||
Glycosylationi | 50 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 107 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 120 ↔ 159 | By similarity | ||
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 141 ↔ 182 | PROSITE-ProRule annotation | ||
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 200 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 233 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 234 ↔ 296 | PROSITE-ProRule annotation | ||
Glycosylationi | 295 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q61098 |
MaxQBi | Q61098 |
PaxDbi | Q61098 |
PRIDEi | Q61098 |
PTM databases
GlyGeni | Q61098, 10 sites |
PhosphoSitePlusi | Q61098 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026070, Expressed in right lung and 85 other tissues |
Genevisiblei | Q61098, MM |
Interactioni
Subunit structurei
Forms a ternary complex with IL18 and IL18RAP (By similarity). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (By similarity).
Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (PubMed:26099046).
By similarity1 PublicationBinary interactionsi
Q61098
With | #Exp. | IntAct |
---|---|---|
Slc12a3 [P59158] | 5 | EBI-13612516,EBI-8366645 |
GO - Molecular functioni
- interleukin-18 binding Source: UniProtKB
Protein-protein interaction databases
IntActi | Q61098, 1 interactor |
STRINGi | 10090.ENSMUSP00000103679 |
Miscellaneous databases
RNActi | Q61098, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 102 | Ig-like C2-type 1Add BLAST | 70 | |
Domaini | 134 – 189 | Ig-like C2-type 2Add BLAST | 56 | |
Domaini | 212 – 312 | Ig-like C2-type 3Add BLAST | 101 | |
Domaini | 370 – 516 | TIRPROSITE-ProRule annotationAdd BLAST | 147 |
Domaini
The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.PROSITE-ProRule annotation
Sequence similaritiesi
Belongs to the interleukin-1 receptor family.Curated
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUAC, Eukaryota |
GeneTreei | ENSGT01000000214361 |
HOGENOMi | CLU_025552_3_1_1 |
InParanoidi | Q61098 |
OMAi | NFLEFWP |
OrthoDBi | 985064at2759 |
PhylomeDBi | Q61098 |
TreeFami | TF325519 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR015621, IL-1_rcpt_fam IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS50104, TIR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q61098-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHHEELILTL CILIVKSASK SCIHRSQIHV VEGEPFYLKP CGISAPVHRN
60 70 80 90 100
ETATMRWFKG SASHEYRELN NRSSPRVTFH DHTLEFWPVE MEDEGTYISQ
110 120 130 140 150
VGNDRRNWTL NVTKRNKHSC FSDKLVTSRD VEVNKSLHIT CKNPNYEELI
160 170 180 190 200
QDTWLYKNCK EISKTPRILK DAEFGDEGYY SCVFSVHHNG TRYNITKTVN
210 220 230 240 250
ITVIEGRSKV TPAILGPKCE KVGVELGKDV ELNCSASLNK DDLFYWSIRK
260 270 280 290 300
EDSSDPNVQE DRKETTTWIS EGKLHASKIL RFQKITENYL NVLYNCTVAN
310 320 330 340 350
EEAIDTKSFV LVRKEIPDIP GHVFTGGVTV LVLASVAAVC IVILCVIYKV
360 370 380 390 400
DLVLFYRRIA ERDETLTDGK TYDAFVSYLK ECHPENKEEY TFAVETLPRV
410 420 430 440 450
LEKQFGYKLC IFERDVVPGG AVVEEIHSLI EKSRRLIIVL SQSYLTNGAR
460 470 480 490 500
RELESGLHEA LVERKIKIIL IEFTPASNIT FLPPSLKLLK SYRVLKWRAD
510 520 530
SPSMNSRFWK NLVYLMPAKA VKPWREESEA RSVLSAP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8C257 | Q8C257_MOUSE | Il18r1 protein | Il18r1 | 372 | Annotation score: | ||
A0A0A6YWA3 | A0A0A6YWA3_MOUSE | Interleukin-18 receptor 1 | Il18r1 | 267 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 317 | Missing . | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43673 mRNA Translation: AAC52437.1 |
CCDSi | CCDS35549.1 |
RefSeqi | NP_032391.1, NM_008365.2 XP_006495790.1, XM_006495727.3 XP_006495791.1, XM_006495728.3 XP_006495792.1, XM_006495729.3 XP_006495793.1, XM_006495730.3 XP_006495795.1, XM_006495732.3 XP_006495797.1, XM_006495734.3 |
Genome annotation databases
Ensembli | ENSMUST00000087983; ENSMUSP00000085298; ENSMUSG00000026070 ENSMUST00000108044; ENSMUSP00000103679; ENSMUSG00000026070 ENSMUST00000195684; ENSMUSP00000142070; ENSMUSG00000026070 |
GeneIDi | 16182 |
KEGGi | mmu:16182 |
UCSCi | uc011wjz.1, mouse |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43673 mRNA Translation: AAC52437.1 |
CCDSi | CCDS35549.1 |
RefSeqi | NP_032391.1, NM_008365.2 XP_006495790.1, XM_006495727.3 XP_006495791.1, XM_006495728.3 XP_006495792.1, XM_006495729.3 XP_006495793.1, XM_006495730.3 XP_006495795.1, XM_006495732.3 XP_006495797.1, XM_006495734.3 |
3D structure databases
SMRi | Q61098 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q61098, 1 interactor |
STRINGi | 10090.ENSMUSP00000103679 |
PTM databases
GlyGeni | Q61098, 10 sites |
PhosphoSitePlusi | Q61098 |
Proteomic databases
EPDi | Q61098 |
MaxQBi | Q61098 |
PaxDbi | Q61098 |
PRIDEi | Q61098 |
Protocols and materials databases
Antibodypediai | 2363, 757 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000087983; ENSMUSP00000085298; ENSMUSG00000026070 ENSMUST00000108044; ENSMUSP00000103679; ENSMUSG00000026070 ENSMUST00000195684; ENSMUSP00000142070; ENSMUSG00000026070 |
GeneIDi | 16182 |
KEGGi | mmu:16182 |
UCSCi | uc011wjz.1, mouse |
Organism-specific databases
CTDi | 8809 |
MGIi | MGI:105383, Il18r1 |
Phylogenomic databases
eggNOGi | ENOG502QUAC, Eukaryota |
GeneTreei | ENSGT01000000214361 |
HOGENOMi | CLU_025552_3_1_1 |
InParanoidi | Q61098 |
OMAi | NFLEFWP |
OrthoDBi | 985064at2759 |
PhylomeDBi | Q61098 |
TreeFami | TF325519 |
Miscellaneous databases
BioGRID-ORCSi | 16182, 0 hits in 17 CRISPR screens |
ChiTaRSi | Il18r1, mouse |
PROi | PR:Q61098 |
RNActi | Q61098, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026070, Expressed in right lung and 85 other tissues |
Genevisiblei | Q61098, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR015621, IL-1_rcpt_fam IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL18R_MOUSE | |
Accessioni | Q61098Primary (citable) accession number: Q61098 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families